"School-based interventions should address malleable factors such as the number of peer connections and received friendships that predict the best social outcomes for children with ASD [autism spectrum disorder]."So said the study findings reported by Jill Locke and colleagues  looking at "the stable (unlikely to change) and malleable (changeable) characteristics of socially successful children with ASD."Mindful that the phrase 'socially successful children' is perhaps not one that I'm p........ Read more »
Locke J, Williams J, Shih W, & Kasari C. (2016) Characteristics of socially successful elementary school-aged children with autism. Journal of child psychology and psychiatry, and allied disciplines. PMID: 27620949
A team of researchers has observed what they believe are the building blocks of memories in a mouse brain. In their paper, the researchers describe how they caused certain neurons to become illuminated when they fired, allowing them to watch in real time as memories were made and then later as they were replayed while the mouse was sitting idle.
... Read more »
Malvache, A., Reichinnek, S., Villette, V., Haimerl, C., & Cossart, R. (2016) Awake hippocampal reactivations project onto orthogonal neuronal assemblies. Science, 353(6305), 1280-1283. DOI: 10.1126/science.aaf3319
One clinical challenge is making an accurate diagnosis in patients with dementia.Alzheimer's disease is typically the predominant diagnosis in dementia. However a significant number of patients will present with dementia due to Lewy Body disease, Parkinson's dementia, frontotemporal dementia or vascular dementia.A recent study helps clinicians to distinguish Lewy Body from Alzheimer's dementia and Parkinson's disease.Douglas Scharre and collegues from Ohio State University conducted ........ Read more »
Scharre, D., Chang, S., Nagaraja, H., Park, A., Adeli, A., Agrawal, P., Kloos, A., Kegelmeyer, D., Linder, S., Fritz, N.... (2016) Paired Studies Comparing Clinical Profiles of Lewy Body Dementia with Alzheimer’s and Parkinson’s Diseases. Journal of Alzheimer's Disease, 1-10. DOI: 10.3233/JAD-160384
For the first time, an antibody was able to target and disrupt the Aβ plaques in the brain.... Read more »
Sevigny, J., Chiao, P., Bussière, T., Weinreb, P., Williams, L., Maier, M., Dunstan, R., Salloway, S., Chen, T., Ling, Y.... (2016) The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature, 537(7618), 50-56. DOI: 10.1038/nature19323
Dietary intake in young athletes seem to meet most recommendations, therefore supplementing may only be necessary for a few select micronutrients based on age and gender. ... Read more »
Parnell, J., Wiens, K., & Erdman, K. (2016) Dietary Intakes and Supplement Use in Pre-Adolescent and Adolescent Canadian Athletes. Nutrients, 8(9), 526. DOI: 10.3390/nu8090526
Please use your full stops wisely.I believe that this is the first time that I've talked about postural tachycardia syndrome (PoTS) on this blog as I bring to your attention some rather intriguing findings reported by Hugo Penny and colleagues  on how PoTS and gluten-related disorders might not be unstrange diagnostic bedfellows.PoTS by the way, describes symptoms where standing upright / sitting down induces dizziness, fainting and other symptoms. As well as being quite prevalent in a c........ Read more »
Penny, H., Aziz, I., Ferrar, M., Atkinson, J., Hoggard, N., Hadjivassiliou, M., West, J., & Sanders, D. (2016) Is there a relationship between gluten sensitivity and postural tachycardia syndrome?. European Journal of Gastroenterology , 1. DOI: 10.1097/MEG.0000000000000740
‘Overpronation’ and achilles tendon blood flow... Read more »
Karzis, K., Kalogeris, M., Mandalidis, D., Geladas, N., Karteroliotis, K., & Athanasopoulos, S. (2016) The effect of foot overpronation on Achilles tendon blood supply in healthy male subjects. Scandinavian Journal of Medicine . DOI: 10.1111/sms.12722
"Elevated peripheral pro-NT [neurotensin] levels reflect more severe forms of active celiac disease, indicating a potential role of NT in intestinal inflammation."The suggestion, from Caroline Montén and colleagues , that the neuropeptide called neurotensin might play a role in paediatric coeliac disease is an interesting one that caught my eye recently. Interesting not only because of the potential implications for the archetypal 'gluten-causing' autoimmune condition cal........ Read more »
Montén C, Torinsson Naluai Å, & Agardh D. (2016) Role of pro-neurotensin as marker of paediatric celiac disease. Clinical and experimental immunology. PMID: 27612962
Why do more men die when they attempt suicide than women? The answer could lie in four traits, finds scientists. There are over 6,000 British lives lost to suicide each year, and nearly 75 per cent of those are male. However, research has found women are more likely to suffer from depression, and to attempt to take their own life.
