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  • November 29, 2014
  • 03:40 AM
  • 1 view

This Month in Blastocystis Research (NOV 2014): Blasting Blastocystis Edition

by Christen Rune Stensvold in Blastocystis Parasite Blog

A few notes on deliberate and inadvertent attempts to eradicate Blastocystis.... Read more »

  • November 29, 2014
  • 03:30 AM
  • 2 views

NICE does increasing access to vitamin D supplements

by Paul Whiteley in Questioning Answers

If you happen to live in England or indeed other parts of the UK, you'll no doubt have heard about NICE - the National Institute for Health and Care Excellence - as the body charged with providing us with appropriate evidence-based guidance on all manner of treatments and technologies for all manner of different diagnoses and conditions. I've talked before on this blog about the NICE guidance in relation to the autism spectrum (see here for example).My name is Elisabeth Shaw, last survivor ........ Read more »

Lucas RM, Ponsonby AL, Dear K, Valery PC, Taylor B, van der Mei I, McMichael AJ, Pender MP, Chapman C, Coulthard A.... (2013) Vitamin D status: multifactorial contribution of environment, genes and other factors in healthy Australian adults across a latitude gradient. The Journal of steroid biochemistry and molecular biology, 300-8. PMID: 23395985  

  • November 28, 2014
  • 04:57 PM
  • 9 views

Fat Talk Free Zone: What is the Impact of Fat Talk on Body Dissatisfaction?

by Andrea in Science of Eating Disorders


There has been a veritable explosion of “anti-fat talk” movements in the body image and eating disorder prevention realms over the past few years. Indeed, campaigns like the Tri-Delta Sorority Fat Talk Free week have become relatively well known. Events like the “Southern Smash,” where participants literally smash scales are other iterations of this social phenomenon encouraging a more positive conversation around bodies.
I am, of course, a fan of the idea that we shouldn’t put o........ Read more »

  • November 28, 2014
  • 11:56 AM
  • 14 views

New discovery sheds light on the forming brain

by Gabriel in Lunatic Laboratories

The cerebral cortex, which controls higher processes such as perception, thought and cognition, is the most complex structure in the mammalian central nervous system. Although much is known about the intricate structure of this brain region, the processes governing its formation remain uncertain. Research has now uncovered how feedback between cells, as well as molecular factors, helps shape cortical development during mouse embryogenesis.... Read more »

  • November 28, 2014
  • 02:34 AM
  • 18 views

The Autism-Spectrum Quotient: overlap between Asperger syndrome and schizophrenia

by Paul Whiteley in Questioning Answers

The paper by Tove Lugnegård and colleagues [1], including mention of one Maria Unenge Hallerbäck who has appeared on this blog previously, is fodder for today's discussions and their finding that a: "significant overlap of AQ [Autism-Spectrum Quotient] scores across the two diagnostic groups clearly reduces the discriminating power of the AQ in the separation of schizophrenia from AS [Asperger syndrome]."They say you're judged by the strength of your enemies.As per that link to ........ Read more »

  • November 27, 2014
  • 12:40 PM
  • 35 views

Fragile X and a new autism treatment

by Gabriel in Lunatic Laboratories

There are many roads to autism, none of them involve vaccination. I get tired of saying that, but it’s simple science, vaccines do not cause autism. Thankfully science knows this and is looking at not only what actually causes autism (Since again there are many different ways to develop on the spectrum). Well they may have found a new treatment for people affected by a common inherited form of autism by using a drug that is being tested as a treatment for cancer.... Read more »

Gkogkas, C., Khoutorsky, A., Cao, R., Jafarnejad, S., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T.... (2014) Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes. Cell Reports. DOI: 10.1016/j.celrep.2014.10.064  

  • November 27, 2014
  • 11:30 AM
  • 31 views

Potential New Roles for Bacteria and B Cells in Promoting the Stomach Flu

by Geoffrey Hannigan in Prophage

We are all unfortunately familiar with the notorious stomach flu. Most of us have experienced that awful nausea, vomiting, diarrhea, and tiredness associated with catching some stomach bug. While there are many viral causes of the stomach flu (also called gastroenteritis), one of the most common is the Norovirus. The Norovirus is a common and contagious virus that is currently the leading cause of viral gastroenteritis...... Read more »

