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  • November 30, 1999
  • 12:00 AM
  • 1,958 views

in indirect support of the hygiene hypothesis

by Ragamuffin in How We Are Hungry

A recent study out of the University of Michigan Medical School suggests that the stomach bacterium Helicobacter pylori protects against inflammation caused by Salmonella in a mouse model of Inflammatory Bowel Disease (IBD).... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,023 views

Let’s Get Cellular: Meth Metabolism

by Dirk Hanson in Addiction Inbox

We know from the work of Nora Volkow and others that meth abusers have chronically low levels of dopamine D2 receptors in their brains. But what is going on in the rest of the body when methamphetamine addiction is running full force?... Read more »

Sun, L., Li, H., Seufferheld, M., Walters, K., Margam, V., Jannasch, A., Diaz, N., Riley, C., Sun, W., Li, Y.... (2011) Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0018215  

  • November 30, 1999
  • 12:00 AM
  • 2,266 views

Let’s Get Cellular: Meth Metabolism

by Dirk Hanson in Addiction Inbox

We know from the work of Nora Volkow and others that meth abusers have chronically low levels of dopamine D2 receptors in their brains. But what is going on in the rest of the body when methamphetamine addiction is running full force?... Read more »

Sun, L., Li, H., Seufferheld, M., Walters, K., Margam, V., Jannasch, A., Diaz, N., Riley, C., Sun, W., Li, Y.... (2011) Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0018215  

  • November 30, 1999
  • 12:00 AM
  • 2,984 views

Friday Weird Science GUEST POST: The distance between your testicles and your anus, 'taint unimportant

by Allie Wilkinson in OH, FOR THE LOVE OF SCIENCE!

A Friday Weird Science guest post on Neurotic Physiology takes a humorous look at anogenital distance and its implication for fertility in adult males.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,332 views

Comparing Apples with Oranges: B&W

by Peter Nollert in Protein Crystallization Blog

Identifying individual amino acid residues within a GPCR and comparing these across different receptors is a routine task that’s helped by a widely accepted nomenclature system: that of Ballesteros and Weinstein.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,549 views

Copyright vs Medicine: If this topic isn’t covered in your newspaper this weekend, get a new newspaper

by Neurobonkers in Neurobonkers

After thirty years of silence, authors of a standard clinical psychiatric bedside test have issued take down orders of new medical research. Doctors who use copies of the bedside test which will have been printed in some of their oldest medical textbooks are liable to be sued for up to $150,000.... Read more »

Newman, J., & Feldman, R. (2011) Copyright and Open Access at the Bedside. New England Journal of Medicine, 365(26), 2447-2449. DOI: 10.1056/NEJMp1110652  

  • November 30, 1999
  • 12:00 AM
  • 2,298 views

Mapping future climate space

by brettcherry in Institute of Hazard, Risk and Resilience Blog

By mapping climate suitability for plant species researchers are able to understand how climate change can affect biodiversity or determine suitable climates in the future for different plants. ... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,584 views

Viral MicroRNA Mimicing Cellular MicroRNA? and a New Dual-Fluuorescent Reporter System

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

Researchers from Chinese Academy of Sciences design a clever, single plasmid, dual-fluorescent reporter system to show more viral microRNAs functioning like cellular microRNAs. ... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,907 views

Babies Are Healthier When There Is a Dog at Home: Research

by United Academics in United Academics

New research published in Pediatrics suggests that children living with a dog are significantly healthier than those living without it. The researchers followed up 397 Finnish children, asking their parents to fill in weekly questionnaires about their health until they were 1 year old. Scientists believe that this is so because dog contact helps the babies build up their immune system.... Read more »

Eija Bergroth, Sami Remes, Juha Pekkanen, Timo Kauppila, Gisela Büchele, & Leea Keski-Nisula. (2012) Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts. Pediatrics. info:/10.1542/peds.2011-2825

  • November 30, 1999
  • 12:00 AM
  • 1,587 views

Detecting Gene Doping in Sports: MicroRNA biomarker sought

by Nicole Kelesoglu in E3 Engaging Epigenetics Experts

WADA funds research into detection of possible gene doping in athletes. While not an easy task, transcriptomics may ID a detection biomarker. ... Read more »

Elmo W.I. Neuberger, Magdelena Jurkiewicz, Dirk A. Moser and Perikles Simon. (2012) Detection of EPO gene doping in blood. Drug Testt. Analysis. DOI: 10.1002/dta.1347  

  • November 30, 1999
  • 12:00 AM
  • 2,240 views

Genes Dealt Made Asians Svelte

by nooffensebut in The Unsilenced Science

Early genome-wide association studies suggest a genetic propensity to thinness in Asians. I review how these kinds of studies might be able reveal genetic racial differences in obesity and intelligence, and I address a few of the challenges to doing so.... Read more »

Belsky DW, Moffitt TE, Houts R, Bennett GG, Biddle AK, Blumenthal JA, Evans JP, Harrington H, Sugden K, Williams B.... (2012) Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. Archives of pediatrics , 166(6), 515-21. PMID: 22665028  

Hsu FC, Lenchik L, Nicklas BJ, Lohman K, Register TC, Mychaleckyj J, Langefeld CD, Freedman BI, Bowden DW, & Carr JJ. (2005) Heritability of body composition measured by DXA in the diabetes heart study. Obesity research, 13(2), 312-9. PMID: 15800289  

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L.... (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature genetics, 43(8), 753-60. PMID: 21706003  

Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R.... (2008) Proportionally more deleterious genetic variation in European than in African populations. Nature, 451(7181), 994-7. PMID: 18288194  

