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  • September 30, 2014
  • 12:34 PM
  • 6 views

This Month in Blastocystis Research (SEP 2014)

by Christen Rune Stensvold in Blastocystis Parasite Blog

Do companion animals contribute to human Blastocystis? Do IBS patients have a higher prevalence of Blastocystis and Dientamoeba fragilis than healthy invididuals? Check out this issue of 'This Month in Blastocystis Research'.... Read more »

Krogsgaard LR, Engsbro AL, Stensvold CR, Vedel Nielsen H, & Bytzer P. (2014) The Prevalence of Intestinal Parasites is not Greater Among Individuals with IBS: a Population-Based Case-Control Study. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. PMID: 25229421  

Wang W, Cuttell L, Bielefeldt-Ohmann H, Inpankaew T, Owen H, & Traub RJ. (2013) Diversity of Blastocystis subtypes in dogs in different geographical settings. Parasites , 215. PMID: 23883734  

Wawrzyniak I, Poirier P, Viscogliosi E, Dionigia M, Texier C, Delbac F, & Alaoui HE. (2013) Blastocystis, an unrecognized parasite: an overview of pathogenesis and diagnosis. Therapeutic advances in infectious disease, 1(5), 167-78. PMID: 25165551  

  • September 30, 2014
  • 05:06 AM
  • 22 views

Autoimmune thyroiditis and depressive disorder

by Paul Whiteley in Questioning Answers

"Our study demonstrates a strong association between anti-TPO levels, which are considered to be of diagnostic value for autoimmune thyroiditis... with uni- or bipolar depression.""Beware the bad cat bearing a grudge"So said the study published by Detlef Degner and colleagues [1]. Anti-TPO antibodies by the way, refers to anti-thyroid peroxidase antibodies which, as the name suggests, are antibodies against thyroid peroxidase, an important step in the production of thyroid hormone........ Read more »

Degner D, Haust M, Meller J, Rüther E, & Reulbach U. (2014) Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients. European archives of psychiatry and clinical neuroscience. PMID: 25193677  

  • September 29, 2014
  • 06:07 PM
  • 37 views

Cat and Dogs: seeking solutions with sniffing canines and science

by Cobb & Hecht in Do You Believe In Dog?

Hi Mia and Julie,  First of all, I LOVE your blog! After meeting at SPARCS this past summer (summer for us in North America.. I take it summer is just beginning in Australia!), I’ve followed it closely.  You do amazing things for the promotion of  canine science. Serious love. A bit of background for the readers: I’m currently doing my PhD at Dalhousie University in Halifax, Nova Scotia in Canada, under the supervision of Dr. Simon Gadbois. Dr. Gadbois........ Read more »

  • September 29, 2014
  • 05:12 PM
  • 34 views

New Protein Implicated in Alzheimer’s

by Gabriel in Lunatic Laboratories

Alzheimer's prevention has made some strides in recent years. We've even identified some new causes, and in some cases we can do both. In fact, researchers have now shown that low levels of the protein progranulin in the brain can increase the formation of amyloid-beta plaques (a hallmark of Alzheimer's disease). These plaques can cause neuroinflammation, and worsen memory deficits in a mouse model of this condition. Conversely, by using a gene therapy approach to elevate progranulin levels, sci........ Read more »

Minami, S., Min, S., Krabbe, G., Wang, C., Zhou, Y., Asgarov, R., Li, Y., Martens, L., Elia, L., Ward, M.... (2014) Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. Nature Medicine. DOI: 10.1038/nm.3672  

  • September 29, 2014
  • 03:04 PM
  • 32 views

Wind Turbines Kill Bats by Impersonating Trees

by Elizabeth Preston in Inkfish

Survival tip: don’t hang around machines that have giant spinning blades. It’s a lesson bats have been slow to learn, judging by the large numbers of their corpses found beneath wind turbines. New video footage suggests some bats are attracted to wind farms because they can’t tell turbines apart from trees. If it’s true, this […]The post Wind Turbines Kill Bats by Impersonating Trees appeared first on Inkfish.... Read more »

Paul. M. Cryan, P. Marcos Gorresen, Cris D. Hein, Michael R. Schirmacher, Robert H. Diehl, Manuela M. Huso, David T. S. Hayman, Paul D. Fricker, Frank J. Bonaccorso, Douglas H. Johnson.... (2014) Behavior of bats at wind turbines. PNAS. info:/10.1073/pnas.1406672111

  • September 29, 2014
  • 04:35 AM
  • 47 views

Term vs. preterm birth and the presentation of autism

by Paul Whiteley in Questioning Answers

The paper by Katherine Bowers and colleagues [1] continues the interest in the concept of 'the autisms' with their observations on the presentation of autism (and its comorbidities) when looking at those "born preterm versus those born at term".We'd better get back, 'cause it'll be dark soon, and they mostly come at night... mostlyBased on an analysis of quite a healthy participant number heading up to 900 "males and females with autism spectrum disorder", authors reported on several phenotypic ........ Read more »

