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  • September 28, 2016
  • 10:20 AM
  • 393 views

A New Hope For Alzheimer’s Disease Immunotherapy

by Agnese Mariotti in United Academics

For the first time, an antibody was able to target and disrupt the Aβ plaques in the brain.... Read more »

Sevigny, J., Chiao, P., Bussière, T., Weinreb, P., Williams, L., Maier, M., Dunstan, R., Salloway, S., Chen, T., Ling, Y.... (2016) The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature, 537(7618), 50-56. DOI: 10.1038/nature19323  

  • September 28, 2016
  • 02:55 AM
  • 405 views

Postural tachycardia syndrome and gluten?

by Paul Whiteley in Questioning Answers

Please use your full stops wisely.I believe that this is the first time that I've talked about postural tachycardia syndrome (PoTS) on this blog as I bring to your attention some rather intriguing findings reported by Hugo Penny and colleagues [1] on how PoTS and gluten-related disorders might not be unstrange diagnostic bedfellows.PoTS by the way, describes symptoms where standing upright / sitting down induces dizziness, fainting and other symptoms. As well as being quite prevalent in a c........ Read more »

Penny, H., Aziz, I., Ferrar, M., Atkinson, J., Hoggard, N., Hadjivassiliou, M., West, J., & Sanders, D. (2016) Is there a relationship between gluten sensitivity and postural tachycardia syndrome?. European Journal of Gastroenterology , 1. DOI: 10.1097/MEG.0000000000000740  

  • September 27, 2016
  • 02:55 AM
  • 394 views

Neurotensin, intestinal inflammation and autism?

by Paul Whiteley in Questioning Answers

"Elevated peripheral pro-NT [neurotensin] levels reflect more severe forms of active celiac disease, indicating a potential role of NT in intestinal inflammation."The suggestion, from Caroline Montén and colleagues [1], that the neuropeptide called neurotensin might play a role in paediatric coeliac disease is an interesting one that caught my eye recently. Interesting not only because of the potential implications for the archetypal 'gluten-causing' autoimmune condition cal........ Read more »

Montén C, Torinsson Naluai Å, & Agardh D. (2016) Role of pro-neurotensin as marker of paediatric celiac disease. Clinical and experimental immunology. PMID: 27612962  

  • September 26, 2016
  • 01:35 PM
  • 393 views

Why do more men than women commit suicide?

by Dr. Jekyll in Lunatic Laboratories

Why do more men die when they attempt suicide than women? The answer could lie in four traits, finds scientists. There are over 6,000 British lives lost to suicide each year, and nearly 75 per cent of those are male. However, research has found women are more likely to suffer from depression, and to attempt to take their own life.

... Read more »

Deshpande, G., Baxi, M., Witte, T., & Robinson, J. (2016) A Neural Basis for the Acquired Capability for Suicide. Frontiers in Psychiatry. DOI: 10.3389/fpsyt.2016.00125  

  • September 26, 2016
  • 02:48 AM
  • 377 views

On HERV-H, autism, ADHD and methylphenidate?

by Paul Whiteley in Questioning Answers

Today's post is a bit of a mash-up including two paper: the first from Emanuela  Balestrieri and colleagues [1] (open-access available here) talking about "increased HERV-H [Human Endogenous Retroviruses - H] transcriptional activity in all autistic patients" included in their cohort (author's words not mine) and the second from D'Agati and colleagues [2] (open-access available here) describing "the reduction of HERV-H expression and the significant improvement of ADHD&n........ Read more »

Balestrieri E, Cipriani C, Matteucci C, Capodicasa N, Pilika A, Korca I, Sorrentino R, Argaw-Denboba A, Bucci I, Miele MT.... (2016) Transcriptional activity of human endogenous retrovirus in Albanian children with autism spectrum disorders. The new microbiologica, 39(3), 228-31. PMID: 27602423  

  • September 25, 2016
  • 02:57 PM
  • 397 views

Linking perception to action

by Dr. Jekyll in Lunatic Laboratories

Researchers studying how the brain uses perception of the environment to guide action offer a new understanding of the neural circuits responsible for transforming sensation into movement.