Jones, M., Watanabe, M., Zhu, S., Graves, C., Keyes, L., Grau, K., Gonzalez-Hernandez, M., Iovine, N., Wobus, C., Vinje, J.... (2014) Enteric bacteria promote human and mouse norovirus infection of B cells. Science, 346(6210), 755-759. DOI: 10.1126/science.1257147  

  • November 27, 2014
  • 04:55 AM
  • 47 views

FC is a technique that has no validity

by Paul Whiteley in Questioning Answers

FC, by the way, refers to Facilitated Communication, a controversial technique which as the name suggests relies on a facilitator to support "the hand or arm of a communicatively impaired individual while using a keyboard or other devices with the aim of helping the individual to point and thereby to communicate." The quote for the title of this post comes from the paper by Ralf Schlosser and colleagues [1] who following systematic review, found "unequivocal evidence for facilitator co........ Read more »

Schlosser RW, Balandin S, Hemsley B, Iacono T, Probst P, & von Tetzchner S. (2014) Facilitated Communication and Authorship: A Systematic Review. Augmentative and alternative communication (Baltimore, Md. : 1985), 1-10. PMID: 25384895  

  • November 26, 2014
  • 03:20 PM
  • 61 views

Need to turn off the pain? Well now we can!

by Gabriel in Lunatic Laboratories

My sister suffers from chronic pain issues. I’ve written several posts about how her autoimmune disease is a special brand of pain that you will thankfully (almost certainly) never have to feel. While great strides have been made in pain management, there are still relatively few options that do not carry the risk of being extremely addictive. Well thankfully there is some new research and it offers hope, not just for my sister, but for the millions of people suffering from chronic pain that ........ Read more »

Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S.... (2014) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a journal of neurology. PMID: 25414036  

  • November 26, 2014
  • 02:35 PM
  • 47 views

Tryptophan vs. The NFL Fan

by Mark Lasbury in The 'Scope

What is tryptophan, and is it indeed responsible for the snoring that follows Thanksgiving dinner? ... Read more »

  • November 26, 2014
  • 11:06 AM
  • 51 views

Treatment Resistance in Eating Disorders

by William Yates, M.D. in Brain Posts

Clinicians treating patients with eating disorders find the challenge great with many treatment-resistant cases.To some extent, this is true of any clinical disorder. Outpatient treatment rolls and inpatient samples are over-represented by those failing to respond to initial interventions.A medical example is helpful here. Endocrinologists specializing in diabetes see more complicated cases where glucose control is difficult and diabetic complications are common.Diabetics with easy glucose contr........ Read more »

  • November 26, 2014
  • 04:54 AM
  • 61 views

The gut microbiome in Down Syndrome

by Paul Whiteley in Questioning Answers

The recent preliminary findings from Elena Biagi and colleagues [1] (open-access) reporting on the constitution of the gut microbiome - the collected bacteria which reside in the deepest, darkest recesses of our gastrointestinal (GI) tract - in a small number of cases of Down's syndrome caught my eye recently.It's a funny feeling being taken under the wing of a dragonPerhaps a little bit unusually looking at the gut microbiome because of the link between premature ageing in Down's syndrome ........ Read more »

Biagi E, Candela M, Centanni M, Consolandi C, Rampelli S, Turroni S, Severgnini M, Peano C, Ghezzo A, Scurti M.... (2014) Gut Microbiome in Down Syndrome. PloS one, 9(11). PMID: 25386941  

  • November 26, 2014
  • 12:05 AM
  • 53 views

Self-Reported Knee Outcomes Can Be Used to Help Determine Functional Assessment Readiness after an ACL Reconstruction

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

The subjective IKDC-2000 form can be used to determine when a participant may be ready to be functionally assessed for a possible return to play. The participants who have IKDC-2000 scores that are lower than normative data have a high likelihood of failing a battery of functional tests. ... Read more »

  • November 25, 2014
  • 01:18 PM
  • 66 views

Oy. I worry about this with cell line studies a lot. Mis-IDed contaminated.

by Mary in OpenHelix

Via NCBI Announce mailing list: NCBI BioSample includes curated list of over 400 known misidentified and contaminated cell lines The NCBI BioSample database now includes a curated list of over 400 known misidentified and contaminated cell lines. Scientists should check this list before they start working with a new cell line to see if that cell line […]... Read more »

