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  • January 9, 2017
  • 04:48 AM
  • 250 views

H255Y and K508R missense mutations in FLCN promote kidney neoplasia

by Joana Guedes in BHD Research Blog

The germline FLCN missense mutations H255Y (Hasumi et al., 2009) and K508R (Toro et al., 2008) have been identified in patients with bilateral multifocal (BMF) kidney tumours and other clinical symptoms of Birt-Hogg-Dube (BHD) syndrome, or with BMF kidney tumours as the only manifestation. Building on their previous work identifying the H255Y mutation in human BHD kidney tumour, Hasumi et al. (2016) investigated whether these mutations have an impact on FLCN function. The authors evaluated the F........ Read more »

  • January 9, 2017
  • 04:26 AM
  • 330 views

T. gondii and OCD?

by Paul Whiteley in Questioning Answers

It's been a while since I've talked about Toxoplasma gondii on this blog; the parasite that more than most, has been linked with all-manner of different psychiatric labels (see here for example). Although still the topic of some discussion, I'm swayed towards the possibility that there may be some important *associations* to be seen when it comes to this survivor and human behaviour(s) outside of just making rats attracted to cat urine (see here) to improve reproduction chances.Indeed, in t........ Read more »

  • January 7, 2017
  • 04:15 AM
  • 310 views

ADHD and vitamin levels

by Paul Whiteley in Questioning Answers

"ADHD [attention-deficit hyperactivity disorder] patients were overrepresented in the group with low levels of some vitamins, possibly indicative of inadequate dietary intake of these micronutrients in a subgroup of patients. It is important to identify these patients in dietary intervention trials of ADHD."So said the study findings reported by Elisabeth Toverud Landaas and colleagues [1] (open-access) providing some potentially important data on how nutritional factors might int........ Read more »

Landaas ET, Aarsland TI, Ulvik A, Halmøy A, Ueland PM, & Haavik J. (2016) Vitamin levels in adults with ADHD. BJPsych open, 2(6), 377-384. PMID: 27990293  

  • January 6, 2017
  • 06:09 AM
  • 353 views

Particulate matter exposure and autism risk systematically reviewed?

by Paul Whiteley in Questioning Answers

"To conclude, the evidence from the studies allows us to conclude that there is an association between PM [particulate matter] exposure and ASD [autism spectrum disorder] whose strength varies according to the particle size studied with the association with PM2.5 and diesel PM being stronger."Although probably not great sentence structure to begin a post with a conclusion, the 'bottom line' reported by María Morales-Suárez-Varela and colleagues [1] summarises the curre........ Read more »

  • January 5, 2017
  • 06:07 AM
  • 383 views

A subtype of autism linked to psychosis?

by Paul Whiteley in Questioning Answers

"Our data show there may be a specific subtype of ASD [autism spectrum disorder] linked to comorbid psychosis. The results support findings that psychosis in people with ASD is often atypical, particularly regarding affective disturbance."So said the findings reported by Felicity Larson and colleagues [1] (open-access available here) who bring an important topic into view that has recently been raised in the media too (see here). I appreciate that to talk about yet more comorbidity pot........ Read more »

Larson, F., Wagner, A., Jones, P., Tantam, D., Lai, M., Baron-Cohen, S., & Holland, A. (2016) Psychosis in autism: comparison of the features of both conditions in a dually affected cohort. The British Journal of Psychiatry. DOI: 10.1192/bjp.bp.116.187682  

  • January 4, 2017
  • 05:43 AM
  • 355 views

A distinctive microbial signature in kids with autism and GI issues?

by Paul Whiteley in Questioning Answers

"Our findings identify distinctive mucosal microbial signatures in ASD [autism spectrum disorder] children with FGID [functional gastrointestinal disorders] that correlate with cytokine and tryptophan homeostasis."So said the study results published by Ruth Ann Luna and colleagues [1] who "compared mucosa-associated microbial communities in children with ASD to previous reports characterizing stool in this population" among other things. If you are eating breakfast/lunch/dinner at........ Read more »

Luna, R., Oezguen, N., Balderas, M., Venkatachalam, A., Runge, J., Versalovic, J., Veenstra-VanderWeele, J., Anderson, G., Savidge, T., & Williams, K. (2016) Distinct microbiome-neuroimmune signatures correlate with functional abdominal pain in children with autism spectrum disorder. CMGH Cellular and Molecular Gastroenterology and Hepatology. DOI: 10.1016/j.jcmgh.2016.11.008  