  • September 28, 2014
  • 03:37 PM
  • 65 views

The Genetic Evolutionary Arms Race

by Gabriel in Lunatic Laboratories

Genes are tricky little buggers, the stuff that makes us up has fought the test of time to make it to where we are today. It is thought that our genes changed in an attempt to outpace other life, albeit random changes.That might only be half right however, new findings suggest that there is an evolutionary arms race going on within the genome against, of all things, itself. This inherent competition of primates drove the evolution of complex regulatory networks that orchestrate the activity of ........ Read more »

Jacobs, Greenberg, Nguyen, Haeussler, Ewing, Katzman, Paten, Salama . (2014) An evolutionary arms race betweenKRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. Nature. info:/10.1038/nature13760

  • September 28, 2014
  • 04:54 AM
  • 69 views

Andinobates Geminisae: New Fingernail Sized Poison Dart Frog from Panama

by beredim in Strange Animals

This is the hololotype specimen that the researchers used to describe the newly discovered Andinobates geminisaeCredit: Cesar Jaramillo, STRIA team of scientists from the Smithsonian Tropical Research Institute, the Universidad Autónoma de Chiriquí in Panama, and the Universidad de los Andes in Colombia recently announced the discovery of a new bright orange poison dart frog. The new species is so small that it can fit on a fingernail and was found in a rain forest near the Caribbean coast, Do........ Read more »

  • September 27, 2014
  • 03:50 AM
  • 80 views

Yes, people with autism do have headaches

by Paul Whiteley in Questioning Answers

I don't mean to be haughty but a sentence included in the paper by Victorio [1] led to the title of today's very quick post. Based on a chart review of patients diagnosed with an autism spectrum disorder (ASD) attending a neurology clinic, the author concluded that "ASD patients, despite being known to have indifference to pain, can experience headaches".Pain is something which has cropped up quite a bit in the autism research arena and has appeared more than once on this blog (see here and see ........ Read more »

  • September 26, 2014
  • 02:15 PM
  • 100 views

“GMO” Foods (Once Again) Proven Safe

by Gabriel in Lunatic Laboratories

GMO, I shudder every time I hear someone talk about the “dangers”. It’s one of the new buzzwords that doesn’t actually mean anything, but still manages to scare people. Well a new scientific review reports that the performance and health of food-producing animals consuming genetically engineered feed, first introduced 18 years ago, has been comparable to that of animals consuming non-GE feed. Not that this will stop people from spreading fear, but it’s a start.... Read more »

  • September 26, 2014
  • 10:30 AM
  • 83 views

Walking Really Is Just Falling and Catching Yourself

by Elizabeth Preston in Inkfish

The flailing of a gymnast who’s missed a step on the balance beam might not be far off from what the rest of us experience every day. Each step we take is really a tiny fall, a mathematical model suggests. The random-looking variation in our footfalls is actually a series of corrections. Our strides are […]The post Walking Really Is Just Falling and Catching Yourself appeared first on Inkfish.... Read more »

  • September 26, 2014
  • 08:14 AM
  • 92 views

Anthropomorphic Neuroscience Driven by Researchers with Large TPJs

by The Neurocritic in The Neurocritic

For immediate release — SEPTEMBER 26, 2014Research from the UCL lab of Professor Geraint Rees has proven that the recent craze for suggesting that rats have “regrets” or show “disappointment” is solely due to the size of the left temporal-parietal junction (TPJ) in the human authors of those papers (Cullen et al., 2014). This startling breakthrough was part of a larger effort to associate every known personality trait, political attitude, and individual difference with the size of a un........ Read more »

  • September 26, 2014
  • 05:32 AM
  • 73 views

Schizophrenia after child and adolescent psychiatric disorders

by Paul Whiteley in Questioning Answers

More of a 'bring to your attention' post today, as I bring to your attention(!) the paper by Cecilie Frejstrup Maibing and colleagues [1] who concluded: "The risk of being diagnosed with schizophrenia spectrum disorders [SSD] after a child and adolescent psychiatric disorder was significantly increased particularly in the short term but also in the long-term period"."I coulda been a contender"The findings were based on an analysis of one of those very informative Scandinavian........ Read more »

  • September 26, 2014
  • 02:53 AM
  • 67 views

Telomere shortening may cause genetic anticipation in VHL syndrome

by Lizzie Perdeaux in BHD Research Blog

Genetic anticipation describes the situation where younger generations of a family with a genetic disease develop symptoms at a younger age, develop more severe symptoms, or both. A study earlier this year showed that there is evidence of genetic anticipation … Continue reading →... Read more »

