Today I'm highlighting the paper by Krystle Graham and colleagues  which talked about a possible association between the presence of urinary tract infections (UTIs) in various types of psychosis. With my interest in all things biology-behaviour, remembering such posts as impulsivity and uric acid (see here), once again we have an example of how the two areas just might fit together.The bullfighter (deceased) @Manet @Wikipedia So, take several groups of adult........ Read more »
That an early pregnancy is protective against breast cancer is something I've known for ten years now. I remember one of my professors, back when I started studying genetics, saying: "Having a baby at 16 may ruin your life but it sure protects you from breast cancer." Today we know a lot more about the cellular and genetic mechanisms that a first pregnancy triggers in the body. And yet how these mechanisms turn out to be protective against breast cancer is still a mystery. "The ovarian hormones,........ Read more »
Medina D. (2005) Mammary developmental fate and breast cancer risk. Endocrine-related cancer, 12(3), 483-95. PMID: 16172188
Meier-Abt F, & Bentires-Alj M. (2014) How pregnancy at early age protects against breast cancer. Trends in molecular medicine, 20(3), 143-153. PMID: 24355762
The Effect of Cadence Manipulation on Plantar Pressures... Read more »
Wellenkotter, J., Kernozek, T., Meardon, S., & Suchomel, T. (2014) The Effects of Running Cadence Manipulation on Plantar Loading in Healthy Runners. International Journal of Sports Medicine. DOI: 10.1055/s-0033-1363236
The paper by Michael Benrós and colleagues  talking about an "increased risk of subsequent autoimmune diseases in individuals with schizophrenia" caught my eye recently. Based on a trawl of the records of several thousands of people with "schizophrenia-like psychosis" or "individuals with autoimmune disease" derived from Danish nationwide registers (see here for some background), the authors were able to conclude that "Autoimmune diseases developed subsequently in 3.6% of people wi........ Read more »
Benrós ME, Pedersen MG, Rasmussen H, Eaton WW, Nordentoft M, & Mortensen PB. (2013) A Nationwide Study on the Risk of Autoimmune Diseases in Individuals With a Personal or a Family History of Schizophrenia and Related Psychosis. The American journal of psychiatry. PMID: 24129899
Engineering artificial teeth without current complications.... Read more »
Bullock, M. (2013) Principles and practice of single implant and restoration. BDJ, 215(2), 100-100. DOI: 10.1038/sj.bdj.2013.733
Patients in the Intensive Care Unit (ICU) often develop cognitive deficits. The symptoms are very similar to Alzheimer’s and other forms of dementia. New research focuses on this link. ... Read more »
Pandharipande PP1, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW; BRAIN-ICU Study Investigators. (2014) Long-Term Cognitive Impairment after Critical Illness. New England Journal of Medicine, 370(2), 184-186. DOI: 10.1056/NEJMc1313886
Bohannon, R., Maljanian, R., & Ferullo, J. (2013) Mortality and readmission of the elderly one year after hospitalization for pneumonia. Aging Clinical and Experimental Research, 16(1), 22-25. DOI: 10.1007/BF03324527
I have an awkward relationship with mathematical oncology, mostly because oncology has an awkward relationship with math. Although I was vaguely familiar that evolutionary game theory (EGT) could be used in cancer research, mostly through Axelrod et al. (2006), I never planned to work on cancer. I wasn’t eager to enter the field because I […]... Read more »
National Eating Disorder Awareness Week came and went (in the US, anyway). Posters were shared, liked, and tweeted. Pretty (but often misguided) infographics made the rounds on the internet. Local ED groups visited schools and college campuses to educate students about eating disorders. To, you know, increase awareness.
The thing is, awareness is not always a good thing. For one, as Carrie over at ED Bites mentioned, there’s a whole lot of misinformation masquerading as fact. An........ Read more »
Park, S., McSweeney, J., & Yun, G. (2009) Intervention of Eating Disorder Symptomatology Using Educational Communication Messages. Communication Research, 36(5), 677-697. DOI: 10.1177/0093650209338910
Ridolfi, D.R., & Vander Wal, J.S. (2008) Eating disorders awareness week: the effectiveness of a one-time body image dissatisfaction prevention session. Eating disorders, 16(5), 428-43. PMID: 18821366
Tillman, K.S., Arbaugh, T. Jr., & Balaban, M.S. (2012) Campus programming for National Eating Disorders Awareness Week: An investigation of stigma, help-seeking, and resource knowledge. Eating Behaviors, 13(3), 281-4. PMID: 22664413
It all starts with a mosquito bite. When a hungry mosquito pierces someone’s skin to gorge herself, she also pumps …Continue reading →... Read more »
Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S, Rockett KA, Amaratunga C, Lim P, Suon S, Sreng S.... (2013) Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nature genetics, 45(6), 648-55. PMID: 23624527
We love gadgets in EMS.
