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  • July 3, 2015
  • 06:06 AM
  • 3 views

A new tissue-specific FLCN-deficient mouse model of renal tumourigenesis

by Danielle Stevenson in BHD Research Blog

Animal models can be useful for understanding disease pathology and as preclinical models for drug testing. As BHD patients develop renal cell carcinomas (RCCs) of varied histologies, associated with a loss of FLCN, BHD animal models could be used to study of a wide range of renal cancer subtypes. Current BHD mouse models include kidney-specific Flcn-knockouts (Chen et al., 2008, Baba et al., 2008) and ubiquitous knockouts (Hasumi et al., 2009, Hartman et al., 2009, Hudon et al., 2010). The form........ Read more »

Chen J, Huang D, Rubera I, Futami K, Wang P, Zickert P, Khoo SK, Dykema K, Zhao P, Petillo D.... (2015) Disruption of tubular Flcn expression as a mouse model for renal tumor induction. Kidney international. PMID: 26083655  

  • July 3, 2015
  • 06:02 AM
  • 3 views

5 Tips For Better Sleep

by Elisabeth Buhl Thubron in United Academics

Adding some ‘worry time’ to your day could work better than pills.... Read more »

  • July 3, 2015
  • 04:56 AM
  • 8 views

Vitamin D metabolic gene variants and risk for autism

by Paul Whiteley in Questioning Answers

I was really rather happy to see the "preliminary evidence" reported by Rebecca Schmidt and colleagues [1] when it came to examining whether selected vitamin D metabolic gene variants might show linkage to autism spectrum disorder (ASD) based on data derived from the CHARGE initiative.For quite a while now I've discussed the various peer-reviewed science on the topic of vitamin D deficiency / insufficiency with autism in mind on this blog (see here and see here for example). Specifically, h........ Read more »

Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Sconberg JL, Schmidt LC, Volk HE, & Tassone F. (2015) Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early human development, 91(8), 483-489. PMID: 26073892  

  • July 2, 2015
  • 06:50 PM
  • 12 views

You are here: Home › Injury › Foot Strike Pattern and Injury Rates Foot Strike Pattern and Injury Rates

by Craig Payne in Running Research Junkie

You are here: Home › Injury › Foot Strike Pattern and Injury Rates
Foot Strike Pattern and Injury Rates... Read more »

  • July 2, 2015
  • 11:57 AM
  • 20 views

Digesting bread and pasta can release biologically active molecules

by Dr. Jekyll in Lunatic Laboratories

Biologically active molecules released by digesting bread and pasta can survive digestion and potentially pass through the gut lining, suggests new research. The study reveals the molecules released when real samples of bread and pasta are digested, providing new information for research into gluten sensitivity.... Read more »

  • July 2, 2015
  • 02:34 AM
  • 28 views

Acute bipolar depression and immune alterations

by Paul Whiteley in Questioning Answers

"Individuals with acute bipolar depression show immune alterations. Some of the alterations are similar to those found in acute mania."That was the bottom line reported by Faith Dickerson and colleagues [1] following their analysis of blood samples provided by "82 individuals with acute bipolar depression, 147 with acute mania, and 280 controls." Looking for the presence of various antibodies to "human herpesviruses, gliadin, Toxoplasma gondii, and endogenous retroviruses as well as for C-reacti........ Read more »

Dickerson F, Katsafanas E, Schweinfurth LA, Savage CL, Stallings C, Origoni A, Khushalani S, Lillehoj E, & Yolken R. (2015) Immune alterations in acute bipolar depression. Acta psychiatrica Scandinavica. PMID: 26061032  

  • July 1, 2015
  • 11:59 PM
  • 29 views

Comparison of running injuries between shod and barefoot

by Craig Payne in Running Research Junkie

Comparison of running injuries between shod and barefoot ... Read more »

  • July 1, 2015
  • 02:19 PM
  • 42 views

New epigenetic mechanism revealed in brain cells

by Dr. Jekyll in Lunatic Laboratories

For decades, researchers in the genetics field have theorized that the protein spools around which DNA is wound, histones, remain constant in the brain, never changing after development in the womb. Now, researchers from the Icahn School of Medicine at Mount Sinai have discovered that histones are steadily replaced in brain cells throughout life – a process which helps to switch genes on and off.... Read more »