  • September 25, 2014
  • 11:34 AM
  • 97 views

September 25, 2014

by Erin Campbell in HighMag Blog

While taking an awesome cell biology course in college, I was coming to terms with my mother’s recent ovarian cancer diagnosis. The scientist in my head couldn’t shake the curiosity about how my mother’s cells could have betrayed her so royally. This intersection of basic cell biology and cancer kick-started my interest in cell biology research. Today’s image is from a paper showing a role for the ARF tumor suppressor in maintaining chromosomal stability. THIS paper is one of the mil........ Read more »

  • September 25, 2014
  • 10:37 AM
  • 105 views

A New Discovery in the Treatment of Autoimmunity and Chronic Inflammation

by Gabriel in Lunatic Laboratories

Lupus, Type 1 diabetes, and multiple sclerosis are all diseases brought on by autoimmunity — the bodies inability to tell itself apart from foreign invaders. Finding a cure, or even a suitable treatment has been to put it gently a long, painful road, with little to show for it. On the forefront of the war against the body betrayal is immunosuppressants, which with them carry their own set of side effects and in most cases only off mild to moderate relief of symptoms. But that is all changing a........ Read more »

Dubiella C, Cui H, Gersch M, Brouwer AJ, Sieber SA, Krüger A, Liskamp RM, & Groll M. (2014) Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site. Angewandte Chemie (International ed. in English). PMID: 25244435  

  • September 25, 2014
  • 09:46 AM
  • 88 views

What’s the Answer? (domain and lollipop mutation diagrams)

by Mary in OpenHelix

Biostars is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the community and find it very useful. Often questions and answers arise at Biostars that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here […]... Read more »

Gao J., U. Dogrusoz, G. Dresdner, B. Gross, S. O. Sumer, Y. Sun, A. Jacobsen, R. Sinha, E. Larsson, & E. Cerami. (2013) Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal. Science Signaling, 6(269). DOI: http://dx.doi.org/10.1126/scisignal.2004088  

  • September 25, 2014
  • 05:10 AM
  • 93 views

Temporal trends in US autism prevalence: mainly real increase

by Paul Whiteley in Questioning Answers

"Diagnosed autism prevalence has risen dramatically in the U.S over the last several decades and continued to trend upward as of birth year 2005. The increase is mainly real and has occurred mostly since the late 1980s"."They call me Cha Cha because I'm the best dancer at St. Bernadette's"That was the conclusion reached in the paper by Cynthia Nevison [1] (open-access) following her analysis of temporal trends in autism diagnosis for birth years between 1970 and 2005. Based on an analysis o........ Read more »

  • September 24, 2014
  • 07:27 PM
  • 75 views

Coronavirus PLpro, PLP2, and N: taking a STING out of antiviral signalling

by thelonevirologist in Virology Tidbits

The antiviral response following the infection of cells with positive RNA viruses involves the expression of genes encoding Interferon-α and -β (IFN-α /-β), both of which induce the expression of a number of Interferon stimulated genes (ISGs) in a an autocrine and paracrine manner. The activation of the expression of IFN-α and -β itself however depends on a cytoplasmic signaling pathway which involves the recognition of viral ssRNA and dsRNA intermediates by cell........ Read more »

Cornelissen T, Haddad D, Wauters F, Van Humbeeck C, Mandemakers W, Koentjoro B, Sue C, Gevaert K, De Strooper B, Verstreken P.... (2014) The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. Human molecular genetics, 23(19), 5227-42. PMID: 24852371  

Oh JE, & Lee HK. (2014) Pattern recognition receptors and autophagy. Frontiers in immunology, 300. PMID: 25009542  

Ablasser A, & Hornung V. (2013) DNA sensing unchained. Cell research, 23(5), 585-7. PMID: 23419517  

van Kasteren PB, Bailey-Elkin BA, James TW, Ninaber DK, Beugeling C, Khajehpour M, Snijder EJ, Mark BL, & Kikkert M. (2013) Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells. Proceedings of the National Academy of Sciences of the United States of America, 110(9). PMID: 23401522  

Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T.... (2009) Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proceedings of the National Academy of Sciences of the United States of America, 106(49), 20842-6. PMID: 19926846  

  • September 24, 2014
  • 03:54 PM
  • 79 views

A new Medicine may help Lupus Sufferers

by Gabriel in Lunatic Laboratories

Lupus, a particularly bad hell on earth for people suffering from it. Lupus is caused by autoimmunity, in where the body attacks itself. I have a special place in my heart for people suffering from the disease because my Uncle suffered from it. There is no cure and only moderately effective treatments for the disorder, which causes, in some cases, the most excruciating pain you will ever feel. Thankfully new findings by a biomedical engineering team raise hope for a new class of drugs to treat l........ Read more »

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