- November 5, 2009
- 10:10 PM
- 270 views
Antivirals and resistance: Adamantanes
by Atila Iamarino in Influenza A (H1N1) Blog – English
In the case of a pandemic, and during the seasonal epidemics, once a person has already contracted the influenza, we can do little, other than monitor and treat him with antivirals. However, they are not always a guarantee of success, especially in the case of resistant viruses.
Amantadine and rimantadine are the first drugs used against [...]... Read more »
Davies, W., Grunert, R., Haff, R., McGahen, J., Neumayer, E., Paulshock, M., Watts, J., Wood, T., Hermann, E., & Hoffmann, C. (1964) Antiviral Activity of 1-Adamantanamine (Amantadine). Science, 144(3620), 862-863. DOI: 10.1126/science.144.3620.862
Pielak, R., Schnell, J., & Chou, J. (2009) Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proceedings of the National Academy of Sciences, 106(18), 7379-7384. DOI: 10.1073/pnas.0902548106
Weinstock, D. (2006) Adamantane Resistance in Influenza A. JAMA: The Journal of the American Medical Association. DOI: 10.1001/jama.295.8.jed60009
, . (2009) Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans. New England Journal of Medicine, 360(25), 2605-2615. DOI: 10.1056/NEJMoa0903810
- November 5, 2009
- 09:59 PM
- 135 views
Antivirales y resistencia: Adamantanas
by Atila Iamarino in Gripe por A (H1N1) Blog
En el caso de una pandemia, y durante las epidemias sazonales, cuando la persona ya contrajo el virus influenza, es poco lo que podemos hacer además de monitorizarla y tratarla con antivirales. Pero ni siempre ellos ofrecen garantía de éxito, principalmente en el caso de virus resistentes.
Amantadina y rimantadina, son las primeras drogas utilizadas contra [...]... Read more »
Davies, W., Grunert, R., Haff, R., McGahen, J., Neumayer, E., Paulshock, M., Watts, J., Wood, T., Hermann, E., & Hoffmann, C. (1964) Antiviral Activity of 1-Adamantanamine (Amantadine). Science, 144(3620), 862-863. DOI: 10.1126/science.144.3620.862
Pielak, R., Schnell, J., & Chou, J. (2009) Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proceedings of the National Academy of Sciences, 106(18), 7379-7384. DOI: 10.1073/pnas.0902548106
, . (2009) Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans. New England Journal of Medicine, 360(25), 2605-2615. DOI: 10.1056/NEJMoa0903810
- October 16, 2009
- 08:26 AM
- 147 views
Antivirais e resistência: Adamantanas
by Atila Iamarino in Influenza A (H1N1) Blog – Português
No caso de uma pandemia, e durante as epidemias sazonais, uma vez que a pessoa já contraiu o Influenza, pouco podemos fazer além de monitorá-la e tratá-la com antivirais. Mas nem sempre eles são garantia de sucesso, principalmente no caso de vírus resistentes.
Amantadina e rimantadina, são as primeiras drogas utilizadas contra o Influenza, ainda de [...]... Read more »
Davies, W., Grunert, R., Haff, R., McGahen, J., Neumayer, E., Paulshock, M., Watts, J., Wood, T., Hermann, E., & Hoffmann, C. (1964) Antiviral Activity of 1-Adamantanamine (Amantadine). Science, 144(3620), 862-863. DOI: 10.1126/science.144.3620.862
Pielak, R., Schnell, J., & Chou, J. (2009) Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proceedings of the National Academy of Sciences, 106(18), 7379-7384. DOI: 10.1073/pnas.0902548106
Weinstock, D. (2006) Adamantane Resistance in Influenza A. JAMA: The Journal of the American Medical Association. DOI: 10.1001/jama.295.8.jed60009
, . (2009) Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans. New England Journal of Medicine, 360(25), 2605-2615. DOI: 10.1056/NEJMoa0903810
- June 1, 2009
- 11:45 PM
- 473 views
How do adamantane drugs block M2?
by Michael Clarkson in Discount Thoughts
Vaccination plays such an important role in our seasonal influenza strategy in part because we don't have many medicines that can be brought to bear on the disease. The neuraminidase inhibitors (specifically Tamiflu) are widely stockpiled, and continue to work for now, but the specter of resistance is already lurking. If these drugs are too widely or too improperly used, there is a good chance that resistance mutations will eventually render these drugs ineffective. Universal drug resistance may........ Read more »
Stouffer, A., Acharya, R., Salom, D., Levine, A., Di Costanzo, L., Soto, C., Tereshko, V., Nanda, V., Stayrook, S., & DeGrado, W. (2008) Structural basis for the function and inhibition of an influenza virus proton channel. Nature, 451(7178), 596-599. DOI: 10.1038/nature06528
Schnell, J., & Chou, J. (2008) Structure and mechanism of the M2 proton channel of influenza A virus. Nature, 451(7178), 591-595. DOI: 10.1038/nature06531
Jing, X., Ma, C., Ohigashi, Y., Oliveira, F., Jardetzky, T., Pinto, L., & Lamb, R. (2008) Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proceedings of the National Academy of Sciences, 105(31), 10967-10972. DOI: 10.1073/pnas.0804958105
Pielak, R., Schnell, J., & Chou, J. (2009) Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proceedings of the National Academy of Sciences, 106(18), 7379-7384. DOI: 10.1073/pnas.0902548106
- May 1, 2009
- 07:49 AM
- 662 views
Why Swine Flu Is Resistant to Adamantane Drugs
by Nick Anthis in The Scientific Activist
On Wednesday, the CDC reported that influenza A H1N1 viruses from 13 patients with confirmed diagnoses of swine flu had been tested for resistance to a variety of antiviral drugs. The good news was that all of the isolates were susceptible to the antiviral drugs oseltamivir (Tamiflu) and zanamivir (Relenza). However, all 13 were resistant to adamantane-based drugs (amantadine and rimantadine). Resistance to adamantane drugs (which were developed first) has actually become quite widespread amo........ Read more »
Schnell, J., & Chou, J. (2008) Structure and mechanism of the M2 proton channel of influenza A virus. Nature, 451(7178), 591-595. DOI: 10.1038/nature06531
Pielak, R., Schnell, J., & Chou, J. (2009) Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.0902548106
Stouffer, A., Acharya, R., Salom, D., Levine, A., Di Costanzo, L., Soto, C., Tereshko, V., Nanda, V., Stayrook, S., & DeGrado, W. (2008) Structural basis for the function and inhibition of an influenza virus proton channel. Nature, 451(7178), 596-599. DOI: 10.1038/nature06528
Stouffer, A., Ma, C., Cristian, L., Ohigashi, Y., Lamb, R., Lear, J., Pinto, L., & DeGrado, W. (2008) The Interplay of Functional Tuning, Drug Resistance, and Thermodynamic Stability in the Evolution of the M2 Proton Channel from the Influenza A Virus. Structure, 16(7), 1067-1076. DOI: 10.1016/j.str.2008.04.011
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