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  • November 30, 1999
  • 12:00 AM
  • 2,314 views

Darwin's contributions and why this matters for Mexico's conifers

by Claire Williams in Conifer Reproductive Biology

For International Darwin Day, February 12. Darwin's birthday inspired an elegant treatise by UNAM professor Antonio Lazcano, published in Science back in 2005. His article traces the cultural, social and science history roots behind widespread acceptance of Darwin's ideas in Mexico. This careful analysis is worthwhile reading, particularly for those working in the USA.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,956 views

Dance Macabre: Will 14th Century Remains Reveal the Pandemic Secrets of the Black Death?

by Sara Klink in Promega Connections

Another group of researchers decided to further analyze the causative agent of the Black Plague by enriching for and sequencing one of the extrachromasomal plasmids present in the bacterial genome: the 9.6kb virulence-associated pPCP1 plasmid.

The recently published research in the Proceedings of the National Association of Science USA chose to use samples from East Smithfield (ES) cemetery in London, England, a burial ground that was established during the medieval Black Death pandemic of 13........ Read more »

Schuenemann VJ, Bos K, Dewitte S, Schmedes S, Jamieson J, Mittnik A, Forrest S, Coombes BK, Wood JW, Earn DJ.... (2011) From the Cover: Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death. Proceedings of the National Academy of Sciences of the United States of America, 108(38). PMID: 21876176  

  • November 30, 1999
  • 12:00 AM
  • 1,752 views

Communication as a network problem

by Becky in It Takes 30

I recently gave a short talk to a group of post-docs who had organized their own mini-symposium and workshop as a way of bringing the Harvard post-doc community in systems biology together. Those of you who haven’t worked in the Boston area may be surprised that we need special events to bring together a community that is separated by only ~4 miles, but in fact the trip from Harvard’s main campus in Cambridge to Harvard Medical School in Boston is a frustrating and lengthy one. Mu........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,171 views

The Fragile Monument of Hominin Diet

by Matt Sponheimer in Originus

Hominin Diet... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,330 views

Evolution of "Natural" Sleep

by Cris Campbell in Originus

If you slept well last night and do so regularly, chances are you don’t give sleep much thought. It happens, is pleasurable, and you are refreshed. If you didn’t sleep well last night and do so irregularly, chances are you have given sleep a great deal of thought. It doesn’t happen, isn’t pleasurable, and you are fatigued.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,583 views

Detecting Gene Doping in Sports: MicroRNA biomarker sought

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

WADA funds research into developing detection methods for the emerging threat of gene doping in sports.... Read more »

Elmo W.I. Neuberger, Magdelena Jurkiewicz, Dirk A. Moser and Perikles Simon. (2012) Detection of EPO gene doping in blood. Drug Testt. Analysis. DOI: 10.1002/dta.1347  

  • November 30, 1999
  • 12:00 AM
  • 3,921 views

Lions And Tigers And Ligers, Oh My!

by Mark Lasbury in As Many Exceptions As Rules

Geographic isolation is often involved in speciation events. Here are examples of hybrid speciation involving a very localized isolation and a mating choice behavior.... Read more »

Jesús Mavárez1, Camilo A. Salazar, Eldredge Bermingham1, Christian Salcedo, Chris D. Jiggins . (2006) Speciation by hybridization in Heliconius butterflies. Nature, 868-871. DOI: 10.1038/nature04738  

  • November 30, 1999
  • 12:00 AM
  • 1,323 views

New Year Resolution, Reflection on Cancer Research

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

Controversial and surprising cancer research news, point to importance of epigenetics and cell signalling research in the war on cancer.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,565 views

Tet1 Enzyme Based Enrichment Method for Methylome Sequencing: TamC-Seq

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

Summary of a recent Nature paper that details a new inexpensive, enzyme based enrichment method for methylome sequencing. ... Read more »

Zhang L, Szulwach KE, Hon GC, Song CX, Park B, Yu M, Lu X, Dai Q, Wang X, Street CR.... (2013) Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing. Nature communications, 1517. PMID: 23443545  

