It was a bit of a breath of fresh air to read the paper by Lauren Singer  (open-access) published in the journal Molecular Autism recently. Detailing the personal experiences of a sibling with a sister with autism who has "gone to walks, raised money via lemonade stands, volunteered in respite programs for families with kids with autism, and participated in autism research studies at the Yale Child Study Center", her very personal account is an important read in amongst the huge peer-rev........ Read more »
Singer L. (2015) Thoughts about sex and gender differences from the next generation of autism scientists. Molecular autism, 52. PMID: 26388981
Chronic pain results from disease or trauma to the nervous system. Damaged nerve fibres with heightened responses to normal stimuli send incorrect messages to pain centres in the brain. This phenomenon, called “peripheral and central sensitization” is one of the key mechanisms involved in the condition which touches people with diabetes, cancer, and those suffering from multiple sclerosis, among others.... Read more »
Cordeiro Matos, S., Zhang, Z., & Seguela, P. (2015) Peripheral Neuropathy Induces HCN Channel Dysfunction in Pyramidal Neurons of the Medial Prefrontal Cortex. Journal of Neuroscience, 35(38), 13244-13256. DOI: 10.1523/JNEUROSCI.0799-15.2015
It's time for yet another colour post! Deadly poisons and useful drugs can cause regions of your body to take on a different colour from normal. In addition to being super weird, these unexpected colours often provide a valuable clue for doctors looking to make a diagnosis. Let's look at a couple of examples...... Read more »
Cohen PR. (2009) Black tongue secondary to bismuth subsalicylate: Case report and review of exogenous causes of macular lingual pigmentation. Journal of Drugs in Dermatology, 8(12), 1132-5. PMID: 20027942
"Children with ADHD [attention-deficit hyperactivity disorder] have a higher prevalence of asthma than the general Quebec pediatric population."So said the findings of the study by Grizenko and colleagues  adding to quite a volume of research potentially connecting the two conditions. During this latest foray into this area of research, researchers also observed that: "Children with ADHD born prematurely and/or those whose mothers experienced stress during pregnancy have a significa........ Read more »
Grizenko N, Osmanlliu E, Fortier MÈ, & Joober R. (2015) Increased Risk of Asthma in Children with ADHD: Role of Prematurity and Maternal Stress during Pregnancy. Journal of the Canadian Academy of Child and Adolescent Psychiatry , 24(2), 109-115. PMID: 26379722
Hormonal treatments administered as part of the procedures for sex reassignment have well-known and well-documented effects on the secondary sexual characteristics of the adult body, shifting a recipient’s physical appearance to that of the opposite sex. New research indicates that these hormonal treatments also alter brain chemistry.... Read more »
Kranz, G., Wadsak, W., Kaufmann, U., Savli, M., Baldinger, P., Gryglewski, G., Haeusler, D., Spies, M., Mitterhauser, M., Kasper, S.... (2015) High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People. Biological Psychiatry, 78(8), 525-533. DOI: 10.1016/j.biopsych.2014.09.010
Part II in our series looking at the scientific evidence behind sunscreen and skin cancer.... Read more »
van der Pols JC, Williams GM, Pandeya N, Logan V, & Green AC. (2006) Prolonged prevention of squamous cell carcinoma of the skin by regular sunscreen use. Cancer epidemiology, biomarkers , 15(12), 2546-8. PMID: 17132769
Lee TK, Rivers JK, & Gallagher RP. (2005) Site-specific protective effect of broad-spectrum sunscreen on nevus development among white schoolchildren in a randomized trial. Journal of the American Academy of Dermatology, 52(5), 786-92. PMID: 15858467
Koh HK, Geller AC, Miller DR, Grossbart TA, & Lew RA. (1996) Prevention and early detection strategies for melanoma and skin cancer. Current status. Archives of dermatology, 132(4), 436-43. PMID: 8629848
Leiter U, & Garbe C. (2008) Epidemiology of melanoma and nonmelanoma skin cancer--the role of sunlight. Advances in experimental medicine and biology, 89-103. PMID: 18348450
Brenner M, & Hearing VJ. (2008) The protective role of melanin against UV damage in human skin. Photochemistry and photobiology, 84(3), 539-49. PMID: 18435612