  • January 4, 2017
  • 04:30 AM
  • 277 views

Debating Early Viscosupplementation

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Viscosupplementation at the time of partial meniscectomy failed to provide better outcomes than surgery alone. ... Read more »

Filardo, G., Di Matteo, B., Tentoni, F., Cavicchioli, A., Di Martino, A., Lo Presti, M., Iacono, F., Kon, E., & Marcacci, M. (2016) No Effects of Early Viscosupplementation After Arthroscopic Partial Meniscectomy: A Randomized Controlled Trial. The American Journal of Sports Medicine, 44(12), 3119-3125. DOI: 10.1177/0363546516660070  

  • January 3, 2017
  • 06:28 AM
  • 340 views

Suicidality in children and young adults with 'high-functioning' autism

by Paul Whiteley in Questioning Answers

"Consistent with the previous findings, [the] rate of suicidality is higher in individuals with ASD [autism spectrum disorder]."That was one of the conclusions reported in the paper by Sevcan Karakoç Demirkaya and colleagues [1] (open-access) yet again touching on a most important topic when it comes to autism, particularly the part of the autism spectrum labelled as 'high-functioning'. Personally, I'm not a great fan of the 'functioning' description typically added to autism to ........ Read more »

  • January 2, 2017
  • 04:30 AM
  • 315 views

How Much Do You Know About How Sunscreen Affects Thermoregulation?

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Athletes need to use sunscreen when exercising outdoors; however, they need to be selective and ensure the sunscreen is not impeding effective sweating.... Read more »

Aburto-Corona, J., & Aragón-Vargas, L. (2016) Sunscreen Use and Sweat Production in Men and Women. Journal of Athletic Training, 51(9), 696-700. DOI: 10.4085/1062-6050-51.11.01  

  • January 2, 2017
  • 04:06 AM
  • 326 views

This Month in Blastocystis Research (DEC 2016)

by Christen Rune Stensvold in Blastocystis Parasite Blog

2016 is coming to an end, and in the last post of the year, I highlight three of the most important articles on Blastocystis published in 2016.... Read more »

Scanlan PD, Knight R, Song SJ, Ackermann G, & Cotter PD. (2016) Prevalence and genetic diversity of Blastocystis in family units living in the United States. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 95-97. PMID: 27545648  

Kurt Ö, Doğruman Al F, & Tanyüksel M. (2016) Eradication of Blastocystis in humans: Really necessary for all?. Parasitology international, 65(6 Pt B), 797-801. PMID: 26780545  

  • January 1, 2017
  • 01:20 AM
  • 268 views

Antibiotic cream is NOT 100% effective in preventing Lyme disease

by Microbe Fan in Spirochetes Unwound

A topical antibiotic cream applied to tick bites did not perform any better than placebo in preventing Lyme disease, according to results of a randomized clinical trial conducted in Europe.  The study was published in Lancet Infectious Diseases.I wasn't planning to blog about the study, but I changed my mind after a reader emailed me a link to a news article reporting that the antibiotic cream was 100% effective.  The lead investigator even claimed, "None of the test subjects went on t........ Read more »

Schwameis M, Kündig T, Huber G, von Bidder L, Meinel L, Weisser R, Aberer E, Härter G, Weinke T, Jelinek T.... (2016) Topical azithromycin for the prevention of Lyme borreliosis: a randomised, placebo-controlled, phase 3 efficacy trial. The Lancet. Infectious Diseases. PMID: 28007428  

  • December 30, 2016
  • 06:30 PM
  • 291 views

This Month in Blastocystis Research (DEC 2016)

by Christen Rune Stensvold in Blastocystis Parasite Blog

2016 is coming to an end, and in the last post of the year, I highlight three of the most important articles on Blastocystis published in 2016.... Read more »

Scanlan PD, Knight R, Song SJ, Ackermann G, & Cotter PD. (2016) Prevalence and genetic diversity of Blastocystis in family units living in the United States. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 95-97. PMID: 27545648  

Kurt Ö, Doğruman Al F, & Tanyüksel M. (2016) Eradication of Blastocystis in humans: Really necessary for all?. Parasitology international, 65(6 Pt B), 797-801. PMID: 26780545  

