- October 8, 2008
- 09:23 AM
- 676 views
The fluorescent flashing shuttles of the enchanted loom
by Mo in Neurophilosophy
In his 1941 book Man on His Nature, the Nobel Prize-winning physiologist Sir Charles Sherrington described the brain as "an enchanted loom where millions of flashing shuttles weave a dissolving pattern." Little could he have known that within 50 years neuroscientists would have at their disposal techniques for visualizing this pattern.
These techniques are collectively known as calcium imaging. Developed in the 1980s, they use synthetic chemical dyes or genetic constructs whose spectral propert........ Read more »
Damian J Wallace, Stephan Meyer zum Alten Borgloh, Simone Astori, Ying Yang, Melanie Bausen, Sebastian Kügler, Amy E Palmer, Roger Y Tsien, Rolf Sprengel, Jason N D Kerr.... (2008) Single-spike detection in vitro and in vivo with a genetic Ca2 sensor. Nature Methods, 5(9), 797-804. DOI: 10.1038/NMETH.1242
- October 1, 2008
- 10:13 PM
- 282 views
Neuro Tech Update: Imaging calcium just got a lot easier
by Noah Gray in Nothing's Shocking
Perusing the latest technological adventures in functional Ca2 imaging in vivo.... Read more »
Wallace, D., zum Alten Borgloh, S., Astori, S., Yang, Y., Bausen, M., Kügler, S., Palmer, A., Tsien, R., Sprengel, R., Kerr, J.... (2008) Single-spike detection in vitro and in vivo with a genetic Ca2 sensor. Nature Methods, 5(9), 797-804. DOI: 10.1038/nmeth.1242
Mank, M., Santos, A., Direnberger, S., Mrsic-Flogel, T., Hofer, S., Stein, V., Hendel, T., Reiff, D., Levelt, C., Borst, A.... (2008) A genetically encoded calcium indicator for chronic in vivo two-photon imaging. Nature Methods, 5(9), 805-811. DOI: 10.1038/nmeth.1243
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