"The relationship between JH/HDCT [joint hypermobility / heritable disorders of connective tissue] and mental disorders merits further attention in order to improve current knowledge and clarify a possible common etiology."There is nothing in the desert and no man needs nothing.That was the conclusion reached in the paper by Carolina Baeza-Velasco and colleagues  looking at the possibility of some interesting connections, outside of just physical presentation, when it come........ Read more »
Baeza-Velasco C, Pailhez G, Bulbena A, & Baghdadli A. (2014) Joint hypermobility and the heritable disorders of connective tissue: clinical and empirical evidence of links with psychiatry. General hospital psychiatry. PMID: 25459977
Bipolar disorder appearing again on this blog this week? It's just the way that the papers fall...With a title like: 'Increased uric acid levels in bipolar disorder subjects during different phases of illness' I was hardly likely to pass up the opportunity to discuss the paper by Umberto Albert and colleagues  and their suggestion that there may be a lot more to see when it comes to "a purinergic dysfunction associated with BD [bipolar disorder]".I lost the defuser gun when I mispla........ Read more »
Albert U, De Cori D, Aguglia A, Barbaro F, Bogetto F, & Maina G. (2014) Increased uric acid levels in bipolar disorder subjects during different phases of illness. Journal of affective disorders, 170-175. PMID: 25462413
The FIFA11 program reduced injuries and improved functional performance. It is more effective if compliance and adherence are high, both of which are better if a coach educated on the program administers the program to the team.... Read more »
Barengo, N., Meneses-Echávez, J., Ramírez-Vélez, R., Cohen, D., Tovar, G., & Bautista, J. (2014) The Impact of the FIFA 11 Training Program on Injury Prevention in Football Players: A Systematic Review. International Journal of Environmental Research and Public Health, 11(11), 11986-12000. DOI: 10.3390/ijerph111111986
Effect of shoe drop on running mechanics... Read more »
Chambon N, Delattre N, Guéguen N, Berton E, & Rao G. (2014) Shoe drop has opposite influence on running pattern when running overground or on a treadmill. European journal of applied physiology. PMID: 25501676
While the anti-vaccine movement enjoys the simple (and very wrong) answer to the cause of autism, there are people who want the actual truth. This drive had lead to a slew of causes (and risk factors) for autism in recent times. Now scientists have found that very small segments of genes called “microexons” influence how proteins interact with each other in the nervous system. In turn, this opens up a new line of research into the cause of autism.... Read more »
Irimia, M., Weatheritt, R., Ellis, J., Parikshak, N., Gonatopoulos-Pournatzis, T., Babor, M., Quesnel-Vallières, M., Tapial, J., Raj, B., O’Hanlon, D.... (2014) A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains. Cell, 159(7), 1511-1523. DOI: 10.1016/j.cell.2014.11.035
"Increased autistic characteristics found in adults with epilepsy without an ASD [autism spectrum disorder] diagnosis suggest that epilepsy syndromes may incorporate behavioral aspects of autism in the absence of some of its core cognitive features."Contrariwise, if you think we're alive you ought to speak to us.That was the intriguing finding reported by Sally Ann Wakeford and colleagues  who examined test performance on the Autism Spectrum Quotient (AQ) and "systemizing ........ Read more »
Metabolic syndrome is linked with an increased frequency and severity of lower urinary tract symptoms, but weight loss surgery may lessen these symptoms. The findings, which come from two studies published in BJU International, indicate that urinary problems may be added to the list of issues that can improve with efforts that address altered metabolism.