MacArthur DG, Balasubramanian S, Frankish A, Huang N, Morris J, Walter K, Jostins L, Habegger L, Pickrell JK, Montgomery SB.... (2012) A systematic survey of loss-of-function variants in human protein-coding genes. Science (New York, N.Y.), 335(6070), 823-8. PMID: 22344438  

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R.... (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature genetics, 42(11), 937-48. PMID: 20935630  

Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G.... (2012) Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (New York, N.Y.), 337(6090), 64-9. PMID: 22604720  

Zuk O, Hechter E, Sunyaev SR, & Lander ES. (2012) The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America, 109(4), 1193-8. PMID: 22223662  

  • November 30, 1999
  • 12:00 AM
  • 2,855 views

A protein purification classic: Ammonium Sulfate Precipitation An underutilized way to purify proteins

by Dave Dilyx in Protein Solubility Blog

In the 'old days' - i.e. when protein purification meant going to the slaughterhouse to get raw materials such as placenta, brain or blood - the first real purification step was typically an ammonium sulfate precipitation. Of course, the natural tissue needs to be homogenized and solids removed by filtration or centrifugation. This first clarified feedstock contains a multitude of protein solutions, not that different from a modern-day E.coli lysate. Such lysates can be fractionated ac........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,361 views

Not happy with expression in E.coli? Time for change.

by Dave Dilyx in Protein Solubility Blog

Sometimes all attempts to optimize the heterologous protein expression your protein aggregates during purification or, even worse, remains stubbornly insoluble. Or may be you just need milligrams of an eukaryotic protein, fast and don’t have time to play around with conditions and E.coli strains. Then it’s time to consider alternative expression systems, closer to the eukaryotic home of your protein.... Read more »

van Ooyen AJ, Dekker P, Huang M, Olsthoorn MM, Jacobs DI, Colussi PA, & Taron CH. (2006) Heterologous protein production in the yeast Kluyveromyces lactis. FEMS yeast research, 6(3), 381-92. PMID: 16630278  

Carlson, E., Gan, R., Hodgman, C., & Jewett, M. (2012) Cell-free protein synthesis: Applications come of age. Biotechnology Advances, 30(5), 1185-1194. DOI: 10.1016/j.biotechadv.2011.09.016  

  • November 30, 1999
  • 12:00 AM
  • 2,381 views

The case of the missing genitalia: copulation costs for male spiders

by Chris Buddle in Arthropod Ecology

Male spiders can be missing their organs (pedipalps) and this is clearly quite a cost for their fitness! This post explores this topic, with some original data, and with some discussion of past literature on the topic.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,562 views

Middle age females are most interested in mating: Lessons from a cricket

by Sue Bertram in Lab Chirps

How age influences phonotaxis in virgin female Jamaican field crickets (Gryllus assimilis)

A new article in PeerJ written by Karen Pacheco, Jeff Dawson, Mike Jutting, and Sue Bertram... Read more »

Karen Pacheco, Jeff Dawson, Mike Jutting, and Sue Bertram. (2013) How age influences phonotaxis in virgin female Jamaican field crickets (Gryllus assimilis). PeerJ. info:/10.7717/peerj.130

  • November 30, 1999
  • 12:00 AM
  • 1,312 views

The Science of Sleep

by Amy Swanston in Antisense Science

Feeling tired? I know I am. But what is it that makes us feel like we need to sleep? And what keeps us awake?
Within our bodies, a lot of systems work antagonistically to maintain homeostasis - that is, one action opposes another, keeping balance. There are two important forces that we use to control sleep: our sleep drive and our alerting signal. As the day goes on, the drive to sleep becomes greater and greater, so our alerting signal has to increase at the same rate to keep us awake. S........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,192 views

Interlukin 32 biomarker which predict relapse of mycobacterium tuberculosis

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

Interlukin 32 a protien which is found in people which do test positie for mycobacterium tuberculosis infection but do not develop pulmonary disease, it is found that interlukin is important in killing micobacterium, thereby protect them from TB disease, this interleukin 32 can be used therapeutically in patients suffering with TB along with chemotherapy, which will enhance efficacy of anti tuberculosis chemo therapy... Read more »

B V Waghmare. (2014) Interlukin 32 biomarker that will predict relapse of tuberculosis infection and will be used in treatment of TB. http://www.medicalwebsite.org/2014/09/protein-that-protect-from-tb-infection.html. info:/

  • November 30, 1999
  • 12:00 AM
  • 529 views

FDA officially refers consumers to Wikipedia for information on food pathogens

by Austin Bouck in Animal Science Review

I was perusing the Bad Bug Book while doing some research on the recent Blue Bell outbreak and came across a hyperlink. After hearing “do you want to know more?” in my head I clicked through on some non-L. mono species of Listeria and was…confused. I quickly doubled back, thinking that maybe I had been redirected, but there it was...... Read more »

Food and Drug Administration. (2012) Listeria Monocytogenes. Bad Bug Book, Foodborne pathogenic microorganisms and natural toxins. Second Edition, 99-100. info:/

  • November 30, 1999
  • 12:00 AM
  • 929 views

Ultrasound might increase autism severity

by vitul in Think, Ask and Resolve

According to a study by University of Washington researchers, diagnostic ultrasound in the first trimester of pregnancy is linked to increased autism severity in the child.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,072 views

Robotic researcher to the rescue

by kylius wilkins in It Ain't Magic

Masaki Watabe talks about automated robotic researchers, future robot rule, and scientific philosophy.... Read more »

Watabe, M., Arjunan, S., Fukushima, S., Iwamoto, K., Kozuka, J., Matsuoka, S., Shindo, Y., Ueda, M., & Takahashi, K. (2015) A Computational Framework for Bioimaging Simulation. PLOS ONE, 10(7). DOI: 10.1371/journal.pone.0130089  

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