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  • February 12, 2016
  • 02:56 PM
  • 23 views

Stem cell gene therapy could be key to treating Duchenne muscular dystrophy

by Dr. Jekyll in Lunatic Laboratories

Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Center for Duchenne Muscular Dystrophy at UCLA have developed a new approach that could eventually be used to treat Duchenne muscular dystrophy. The stem cell gene therapy could be applicable for 60 percent of people with Duchenne, which affects approximately 1 in 5,000 boys in the U.S. and is the most common fatal childhood genetic disease.

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  • February 12, 2016
  • 06:34 AM
  • 42 views

Evidence, Shmevidence

by AG McCluskey in Zongo's Cancer Diaries

The world is full of ideas. How does science decide which ideas are good and which are bad...?... Read more »

Scott O. Lilienfeld, Steven Jay Lynn, Rachel J. Ammirati. (2015) Science Versus Pseudoscience. The Encyclopedia of Clinical Psychology. DOI: 10.1002/9781118625392.wbecp572  

AG McCluskey. (2016) Evidence, Shmevidence. Zongo's Cancer Diaries. info:/

  • February 11, 2016
  • 03:18 PM
  • 46 views

Synthetic biology breakthrough creates biosensors on demand

by Dr. Jekyll in Lunatic Laboratories

Biosensors are powerful tools in synthetic biology for engineering metabolic pathways or controlling synthetic and native genetic circuits in bacteria. Scientists have had difficulty developing a method to engineer "designer" biosensor proteins that can precisely sense and report the presence of specific molecules, which has so far limited the number and variety of biosensor designs able to precisely regulate cell metabolism, cell biology, and synthetic gene circuits.

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Taylor, N., Garruss, A., Moretti, R., Chan, S., Arbing, M., Cascio, D., Rogers, J., Isaacs, F., Kosuri, S., Baker, D.... (2015) Engineering an allosteric transcription factor to respond to new ligands. Nature Methods, 13(2), 177-183. DOI: 10.1038/nmeth.3696  

  • February 11, 2016
  • 03:15 PM
  • 46 views

Science Teachers Confused About … Um, Science

by Jenny Ludmer in Rooster's Report

Scientists may be in agreement on the causes of climate change, but the US public is not. We can blame biased news sources all we want for this disconnect, but a new study suggests yet another explanation: our science teachers. Although most are teaching about global warming, many simply aren’t doing it right.... Read more »

Eric Plutzer, Mark McCaffrey, A. Lee Hannah, Joshua Rosenau, Minda Berbeco, & Ann H. Reid. (2016) Climate confusion among U.S. teachers. Science, 351(6274). info:/10.1126/science.aab3907

  • February 10, 2016
  • 03:07 PM
  • 63 views

Starting age of marijuana use may have long-term effects on brain development

by Dr. Jekyll in Lunatic Laboratories

The age at which an adolescent begins using marijuana may affect typical brain development, according to researchers at the Center for BrainHealth at The University of Texas at Dallas. In a paper recently published, scientists describe how marijuana use, and the age at which use is initiated, may adversely alter brain structures that underlie higher order thinking.

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  • February 9, 2016
  • 02:41 PM
  • 84 views

Brain power: Wirelessly supplying power to the brain

by Dr. Jekyll in Lunatic Laboratories

Human and animal movements generate slight neural signals from their brain cells. These signals obtained using a neural interface are essential for realizing brain-machine interfaces (BMI). Such neural recording systems using wires to connect the implanted device to an external device can cause infections through the opening in the skull. One method of solving this issue is to develop a wireless neural interface that is fully implantable on the brain.

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  • February 8, 2016
  • 01:59 PM
  • 148 views

We can build it better: Synthetic biopathway turns agriculture waste into ‘green’ products

by Dr. Jekyll in Lunatic Laboratories

Researchers at the University of Minnesota have engineered a new synthetic biopathway that can more efficiently and cost-effectively turn agricultural waste, like corn stover and orange peels, into a variety of useful products ranging from spandex to chicken feed.