Lower urinary tract symptoms related to urinary frequency and urgency, bladder leakage, the need to urinate at night, and incomplete bladder........ Read more »
Pashootan, P., Ploussard, G., Cocaul, A., de Gouvello, A., & Desgrandchamps, F. (2014) Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort. BJU International. DOI: 10.1111/bju.12931
Despite what you may think, the supposed “explosion” of children diagnosed with autism can directly attributed to better diagnosing techniques and — more importantly — the change of definition to make Autism spectrum disorders more broad. Thankfully more causes of autism have been found, none of them remotely related to vaccines and now scientists have found that chemical modifications to DNA’s packaging—known as epigenetic changes—can activate or repress genes involved in autism s........ Read more »
Gao, Z., Lee, P., Stafford, J., von Schimmelmann, M., Schaefer, A., & Reinberg, D. (2014) An AUTS2–Polycomb complex activates gene expression in the CNS. Nature, 516(7531), 349-354. DOI: 10.1038/nature13921
Ntziachristos, P., Tsirigos, A., Welstead, G., Trimarchi, T., Bakogianni, S., Xu, L., Loizou, E., Holmfeldt, L., Strikoudis, A., King, B.... (2014) Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia. Nature, 514(7523), 513-517. DOI: 10.1038/nature13605
Image credits: frauczepluch.blogspot.com Communications is key in any relationship, particularly that between patients and doctors. So what happens when the two parties don’t speak the same...... Read more »
Patil S, & Davies P. (2014) Use of Google Translate in medical communication: evaluation of accuracy. BMJ (Clinical research ed.). PMID: 25512386
Your Christmas tree can kill you, but it can also save your life. The same holds true for mistletoe, ivy, and holly. Each is toxic, but each has uses in medicine. The least toxic Christmas plant is the most often thought of as poisonous – poinsettias really aren’t that bad, kids would have to eat 500 leaves to bring on the nastiest effects.... Read more »
Liu, B., Zhou, J., Li, Y., Zou, X., Wu, J., Gu, J., Yuan, J., Zhao, B., Feng, L., Jia, X.... (2014) Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway. BMC Complementary and Alternative Medicine, 14(1), 412. DOI: 10.1186/1472-6882-14-412
Tröger W, Galun D, Reif M, Schumann A, Stanković N, & Milićević M. (2014) Quality of life of patients with advanced pancreatic cancer during treatment with mistletoe: a randomized controlled trial. Deutsches Arzteblatt international, 111(29-30), 493. PMID: 25142075
Tsui, K., Wang, J., Wu, L., & Chiu, C. (2012) Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis. Evidence-Based Complementary and Alternative Medicine, 1-12. DOI: 10.1155/2012/190107
Earl, E., Altaf, M., Murikoli, R., Swift, S., & O'Toole, R. (2010) Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis. BMC Complementary and Alternative Medicine, 10(1), 25. DOI: 10.1186/1472-6882-10-25
I am the league's director, Silas Ramsbottom.Upon reading the paper published by Ramaekers and colleagues  talking about the use of folinic acid in cases of schizophrenia as a function of the presence of "Auto-antibodies against folate receptor alpha (FRα)", I raised a little smile. Not only because the authors suggested that there may be quite a lot more to see in this area on top of some already interesting discussions about the folate cycle and schizophrenia, but also because of the ........ Read more »
Ramaekers VT, Thöny B, Sequeira JM, Ansseau M, Philippe P, Boemer F, Bours V, & Quadros EV. (2014) Folinic acid treatment for schizophrenia associated with folate receptor autoantibodies. Molecular genetics and metabolism. PMID: 25456743
While multiple certifications exist for strength and conditioning coaches, both the CSCS and SCCC do not adequately prepare coaches to recognize or prevent exertional heat stroke during high-intensity training sessions.... Read more »
Valdes, A., Hoffman, J., Clark, M., & Stout, J. (2014) National Collegiate Athletic Association Strength and Conditioning Coachesʼ Knowledge and Practices Regarding Prevention and Recognition of Exertional Heat Stroke. Journal of Strength and Conditioning Research, 28(11), 3013-3023. DOI: 10.1519/JSC.0000000000000365
We’ve all seen the PSA’s trying to show the effects of meth use and in particular, what it does to your teeth. Typically, when it comes to drug use, people will not look at the long term side effects from their addiction instead thinking in the short term. This is unfortunate because as it turns out, methamphetamine users are three times more at risk for getting Parkinson’s disease than non-illicit drug users with even worse news for women, new research shows.... Read more »
Curtin K, Fleckenstein AE, Robison RJ, Crookston MJ, Smith KR, & Hanson GR. (2014) Methamphetamine/amphetamine abuse and risk of Parkinson's disease in Utah: A population-based assessment. Drug and alcohol dependence. PMID: 25479916
