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  • March 12, 2015
  • 09:25 AM
  • 138 views

The Last Man And Woman On Earth – Can Two People Repopulate The Planet?

by Bill Sullivan in The 'Scope

In the new hit TV show, "Last Man On Earth", two survivors of a great plague are left with the task of repopulating the Earth. Can this really be done? ... Read more »

  • March 12, 2015
  • 06:41 AM
  • 16 views

Pre-pregnancy BMI And Gestational Weight Gain Linked To Childhood Obesity

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Elizabeth M. Widen, PhD, RD Postdoctoral Fellow in the Institute of Human Nutrition & Department of Epidemiology Columbia University Mailman School of Public Health New York, NY 10032 Medical Research: What is the background for this study? … Continue reading →
The post Pre-pregnancy BMI And Gestational Weight Gain Linked To Childhood Obesity appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

MedicalResearch.com Interview with:, & Elizabeth M. Widen, PhD, RD. (2015) Pre-pregnancy BMI And Gestational Weight Gain Linked To Childhood Obesity. MedicalResearch.com. info:/

  • March 12, 2015
  • 05:49 AM
  • 96 views

More evidence for non-coeliac gluten sensitivity?

by Paul Whiteley in Questioning Answers

"In a cross-over trial of subjects with suspected NCGS [non-coeliac gluten sensitivity], the severity of overall symptoms increased significantly during 1 week of intake of small amounts of gluten, compared with placebo."That was the conclusion reached in the study by Antonio Di Sabatino and colleagues [1] who applied the gold standard research methodology - "a randomized, double-blind, placebo-controlled, cross-over trial" - to studying the effects of small amounts of gluten on those "who believe ingestion of gluten-containing food to be the cause of their intestinal and extra-intestinal symptoms" despite being free of the autoimmune condition coeliac (celiac) disease or wheat allergy. Further information about this research can be seen on the trial registration page.Various symptoms were reported to be increased following gluten ingestion (4.375 g/day gluten) over and above placebo (rice starch) including abdominal bloating/pain. Extra-intestinal symptoms - that is symptoms that are not necessarily centred on the gastrointestinal (GI) tract - also seemed to increase during the active supplementation of gluten including: "foggy mind.., depression..., and aphthous stomatitis [mouth ulcers]". Depression potentially being linked to gluten consumption is something that has appeared [in quite preliminary form] before in the peer-reviewed research literature and this blog (see here). 'Foggy mind' is not a very technical term but again has been mentioned in other research papers talking about the use of a gluten-free diet and cognitive performance in cases of coeliac disease (CD) (see here).I was rather interested in these results given that NCGS has been to topic of quite a bit of material on this blog (see here for example) and the idea of something of a spectrum of gluten-related issues being present outside of those classical examples of coeliac disease and wheat allergy (see here). In recent times, attention has shifted away from gluten (or wheat) as being the potential culprit in such cases as per the rise and rise of FODMAP sensitivity as another potential explanator based on research such as that from Jessica Biesiekierski and colleagues [2]. I've watched this area closely and often thought that there may be room for both FODMAP sensitivity and NCGS being present in different people or even the same person. It appears from the results of the controlled trial from Di Sabatino et al, this might not be too far off the mark. Other research might also agree with such sentiments [3].Then to the questions: (a) what is the potential mechanism/s of effect? and (b) are we moving closer to identifying those who might fall into that NCGS category and so benefit from a gluten-free diet or even beyond [4]? Well, unfortunately I can't definitively answer either of those questions at the moment, but can perhaps offer a few areas where further investigations might be indicated.I was privileged to review the paper by Catassi and colleagues [5] (open-access) which provides quite a nice overview of NCGS and some directions where science is heading. One of the papers cited in that overview was that from Anna Sapone and colleagues [6] and their 2012 consensus paper on "new nomenclature and classification" when it came to gluten sensitivity (see here). I'm not altogether sure how well their 'proposed algorithm' has done in clinical practice but it strikes me that it's a good start when ruling out CD and wheat allergy. I might also add that there may be quite a bit more to see when it comes to looking at serology vs. histopathology at differentiating CD from NCGS [7] as per what has been talked about with [some] autism in mind (see here) and [some] cases of schizophrenia too (see here). Transglutaminase is also something in need of a lot more study with autism in mind (see here) by the way.The other area that I think would be rather interesting to look at is gut barrier function. Again, wearing my autism research hat, I'm pretty impressed with what has been reported in the peer-reviewed literature when it comes to 'leaky gut' and some autism (see here). Although by no means a universal aspect to autism (see here) it does happen, and more generally is in the research ascendancy (see here) for quite a few reasons. Allied to the the idea that (General) zonulin might be something related (see here) I'm also wondering whether it might be a good idea to look at this parameter comparing CD, wheat allergy and NCGS? I'm not expecting too much based on the work by Hollon and colleagues [8] on intestinal permeability and gluten for example, but you never know.And then there is the review from Molina-Infante and colleagues [9] to bring to your attention...Music then. Hey Joe by Jimi et al.----------[1] Di Sabatino A. et al. Small Amounts of Gluten in Subjects with Suspected Nonceliac Gluten Sensitivity: a Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial. Clin Gastroenterol Hepatol. 2015 Feb 19. pii: S1542-3565(15)00153-6.[2] Biesiekierski JR. et al. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology. 2013 Aug;145(2):320-8.e1-3.[3] Carroccio A. et al. Non-Celiac Wheat Sensitivity Diagnosed by Double-Blind Placebo-Controlled Challenge: Exploring a New Clinical Entity. Am J Gastroenterol 2012; 107:1898–1906.[4] Makharia GK. Current and emerging therapy for celiac disease. Front Med (Lausanne). 2014 Mar 24;1:6.[5] Catassi C. et al. Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients. 2013 Sep 26;5(10):3839-53.[6] Sapone A. et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. 2012 Feb 7;10:13.[7] Brottveit M. et al. Mucosal Cytokine Response... Read more »