... Read more »
Deshpande, G., Baxi, M., Witte, T., & Robinson, J. (2016) A Neural Basis for the Acquired Capability for Suicide. Frontiers in Psychiatry. DOI: 10.3389/fpsyt.2016.00125
Exergaming using the XBOX Kinect system has the potential to enhance postural control compared to standard gym-based exercise.... Read more »
Barry, G., van Schaik, P., MacSween, A., Dixon, J., & Martin, D. (2016) Exergaming (XBOX Kinect™) versus traditional gym-based exercise for postural control, flow and technology acceptance in healthy adults: a randomised controlled trial. BMC Sports Science, Medicine and Rehabilitation, 8(1). DOI: 10.1186/s13102-016-0050-0
Today's post is a bit of a mash-up including two paper: the first from Emanuela Balestrieri and colleagues  (open-access available here) talking about "increased HERV-H [Human Endogenous Retroviruses - H] transcriptional activity in all autistic patients" included in their cohort (author's words not mine) and the second from D'Agati and colleagues  (open-access available here) describing "the reduction of HERV-H expression and the significant improvement of ADHD&n........ Read more »
Balestrieri E, Cipriani C, Matteucci C, Capodicasa N, Pilika A, Korca I, Sorrentino R, Argaw-Denboba A, Bucci I, Miele MT.... (2016) Transcriptional activity of human endogenous retrovirus in Albanian children with autism spectrum disorders. The new microbiologica, 39(3), 228-31. PMID: 27602423
D'Agati E, Pitzianti M, Balestrieri E, Matteucci C, Sinibaldi Vallebona P, & Pasini A. (2016) First evidence of HERV-H transcriptional activity reduction after methylphenidate treatment in a young boy with ADHD. The new microbiologica, 39(3), 237-9. PMID: 27602426
iPS cell-derived retinal cells have been successfully transplanted from one money to another without need of immunosuppressant drugs.... Read more »
Sugita S, Iwasaki Y, Makabe K, Kamao H, Mandai M, Shiina T, Ogasawara K, Hirami Y, Kurimoto Y, & Takahashi M. (2016) Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models. Stem cell reports. PMID: 27641649
Researchers studying how the brain uses perception of the environment to guide action offer a new understanding of the neural circuits responsible for transforming sensation into movement.