Dr. Bryan Bledsoe tells us that if we paint it orange and put a star of life on it, we can sell any product for a lot more money.
How much would you pay to not improve outcomes?
$50,000.00?... Read more »
Rubertsson S, Lindgren E, Smekal D, Östlund O, Silfverstolpe J, Lichtveld RA, Boomars R, Ahlstedt B, Skoog G, Kastberg R.... (2014) Mechanical chest compressions and simultaneous defibrillation vs conventional cardiopulmonary resuscitation in out-of-hospital cardiac arrest: the LINC randomized trial. JAMA : the journal of the American Medical Association, 311(1), 53-61. PMID: 24240611
Tracy Young-Pearse (left) and Christina Muratore (right)Researchers from Harvard have successfully converted skins cells from patients with early onset Alzheimer’s into the types of neurons that are affected by the disease, making it possible for the first time to study this leading form of dementia in living human cells. The research may also help in developing therapies more quickly and accurately than before.The study, led by Tracy Young-Pearse and published in the journal Human Molecular ........ Read more »
Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, & Young-Pearse TL. (2014) The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Human molecular genetics. PMID: 24524897
The dissociative anesthetic and ravey club drug ketamine has been hailed as a possible “miracle” cure for depression. In contrast to the delayed action of standard antidepressants such as SSRIs, the uplifting effects of Special K are noticeable within an hour. “Experimental Medication Kicks Depression in Hours Instead of Weeks,” says the National Institute of Mental Health. NIMH has been bullish on ketamine for years now. Prominent researchers Duman and Aghajanian called it the “the mo........ Read more »
At the time of writing this post, the media is awash with two stories with an autism research slant to them. So we have the paper by Brian D’Onofrio and colleagues  talking about older, sorry, advancing paternal age and the risk of various conditions for offspring, including autism, and the paper by Sébastien Jacquemont and colleagues  on a female protective model for autism. Y'know these are serious pieces of research when the good old BBC (Auntie) puts it........ Read more »
Adler BA, Wink LK, Early M, Shaffer R, Minshawi N, McDougle CJ, & Erickson CA. (2014) Drug-refractory aggression, self-injurious behavior, and severe tantrums in autism spectrum disorders: A chart review study. Autism : the international journal of research and practice. PMID: 24571823
The risk of anterior cruciate ligament (ACL) revision is relatively low after an autograft reconstruction. Revision rates may be slightly lower for patellar autografts compared with hamstring autografts.... Read more »
Rahr-Wagner, L., Thillemann, T., Pedersen, A., & Lind, M. (2013) Comparison of Hamstring Tendon and Patellar Tendon Grafts in Anterior Cruciate Ligament Reconstruction in a Nationwide Population-Based Cohort Study: Results From the Danish Registry of Knee Ligament Reconstruction. The American Journal of Sports Medicine, 42(2), 278-284. DOI: 10.1177/0363546513509220
Persson, A., Fjeldsgaard, K., Gjertsen, J., Kjellsen, A., Engebretsen, L., Hole, R., & Fevang, J. (2013) Increased Risk of Revision With Hamstring Tendon Grafts Compared With Patellar Tendon Grafts After Anterior Cruciate Ligament Reconstruction: A Study of 12,643 Patients From the Norwegian Cruciate Ligament Registry, 2004-2012. The American Journal of Sports Medicine, 42(2), 285-291. DOI: 10.1177/0363546513511419
Vascular compliance is a characteristic of the blood vessel wall to expand or contract with changes in pressure, and is reduced with aging or diseases like arteriosclerosis. Our goal was to investigate how hand-volume changes differ with age and to provide a simple non-invasive method to assess vascular compliance. We hypothesized that gravity-related, hand-wrist volume changes are greater in younger than in older healthy volunteers. Thirty-five healthy volunteers were classified into two age gr........ Read more »
