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  • November 30, -1
  • 12:00 AM
  • 2,202 views

HIV vaccine research heading towards success,so near but so far, latest research and development towards developing HIV vaccine

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

There are few cases observed where some people are tested HIV positive long ago but have not developed AIDS symptoms or the AIDS disease in their entire life and are called by researchers for finding out what is the key difference in them and the other peoples which is imparting capability for not developing HIV infection in to disease AIDS in such individuals.

Researchers have observed that there is a key difference in the genetic constitution of such peoples and they are termed as controlle........ Read more »

B V Waghmare. (2010) Information on HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets . www.bvwaghmare.blogspot.com. info:/DOI/arXiv/bvwaghmare

  • November 30, -1
  • 12:00 AM
  • 2,376 views

Let’s Get Cellular: Meth Metabolism

by Dirk Hanson in Addiction Inbox

We know from the work of Nora Volkow and others that meth abusers have chronically low levels of dopamine D2 receptors in their brains. But what is going on in the rest of the body when methamphetamine addiction is running full force?... Read more »

Sun, L., Li, H., Seufferheld, M., Walters, K., Margam, V., Jannasch, A., Diaz, N., Riley, C., Sun, W., Li, Y.... (2011) Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0018215  

  • November 30, -1
  • 12:00 AM
  • 2,445 views

Comparing Apples with Oranges: B&W

by Peter Nollert in Protein Crystallization Blog

Identifying individual amino acid residues within a GPCR and comparing these across different receptors is a routine task that’s helped by a widely accepted nomenclature system: that of Ballesteros and Weinstein.... Read more »

  • November 30, -1
  • 12:00 AM
  • 1,842 views

“Beware of Exercise” is a Sexy Headline

by nooffensebut in The Unsilenced Science

A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »

Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887

  • November 30, -1
  • 12:00 AM
  • 1,494 views

Making sense of a small worm from big data

by Michael Hsieh in Hsieh Lab Blog

We recently published a gene expression microarray-based paper in PLOS Neglected Tropical Diseases. As a "reductionist", it was challenging for me to deal with the massive amount of data associated with the paper. ... Read more »

  • November 30, -1
  • 12:00 AM
  • 1,688 views

A Holiday Without Helminths

by Michael Hsieh in Hsieh Lab Blog

What would a holiday without helminths, also known as parasitic worms, look like?... Read more »

Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, McCarthy JS, & Basáñez MG. (2012) A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS neglected tropical diseases, 6(4). PMID: 22545164  

  • November 30, -1
  • 12:00 AM
  • 2,000 views

Fructose: friend or foe? Preliminary findings.

by Kismet in Biogerontology and Health

This discussion has been going on for quite some time and it is certainly not limited to the lay press and lay population. I have always been interested in double checking pop-sci claims, in this case the "evil fructose" meme.... Read more »

  • November 30, -1
  • 12:00 AM
  • 2,429 views

Understanding PREDIMED and the Mediterranean diet: heart-healthy or hype?

by Kismet in Biogerontology and Health

I am going to discuss the failings of the PREDIMED study, real and imagined. I will do this in a Question & Answer style. Several questions are inspired by theheart.org and NEJM comments and even statements by the low fat "gurus", Essselstyn, Ornish, McDougall or Pritikin. It is no surprise they are up in arms after the study has been published. It threatens their livelihood.... Read more »

Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J.... (2013) Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. New England Journal of Medicine, 368(14), 1279-1290. DOI: 10.1056/NEJMoa1200303  

  • November 30, -1
  • 12:00 AM
  • 1,844 views

Electron-spin clue to solving general anesthesia mystery

by This Science is Crazy! in This Science Is Crazy!

New study on fruit flies suggests general anesthetics can affect electron-spin properties... Read more »

Turin Luca, Skoulakis Efthimios, & Horsfield Andrew. (2014) Electron spin changes during general anesthesia in Drosophila. PNAS, Early edition(N/A). DOI: 10.1073/pnas.1404387111  

  • November 30, -1
  • 12:00 AM
  • 1,038 views

PD-L1 expression associates with non-inactivated VHL ccRCC

by Joana Guedes in BHD Research Blog

The loss of the of the tumor suppressor gene VHL and the subsequent deregulation of VHL/HIF/VEGF signalling are known to play a role in development of clear cell renal cell carcinoma (ccRCC). Renal tumours associated with BHD syndrome are histologically diverse and include a percentage of ccRCC (Pavlovich et al., 2002). Anti-angiogenic therapies targeting the VHL/HIF/VEGF pathway have emerged in past years (Rini et al., 2006) but the development of resistance to these therapeutic agents is leadi........ Read more »

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