Di Sabatino A, Volta U, Salvatore C, Biancheri P, Caio G, De Giorgio R, Di Stefano M, & Corazza GR. (2015) Small Amounts of Gluten in Subjects with Suspected Nonceliac Gluten Sensitivity: a Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. PMID: 25701700  

  • March 11, 2015
  • 09:33 PM
  • 100 views

NSAIDS May Be Helpful In Bladder Cancer Prevention

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: James Scheiman, M.D. Professor of Gastroenterology University of Michigan Medical School Medical Research: What is the background for this study? What are the main findings? Dr. Scheiman: Using aspirin or other nsaids to reduce the risk of … Continue reading →... Read more »

MedicalResearch.com Interview with:, & James Scheiman, M.D. (2015) NSAIDS May Be Helpful In Bladder Cancer Prevention. MedicalResearch.com. info:/

  • March 11, 2015
  • 08:09 PM
  • 80 views

Epigenetics, Not Just Genes, Control Many Complex Traits

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Prof. Moshe Szyf Ph.D. James McGill Professor of Pharmacology and Therapeutics McGill University Medical Research: What is the background for this study? What are the main findings? Dr. Szyf: Humans exhibit a marked variation in traits both … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Prof. Moshe Szyf Ph.D. (2015) Epigenetics, Not Just Genes, Control Many Complex Traits. MedicalResearch.com. info:/

  • March 11, 2015
  • 07:54 PM
  • 73 views

ESCAPE Study Evaluates Stepped Care For Chronic Pain in Veterans

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Matthew J. Bair, MD, MS Research Service, Veterans Affairs Health Services Research and Development, Center for Health Information and Communication Richard L. Roudebush Veterans Affairs Medical Center, Department of Medicine, Indiana University School of Medicine, Health Services Research, Regenstrief … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Matthew J. Bair, MD, MS. (2015) ESCAPE Study Evaluates Stepped Care For Chronic Pain in Veterans. MedicalResearch.com. info:/

  • March 11, 2015
  • 06:38 PM
  • 54 views

Nonsurgical Treatments May Equal Surgery For Many Broken Shoulders

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Prof. Amar Rangan Clinical Professor, Trauma & Orthopaedic Surgery School of Medicine & Health, Durham University & Consultant Orthopaedic Surgeon The James Cook University Hospital Middlesbrough Medical Research: What is the background for this study? What are the … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Prof. Amar Rangan. (2015) Nonsurgical Treatments May Equal Surgery For Many Broken Shoulders. MedicalResearch.com. info:/

  • March 11, 2015
  • 05:11 PM
  • 76 views

Familial Hypercholesterolemia Linked To Lower Type2 Diabetes Risk

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Joost Besseling PhD-student Academic Medical Center Dept. of Vascular Medicine Amsterdam Medical Research: What is the background for this study? What are the main findings? Response: Statins are associated with an increased risk for type 2 diabetes … Continue reading →... Read more »

Joost Besseling PhD-student, Academic Medical Center, Dept. of Vascular Medicine, & Amsterdam. (2015) Familial Hypercholesterolemia Linked To Lower Type2 Diabetes Risk. MedicalResearch.com. info:/