EA Kraus, JM Kim, AR Hargens. (2014) Gravitational Changes in Hand -Wrist Volume are Smaller in Older Adults as Compared to Younger Adults. Journal of Cardiology and Vascular Medicine, 2(1), 1-6. info:/2: 102
An embryonic stem cell differentiating into a neuronal cell under the microscope.Credit: Anne Rupprecht/Vetmeduni ViennaCells have a metabolism that can be altered according to its function and requirements. If cellular metabolism is disturbed, it can lead to disease of the entire organism. Now, researchers at the University of Veterinary Medicine in Vienna say that they have discovered that the uncoupling proteins UCP2 and UPC4 are involved in different types of cellular metabolism.The protein........ Read more »
Rupprecht A, Sittner D, Smorodchenko A, Hilse KE, Goyn J, Moldzio R, Seiler AE, Bräuer AU, & Pohl EE. (2014) Uncoupling Protein 2 and 4 Expression Pattern during Stem Cell Differentiation Provides New Insight into Their Putative Function. PloS one, 9(2). PMID: 24523901
The RASopathies are a class of developmental disorders caused by a genetic mutation in the Ras signaling pathway and associated mitogen-activated protein kinases that control the cell cycle, differentiation and senescence. These diseases encompass a diverse set of clinical syndromes including neurofibromatosis type 1 and Noonan syndrome. Although the pathophysiological manifestations of these conditions are diverse, they share some common phenotypic features. The prevalence of pulmonary hyperten........ Read more »
Krishna S. Vyas, Jacqueline A. Noonan. (2014) Pulmonary Hypertension in the RASopathies. Journal of Cardiology and Vascular Medicine, 2(1), 1-6. info:/2: 101
Is the rearfoot pattern the most frequently foot strike pattern among recreational shod distance runners?... Read more »
de Almeida, M., Saragiotto, B., Yamato, T., & Lopes, A. (2014) Is the rearfoot pattern the most frequently foot strike pattern among recreational shod distance runners?. Physical Therapy in Sport. DOI: 10.1016/j.ptsp.2014.02.005
This month’s Nature Methods issue has several interesting imaging items & articles, including two super-resolution reviews, two optogenetics articles, and more. This post will be dedicated to three items in the “tools in brief” section. Blue transcription Optogenetics usually refers to … Continue reading →... Read more »
Tools in brief. (2014) Chemical biology: Optimized optogenetic gene expression. Nature Methods, 11(3), 230-230. DOI: 10.1038/nmeth.2867
Tools in brief. (2014) Sensors and probes: Expanding Spinach2's spectral properties. Nature Methods, 11(3), 230-230. DOI: 10.1038/nmeth.2865
Pu K, Shuhendler AJ, Jokerst JV, Mei J, Gambhir SS, Bao Z, & Rao J. (2014) Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice. Nature nanotechnology. PMID: 24463363
Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, & Gardner KH. (2014) An optogenetic gene expression system with rapid activation and deactivation kinetics. Nature chemical biology, 10(3), 196-202. PMID: 24413462
Song W, Strack RL, Svensen N, & Jaffrey SR. (2014) Plug-and-Play Fluorophores Extend the Spectral Properties of Spinach. Journal of the American Chemical Society, 136(4), 1198-201. PMID: 24393009
Strack RL, Disney MD, & Jaffrey SR. (2013) A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA. Nature methods, 10(12), 1219-24. PMID: 24162923
Child with microtiaA new study by researchers at the Great Ormond Street Hospital (GOSH) and the UCL Institute of Child Health (ICH) shows that adipose (fat) derived stem cells may be a viable alternative to the currently used approaches for facial cartilage reconstruction, like ear and nose reconstruction.GOSH already has a good track record of successfully treating patients born with a malformed or missing ear, a condition known as microtia. The two-stage ear reconstruction takes cartilage fro........ Read more »
Guasti L, Vagaska B, Bulstrode NW, Seifalian AM, & Ferretti P. (2014) Chondrogenic differentiation of adipose tissue-derived stem cells within nanocaged POSS-PCU scaffolds: A new tool for nanomedicine. Nanomedicine : nanotechnology, biology, and medicine, 10(2), 279-89. PMID: 24008020
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