Maze, I., Wenderski, W., Noh, K., Bagot, R., Tzavaras, N., Purushothaman, I., Elsässer, S., Guo, Y., Ionete, C., Hurd, Y.... (2015) Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron, 87(1), 77-94. DOI: 10.1016/j.neuron.2015.06.014  

  • July 1, 2015
  • 02:16 PM
  • 29 views

Ethics in research: how to improve the integrity of scientists in their work

by SciELO in SciELO in Perspective

Scientific activity as a social enterprise must maintain its credibility. The Transparency and Openness Promotion (TOP) Guidelines are presented as a recent and innovative initiative for scientific journals, and as one of the ways to guard this social value. … Read More →... Read more »

Alberts, B., Cicerone, R., Fienberg, S., Kamb, A., McNutt, M., Nerem, R., Schekman, R., Shiffrin, R., Stodden, V., Suresh, S.... (2015) Self-correction in science at work. Science, 348(6242), 1420-1422. DOI: 10.1126/science.aab3847  

Nosek, B., Alter, G., Banks, G., Borsboom, D., Bowman, S., Breckler, S., Buck, S., Chambers, C., Chin, G., Christensen, G.... (2015) Promoting an open research culture. Science, 348(6242), 1422-1425. DOI: 10.1126/science.aab2374  

  • July 1, 2015
  • 08:30 AM
  • 31 views

Thinking Asymmetrically About Hormones

by Mark Lasbury in As Many Exceptions As Rules

Your endocrine glands are stimulated or suppressed by hormones. They in turn dump hormones into the blood. Blood goes everywhere equally. So why is your left adrenal gland bigger than your right? And why is the size difference larger in domesticated foxes as opposed to wild foxes? For that matter, why is the size of the right lobe of your thyroid gland depend on which hand you use to write!?... Read more »

Trut LN, Prasolova LA, Kharlamova AV, & Plyusnina IZ. (2002) Directional left-sided asymmetry of adrenals in experimentally domesticated animals. Bulletin of experimental biology and medicine, 133(5), 506-9. PMID: 12420075  

Hojaij, F., Vanderlei, F., Plopper, C., Rodrigues, C., Jácomo, A., Cernea, C., Oliveira, L., Marchi, L., & Brandão, L. (2011) Parathyroid gland anatomical distribution and relation to anthropometric and demographic parameters: a cadaveric study. Anatomical Science International, 86(4), 204-212. DOI: 10.1007/s12565-011-0111-0  

  • July 1, 2015
  • 06:24 AM
  • 37 views

Offspring autism risk and advancing parental age (differences)

by Paul Whiteley in Questioning Answers

Parental age at offspring conception/birth in relation to offspring autism risk has been a recurrent theme in autism research circles for quite a few years now. I've covered it more than once on this blog (see here for example) and the various suggestions that advancing parental age in particular, might elevate the risk of offspring autism.Set in this context, the paper by Sven Sandin and colleagues [1] (open-access) (a name not unfamiliar to this blog) adds to the research evidence based on the........ Read more »

Sandin S, Schendel D, Magnusson P, Hultman C, Surén P, Susser E, Grønborg T, Gissler M, Gunnes N, Gross R.... (2015) Autism risk associated with parental age and with increasing difference in age between the parents. Molecular psychiatry. PMID: 26055426  

  • July 1, 2015
  • 12:05 AM
  • 38 views

The Power of the Mind May not be as Well Utilized as it could be

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Of 1283 survey respondents, only 27% of athletes reported using mental skills such as goal setting, positive self-talk, imagery, and relaxation. Of the 249 respondents who used mental skills 72% reported they felt it helped expedite their recovery process.... Read more »

Arvinen-Barrow M, Clement D, Hamson-Utley JJ, Zakrajsek RA, Lee SM, Kamphoff C, Lintunen T, Hemmings B, & Martin SB. (2015) Athletes' use of mental skills during sport injury rehabilitation. Journal of Sport Rehabilitation, 24(2), 189-97. PMID: 25996227  

  • June 30, 2015
  • 03:28 PM
  • 37 views

Molecular bits of living things with fun names

by Rosin Cerate in Rosin Cerate

Most of the fancy words used by life science folks are dry but effective. However, every once in a while a researcher will discover a new gene or small molecule and decide to gift it with a fun and creative name.The bacterium Photorhabdus luminescens has a gene called makes caterpillars floppy (mcf), which encodes a toxin that causes caterpillars to go all floppy like before it kills them. P. luminescens is a super interesting little bug. It hangs out in the gut of a worm that infects insects, h........ Read more »

