A collaboration between researchers at the Babraham Institute and the University of Manchester has mapped the physical connections occurring in the genome to shed light on the parts of the genome involved in autoimmune diseases. Using a new technique, called Capture Hi-C, the team revealed novel insights into how changes in the genetic sequence have a biological effect and increase the risk of disease.... Read more »
Martin, P., McGovern, A., Orozco, G., Duffus, K., Yarwood, A., Schoenfelder, S., Cooper, N., Barton, A., Wallace, C., Fraser, P.... (2015) Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci. Nature Communications, 10069. DOI: 10.1038/ncomms10069
Researchers have found anxiety around the arrival of a new baby is just as common as postnatal depression, and the risks for men are nearly as high as for women. Mental health researcher Dr Liana Leach reviewed 43 separate studies and found anxiety before and after a child arrives is just as prevalent as depression, affecting around one in ten men, around half the rate for women.... Read more »
Leach, L., Poyser, C., Cooklin, A., & Giallo, R. (2016) Prevalence and course of anxiety disorders (and symptom levels) in men across the perinatal period: A systematic review. Journal of Affective Disorders, 675-686. DOI: 10.1016/j.jad.2015.09.063
Antibodies developed in HIV infected individuals do not protect them against further proliferation of HIV, but protect proliferation of HIV in animals.
That means it is possible to develop a vaccine which will completely protect human from HIV infection.... Read more »
B V Waghmare. (2015) HIV Vaccine heading toward success. Combination of HIV neutralizing antibodies and Nanoparticle protien eOD-GT8 60mer are good hope for getting a effective anti HIV vaccine. http://bvwaghmare.blogspot.com. info:/
Research led by Dr. Keiji Tanimoto from the University of Tsukuba, Japan, has brought us closer to understanding the mechanisms underlying the phenomenon of genomic imprinting. In this intriguing event, one copy of a gene is ‘turned off’, or silenced, depending on whether it was derived from the mother or the father.... Read more »
Matsuzaki H, Okamura E, Takahashi T, Ushiki A, Nakamura T, Nakano T, Hata K, Fukamizu A, & Tanimoto K. (2015) De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis. Development (Cambridge, England), 142(22), 3833-44. PMID: 26417043
A team of researchers led by UNSW Australia scientists has discovered how connections between brain cells are destroyed in the early stages of Alzheimer’s disease – work that opens up a new avenue for research on possible treatments for the degenerative brain condition.... Read more »
Leshchyns’ka, I., Liew, H., Shepherd, C., Halliday, G., Stevens, C., Ke, Y., Ittner, L., & Sytnyk, V. (2015) Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer’s disease. Nature Communications, 8836. DOI: 10.1038/ncomms9836
Stem cells that have been specifically developed for use as clinical therapies are fit for use in patients, an independent study of their genetic make-up suggests. The research – which focused on human embryonic stem cells – paves the way for clinical trials of cell therapies to treat conditions such as Parkinson’s disease, age-related degeneration of the eyes and spinal cord injury.... Read more »
Canham, M., Van Deusen, A., Brison, D., De Sousa, P., Downie, J., Devito, L., Hewitt, Z., Ilic, D., Kimber, S., Moore, H.... (2015) The Molecular Karyotype of 25 Clinical-Grade Human Embryonic Stem Cell Lines. Scientific Reports, 17258. DOI: 10.1038/srep17258
Nearly 37 million people worldwide are living with HIV. When the virus destroys so many immune cells that the body can’t fight off infection, AIDS will develop. The disease took the lives of more than a million people last year.... Read more »
Lu, M., Hou, G., Zhang, H., Suiter, C., Ahn, J., Byeon, I., Perilla, J., Langmead, C., Hung, I., Gor'kov, P.... (2015) Dynamic allostery governs cyclophilin A–HIV capsid interplay. Proceedings of the National Academy of Sciences, 201516920. DOI: 10.1073/pnas.1516920112
The peer review of research proposals (grants) aims to judge the merit of projects and researchers and enable the best to be contemplated. The director of an institution in the United Kingdom shared on Twitter his struggle in evaluating the numerous proposals received and started a discussion forum from which ideas and suggestions emerged. … Read More →... Read more »
This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.
Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »
Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139
Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521
Researchers at the University of Waterloo have discovered a new way to create designer proteins that have the potential to transform biotechnology and personalized medicines.