  • November 30, 1999
  • 12:00 AM
  • 2,125 views

The good, bad, and ugly of protein refolding

by Scott Jeffers in Protein Solubility Blog

The good news is that 95% of the protein aggregates in the inclusion body are your protein of interest. To get a 95% pure sample of protein you just have to lyse the cells using your preferred method (sonication works well, as does French press) in a lyses buffer containing Triton X-100. You then centrifuge your inclusion bodies containing your aggregated protein and discard the soluble supernatant. Next, you wash your inclusion body pellet in lysis buffer without Triton X-100 to remove the dete........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,075 views

Five things to think about when preparing glycoproteins for crystallization:

by Dave Dilyx in Protein Solubility Blog

So, you have decided to crystallize your glycoprotein. First for the bad news, protein crystallization is difficult; it is not called the bottleneck of crystallography for nothing. When you want to crystallize a glycoprotein your problems are compounded because glycosylation is usually heterogeneous and can interfere with crystallization. However, there is good news, crystallographers believe that all proteins can be crystallized; it is just a matter of hard work and determination. A major prob........ Read more »

Chang, V., Crispin, M., Aricescu, A., Harvey, D., Nettleship, J., Fennelly, J., Yu, C., Boles, K., Evans, E., Stuart, D.... (2007) Glycoprotein Structural Genomics: Solving the Glycosylation Problem. Structure, 15(3), 267-273. DOI: 10.1016/j.str.2007.01.011  

  • November 30, 1999
  • 12:00 AM
  • 2,180 views

I WILL FEAR NO EVIL: THE FIRST HEAD TRANSPLANT ON HUMAN

by Eugenio Maria Battaglia in Science to Grok

In 2008, doctor Sergio Canavero, an italian neurosurgeon based in Turin, IT, have awakened a 20 years old lady from a permanent post-traumatic vegetative state, by means of a bifocal extradural cortical electro-stimulation. Today, while Science still find it hard to explain consciousness and embodied cognition – the world-class neurosurgeon made a shock announcement: “I’m ready for the first head transplant on a man.”

In the manuscript published on Surgical Neurology I........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,236 views

Medicine goes under the Needle

by James Dunce in Antisense Science

Tattoo artists may soon be faced with the prospect of a career change into the world of medicine thanks to the revelation that tattooing technology can be effectively applied in the delivery of vaccines and anti-parasitic drugs to the upper layers of the dermis.... Read more »

Shio MT, Paquet M, Martel C, Bosschaerts T, Stienstra S, Olivier M, & Fortin A. (2014) Drug delivery by tattooing to treat cutaneous leishmaniasis. Scientific reports, 4156. PMID: 24561704  

  • November 30, 1999
  • 12:00 AM
  • 742 views

Identified a new possible target to combat muscle wasting

by IRBBarcelona in the Node

A study by scientists at the Institute for Research in Biomedicine (IRB), headed by Antonio Zorzano, also full professor of the University of Barcelona, reveals a potential therapeutic target to tackle muscle wasting in risk populations.... Read more »

Sala D, Ivanova S, Plana N, Ribas V, Duran J, Bach D, Turkseven S, Laville M, Vidal H, Karczewska-Kupczewska M.... (2014) Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes. The Journal of clinical investigation. PMID: 24713655  

  • November 30, 1999
  • 12:00 AM
  • 1,508 views

A field guide to whole-genome analyses

by Mauro Mandrioli in The aphid room

Genome sequencing projects have been for long time possible goals for few model organisms and required the concerted effort of large consortia, but now...... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,437 views

At the origin of the aphid-ant mutualism

by Mauro Mandrioli in The aphid room

Several hemipteran species are involved in mutualistic relationships with ants so that aphids produce honeydew, a sweet waste product enriched in sugar and aminoacids, that ants collect as a supply for their diet. In return...... Read more »