American Type Culture Collection Standards Development Organization Workgroup ASN-0002. (2010) Cell line misidentification: the beginning of the end. Nature Reviews Cancer, 10(6), 441-448. DOI: http://dx.doi.org/10.1038/nrc2852  

  • November 25, 2014
  • 03:20 AM
  • 55 views

Serotonin - melatonin (and the in-betweeners) linked to autism

by Paul Whiteley in Questioning Answers

The paper by Pagan and colleagues [1] (open-access) looking at "serotonin, melatonin and the intermediate N-acetylserotonin (NAS) in a large cohort of patients with ASD [autism spectrum disorder] and their relatives" set the old grey-pink matter into action recently. Not only because I have some real interest in the starting material for these compounds - the aromatic amino acid known as tryptophan - but because this research group included some quite important analysis of the enz........ Read more »

Pagan C, Delorme R, Callebert J, Goubran-Botros H, Amsellem F, Drouot X, Boudebesse C, Le Dudal K, Ngo-Nguyen N, Laouamri H.... (2014) The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders. Translational psychiatry. PMID: 25386956  

  • November 25, 2014
  • 12:05 AM
  • 56 views

Kinesiotaping with Exercise Versus Manual Therapy with Exercise in Patients with Subacromial Impingement Syndrome

by Lauren Hankle, Kayla Green in Sports Medicine Research (SMR): In the Lab & In the Field

Kinesiotaping with exercise and manual therapy with exercise are both effective in decreasing pain and disability in patients with subacromial impingement syndrome. The kinesiotaping with exercise intervention was more effective in decreasing pain at night than the manual therapy with exercise treatment group. ... Read more »

  • November 24, 2014
  • 03:26 PM
  • 53 views

Hiding cells to prevent HIV transmission

by Gabriel in Lunatic Laboratories

The fight against HIV is ongoing and despite our rapid progression against the disease we still lack a cure or even adequate treatment for people infected. However, new research suggests that cloaking immune cells with antibodies that block T cell trafficking to the gut can substantially reduce the risk of viral transmission, at least in a non-human primate model of HIV infection. If it works out, this could help slow down the spread of HIV and give people a better shot at a normal life.... Read more »

  • November 24, 2014
  • 05:15 AM
  • 60 views

Helicobacter pylori and stem cells in the gastric crypt

by Artem Kaznatcheev in Evolutionary Games Group

Last Friday, the 4th Integrated Mathematical Oncology Workshop finished here at Moffitt. The event drew a variety of internal and external participants — you can see a blurry photo of many of them above — and was structured as a competition between four teams specializing in four different domains: Microbiome, Hepatitis C, Human papillomavirus, and […]... Read more »

Houghton, J., Stoicov, C., Nomura, S., Rogers, A.B., Carlson, J., Li, H., Cai, X., Fox, J.G., Goldenring, J.R., & Wang, T.C. (2004) Gastric cancer originating from bone marrow-derived cells. Science, 306(5701), 1568-71. PMID: 15567866  

  • November 24, 2014
  • 04:29 AM
  • 53 views

Finland, parental migration and offspring Asperger syndrome

by Paul Whiteley in Questioning Answers

A quote from the paper by Venla Lehti and colleagues [1] to start things off: "The study showed that children whose parents are both immigrants have a significantly lower likelihood of being diagnosed with Asperger's syndrome than those with two Finnish parents."Can I cook, or can't I?Based on an analysis of data derived from "the Finnish Hospital Discharge Register" and "the Finnish Medical Birth Register", researchers looked at the records of children with a diagnosis of Asperger syndrome (AS)........ Read more »

Lehti V, Cheslack-Postava K, Gissler M, Hinkka-Yli-Salomäki S, Brown AS, & Sourander A. (2014) Parental migration and Asperger's syndrome. European child . PMID: 25381114  

  • November 24, 2014
  • 12:05 AM
  • 51 views

Experiences With Workplace Bullying Among Athletic Trainers in the Collegiate Setting

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Among athletic trainers working in a college setting 14% reported that they were bullied, and 20% reported that they witnessed bullying. There were no differences between who experienced bullying, but most of the bullying perpetrators were males with the majority being coaches.... Read more »

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