In a range of experiments Professor Elizabeth Meiering, in collaboration with colleagues from India and the United States, created a protein that can withstand a range of physiological and environmental conditions – a problem that has challenged chemists looking to create super stable, highly functional proteins.... Read more »
Broom, A., Ma, S., Xia, K., Rafalia, H., Trainor, K., Colon, W., Gosavi, S., & Meiering, E. (2015) Designed protein reveals structural determinants of extreme kinetic stability. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1510748112
Virginia Tech Carilion Research Institute scientists have reported measurements of dopamine release with unprecedented temporal precision in the brains of people with Parkinson’s disease. The measurements, collected during brain surgery as the conscious patients played an investment game, demonstrate how rapid dopamine release encodes information crucial for human choice.... Read more »
Kenneth T. Kishida, Ignacio Saez, Terry Lohrenz, Mark R. Witcher, Adrian W. Laxton, Stephen B. Tatter, Jason P. White, Thomas L. Ellis, Paul E. M. Phillips, & P. Read Montague. (2015) Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward. Proceedings of the natural sciences academy of the United States of America. info:/10.1073/pnas.1513619112
Exercising, meditating, scouring self-help books… we go out of our way to be happy, but do we really know what happiness is? Wataru Sato and his team at Kyoto University have found an answer from a neurological perspective.... Read more »
Sato, W., Kochiyama, T., Uono, S., Kubota, Y., Sawada, R., Yoshimura, S., & Toichi, M. (2015) The structural neural substrate of subjective happiness. Scientific Reports, 16891. DOI: 10.1038/srep16891
Most psychology findings are not replicable. What can be done? In his Psychological Science editorial, Stephen Lindsay advertises pre-registration as the solution, writing that “Personally, I aim never again to submit for publication a report of a study that was not preregistered”. I took a look at whether pre-registrations are effective and feasible [TL;DR: no […]... Read more »
Chan AW, Krleza-Jerić K, Schmid I, & Altman DG. (2004) Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research. CMAJ : Canadian Medical Association journal , 171(7), 735-40. PMID: 15451835
Chan, A., Hróbjartsson, A., Haahr, M., Gøtzsche, P., & Altman, D. (2004) Empirical Evidence for Selective Reporting of Outcomes in Randomized Trials. JAMA, 291(20), 2457. DOI: 10.1001/jama.291.20.2457
Franco, A., Malhotra, N., & Simonovits, G. (2015) Underreporting in Psychology Experiments: Evidence From a Study Registry. Social Psychological and Personality Science. DOI: 10.1177/1948550615598377
Mathieu, S., Boutron, I., Moher, D., Altman, D.G., & Ravaud, P. (2009) Comparison of Registered and Published Primary Outcomes in Randomized Controlled Trials. JAMA, 302(9), 977. DOI: 10.1001/jama.2009.1242
Mathieu, S., Chan, A., & Ravaud, P. (2013) Use of Trial Register Information during the Peer Review Process. PLoS ONE, 8(4). DOI: 10.1371/journal.pone.0059910
Nosek, B., & Bar-Anan, Y. (2012) Scientific Utopia: I. Opening Scientific Communication. Psychological Inquiry, 23(3), 217-243. DOI: 10.1080/1047840X.2012.692215
Open Science Collaboration. (2015) PSYCHOLOGY. Estimating the reproducibility of psychological science. Science (New York, N.Y.), 349(6251). PMID: 26315443
Researchers at the University of Toronto examined fungi in the mucus of patients with cystic fibrosis and discovered how one particularly cunning fungal species has evolved to defend itself against neighbouring bacteria. A regular resident of our microbiome – and especially ubiquitous in the lungs of cystic fibrosis patients -the Candida albicans fungus is an “opportunistic pathogen.”
... Read more »
Kim, S., Clark, S., Surendra, A., Copeland, J., Wang, P., Ammar, R., Collins, C., Tullis, D., Nislow, C., Hwang, D.... (2015) Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation. PLOS Pathogens, 11(11). DOI: 10.1371/journal.ppat.1005308
About one third of people with depression have high levels of inflammation markers in their blood. New research indicates that persistent inflammation affects the brain in ways that are connected with stubborn symptoms of depression, such as anhedonia, the inability to experience pleasure.... Read more »
Felger, J., Li, Z., Haroon, E., Woolwine, B., Jung, M., Hu, X., & Miller, A. (2015) Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Molecular Psychiatry. DOI: 10.1038/mp.2015.168
Low levels of serotonin in the brain are known to play a role in depression and anxiety, and it is customary to treat these disorders with medications that increase the amount of this neurotransmitter. However, a new study carried out by researchers suggests that this approach may be too simple. It appears that neighboring serotonin-producing brainstem regions exert different and sometimes opposing effects on behavior.... Read more »
Anne Teissier, Alexei Chemiakine, Benjamin Inbar, Susan M. Dymecki, Holly Moore, & Mark S. Ansorge. (2015) Activity of Raphe´ Serotonergic Neurons Controls Emotional Behaviors. Cell Reports. info:/http://dx.doi.org/10.1016/j.celrep.2015.10.061
Scientists at the Institute of Molecular Biology (IMB) in Mainz have unraveled a complex regulatory mechanism that explains how a single gene can drive the formation of brain cells. The research is an important step towards a better understanding of how the brain develops. It also harbors potential for regenerative medicine.... Read more »
Pataskar, A., Jung, J., Smialowski, P., Noack, F., Calegari, F., Straub, T., & Tiwari, V. (2015) NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program. The EMBO Journal. DOI: 10.15252/embj.201591206
More than 80% of the US population lives in cities, making their adaptation strategies one of the most important political decisions in the coming decades. Here we discuss a new study that identifies reasons why some cities have already prepared response programs while others haven't yet started.... Read more »
Carlson, K., & McCormick, S. (2015) American adaptation: Social factors affecting new developments to address climate change. Global Environmental Change, 360-367. DOI: 10.1016/j.gloenvcha.2015.09.015
What’s in a name? In the case of the usernames of video gamers, a remarkable amount of information about their real world personalities, according to research. Analysis of anonymised data from one of the world’s most popular computer games by scientists in the Department of Psychology at York also revealed information about their ages.... Read more »
Kokkinakis, A., Lin, J., Pavlas, D., & Wade, A. (2016) What's in a name? Ages and names predict the valence of social interactions in a massive online game. Computers in Human Behavior, 605-613. DOI: 10.1016/j.chb.2015.09.034
A direct and positive link between pupils’ breakfast quality and consumption, and their educational attainment, has for the first time been demonstrated in a ground-breaking new study carried out by public health experts at Cardiff University. The study of 5000 9-11 year-olds from more than 100 primary schools sought to examine the link between breakfast consumption and quality and subsequent attainment in Key Stage 2 Teacher Assessments* 6-18 months later.... Read more »
Littlecott, H., Moore, G., Moore, L., Lyons, R., & Murphy, S. (2015) Association between breakfast consumption and educational outcomes in 9–11-year-old children – CORRIGENDUM. Public Health Nutrition, 1. DOI: 10.1017/S1368980015003365
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