Thin layer chromatography, or TLC, is a technique used for the separation and analysis of molecules in a sample (Note- NOT DNA!). It can be used on amino acids1, although in my lab it has been used to analyze the degradation (or lack of!) of large polymeric sugars by whole metabolically inactivated cells or by simple enzymes. Because of this, I’ll be focusing on the analysis of saccharides (sugars).
So far, good stuff! But! How does it work, and what the HELL do these results mean!?!... Read more »
Bhawani SA, Albishri HM, Khan ZA, Mohamad Ibrahim MN, & Mohammad A. (2013) Surfactant Modified/Mediated Thin-Layer Chromatographic Systems for the Analysis of Amino Acids. Journal of analytical methods in chemistry, 973280. PMID: 24455427
Anaesthesia and Intensive Care (AIC) is an Australian medical journal. The latest issue, just published online, contains a remarkable – and possibly even unique – pair of Letters. These letters take the form of apologies for the distress caused by the publication of an article – I do not know of any similar cases in […]The post Medical Journal Apologizes “For The Distress Caused” By A Paper appeared first on Neuroskeptic.... Read more »
Simpson RS, & Van K. (2013) Fatal rhabdomyolysis following volatile induction in a six-year-old boy with Duchenne Muscular Dystrophy. Anaesthesia and intensive care, 41(6), 805-7. PMID: 24180726
Gibbs N. (2014) Apology for distress caused by the publication of recent correspondence describing fatal rhabdomyolysis in a patient with Duchenne muscular dystrophy. Anaesthesia and intensive care, 42(1), 134. PMID: 24471672
Simpson R, & Van K. (2014) Apology in relation to our recent letter describing a case of fatal rhabdomyolysis in a patient with Duchenne muscular dystrophy. Anaesthesia and intensive care, 42(1), 134. PMID: 24471673
Race is a hotly debated topic in both the sciences and politics. One contended issue is whether or not race, as a human classification, exists at a biological level. Richard Lewontin in 1972 argued that it is not so, but one famous paper by AWF Edwards contested his conclusions. So was Lewontin right? This post examines the arguments on both sides and comes to the conclusion, in the author's opinion, that race is not a valuable taxonomy for humans.... Read more »
Rosenberg, NA. (2002) Genetic structure of human populations. Science. info:/
I am often questions, like “What are you doing as a science writer?”, “Why do we need one?” or “Why our scientist cannot do the job?”... Read more »
In show business, they say that you should never work with animals or small children. The reasons are obvious: they are both unpredictable and you never know exactly what they are thinking. Children grow up and learn to communicate via […]The post The direction a dog’s tail wags says what it’s thinking appeared first on Guru Magazine.... Read more »
Siniscalchi M, Lusito R, Vallortigara G, & Quaranta A. (2013) Seeing left- or right-asymmetric tail wagging produces different emotional responses in dogs. Current biology : CB, 23(22), 2279-82. PMID: 24184108
Science is awesome. But I expect you already knew that, dear readers o'mine. In science laboratories across the world, every day dedicated researchers are testing ideas, generating and evaluating hypotheses, critically analyzing observations, and thereby, making significant contribution to the humanity's attempts to understand in greater depth and detail the wonderful natural world that surrounds us, of which we, along with other living beings and non-living objects, form a part. Ho hum, you say........ Read more »
Carolina S. Ilkow, Stephanie L. Swift, John C. Bell, & Jean-Simon Diallo. (2014) From Scourge to Cure: Tumour-Selective Viral Pathogenesis as a New Strategy against Cancer. PLOS Pathogen, 10(1). DOI: 10.1371/journal.ppat.1003836
Researchers find three communicative functions of smileys... Read more »
Skovholt, K., Grønning, A., & Kankaanranta, A. (2014) The Communicative Functions of Emoticons in Workplace E-Mails: :). Journal of Computer-Mediated Communication. DOI: 10.1111/jcc4.12063
Lactobacillus (the purple rod-shaped things) is a common bacterial species in reproductive tracts. Image by Janice Carr from the CDC at Wikimedia Commons. In our world of antibacterial soaps, we have learned that bacteria are evil, dirty, sickness-causing agents to be eliminated at all costs. Although some bacteria can cause sickness, bacteria in general are actually a critical component of animal bodies. A human body has ten times as many bacterial cells as human cells and a hundred times........ Read more »
By coating germanium nanowires with a layer of silicon, Liu and colleagues show that lithium no longer wants to diffuse into the nanowire, known as lithiation, but rather creates a layer that grows along the axis of the nanowire. This could lead to a new architecture for battery electrodes and limit volume expansion.... Read more »
Liu Yang, Liu Xiao Hua, Nguyen Binh-Minh, Yoo Jinkyoung, Sullivan John P., Picraux S. Tom, Huang Jian Yu, & Dayeh Shadi A. (2013) Tailoring Lithiation Behavior by Interface and Bandgap Engineering at the Nanoscale. Nano Letters, 13(10), 4876-4883. DOI: 10.1021/nl4027549
Want thicker, shinier hair? Just try nature’s solution – get pregnant! During pregnancy, hair falls out less and many women say it looks incredible. The reason: hormones. When expecting, levels of the hormone oestrogen (US: estrogen) steadily increase. This, alongside […]The post Why do women stop losing their hair when pregnant? appeared first on Guru Magazine.... Read more »
Riedel-Baima B, & Riedel A. (2008) Female pattern hair loss may be triggered by low oestrogen to androgen ratio. Endocrine regulations, 42(1), 13-6. PMID: 18333699
