Health posts
- September 2, 2010
- 12:17 PM
- 11 views
Six Months to a Sexy New Body
by Paul Statt in Paul Statt Communications
Public transportation, like, say, public health or the public library, just isn’t sexy. But a fat slob isn’t sexy, either, is he? And with public transportation, he could build a sexy new physique in only 6 to 8 months, according to a recent publication in the the American Journal of Preventive Medicine.... Read more »
MacDonald JM, Stokes RJ, Cohen DA, Kofner A, & Ridgeway GK. (2010) The effect of light rail transit on body mass index and physical activity. American journal of preventive medicine, 39(2), 105-12. PMID: 20621257
- September 2, 2010
- 12:08 PM
- 6 views
Diabetes drug may protect against cancer
by Sally Church in Pharma Strategy Blog
Yesterday, I covered some of the key pathways and kinases associated with cell energy metabolism, LKB1 and AMPK. These, together with Insulin-like Growth Factor-I (IGF-I) and the insulin receptor (IR), appear to play important roles in the broader regulation of...... Read more »
Douglas JB, Silverman DT, Pollak MN, Tao Y, Soliman AS, & Stolzenberg-Solomon RZ. (2010) Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 Molar Ratio and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cancer epidemiology, biomarkers . PMID: 20699371
Tao Y, Pinzi V, Bourhis J, & Deutsch E. (2007) Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway--therapeutic perspectives in cancer. Nature clinical practice. Oncology, 4(10), 591-602. PMID: 17898809
Chitnis MM, Yuen JS, Protheroe AS, Pollak M, & Macaulay VM. (2008) The type 1 insulin-like growth factor receptor pathway. Clinical cancer research : an official journal of the American Association for Cancer Research, 14(20), 6364-70. PMID: 18927274
- September 2, 2010
- 09:32 AM
- 17 views
Briefings in Bioinformatics – our education paper is available now
Back in April I happened to mention that we (OpenHelix) were writing a paper on informal sources of bioinformatics education (in a Friday SNPets item) and we were asked to announce when the paper came out. Well, we got word late last week that the article has been published. The article appears in a special issue of Briefings in Bioinformatics that is devoted to bioinformatics education. I’m not sure if all the articles in the issue are available yet, but it looks like several are in the j........ Read more »
Williams, J., Mangan, M., Perreault-Micale, C., Lathe, S., Sirohi, N., & Lathe, W. (2010) OpenHelix: bioinformatics education outside of a different box. Briefings in Bioinformatics. DOI: 10.1093/bib/bbq026
- September 1, 2010
- 09:00 PM
- 41 views
Amazingly Awesome, Circadian Innovation: The Hair Follicle
by Allison in Dormivigilia
Japanese researchers have brainstormed an innovative and noninvasive technique for measuring clock gene expression in living humans and how such expression is modified by lifestyle changes....the hair follicle!!!... Read more »
Akashi M, Soma H, Yamamoto T, Tsugitomi A, Yamashita S, Yamamoto T, Nishida E, Yasuda A, Liao JK, & Node K. (2010) Noninvasive method for assessing the human circadian clock using hair follicle cells. Proceedings of the National Academy of Sciences of the United States of America. PMID: 20798039
- September 1, 2010
- 02:27 PM
- 33 views
LKB1 is a master kinase in cancer
by Sally Church in Pharma Strategy Blog
"LKB1 is a master kinase" What a great subheader in a paper last year by Reuben Shaw (journal link below). Liver kinase B1 (LKB1) first got my attention at the AACR lung cancer meeting in San Diego earlier this year,...... Read more »
Shaw RJ. (2009) LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta physiologica (Oxford, England), 196(1), 65-80. PMID: 19245654
Shackelford DB, & Shaw RJ. (2009) The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nature reviews. Cancer, 9(8), 563-75. PMID: 19629071
- September 1, 2010
- 02:13 PM
- 43 views
The Stress Symphony a Prelude to Neurogensis et Stress
by neurobites in Neurobites
Hi there! Been a long time eh? Not sure what happened there, but I blame Harry. Somehow, somewhere he was involved. So let’s just jump right into it Stress. Your reason for not calling your mother, a graduate student’s excuse for overeating, not sleeping, forgetting to hand in an abstract, walking into walls and lying [...]... Read more »
Bruce S. McEwen. (2007) Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain. Physiological Reviews, 873-904. info:/
- September 1, 2010
- 01:00 PM
- 382 views
What Hurts Fitness More: 30 Years of Aging or 3 Weeks of Bed Rest?
