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  • November 30, 1999
  • 12:00 AM
  • 3,280 views

Nicotine and the Humphrey Bogart Gene

by Dirk Hanson in Addiction Inbox

You can lead a fish to water, but can you make it smoke?

... Read more »

Petzold AM, Balciunas D, Sivasubbu S, Clark KJ, Bedell VM, Westcot SE, Myers SR, Moulder GL, Thomas MJ, & Ekker SC. (2009) Nicotine response genetics in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America, 106(44), 18662-7. PMID: 19858493  

  • November 30, 1999
  • 12:00 AM
  • 2,666 views

New GPCR structure: CXCR4 Chemokine Receptor (HIV and cancer target)

by Peter Nollert in Protein Crystallization Blog

Congratulations to Ray Stevens and team to determining and publishing the crystallographic structure of the CXCR4 Chemokine receptor in Science. The diffenent binding areas for the small molecule and peptide antagonist are nicely resolved and show extensive interactions with binding pocket residues in the 2.5 – 3.1 A crystal structures.... Read more »

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC.... (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.), 330(6007), 1066-71. PMID: 20929726  

  • November 30, 1999
  • 12:00 AM
  • 2,405 views

New GPCR structure: CXCR4 Chemokine Receptor (HIV and cancer target)

by Peter Nollert in Emerald BioStructures Blog

Congratulations to Ray Stevens and team to determining and publishing the crystallographic structure of the CXCR4 Chemokine receptor in Science. The diffenent binding areas for the small molecule and peptide antagonist are nicely resolved and show extensive interactions with binding pocket residues in the 2.5 – 3.1 A crystal structures... Read more »

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC.... (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.), 330(6007), 1066-71. PMID: 20929726  

  • November 30, 1999
  • 12:00 AM
  • 2,108 views

HIV vaccine research heading towards success,so near but so far, latest research and development towards developing HIV vaccine

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

There are few cases observed where some people are tested HIV positive long ago but have not developed AIDS symptoms or the AIDS disease in their entire life and are called by researchers for finding out what is the key difference in them and the other peoples which is imparting capability for not developing HIV infection in to disease AIDS in such individuals.

Researchers have observed that there is a key difference in the genetic constitution of such peoples and they are termed as controlle........ Read more »

B V Waghmare. (2010) Information on HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets . www.bvwaghmare.blogspot.com. info:/DOI/arXiv/bvwaghmare

  • November 30, 1999
  • 12:00 AM
  • 2,569 views

Cellular Feast or Famine

by Sanford- Burnham in Beaker

Not all cholesterol is bad. Every cell requires it for growth – they either have to get cholesterol somewhere or they die. A sensor called sterol regulatory element-binding protein 2 (SREBP-2) monitors cellular cholesterol levels and responds to low levels by switching on genes that allow the cell to either 1) take up more from the bloodstream or 2) manufacture more from cholesterol building blocks inside the cell. Now researchers have uncovered a third cholesterol source also controlled b........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,292 views

Let’s Get Cellular: Meth Metabolism

by Dirk Hanson in Addiction Inbox

We know from the work of Nora Volkow and others that meth abusers have chronically low levels of dopamine D2 receptors in their brains. But what is going on in the rest of the body when methamphetamine addiction is running full force?... Read more »

Sun, L., Li, H., Seufferheld, M., Walters, K., Margam, V., Jannasch, A., Diaz, N., Riley, C., Sun, W., Li, Y.... (2011) Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine. PLoS ONE, 6(4). DOI: 10.1371/journal.pone.0018215  

  • November 30, 1999
  • 12:00 AM
  • 1,954 views

HIV vaccine research: Protein which train B cells for production of antibodies against HIV which successfully neutralize HIV

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

HIV virus rapidly undergoes mutation, which is main hurdle in developing vaccine against HIV.There is a region on HIV virus which shows less variations, called as Cd4 binding site ,therefore a protein which stimulate antibody formation against this region can be developed and used as a vaccine.
Researchers at Vaccine Research Center (VRC) and the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health have studied genes which code for such proteins which can........ Read more »

B V Waghmare. (2011) HIV vaccine development : Proteins which trains B Cells for production of antibodies which successfully neutralize HIV by binding with it . http://bvwaghmare.blogspot.com. info:/(DOI/arXiv/etc.)