Pine Cone and Peacocks from Vatican MuseumTestosterone displays effects on brain function in both males and females.Emanuela Mhillaj and colleagues recently published a nice summary of what is currently known about the effects of anabolic-androgen steroids (AAS) on the brain.Their review highlighted the potential for AAS to modulate brain reward function and potentially lead to a drug dependence type of abuse pattern.Here are some of my notes on their discussion of AAS and the brain reward syste........ Read more »
Mhillaj E, Morgese MG, Tucci P, Bove M, Schiavone S, & Trabace L. (2015) Effects of anabolic-androgens on brain reward function. Frontiers in neuroscience, 295. PMID: 26379484
Yates WR, Perry PJ, & Andersen KH. (1990) Illicit anabolic steroid use: a controlled personality study. Acta psychiatrica Scandinavica, 81(6), 548-50. PMID: 2378247
My attention was grabbed recently by the paper published by Jon Kaiser  (open-access available here) detailing the results of a 'proof-of-concept investigation' examining the use of something called KPAX002 on a small number of participants diagnosed with Chronic Fatigue Syndrome (CFS).Looking at how KPAX002 - "a combination of low-dose methylphenidate hydrochloride and mitochondrial support nutrients currently under development by K-PAX Pharmaceuticals" - impacted on fatigue symptoms and "co........ Read more »
Kaiser JD. (2015) A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome. International journal of clinical and experimental medicine, 8(7), 11064-74. PMID: 26379906
MedicalResearch.com Interview with: Dr. Madeleine M A Tilanus-Linthorst PhD Department of Surgery Erasmus University Medical Centre – Cancer Institute Rotterdam, Netherlands Medical Research: What is the background for this study? Medical Research: Why is this study important? Response: This prospective … Continue reading →
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Dr. Madeleine M A Tilanus-Linthorst PhD. (2015) Catching Breast Cancer Early Is Still Critical. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Ambarish Pandey, MD Cardiology Fellow, PGY5 University of Texas Southwestern Medical Center, Dallas, Texas 75390 Medical Research: What is the background for this study? What are the main findings? Dr. Berry: Physical inactivity is considered a major … Continue reading →
The post Heart Failure Risk Reduced With Increased Physical Activity appeared first on MedicalResearch.com.
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Ambarish Pandey, MD. (2015) Heart Failure Risk Reduced With Increased Physical Activity. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Prof. Peter JD Andrews Honorary Professor Department of Anaesthesia University of Edinburgh Medical Research: What is the background for this study? Prof. Andrews: Therapeutic hypothermia has shown considerable promise as a neuro-protective intervention in many species and … Continue reading →
The post Hypothermia Did Not Improve Outcomes After Traumatic Brain Injury appeared first on MedicalResearch.com.
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Prof. Peter JD Andrews. (2015) Hypothermia Did Not Improve Outcomes After Traumatic Brain Injury. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Holly G. Prigerson, Ph.D. Irving Sherwood Wright Professor in Geriatrics Professor of Sociology in Medicine Director, Center for Research on End of Life Care Weill Cornell Medical College New York Presbyterian Hospital New York City, New York … Continue reading →
The post Most Terminally Ill Cancer Patients Not Aware Of Their Life Expectancy appeared first on MedicalResearch.com.
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Holly G. Prigerson, Ph.D. (2015) Most Terminally Ill Cancer Patients Not Aware Of Their Life Expectancy. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Michael M. McNeil, MD, MPH Centers for Disease Control and Prevention Atlanta, GA Medical Research: What is the background for this study? What are the main findings? Dr. McNeil : Anaphylaxis is an uncommon potentially life-threatening allergic reaction … Continue reading →
The post CDC Study Finds Anaphylaxis Rare After Vaccinations, With No Fatalities appeared first on MedicalResearch.com.
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Michael M. McNeil, MD, MPH. (2015) CDC Study Finds Anaphylaxis Rare After Vaccinations, With No Fatalities. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Mark DeBoer, MD Children’s Hospital’s Department of Pediatrics University of Virginia Medical Research: What is the background for this study? What are the main findings? Dr. DeBoer: We have been interested in how the severity of the … Continue reading →
The post Metabolic Syndrome In Youth Linked To Later Life Heart Disease appeared first on MedicalResearch.com.