by Travis Saunders, MSc, CEP in Obesity Panacea
I recently came across a very interesting study published in Circulation in 2001. In it, authors Darren McGuire and colleagues perform the 30-year follow-up on a group of 5 men who had taken part in the Dallas Bed Rest and Training Study (DBRTS). The DBRTS took place in 1966, when all 5 men were healthy 20 year-olds. They were assessed extensively at 3 different time points: baseline, following 3 months of bed rest, and following 8 weeks of physical training. In 1996 these same 5 men were as........ Read more »
McGuire DK, Levine BD, Williamson JW, Snell PG, Blomqvist CG, Saltin B, & Mitchell JH. (2001) A 30-year follow-up of the Dallas Bedrest and Training Study: I. Effect of age on the cardiovascular response to exercise. Circulation, 104(12), 1350-7. PMID: 11560849
- September 1, 2010
- 08:30 AM
- 28 views
The complex lipidome quantified
by Colby in Nutritional Blogma
There are thousands of lipid species in our bodies that represent 6 categories, but we only usually hear about the subcategories of cholesterol and triglycerides. We don’t yet understand how they are all altered in response to various nutrients, dietary … Continue reading →... Read more »
Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL.... (2010) Lipidomics reveals a remarkable diversity of lipids in human plasma. Journal of lipid research. PMID: 20671299
- September 1, 2010
- 05:32 AM
- 41 views
Were does Resilience against Depression Reside in the Brain?
by Dr Shock in Dr Shock MD PhD
Resilience is in psychiatry the positive capacity of people to cope with stress and catastrophe. In this post it’s used as having an adaptive system that uses exposure to stress to provide resistance to future negative events.
Stress can lead to depression accompanied by atrophy and loss of neurons in the adult hippocampus in experimental [...]
Related posts:Were is Depression Located in the Brain?
Adolescents brain and Depression
Neurobiology of Psychosocial Stress and Depression
... Read more »
Thomas Frodl,, Angela Carballedo1,, Andrew J. Fagan,, Danusia Lisiecka1,, Yolande Ferguson,, Ian Daly,, James F. Meaney,, & Dermot Kelleher. (2010) Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms?. Nature Precedings. info:/
- September 1, 2010
- 05:00 AM
- 29 views
Another Good Reason to Lose the Fat: Stop Urine Leakage
by Steve Parker, M.D. in Advanced Mediterranean Diet Blog
For overweight and obese women, loss of between five and 10% of body weight significantly reduces urine leakage. According to the research report in last month’s Obstetrics & Gynecology journal, weight loss should be the first approach to urine leakage in overweight and obese women.
The other word for urine leakage is incontinence: an involuntary loss of [...]... Read more »
Wing RR, Creasman JM, West DS, Richter HE, Myers D, Burgio KL, Franklin F, Gorin AA, Vittinghoff E, Macer J.... (2010) Improving urinary incontinence in overweight and obese women through modest weight loss. Obstetrics and gynecology, 116(2 Pt 1), 284-92. PMID: 20664387
- August 31, 2010
- 10:18 PM
- 62 views
The Link Between Positive Psychology and Cancer Survival
by Walter Jessen in Highlight HEALTH
The seemingly common idea that a positive outlook will help someone in poor health is currently under scientific investigation. A special supplement of the Annals of Behavioural Medicine directly addressed this topic and a recent article in the Lancet explored the relationship between positive psychology and cancer pathology.... Read more »
Ondicova K, & Mravec B. (2010) Role of nervous system in cancer aetiopathogenesis. The lancet oncology, 11(6), 596-601. PMID: 20522385
- August 31, 2010
- 07:09 PM
- 37 views
Barriers to Long-Term Living Kidney Donor Follow-up
by Cristy at Living Donor 101 in Living Donors Are People Too
FYI: OPTN requires indefinite follow-up of all transplant recipients, but surgeons and transplant centers have consistently opposed following up on living donors. Keep that in mind as I give a guided tour of this article. Since 1999, UNOS has required transplant programs to report information about living donors at postoperative discharge, 6months, and 12 months (10). In June 2007, this reporting requirement was extended to 24 months (11).UNOS doesn't require anything; OPTN does. UNOS is simply ........ Read more »
Mandelbrot DA, Pavlakis M, Karp SJ, Johnson SR, Hanto DW, & Rodrigue JR. (2009) Practices and barriers in long-term living kidney donor follow-up: a survey of U.S. transplant centers. Transplantation, 88(7), 855-60. PMID: 19935453
- August 31, 2010
- 05:33 PM
- 33 views
Monkeypox infections on the increase in Africa
by geekheartsscience in geek!