... Read more »
Goard, M., Pho, G., Woodson, J., & Sur, M. (2016) Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions. eLife. DOI: 10.7554/eLife.13764
Impacts and injury and the transition to minimalist running shoes... Read more »
Salzler, M., Kirwan, H., Scarborough, D., Walker, J., Guarino, A., & Berkson, E. (2016) Injuries observed in a prospective transition from traditional to minimalist footwear: correlation of high impact transient forces and lower injury severity. The Physician and Sportsmedicine. DOI: 10.1080/00913847.2016.1238282
'Does Correction of Strabismus Improve Quality of Life in Children with Autism Spectrum Disorder?' went the title of the paper by Pinar Ozer and colleagues . Yes, it may very well do was the answer (but with certain caveats and the requirement for a lot more research in this area).Strabismus, a condition where the eyes don't line up in the same direction, can sometime have some quite noticeable effects on a person's vision and indeed, has been linked to various other non-vision related sympto........ Read more »
Ozer PA, Kabatas EU, Bicer BK, Bodur S, & Kurtul BE. (2016) Does Correction of Strabismus Improve Quality of Life in Children with Autism Spectrum Disorder: Results of a Parent Survey by Ophthalmologists. Seminars in ophthalmology, 1-6. PMID: 27599387
The loss of the of the tumor suppressor gene VHL and the subsequent deregulation of VHL/HIF/VEGF signalling are known to play a role in development of clear cell renal cell carcinoma (ccRCC). Renal tumours associated with BHD syndrome are histologically diverse and include a percentage of ccRCC (Pavlovich et al., 2002). Anti-angiogenic therapies targeting the VHL/HIF/VEGF pathway have emerged in past years (Rini et al., 2006) but the development of resistance to these therapeutic agents is leadi........ Read more »
Kammerer-Jacquet SF, Crouzet L, Brunot A, Dagher J, Pladys A, Edeline J, Laguerre B, Peyronnet B, Mathieu R, Verhoest G.... (2016) Independent association of PD-L1 expression with non-inactivated VHL clear cell renal cell carcinoma - a finding with therapeutic potential. International journal of cancer. PMID: 27623354
by Piter Kehoma Boll If you are walking through a forest in Europe you may find the bark of some trees covered by a thin rosy or orange crust. Commonly known as rosy crust, its scientific name is Peniophora incarnata. As … Continue reading →... Read more »
Lee, H., Yun, S., Jang, S., Kim, G., & Kim, J. (2015) Bioremediation of Polycyclic Aromatic Hydrocarbons in Creosote-Contaminated Soil by Peniophora incarnata KUC8836. Bioremediation Journal, 19(1), 1-8. DOI: 10.1080/10889868.2014.939136
Suay, I., Arenal, F,, Asensio, F. J., Basilio, A., Cabello, M. A., Díez, M. T., García, J. B., González del Val, A., Gorrochategui, J., Hernández, P.... (2000) Screening of basidiomycetes for antimicrobial activities. Antonie van Leeuwenhoek, 78(2), 129-140. DOI: 10.1023/A:1026552024021
A couple of years back on this blog I talked about some rather intriguing research suggesting that epilepsy and autoimmune disease might not be unstrange diagnostic bedfellows (see here) and that a "potential role of autoimmunity must be given due consideration in epilepsy." Today, I'm continuing that research theme as the findings from Zhang Lin and colleagues  caught my eye concluding that: "There is an association between epilepsy and SAD [systemic autoimmune diseases], which ........ Read more »
Lin Z, Si Q, & Xiaoyi Z. (2016) Association between epilepsy and systemic autoimmune diseases: A meta-analysis. Seizure, 160-166. PMID: 27592469
Using archival documents, a new report examines the sugar industry's role in coronary heart disease research and suggests the industry sponsored research to influence the scientific debate to cast doubt on the hazards of sugar and to promote dietary fat as the culprit in heart disease.
... Read more »
Kearns, C., Schmidt, L., & Glantz, S. (2016) Sugar Industry and Coronary Heart Disease Research. JAMA Internal Medicine. DOI: 10.1001/jamainternmed.2016.5394
The mighty water bear Tardigrades, aka water bears, are tiny animals that can be found just about everywhere on earth, with a slight preference for the moisture in moss. They happily amble along on their four pairs of legs and slurp up plant cells, algae, and even smaller invertebrates that can’t get away fast enough […]... Read more »
Boothby TC, Tenlen JR, Smith FW, Wang JR, Patanella KA, Nishimura EO, Tintori SC, Li Q, Jones CD, Yandell M.... (2015) Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade. Proceedings of the National Academy of Sciences of the United States of America, 112(52), 15976-81. PMID: 26598659
Koutsovoulos G, Kumar S, Laetsch DR, Stevens L, Daub J, Conlon C, Maroon H, Thomas F, Aboobaker AA, & Blaxter M. (2016) No evidence for extensive horizontal gene transfer in the genome of the tardigrade Hypsibius dujardini. Proceedings of the National Academy of Sciences of the United States of America, 113(18), 5053-8. PMID: 27035985
Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T.... (2016) Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nature communications, 12808. PMID: 27649274
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