  • November 30, 1999
  • 12:00 AM
  • 989 views

Recent reports on BHD and skin symptoms – misdiagnosis and new manifestations

by Joana Guedes in BHD Research Blog

Patients with Birt-Hogg-Dubé (BHD) syndrome usually develop benign hair follicle tumours (BHFTs) which appear as multiple whitish papules developing primarily on the face, neck and torso (Menko et al., 2009). BHFTs such as fibrofolliculomas and trichodiscomas (skin-coloured tumours occurring on the upper body) can be associated with various genetic conditions and their histology is often key to differential diagnosis. The morphology and histology of various BHFTs is discussed in a recent ........ Read more »

Del Rosso JQ, Silverberg N, & Zeichner JA. (2016) When Acne is Not Acne. Dermatologic clinics, 34(2), 225-8. PMID: 27015783  

  • November 30, 1999
  • 12:00 AM
  • 907 views

PD-L1 expression associates with non-inactivated VHL ccRCC

by Joana Guedes in BHD Research Blog

The loss of the of the tumor suppressor gene VHL and the subsequent deregulation of VHL/HIF/VEGF signalling are known to play a role in development of clear cell renal cell carcinoma (ccRCC). Renal tumours associated with BHD syndrome are histologically diverse and include a percentage of ccRCC (Pavlovich et al., 2002). Anti-angiogenic therapies targeting the VHL/HIF/VEGF pathway have emerged in past years (Rini et al., 2006) but the development of resistance to these therapeutic agents is leadi........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 788 views

The geometry of consciousness is a multi-dimensional math trip

by amanda alvarez in It Ain't Magic

Amanda Alvarez writes about how neuroscientists are studying consciousness with mathematics.... Read more »

Oizumi M, Tsuchiya N, & Amari SI. (2016) Unified framework for information integration based on information geometry. Proceedings of the National Academy of Sciences of the United States of America, 113(51), 14817-14822. PMID: 27930289  

  • November 30, 1999
  • 12:00 AM
  • 384 views

Impairment of neurogenesis in ZIKV infected neuronal cells: strain specific ? Asian/American v. African strains

by thelonevirologist in Virology Tidbits

During the current Zika Virus (ZIKV) outbreaks in the Americas, an increased number of cognitive malformations including but not limited to microcephaly in foetuses and neonates of mothers who had been infected with ZIKV during pregnancy, lead to the conclusion that ZIKV might be neuroteratogenic, a hypothesis that has been supported by findings that various ZIKV strains –including isolates from Asia such ZIKV SZ 01, ZIKV FSS13025 and H/PF/2013 as well as isolates from the Americas such a........ Read more »

Li H, Saucedo-Cuevas L, Shresta S, & Gleeson JG. (2016) The Neurobiology of Zika Virus. Neuron, 92(5), 949-958. PMID: 27930910  

van den Pol AN, Mao G, Yang Y, Ornaghi S, & Davis JN. (2017) Zika virus targeting in the developing brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. PMID: 28123079  

Li H, Saucedo-Cuevas L, Regla-Nava JA, Chai G, Sheets N, Tang W, Terskikh AV, Shresta S, & Gleeson JG. (2016) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation. Cell stem cell, 19(5), 593-598. PMID: 27545505  

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell, 18(5), 587-90. PMID: 26952870  

Garcez PP, Nascimento JM, de Vasconcelos JM, Madeiro da Costa R, Delvecchio R, Trindade P, Loiola EC, Higa LM, Cassoli JS, Vitória G.... (2017) Zika virus disrupts molecular fingerprinting of human neurospheres. Scientific reports, 40780. PMID: 28112162  

Gabriel, E., Ramani, A., Karow, U., Gottardo, M., Natarajan, K., Gooi, L., Goranci-Buzhala, G., Krut, O., Peters, F., Nikolic, M.... (2017) Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. Cell Stem Cell. DOI: 10.1016/j.stem.2016.12.005  

Gromley A, Jurczyk A, Sillibourne J, Halilovic E, Mogensen M, Groisman I, Blomberg M, & Doxsey S. (2003) A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. The Journal of cell biology, 161(3), 535-45. PMID: 12732615  

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK.... (2016) 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. The Journal of cell biology, 214(2), 155-66. PMID: 27432897  

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