  • June 30, 2015
  • 12:55 PM
  • 42 views

Bipolar Disorder: Novel Clinical Trials II

by William Yates, M.D. in Brain Posts

This is the second post reviewing recent novel trials for the treatment of bipolar disorder.Again, for my sources I am using are clinicaltrials.gov and PubMed.Clicking on the study title will take you to the clinicaltrials.gov site for more detailed protocol information.Allopurinol Maintenance Study for Bipolar DisorderThis completed study examined the effect of 300 to 600 mg per day of allopurinol on mania prevention. Allopurinol is a drug used primarily for the treatment of gout or kidney ston........ Read more »

  • June 30, 2015
  • 12:32 PM
  • 35 views

Omega-3 supplements and antioxidants may help with preclinical Alzheimer’s disease

by Dr. Jekyll in Lunatic Laboratories

Here’s more evidence that fish oil supplementation and antioxidants might be beneficial for at least some people facing Alzheimer’s disease. A new report describes the findings of a very small study in which people with mild clinical impairment, such as those in the very early stages of the disease, saw clearance of the hallmark amyloid-beta protein and reduced inflammation in neurological tissues. Although the findings involved just 12 patients over the course of 4 to 17 months, the finding........ Read more »

Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, & Bredesen DE. (2015) ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. PMID: 25805829  

  • June 30, 2015
  • 05:14 AM
  • 51 views

Did Parkinson's Disease Influence Hitler?

by Neuroskeptic in Neuroskeptic_Discover

A new paper from a group of American neurologists makes the case that Hitler suffered from Parkinson's disease for much of his life, and that some of his most fateful decisions were influenced by the neurological disorder.



The article is by Raghav Gupta and colleagues and it appears in World Neurosurgery - a journal with an interesting political history of its own.

Gupta et al. note that
The possibility of Hitler suffering from Parkinson's has long been the subject of debate... [a res... Read more »

  • June 30, 2015
  • 05:06 AM
  • 43 views

Low glycemic index diet reduces symptoms of mouse autism

by Paul Whiteley in Questioning Answers

A quote to begin: "Overall, the manuscript supports the idea that ASD [autism spectrum disorder] results from gene–environment interactions and that in the presence of a genetic predisposition to ASD, diet can make a large difference in the expression of the condition."The manuscript in question was by Antonio Currais and colleagues [1] reporting some rather interesting results based on the 'dangermouse' that is the BTBR mouse model of autism. Researchers from the Salk Inst........ Read more »

  • June 29, 2015
  • 07:55 PM
  • 56 views

You may already be beating cancer

by Angela Reisetter in Steeped in Science

A look at living with disease close at hand, using a couple different papers. Living with Risk.... Read more »

  • June 29, 2015
  • 03:26 PM
  • 61 views

How your brain knows it’s summer

by Dr. Jekyll in Lunatic Laboratories

Researchers led by Toru Takumi at the RIKEN Brain Science Institute in Japan have discovered a key mechanism underlying how animals keep track of the seasons. The study shows how circadian clock machinery in the brain encodes seasonal changes in daylight duration through GABA activity along with changes in the amount of chloride located inside certain neurons.... Read more »

Myung J, Hong S, DeWoskin D, Schutter E, Forger, DB, and Takumi T. (2015) GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time. Proceedings of the National Academy of Sciences. info:/10.1073/pnas.1421200112

  • June 29, 2015
  • 06:49 AM
  • 50 views

Cancer Breakthrough: New Devise Optomizes Lymphoma Treatment

by Agnese Mariotti in United Academics

CIVO tests cancer drugs in human lymphomas in only 72 hours.... Read more »

Klinghoffer, R., Bahrami, S., Hatton, B., Frazier, J., Moreno-Gonzalez, A., Strand, A., Kerwin, W., Casalini, J., Thirstrup, D., You, S.... (2015) A technology platform to assess multiple cancer agents simultaneously within a patient's tumor. Science Translational Medicine, 7(284), 284-284. DOI: 10.1126/scitranslmed.aaa7489  

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