  • November 30, 1999
  • 12:00 AM
  • 1,857 views

Using folate receptor alpha flurorescence imaging in ovarian cancer

by Sally Church in Pharma Strategy Blog

The idea behind this concept is that fluorescence technology can be used to help guide ovarian cancer surgery more effectively, since the tumors tend to be small and hard to see for surgeons performing the excision.... Read more »

van Dam, G., Themelis, G., Crane, L., Harlaar, N., Pleijhuis, R., Kelder, W., Sarantopoulos, A., de Jong, J., Arts, H., van der Zee, A.... (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nature Medicine. DOI: 10.1038/nm.2472  

  • November 30, 1999
  • 12:00 AM
  • 2,672 views

Is this journal for real?

by Neurobonkers in Neurobonkers

This year 134 suspect new journals have appeared from the abyss, all published by the same clandestine company “Scientific & Academic Publishing, USA“... Read more »

Morrison, Heather. (2012) Scholarly Communication in Crisis. Freedom for scholarship in the internet age. Simon Fraser University School of Communication. info:/

  • November 30, 1999
  • 12:00 AM
  • 2,404 views

Dizziness When Standing Up Linked to Greater Risk of Heart Failure: Research

by United Academics in United Academics

Many people feel suddenly dizzy when they stand up too quickly. This is caused by orthostatic hypotension, a rapid drop in blood pressure. Now a team of scientists at the University of North Carolina suggest that people with orthostatic hypotension might have a greater risk of developing heart failure.... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,739 views

“Beware of Exercise” is a Sexy Headline

by nooffensebut in The Unsilenced Science

A new study that raised concerns about exercise should instead raise concerns about obesity.... Read more »

Claude Bouchard, Steven Blair, Timothy Church, Conrad Earnest, James Hagberg, Keijo Häkkinen, Nathan Jenkins, Laura Karavirta, William Kraus, Arthur Leon.... (2012) Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?. PLOS One, 7(5). info:/10.1371/journal.pone.0037887

  • November 30, 1999
  • 12:00 AM
  • 2,398 views

The Aging Effects of the Sun Revealed on Trucker’s Face

by United Academics in United Academics

The man on the picture, William McElligott, spent 28 years of his life driving a delivery truck in Chicago. Only the left side of his face was exposed to the sun, with the result that it now looks much older than his right side. His case is a rare reminder of the aging effects of the sun, but also of the need to take precautions when working under certain conditions.... Read more »

Gordon, J., & Brieva, J. (2012) Unilateral Dermatoheliosis. New England Journal of Medicine, 366(16). DOI: 10.1056/NEJMicm1104059  

  • November 30, 1999
  • 12:00 AM
  • 1,924 views

Babies Are Healthier When There Is a Dog at Home: Research

by United Academics in United Academics

New research published in Pediatrics suggests that children living with a dog are significantly healthier than those living without it. The researchers followed up 397 Finnish children, asking their parents to fill in weekly questionnaires about their health until they were 1 year old. Scientists believe that this is so because dog contact helps the babies build up their immune system.... Read more »

Eija Bergroth, Sami Remes, Juha Pekkanen, Timo Kauppila, Gisela Büchele, & Leea Keski-Nisula. (2012) Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts. Pediatrics. info:/10.1542/peds.2011-2825

  • November 30, 1999
  • 12:00 AM
  • 1,404 views

Making sense of a small worm from big data

by Michael Hsieh in Hsieh Lab Blog

We recently published a gene expression microarray-based paper in PLOS Neglected Tropical Diseases. As a "reductionist", it was challenging for me to deal with the massive amount of data associated with the paper. ... Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,627 views

A Holiday Without Helminths

by Michael Hsieh in Hsieh Lab Blog

What would a holiday without helminths, also known as parasitic worms, look like?... Read more »

Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, McCarthy JS, & Basáñez MG. (2012) A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS neglected tropical diseases, 6(4). PMID: 22545164  

  • November 30, 1999
  • 12:00 AM
  • 2,254 views

I WILL FEAR NO EVIL: THE FIRST HEAD TRANSPLANT ON HUMAN

by Eugenio Maria Battaglia in Science to Grok

In 2008, doctor Sergio Canavero, an italian neurosurgeon based in Turin, IT, have awakened a 20 years old lady from a permanent post-traumatic vegetative state, by means of a bifocal extradural cortical electro-stimulation. Today, while Science still find it hard to explain consciousness and embodied cognition – the world-class neurosurgeon made a shock announcement: “I’m ready for the first head transplant on a man.”

In the manuscript published on Surgical Neurology I........ Read more »

  • November 30, 1999
  • 12:00 AM
  • 1,424 views

...How to Fix Science

by Viputheshwar Sitaraman in Draw Science

(Part 2/2) However, we can fix science. [Infographic]... Read more »

Alberts, B., Kirschner, M., Tilghman, S., & Varmus, H. (2014) Rescuing US biomedical research from its systemic flaws. Proceedings of the National Academy of Sciences, 111(16), 5773-5777. DOI: 10.1073/pnas.1404402111  

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