... Read more »

  • September 24, 2016
  • 03:26 AM
  • 387 views

Correcting ophthalmic problems in autism

by Paul Whiteley in Questioning Answers

'Does Correction of Strabismus Improve Quality of Life in Children with Autism Spectrum Disorder?' went the title of the paper by Pinar Ozer and colleagues [1]. Yes, it may very well do was the answer (but with certain caveats and the requirement for a lot more research in this area).Strabismus, a condition where the eyes don't line up in the same direction, can sometime have some quite noticeable effects on a person's vision and indeed, has been linked to various other non-vision related sympto........ Read more »

  • September 23, 2016
  • 04:14 PM
  • 411 views

PD-L1 expression associates with non-inactivated VHL ccRCC

by Joana Guedes in BHD Research Blog

The loss of the of the tumor suppressor gene VHL and the subsequent deregulation of VHL/HIF/VEGF signalling are known to play a role in development of clear cell renal cell carcinoma (ccRCC). Renal tumours associated with BHD syndrome are histologically diverse and include a percentage of ccRCC (Pavlovich et al., 2002). Anti-angiogenic therapies targeting the VHL/HIF/VEGF pathway have emerged in past years (Rini et al., 2006) but the development of resistance to these therapeutic agents is leadi........ Read more »

  • September 23, 2016
  • 02:42 AM
  • 406 views

Epilepsy and systemic autoimmune diseases: birds of a feather?

by Paul Whiteley in Questioning Answers

A couple of years back on this blog I talked about some rather intriguing research suggesting that epilepsy and autoimmune disease might not be unstrange diagnostic bedfellows (see here) and that a "potential role of autoimmunity must be given due consideration in epilepsy." [1]Today, I'm continuing that research theme as the findings from Zhang Lin and colleagues [2] caught my eye concluding that: "There is an association between epilepsy and SAD [systemic autoimmune diseases], which ........ Read more »

  • September 22, 2016
  • 03:14 PM
  • 456 views

Historical analysis examines sugar industry role in heart disease research

by Dr. Jekyll in Lunatic Laboratories

Using archival documents, a new report examines the sugar industry's role in coronary heart disease research and suggests the industry sponsored research to influence the scientific debate to cast doubt on the hazards of sugar and to promote dietary fat as the culprit in heart disease.

... Read more »

  • September 22, 2016
  • 09:27 AM
  • 603 views

Will tardigrades get humanity into space?

by gdw in FictionalFieldwork

The mighty water bear Tardigrades, aka water bears, are tiny animals that can be found just about everywhere on earth, with a slight preference for the moisture in moss. They happily amble along on their four pairs of legs and slurp up plant cells, algae, and even smaller invertebrates that can’t get away fast enough […]... Read more »

Boothby TC, Tenlen JR, Smith FW, Wang JR, Patanella KA, Nishimura EO, Tintori SC, Li Q, Jones CD, Yandell M.... (2015) Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade. Proceedings of the National Academy of Sciences of the United States of America, 112(52), 15976-81. PMID: 26598659  

Koutsovoulos G, Kumar S, Laetsch DR, Stevens L, Daub J, Conlon C, Maroon H, Thomas F, Aboobaker AA, & Blaxter M. (2016) No evidence for extensive horizontal gene transfer in the genome of the tardigrade Hypsibius dujardini. Proceedings of the National Academy of Sciences of the United States of America, 113(18), 5053-8. PMID: 27035985  

Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T.... (2016) Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nature communications, 12808. PMID: 27649274  

  • September 22, 2016
  • 03:14 AM
  • 405 views

"Paediatricians are seeing more children with developmental-behavioural conditions"

by Paul Whiteley in Questioning Answers

The findings reported by Harriet Hiscock and colleagues [1] are brought to the blogging table today, specifically that suggestion that paediatricians, at least in Australia, might be encountering an increased number of "developmental/behavioural conditions" as part of their workload.Looking at the clinical experiences of some 180 paediatricians who took part in the study in late 2013 and comparing them with data from 2008, researchers probed a number of practices relating to "(i) conditions seen........ Read more »

  • September 21, 2016
  • 12:35 PM
  • 364 views

Protect kids from toxic secondhand smoke, experts urge

by Dr. Jekyll in Lunatic Laboratories

It's advice most smokers with children probably take lightly, but they shouldn't. Parents and policy advocates should take a "zero tolerance" approach to exposing children to secondhand cigarette smoke, which can be responsible for lifelong cardiovascular consequences in addition to respiratory and other health issues.