The incidence of a smallpox-like disease—caused by the monkeypox virus—has increased 20-fold in the Demoncratic Republic of Congo (DRC) over the past 30 years, according to new research published online in the journal PNAS. The findings suggest that, as smallpox vaccination programmes ceased in the DRC in 1980, people are now immunologically ‘naïve’ to orthopoxviruses [...]... Read more »
Anne W. Rimoin, Prime M. Mulembakani, Sara C. Johnston, James O. Lloyd Smith, Neville K. Kisalu, Timothee L. Kinkela, Seth Blumberg, Henri A. Thomassen, Brian L. Pike, Joseph N. Fair, Nathan D. Wolfe, Robert L. Shongo, Barney S. Graham, Pierre Formenty, E, & Major. (2010) Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proceedings of the National Academy of Sciences USA. DOI: 10.1073/pnas.1005769107
- August 31, 2010
- 03:35 PM
- 33 views
Measuring changes during graded exposure & acceptance treatment
by Adiemusfree in Healthskills: Skills for Healthy Living
I have been pondering about the best way to monitor ‘Matt’s progress during graded exposure therapy for his avoidance of activities involving back movement. I introduced you to Matt yesterday. He’s a ‘man’s man’, a real bloke who, for the past four years since he had surgery for a prolapsed disc, has avoided things like … Read more... Read more »
Wicksell, R., Lekander, M., Sorjonen, K., & Olsson, G. (2010) The Psychological Inflexibility in Pain Scale (PIPS) – Statistical properties and model fit of an instrument to assess change processes in pain related disability. European Journal of Pain, 14(7), 7710-2147483647. DOI: 10.1016/j.ejpain.2009.11.015
- August 31, 2010
- 01:51 PM
- 57 views
Seeing double: perhaps is simply optical diplopia
by Pablo Artal in Optics confidential
Changes in the optics of the eye can produce double or even multiple images... a real case is explained as an example and more... ... Read more »
Pérez, G., Abenza, S., De Casas, A., Marín, J., & Artal, P. (2010) Cause of Monocular Diplopia Diagnosed by Combining Double-pass Retinal Image Assessment and Hartmann-Shack Aberrometry. Journal of Refractive Surgery, 26(4), 301-304. DOI: 10.3928/1081597X-20100218-05
- August 31, 2010
- 01:47 PM
- 30 views
Adolescent Menstrual Variation and Oral Contraceptives
by Kate Clancy in Laboratory for Evolutionary Endocrinology
This post reviews current knowledge about adolescent menstrual cycling and oral contraceptive use, making recommendations for future research.... Read more »
American Academy of Pediatrics Committee on Adolescence, American College of Obstetricians and Gynecologists Committee on Adolescent Health Care, Diaz A, Laufer MR, & Breech LL. (2006) Menstruation in girls and adolescents: using the menstrual cycle as a vital sign. Pediatrics, 118(5), 2245-50. PMID: 17079600
Andrist LC, Arias RD, Nucatola D, Kaunitz AM, Musselman BL, Reiter S, Boulanger J, Dominguez L, & Emmert S. (2004) Women's and providers' attitudes toward menstrual suppression with extended use of oral contraceptives. Contraception, 70(5), 359-63. PMID: 15504373
APTER, D. (1997) Development of the Hypothalamic-Pituitary-Ovarian Axis. Annals of the New York Academy of Sciences, 816(1 Adolescent Gy), 9-21. DOI: 10.1111/j.1749-6632.1997.tb52125.x
Christo, K., Cord, J., Mendes, N., Miller, K., Goldstein, M., Klibanski, A., & Misra, M. (2008) Acylated ghrelin and leptin in adolescent athletes with amenorrhea, eumenorrheic athletes and controls: a cross-sectional study. Clinical Endocrinology, 69(4), 628-633. DOI: 10.1111/j.1365-2265.2008.03237.x
Cromer BA, Bonny AE, Stager M, Lazebnik R, Rome E, Ziegler J, Camlin-Shingler K, & Secic M. (2008) Bone mineral density in adolescent females using injectable or oral contraceptives: a 24-month prospective study. Fertility and sterility, 90(6), 2060-7. PMID: 18222431
El-Khayat, H., Soliman, N., Tomoum, H., Omran, M., El-Wakad, A., & Shatla, R. (2008) Reproductive hormonal changes and catamenial pattern in adolescent females with epilepsy. Epilepsia, 49(9), 1619-1626. DOI: 10.1111/j.1528-1167.2008.01622.x