It’s time to search out Christmas gifts! Let brain research guide you in your giving. We now know why women are often better at picking out gifts, and we know that you expect people to like your homemade gifts more than you should. We have learned that we give gifts to make ourselves feel good, and that too many gifts can screw your kids up for life. But most importantly, it actually is the thought that counts! Merry Christmas.... Read more »
Dunn, E., Huntsinger, J., Lun, J., & Sinclair, S. (2008) The Gift of Similarity: How Good and Bad Gifts Influence Relationships. Social Cognition, 26(4), 469-481. DOI: 10.1521/soco.2008.26.4.469
Moll, J., Krueger, F., Zahn, R., Pardini, M., de Oliveira-Souza, R., & Grafman, J. (2006) Human fronto-mesolimbic networks guide decisions about charitable donation. Proceedings of the National Academy of Sciences, 103(42), 15623-15628. DOI: 10.1073/pnas.0604475103
My name's Buttercup. You've met Baron von Shush."Our study demonstrated that serum TRX [thioredoxin] levels were associated with ASD [autism spectrum disorder], and elevated levels could be considered as a novel, independent diagnosis indicator of ASD." So was the conclusion reported by Qing-biao Zhang and colleagues  looking at serum levels of TRX in 80 children diagnosed with an ASD compared against "100 sex and age matched typically developing children".I'll freely admi........ Read more »
Zhang QB, Gao SJ, & Zhao HX. (2014) Thioredoxin: A novel, independent diagnosis marker in children with autism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. PMID: 25433158
What’s that over there!? The next time you are around people, count how many people are on their phone? Distractions invade every aspect of our lives. Status updates, text messages, email notifications all threaten to steal our attention away from the moment. While we fight the urge to check the phone, our brains are making constant judgment calls about where to focus attention. The brain must continually filter important information from irrelevant interference.... Read more »
Ahrens, S., Jaramillo, S., Yu, K., Ghosh, S., Hwang, G., Paik, R., Lai, C., He, M., Huang, Z., & Li, B. (2014) ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection. Nature Neuroscience. DOI: 10.1038/nn.3897
My research training is in psychiatric epidemiology. Alcohol and drug dependence have been two of my topic areas of research.So I found a recent novel study of the epidemiology of illicit drug use in Europe intriguing.Typical methods of looking for the prevalence of drug use in populations are direct diagnostic interviews and studies of emergency room attendees or autopsy cases with medical complications of drug use.However, Christopher Ort from Switzerland along with a host of European col........ Read more »
Ort C, van Nuijs AL, Berset JD, Bijlsma L, Castiglioni S, Covaci A, de Voogt P, Emke E, Fatta-Kassinos D, Griffiths P.... (2014) Spatial differences and temporal changes in illicit drug use in Europe quantified by wastewater analysis. Addiction (Abingdon, England), 109(8), 1338-52. PMID: 24861844
I've mentioned a few times on this blog that a diagnosis of autism or autism spectrum disorder (ASD) is by no means protective against any other diagnosis being received, be it based on a somatic illness or condition, or something more behaviourally defined.Reading through the paper by Liz Forty and colleagues  (open-access) it appears that a similar scenario might also pertain to other behaviourally-defined conditions as per the example of bipolar disorder (BD) and their conclusion: "Bi........ Read more »
A new analysis has found that while clinical trial data support omitting radiation treatments in elderly women with early stage breast cancer, nearly two-thirds of these women continue to receive it. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.
Results published in 2004 from a large, randomized clinical trial showed that adding radiation therapy to surgery plus tamoxifen does not reduce 5-year recurrence rates or prolong survival i........ Read more »
Palta, M., Palta, P., Bhavsar, N., Horton, J., & Blitzblau, R. (2014) The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: Changes in practice patterns after publication of Cancer and Leukemia Group B 9343. Cancer. DOI: 10.1002/cncr.28937
Returning the same season from a traumatic anterior shoulder dislocation or subluxation likely results in additional episodes of instability even after undergoing a strengthening and stability protocol. Self-report questionnaires immediately after initial injury may be useful in determining a return to play timeline.... Read more »
Dickens, J., Owens, B., Cameron, K., Kilcoyne, K., Allred, C., Svoboda, S., Sullivan, R., Tokish, J., Peck, K., & Rue, J. (2014) Return to Play and Recurrent Instability After In-Season Anterior Shoulder Instability: A Prospective Multicenter Study. The American Journal of Sports Medicine, 42(12), 2842-2850. DOI: 10.1177/0363546514553181
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