... Read more »

  • September 21, 2016
  • 11:46 AM
  • 419 views

Brain Imaging: UK Biobank Epidemiology Study

by William Yates, M.D. in Brain Posts

I wanted to alert Brain Posts readers to a very important ongoing study out of the United Kingdom.The UK Biobank prospective epidemiological study is a study designed to identify imaging markers for a wide variety of diseases. Additionally, a goal of the study is to better understand disease mechanisms.Here is what is being collected on 100,000 healthy participants who will be tracked over decades:Brain structural and functional imaging (fMRI)Brain diffusion tensor imaging (DTI)Neuropsychologica........ Read more »

Miller KL, Alfaro-Almagro F, Bangerter NK, Thomas DL, Yacoub E, Xu J, Bartsch AJ, Jbabdi S, Sotiropoulos SN, Andersson JL.... (2016) Multimodal population brain imaging in the UK Biobank prospective epidemiological study. Nature neuroscience. PMID: 27643430  

  • September 21, 2016
  • 02:41 AM
  • 387 views

Respite care and parent stress with autism in mind

by Paul Whiteley in Questioning Answers

"While most studies found that respite care was associated with lower stress, several found that respite care was associated with higher stress."That sentence is perhaps the most important finding recorded in the 'integrative review' published by Kim Whitmore [1] looking at "the relationship between respite care and stress among caregivers of children with ASD [autism spectrum disorder]."Covering a "final sample of 11 primary research reports" the author provides yet another example of how ........ Read more »

  • September 20, 2016
  • 04:31 PM
  • 510 views

Potentially harmful chemicals widespread in household dust

by Dr. Jekyll in Lunatic Laboratories

Household dust exposes people to a wide range of toxic chemicals from everyday products, according to a new study. A multi-institutional team conducted a first-of-a-kind meta-analysis, compiling data from dust samples collected throughout the United States to identify the top ten toxic chemicals commonly found in dust.

... Read more »

  • September 20, 2016
  • 09:30 AM
  • 156 views

Incompatible Kidneys Are Twice As Expensive, Half as Good

by in Living Donors Are People Too

Desensitization protocols and the unimportance of tissue matching are all the rage in the transplant world these days. They’re heralded as a solution to the so-called organ shortage (no matter that the ‘active’ kidney transplant list has been flat, if not declining, for many years now), and a plethora of propaganda-type media articles have followed. …
Continue reading »
The post Incompatible Kidneys Are Twice As Expensive, Half as Good appeared first on Living Donor........ Read more »

  • September 20, 2016
  • 03:11 AM
  • 479 views

First trimester maternal vitamin D status and offspring autism risk?

by Paul Whiteley in Questioning Answers

Vitamin D - the sunshine vitamin/hormone - is seemingly everywhere these days in research terms. At the time of writing this post we have news that vitamin D might cut the risk of severe asthma attacks if taken alongside prescribed asthma medication. The week before that it was the suggestion that vitamin D might be part of the explanation as to why childhood learning difficulties were more commonly found in children conceived during the winter months. Vitamin D is seemingly shouldering quite a ........ Read more »

  • September 19, 2016
  • 11:11 AM
  • 432 views

Preventing Depression Following Brain Injury

by William Yates, M.D. in Brain Posts

Depression is a common feature following traumatic brain injury (TBI). Post-TBI depression may be difficult to treat and evolve into a chronic depression syndrome.A recent published study demonstrates that prophylactic SSRI antidepressant treatment may reduce the incidence of depression following TBI.This study was conducted by investigators affiliated with Baylor College of Medicine and the Department of Psychiatry at the University of Iowa.Ninety four subjects were recruited to this randomized........ Read more »

  • September 19, 2016
  • 02:59 AM
  • 419 views

Constipation in schizophrenia

by Paul Whiteley in Questioning Answers

"Constipation and dyspepsia are disturbing gastrointestinal symptoms that are often ignored in research on physical comorbidities of schizophrenia."Go on."The prevalence of constipation was 31.3%, and of dyspepsia 23.6%."So said the findings reported by Tomi Virtanen and colleagues [1] who assessed "dyspepsia and constipation in a sample of outpatients with schizophrenia spectrum psychoses." Alongside the general practitioner assessment of such functional bowel complaints, researchers also ........ Read more »

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