GERSCHULTZ, K., SUCATO, G., HENNON, T., MURRAY, P., & GOLD, M. (2007) Extended Cycling of Combined Hormonal Contraceptives in Adolescents: Physician Views and Prescribing Practices. Journal of Adolescent Health, 40(2), 151-157. DOI: 10.1016/j.jadohealth.2006.09.013
Morimatsu, Y., Matsubara, S., Watanabe, T., Hashimoto, Y., Matsui, T., Asada, K., & Suzuki, M. (2009) Future recovery of the normal menstrual cycle in adolescent patients with secondary amenorrhea. Journal of Obstetrics and Gynaecology Research, 35(3), 545-550. DOI: 10.1111/j.1447-0756.2009.01014.x
Omar H, Kives S, & Allen L. (2005) Extended use of the oral contraceptive pill--is it an acceptable option for the adolescent?. Journal of pediatric and adolescent gynecology, 18(4), 285-8. PMID: 16171734
Singer, K., Rosenthal, A., & Kasa-Vubu, J. (2009) Elevated Testosterone and Hypergonadotropism in Active Adolescents of Normal Weight with Oligomenorrhea. Journal of Pediatric and Adolescent Gynecology, 22(5), 323-327. DOI: 10.1016/j.jpag.2008.12.010
- August 31, 2010
- 12:30 PM
- 23 views
Genomic analysis can be powerful – in the right hands
by Rachel Bernstein in Berkeley Science Review Blog
You may have heard about the controversial genetics study connecting a set of 150 genetic markers to “exceptional longevity” (people living past 100). Everybody’s interested in living longer, so it’s not surprising that the work, published by Boston University researchers in July in the journal Science, was covered with much fanfare in many main-stream news outlets (for example, in the NY Times and Scientific American). Science even hosted a media teleconference to promote the story. Con........ Read more »
Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ.... (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature, 466(7307), 707-13. PMID: 20686565
- August 31, 2010
- 10:34 AM
- 22 views
What causes resistance to BRAF inhibition in melanoma?
by Sally Church in Pharma Strategy Blog
Last week there was lot of excitement and interest surrounding the blog post on Roche/Plexxikon's data on PLX4032 in metastatic melanoma published in the New England Journal of Medicine. A number of the discussions on Twitter and email centred around...... Read more »
Dibb, N., Dilworth, S., & Mol, C. (2004) Opinion: Switching on kinases: oncogenic activation of BRAF and the PDGFR family. Nature Reviews Cancer, 4(9), 718-727. DOI: 10.1038/nrc1434
Shao, Y., & Aplin, A. (2010) Akt3-Mediated Resistance to Apoptosis in B-RAF-Targeted Melanoma Cells. Cancer Research, 70(16), 6670-6681. DOI: 10.1158/0008-5472.CAN-09-4471
Crouthamel, M., Kahana, J., Korenchuk, S., Zhang, S., Sundaresan, G., Eberwein, D., Brown, K., & Kumar, R. (2009) Mechanism and Management of AKT Inhibitor-Induced Hyperglycemia. Clinical Cancer Research, 15(1), 217-225. DOI: 10.1158/1078-0432.CCR-08-1253
- August 31, 2010
- 08:00 AM
- 30 views
Kidney Fat Predicts Kidney Disease?
by Arya M. Sharma in Dr. Sharma's Obesity Notes
Yesterday, at the ongoing 2010 European Society of Cardiology, I attended as session focussing on the potential role of excess fat tissue that may surround blood vessels or the heart. Regular readers will recall, that the role of these fat depots have been a focus of my interest in past years.
A new study by Olga [...]... Read more »
Lamacchia O, Nicastro V, Camarchio D, Valente U, Grisorio R, Gesualdo L, & Cignarelli M. (2010) Para- and perirenal fat thickness is an independent predictor of chronic kidney disease, increased renal resistance index and hyperuricaemia in type-2 diabetic patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. PMID: 20798120
- August 31, 2010
- 08:00 AM
- 24 views
Hot and getting HOTTER… Heatwave preparedness since 2003, Part I
by Elements Team in Elements
By: Rosemary Stephen PMed, (cert) EOH, IPM, Elements: Environmental Health Intelligence
Even just a few years ago heatwaves were limited and isolated events, but now they occur regularly world wide. Each year climatologists tell us that the current year has become the new “hottest on record”. [...]... Read more »
Rosemary Stephen PMed, (cert) EOH, IPM. (2010) Hot and getting HOTTER.. Heatwave preparedness since 2003, Part I. Elements: Environmental Health Intelligence. info:/
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