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Tai, Y., Xiong, M., Jambunathan, P., Wang, J., Wang, J., Stapleton, C., & Zhang, K. (2016) Engineering nonphosphorylative metabolism to generate lignocellulose-derived products. Nature Chemical Biology. DOI: 10.1038/nchembio.2020  

  • February 8, 2016
  • 12:41 PM
  • 142 views

Why Ask for Directions? (A Guest Post)

by Miss Behavior in The Scorpion and the Frog

by Anna Schneider For the iconic monarch butterfly, the shorter days in fall mean it’s time to pack up and head south to a warmer climate! Just like clockwork, the Eastern population of monarch butterflies makes a 2000 mile journey to their winter paradise roosts in central Mexico. The journey in itself is one of the greatest migrations among all animals. But here’s the catch: none of these butterflies has made this trip before. Several generations of monarchs have come and gon........ Read more »

  • February 7, 2016
  • 03:07 PM
  • 171 views

The molecular link between psychiatric disorders and type 2 diabetes

by Dr. Jekyll in Lunatic Laboratories

There may be a genetic connection between some mental health disorders and type 2 diabetes. In a new report, scientists show that a gene called “DISC1,” which is believed to play a role in mental health disorders, such as schizophrenia, bipolar disorder and some forms of depression, influences the function of pancreatic beta cells which produce insulin to maintain normal blood glucose levels.

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Jurczyk A, Nowosielska A, Przewozniak N, Aryee KE, DiIorio P, Blodgett D, Yang C, Campbell-Thompson M, Atkinson M, Shultz L.... (2016) Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(2), 983-93. PMID: 26546129  

  • February 6, 2016
  • 03:49 PM
  • 182 views

Brain plasticity assorted into functional networks

by Dr. Jekyll in Lunatic Laboratories

Plasticity of the brain, what does that even mean? Well the good news is that it isn’t just a marketing ploy, the brain needs to be “plastic” because we need to be able to adapt. Frankly speaking, the brain still has a lot to learn about itself. Scientists at the Virginia Tech Carilion Research Institute have made a key finding of the striking differences in how the brain’s cells can change through experience.

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  • February 6, 2016
  • 09:52 AM
  • 154 views

Do songbirds perceive melody different from humans?

by Henkjan Honing in Music Matters

Last week a fascinating study appeared in PNAS on melody cognition in sparrows (Sturnus vulgaris). It provides an alternative interpretation to the widespread believe that songbirds have a strong bias to rely on absolute pitch (AP) for the recognition of melodies (e.g. Hulse et al., 1992).... Read more »

Hulse, S., Takeuchi, A., & Braaten, R. (1992) Perceptual Invariances in the Comparative Psychology of Music. Music Perception: An Interdisciplinary Journal, 10(2), 151-184. DOI: 10.2307/40285605  

Bregman, M., Patel, A., & Gentner, T. (2016) Songbirds use spectral shape, not pitch, for sound pattern recognition. Proceedings of the National Academy of Sciences, 201515380. DOI: 10.1073/pnas.1515380113  

  • February 5, 2016
  • 03:27 PM
  • 182 views

Man-made underwater sound may have wider ecosystem effects

by Dr. Jekyll in Lunatic Laboratories

Underwater sound linked to human activity could alter the behaviour of seabed creatures that play a vital role in marine ecosystems, according to new research from the University of Southampton. The study found that exposure to sounds that resemble shipping traffic and offshore construction activities results in behavioural responses in certain invertebrate species that live in the marine sediment.

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  • February 4, 2016
  • 03:27 PM
  • 124 views

Taser shock disrupts brain function, has implications for police interrogations

by Dr. Jekyll in Lunatic Laboratories

More than two million citizens have been Tased by police as Taser stun guns have become one of the preferred less-lethal weapons by police departments across the United States during the past decade. But what does that 50,000-volt shock do to a person's brain?