  • December 30, 2016
  • 02:51 PM
  • 307 views

What is Turmeric and How to Use it to Prevent of Heart Diseases

by Maggie Martin in United Academics

If you are thinking of using turmeric for heart disease, first understand how it works and then know how it is supposed to be consumed. Turmeric works in numerous ways to boost heart health. It is considered a powerful antioxidant with an active ingredient known as curcumin, responsible for the antioxidant, anti-inflammatory and antiseptic properties of turmeric.... Read more »

Govindarajan, V., & Stahl, W. (2009) Turmeric — chemistry, technology, and quality. C R C Critical Reviews in Food Science and Nutrition, 12(3), 199-301. DOI: 10.1080/10408398009527278  

  • December 30, 2016
  • 07:05 AM
  • 297 views

Annual review 2016

by Joana Guedes in BHD Research Blog

2016 has been a busy year for BHD research. With the new year approaching, this week’s blog will review the studies we’ve particularly enjoyed writing about and revisit the year’s highlights.... Read more »

Gupta, N., Sunwoo, B., & Kotloff, R. (2016) Birt-Hogg-Dubé Syndrome. Clinics in Chest Medicine, 37(3), 475-486. DOI: 10.1016/j.ccm.2016.04.010  

  • December 29, 2016
  • 08:20 PM
  • 349 views

Believe in miracles... and yourself

by Aurametrix team in Aurametrix Blog

End of the year is a very special time as Holiday lights melt away our inner Grinch and we start to believe in miracles and new beginnings. ​Belief is not a religious phenomenon. It is our way of coping with the future and finding existential meaning. Scientific studies show that belief in miracles contributes to greater life satisfaction. Belief in science and technological progress can make people satisfied with their lives even more. The stronger the sense of personal control, the higher s........ Read more »

  • December 28, 2016
  • 05:00 AM
  • 301 views

Sometimes academics do overthink things

by Craig Payne in Running Research Junkie

Sometimes academics do overthink things. I call it limping... Read more »

  • December 28, 2016
  • 04:30 AM
  • 322 views

Ocular Injuries May Not Be the Most Common, But Are They Easily Preventable?

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Sport-related ocular injuries are most commonly open wounds to the eye or surrounding visual structures. Advocating for, or implementing rule changes to require protective eyewear could greatly mitigate this risk.... Read more »

Haring RS, Sheffield ID, Canner JK, & Schneider EB. (2016) Epidemiology of Sports-Related Eye Injuries in the United States. JAMA ophthalmology, 134(12), 1382-1390. PMID: 27812702  

  • December 27, 2016
  • 06:10 AM
  • 368 views

2016 autism research review on Questioning Answers

by Paul Whiteley in Questioning Answers

Time flies! Once again, I'm posting my annual 'state of the science' autism research review, this time covering the particularly unusual year of 2016.With around 300 blog entries to choose from, I'm changing the format this year to list a 'top 5' of areas where I think some scientific progress has been made. The caveat as ever being that there are still mountains to climb in terms of delineating aetiology, nature and importantly, how one can actually improve quality of life for those on the........ Read more »

Waterhouse, L., London, E., & Gillberg, C. (2016) ASD Validity. Review Journal of Autism and Developmental Disorders, 3(4), 302-329. DOI: 10.1007/s40489-016-0085-x  

  • December 23, 2016
  • 06:43 AM
  • 359 views

Establishment of a new BHD Syndrome cell line

by Joana Guedes in BHD Research Blog

Birt-Hogg-Dubé syndrome is caused by mutations in the FLCN gene. The FLCN protein acts as a tumour suppressor and BHD patients have a high risk of developing renal cell carcinoma (RCC). The mechanisms of tumour formation in BHD have been investigated using mouse models and human RCC tissues. However, in vitro signalling studies of human renal cells with mutant FLCN are still scarce. In a recent study, Furuya et al. (2016) established a new cell line from a BHD patient’s chromophobe ........ Read more »

  • December 23, 2016
  • 05:13 AM
  • 370 views

Bad news for DARPA's RAM program: Electrical Stimulation of Entorhinal Region Impairs Memory

by The Neurocritic in The Neurocritic





The neural machinery that forms new memories is fragile and vulnerable to insults arising from brain injuries, cerebral anoxia, and neurodegenerative diseases such as Alzheimer's. Unlike language, which shows a great deal of plasticity after strokes and other injuries, episodic memory – memory for autobiographical events and contextual details of past experiences – doesn't recover after

... Read more »

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