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Mark DeBoer, MD. (2015) Metabolic Syndrome In Youth Linked To Later Life Heart Disease. MedicalResearch.com. info:/
The manuscript in this post is two years old but I thought it was worthy of comment.The Global Burden of Disease study seeks to provide an estimate of the relative contribution of a variety of medical disorders on disability and death.I have summarized data with an original chart with data abstracted on the leading causes of early death in the U.S. This is provided by the chart in numbers (x1000). The most recent estimate rates heart disease as the continuing cause of years of life lost (2010 es........ Read more »
Murray CJ, Atkinson C, Bhalla K, Birbeck G, Burstein R, Chou D, Dellavalle R, Danaei G, Ezzati M, Fahimi A.... (2013) The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA, 310(6), 591-608. PMID: 23842577
Can a pregnant woman get pregnant? Sounds like a riddle, but really it is superfetation. Getting pregnant in two successive cycles and having twins with different fathers really creates a problem in defining what twins actually are. Twins don’t have to be conceived at the same time, born at the same time, have the same father, or even be of the same “race.”... Read more »
Pollux, B., Meredith, R., Springer, M., Garland, T., & Reznick, D. (2014) The evolution of the placenta drives a shift in sexual selection in livebearing fish. Nature, 513(7517), 233-236. DOI: 10.1038/nature13451
Peigné, M., Andrieux, J., Deruelle, P., Vuillaume, I., & Leroy, M. (2011) Quintuplets after a transfer of two embryos following in vitro fertilization: a proved superfecundation. Fertility and Sterility, 95(6), 2147483647-2147483647. DOI: 10.1016/j.fertnstert.2011.01.029
James WH. (1993) The incidence of superfecundation and of double paternity in the general population. Acta geneticae medicae et gemellologiae, 42(3-4), 257-62. PMID: 7871943
Baijal N, Sahni M, Verma N, Kumar A, Parkhe N, & Puliyel JM. (2007) Discordant twins with the smaller baby appropriate for gestational age--unusual manifestation of superfoetation: a case report. BMC pediatrics, 2. PMID: 17239246
MedicalResearch.com Interview with: Giancarlo Marenzi, M.D. Centro Cardiologico Monzino Milan, Italy Medical Research: What is the background for this study? What are the main findings? Dr. Marenzi: Pre-treatment with statins in patients with stable angina or non-ST-elevation acute coronary syndromes … Continue reading →
The post Chronic Statins Reduce Heart Attack Damage appeared first on MedicalResearch.com.
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Giancarlo Marenzi, M.D. (2015) Chronic Statins Reduce Heart Attack Damage. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Keiji Tanimoto, D.D.S., Ph.D Assistant Professor Research Institute for Radiation Biology and Medicine Hiroshima University Hiroshima Japan Medical Research: What is the background for this study? Dr. Tanimoto: Hypoxia-inducible factor-2α (HIF-2αor EPAS1) is important for cancer progression, … Continue reading →
The post Genotyping May Lead To Personalized Lung Cancer Therapy appeared first on MedicalResearch.com.
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Keiji Tanimoto, D.D.S., Ph.D. (2015) Genotyping May Lead To Personalized Lung Cancer Therapy. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Dr. Anne Moseley Senior Research Fellow, Musculoskeletal Division The George Institute for Global Health Sydney Australia Medical Research: What is the background for this study? What are the main findings? Dr. Moseley: Ankle fracture is a common … Continue reading →
The post Single Session Advice From Physical Therapist Sufficient After Uncomplicated Ankle Fracture appeared first on MedicalResearch.com.
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Dr. Anne Moseley. (2015) Single Session Advice From Physical Therapist Sufficient After Uncomplicated Ankle Fracture. MedicalResearch.com. info:/
Glyphosate use and autism rates - should I blog about it?Well, after some deliberation I decided it was a topic worthy of an entry. There is some peer-reviewed science discussions behind it and, as per other areas of controversy on the autism research landscape, the idea that 'science is about debate' (why else does everyone keep going on about open-access and transparency) should always prevail.I'm assuming most people have heard of the organophosphonate (that's phosphonate not p........ Read more »
Faria MA. (2015) Glyphosate, neurological diseases - and the scientific method. Surgical neurology international, 132. PMID: 26322242
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