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  • February 3, 2016
  • 03:06 PM
  • 125 views

Investigating potential fetal exposure to antidepressants

by Dr. Jekyll in Lunatic Laboratories

Depression is a serious issue for expecting mothers. Left untreated, depression could have implications for a fetus’s health. But treating the disease during pregnancy may carry health risks for the developing fetus, which makes an expecting mother’s decision whether to take medication a very difficult one. To better understand how antidepressants affect fetuses during pregnancy, scientists studied exposure in mice.

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  • February 2, 2016
  • 03:03 PM
  • 146 views

Depressed or inflamed? Inflammation attacks brain’s reward center

by Dr. Jekyll in Lunatic Laboratories

Inflammation is a good thing, it helps the body fight disease, and without it we wouldn't survive. Unfortunately, when inflammation isn't kept under control it can wreak havoc on the body. From potentially causing alzheimer's to arthritis it seems that unchecked inflammation can cause all sorts of issues. In fact, a new study adds to the list of issues out of control inflammation causes in the body.

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  • February 2, 2016
  • 11:53 AM
  • 97 views

Are ‘predatory’ journals completely negative, or also a sign of something positive?

by SciELO in SciELO in Perspective

Something that is generally, and justifiably, considered negative, can, however, also be a harbinger of an underlying positive development. The case in point is the existence of so-called ‘predatory’ journals, which have – inevitably – emerged in an environment in which a true market for scientific publishing services is slowly taking shape. … Read More →... Read more »

Ding, X., Wellman, H., Wang, Y., Fu, G., & Lee, K. (2015) Theory-of-Mind Training Causes Honest Young Children to Lie. Psychological Science, 26(11), 1812-1821. DOI: 10.1177/0956797615604628  

  • February 1, 2016
  • 03:41 PM
  • 118 views

Blood pressure medicine may improve conversational skills of individuals with autism

by Dr. Jekyll in Lunatic Laboratories

An estimated 1 in 68 children in the United States has autism. The neurodevelopmental disorder, which impairs communication and social interaction skills, can be treated with medications and behavioral therapies, though there is no cure. Now, University of Missouri researchers have found that a medication commonly used to treat high blood pressure and irregular heartbeats may have the potential to improve some social functions of individuals with autism.

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  • January 31, 2016
  • 02:57 PM
  • 178 views

The brains of patients with schizophrenia vary depending on the type of schizophrenia

by Dr. Jekyll in Lunatic Laboratories

I have a friend who lost an eye to his brother. Yes, you read that correctly, his brother tried to kill him and in the process he lost his eye. I’ve told this story before, but whenever new schizophrenia research comes out I feel the need to tell it again. While he has forgiven his brother (partly because not long after, he was diagnosed as schizophrenic), he will not be able to see him again until he is released from prison. A tragedy that could’ve been avoided had he been diagnosed sooner......... Read more »

  • January 30, 2016
  • 03:21 PM
  • 159 views

Neurological adaptations to the presence of toxic HIV protein

by Dr. Jekyll in Lunatic Laboratories

Nearly half of HIV infected patients suffer from impaired neurocognitive function. The HIV protein transactivator of transcription (Tat) is an important contributor to HIV neuropathogenesis because it is a potent neurotoxin that continues to be produced despite treatment with antiretroviral therapy.

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  • January 29, 2016
  • 01:51 PM
  • 155 views

How to unlock inaccessible genes

by Dr. Jekyll in Lunatic Laboratories

An international team of biologists has discovered how specialized enzymes remodel the extremely condensed genetic material in the nucleus of cells in order to control which genes can be used. It was known that the DNA in cells is wrapped around proteins in structures called nucleosomes that resemble beads on a string, which allow the genetic material to be folded and compacted into a structure called chromatin.

... Read more »

de Dieuleveult, M., Yen, K., Hmitou, I., Depaux, A., Boussouar, F., Dargham, D., Jounier, S., Humbertclaude, H., Ribierre, F., Baulard, C.... (2016) Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells. Nature. DOI: 10.1038/nature16505  

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