A recent paper published in Circulation Research, a major cardiovascular research journal, challenges the assumption that the scores a grant application receives can reliably predict the future impact of the research.... Read more »
Narasimhan Danthi, Colin O Wu, Peibei Shi, & Michael S Lauer. (2014) Percentile Ranking and Citation Impact of a Large Cohort of NHLBI-Funded Cardiovascular R01 Grants. Circulation Research. info:/
It's been estimated that as much as 85% of funded research is never published. Sometimes it doesn't get done because gremlins get in the way, but often completed research is still not written up. I discuss three reasons for this and suggest solutions that researchers, funders and journals could adopt.... Read more »
Chan, A., Song, F., Vickers, A., Jefferson, T., Dickersin, K., Gotzsche, P., Krumholz, H. M., Ghersi, D., & van der Worp, H. B. (2014) Increasing value and reducing waste: addressing inaccessible research. Lancet. info:/10.1016/S0140-6736(13)62296-5
Lake Waiau at the top of Mauna Kea is shrinking. For some unknown reasons, for the last few years the lake has shrunk significantly and in September 2013 its diameter was only 15 m. In early 2010, the lake surface area began to shrink rapidly and, by late September 2013, had declined to just 115 m^2 (0.03 acres) – that is, about 2% of its normal surface area. ... Read more »
Andre Heath. (2013) GEOLOGICAL UPHEAVAL: Hawaii’s Only Alpine Lake Is Now Shrinking At An Alarming And "Unprecedented" Rate – Lake Waiau Is ALMOST GONE!. thecelestialconvergence. info:other/
United States Geological Survey. (2009) Complete Report for Mauna Kea Volcano (Class B) No. 2601. United States Geological Survey. info:other/United States Geological Survey. 26 October 2009.
Systematic reviews are a vital resource to ensure that new research takes into account what has gone before. They are, however, undervalued. ... Read more »
Chalmers, Iain, Bracken, Michael B., Djulbegovic, Ben, Garattini, Silvio, Grant, Jonathan, Gülmezoglu, A. Metin, Howells, David W., Ioannidis, John P. A., & Oliver, Sandy. (2014) How to increase value and reduce waste when research priorities are set. Lancet. info:/10.1016/S0140-6736(13)62229-1
The clutches of the Polar Vortex are finally releasing its grasp on us and we can be thankful for our home heating, our layers of warm clothing, and most of all, our bodies’ abilities to generate heat. But it is times like these that make me wonder about our friends that live outside year-round… especially those that don’t generate most of their own body heat. How do they survive these periods of intense cold? There are several species of North American frogs that have an unusual trick up ........ Read more »
Storey, K.B. (2004) Strategies for exploration of freeze responsive gene expression: advances in vertebrate freeze tolerance. Cryobiology, 134-145. DOI: 10.1016/j.cryobiol.2003.10.008
by Piter Kehoma Boll As already alerted by Ted Goertzel (2010): “Conspiracy theories that target specific research can have serious consequences for public health and environmental policies”. The above quote is in the article from 2010 published in EMBO reports by … Continue reading →... Read more »
Dr. Kevin Beaver followed my advice and was able to show that black men with MAOA-2R are especially likely to shoot or stab. Self-righteous critics sternly wag their fingers.... Read more »
Beaver KM, Barnes JC, & Boutwell BB. (2013) The 2-Repeat Allele of the MAOA Gene Confers an Increased Risk for Shooting and Stabbing Behaviors. The Psychiatric quarterly. PMID: 24326626
Piton A, Redin C, & Mandel JL. (2013) XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing. American journal of human genetics, 93(2), 368-83. PMID: 23871722
Tielbeek JJ, Medland SE, Benyamin B, Byrne EM, Heath AC, Madden PA, Martin NG, Wray NR, & Verweij KJ. (2012) Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study. PloS one, 7(10). PMID: 23077488
Vimaleswaran KS, Tachmazidou I, Zhao JH, Hirschhorn JN, Dudbridge F, & Loos RJ. (2012) Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI. Human molecular genetics, 21(20), 4537-42. PMID: 22791748
This probably would have best been posted a few days ago, but this week is computer science education week, or "code week" (coding just means writing computer programs). From December 9th to the 15th, over a million people all over the US are promoting computer science for students ranging from elementary school to college, as well as those of us finished with school. This is not only really cool because it is generating enthusiasm for computer science education, but it is also provi........ Read more »
Libeskind-Hadas R, & Bush E. (2013) A first course in computing with applications to biology. Briefings in bioinformatics, 14(5), 610-7. PMID: 23449003
This is a thorough review of everything stupid ever said about the warrior gene, MAOA.... Read more »
Byrd AL, & Manuck SB. (2013) MAOA, Childhood Maltreatment, and Antisocial Behavior: Meta-analysis of a Gene-Environment Interaction. Biological psychiatry. PMID: 23786983
When in trouble or in doubt, invent new words. We have bibliometrics and scientometrics from the Age of Print. Now they are joined by informetrics, cybermetrics, webometrics and altmetrics, which...
-- Read more on ScientificAmerican.com
... Read more »
Li, X, Thelwall, M, & Giustini, D. (2012) Validating online reference managers for scholarly. Scientometrics, 461-471. DOI: 10.1007/s11192-011-0580-x
Ludo Waltman, & Rodrigo Costas. (2013) F1000 recommendations as a new data source for research evaluation: A comparison with citations. JASIST. arXiv: 1303.3875v1
Taylor, M. (2013) Towards a common model of citation: some thoughts on merging altmetrics and bibliometrics. Research Trends. info:/
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