- March 25, 2009
- 02:02 PM
- 579 views
optogenetic control of intracellular signaling
by 96well in Reportergene
Pharmacokinetics and pharmacodynamics should include in future opto-kinetic and opto-dynamic disciplines. At Stanford, Raag Airan and colleagues developed opsin-receptor chimaeras (the optoXR family) as a new class of retinal-based tools. In a Nature letter, they show that the class of OptoXRs can be functionally expressed in vivo, to permit differential photoactivable control of intracellular cascades with significant impact on the phenotype (i.e., behavior when light was targeted in brain via ........ Read more »
Airan, R., Thompson, K., Fenno, L., Bernstein, H., & Deisseroth, K. (2009) Temporally precise in vivo control of intracellular signalling. Nature. DOI: 10.1038/nature07926
- March 24, 2009
- 07:50 AM
- 681 views
Optogenetics controls brain signalling and sheds light on Parkinson's therapy
by Mo in Neurophilosophy
Optogenetics is a recently developed technique based on a group of light-sensitive proteins called channelrhodopsins, which which were isolated recently from various species of micro-organism. Although relatively new, this technique has already proven to be extremely powerful, because channelrhodopsins can be targeted to specific cells, so that their activity can be controlled by light, on a millisecond-by-millisecond timescale.
A group of researchers from Stanford University now report a new a........ Read more »
Airan, R., Thompson, K., Fenno, L., Bernstein, H., & Deisseroth, K. (2009) Temporally precise in vivo control of intracellular signalling. Nature. DOI: 10.1038/nature07926
Gradinaru, V., Mogri, M., Thompson, K., Henderson, J., & Deisseroth, K. (2009) Optical Deconstruction of Parkinsonian Neural Circuitry. Science. DOI: 10.1126/science.1167093
- March 18, 2009
- 06:34 PM
- 475 views
Biochemists rejoice as they receive optogenetic control of signaling pathways
by Noah Gray in Nothing's Shocking
The Deisseroth lab (Stanford) has created chimeric molecules combining parts from rhodopsin and adrenergic receptors. The result? Light-activated signaling molecules, giving biochemists control over signaling.... Read more »
Airan, R., Thompson, K., Fenno, L., Bernstein, H., & Deisseroth, K. (2009) Temporally precise in vivo control of intracellular signalling. Nature. DOI: 10.1038/nature07926
topics
join us!
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