  • March 11, 2015
  • 04:58 PM
  • 63 views

Intranasal Oxytocin Reduced Calorie Consumption in Men

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Elizabeth A. Lawson, M.D., M.M.Sc. Assistant Professor of Medicine Harvard Medical School Director, Interdisciplinary Oxytocin Research Program Neuroendocrine Unit Massachusetts General Hospital Boston, MA 02114 Medical Research: What is the background for this study? What are the … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Elizabeth A. Lawson, M.D., M.M.Sc. (2015) Intranasal Oxytocin Before Meal Reduced Calorie Consumption in Men. MedicalResearch.com. info:/

  • March 11, 2015
  • 04:43 PM
  • 61 views

Interarm Blood Pressure Variability Linked To Greater Cardiovascular Risk in CKD

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. Borja Quiroga MD Ph.D. Nephrology Unit, Hospital General Universitario Gregorio Marañón Madrid, Spain Medical Research: What is the background for this study? What are the main findings? Dr. Quiroga: Chronic kidney disease patients are at high-risk … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Dr. Borja Quiroga MD Ph.D. (2015) Interarm Blood Pressure Variability Linked To Greater Cardiovascular Risk in CKD. MedicalResearch.com. info:/

  • March 11, 2015
  • 04:20 PM
  • 65 views

Nearly All Babies Born With Neonatal Abstinence Syndrome Were Exposed To Opioids

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dr. Jennifer Lind PharmD, MPH Division of Birth Defects and Developmental Disabilities, CDC Medical Research: What is the background for this study? Dr. Lind: CDC and Florida investigators published a new report describing the characteristics of infants … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Dr. Jennifer Lind PharmD, MPH. (2015) Nearly All Babies Born With Neonatal Abstinence Syndromes Were Exposed To Opioids. MedicalResearch.com. info:/

  • March 11, 2015
  • 04:20 PM
  • 81 views

The cerebral cortex: we can rebuild it, we have the technology

by Dr. Jekyll in Lunatic Laboratories

While the first actual bionic man (or woman) might still be a ways off, the writers of the show might be impressed at this. A international team of researchers, have just taken an important step in the area of cell therapy: repairing the cerebral cortex of the adult mouse using a graft of cortical neurons derived from embryonic stem cells.... Read more »

  • March 11, 2015
  • 03:27 PM
  • 73 views

Part of the diabetes puzzle solved… with breast milk

by Dr. Jekyll in Lunatic Laboratories

There is a long-standing puzzle in the diabetes field, only a small subset of insulin-producing beta cells in the pancreas of adult organisms can replicate (and hence contribute to beta cell regeneration in diabetes). Furthermore, this subset of replicating cells continues to decline with advancing age. This means that the typical risk for diabetes gets higher as you age, well now researchers have discovered an important piece of the puzzle.... Read more »

Stolovich-Rain, M., Enk, J., Vikesa, J., Nielsen, F., Saada, A., Glaser, B., & Dor, Y. (2015) Weaning Triggers a Maturation Step of Pancreatic β Cells. Developmental Cell, 32(5), 535-545. DOI: 10.1016/j.devcel.2015.01.002  

  • March 11, 2015
  • 11:09 AM
  • 63 views

‘Leadership Saves Lives’ Program Aims To Reduce Heart Attack Mortality

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Leslie Curry PhD, MPH Senior Research Scientist in and Lecturer in Public Health (Health Policy) Co-Director, Robert Wood Johnson Clinical Scholars Program Yale School of Public Health Medical Research: What is the background for this study? What … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Leslie Curry PhD, MPH. (2015) MAYO 'Leadership Saves Lives' Program Aims To Reduce Heart Attack Mortality. MedicalResearch.com. info:/

  • March 11, 2015
  • 09:03 AM
  • 52 views

After Consulting Dr. Wiki, You Should Get a Second Opinion

by Vivek Misra in The UberBrain

We have all been there: waking up in the middle of the night with a pounding headache, nausea, rashes on skin or another ailment with an unexplained origin. More often than not, first thing we’re inclined to do is begin... Read more »

Hasty RT, Garbalosa RC, Barbato VA, Valdes PJ Jr, Powers DW, Hernandez E, John JS, Suciu G, Qureshi F, Popa-Radu M.... (2014) Wikipedia vs peer-reviewed medical literature for information about the 10 most costly medical conditions. The Journal of the American Osteopathic Association, 114(5), 368-73. PMID: 24778001  

  • March 11, 2015
  • 08:18 AM
  • 63 views

Conflicts of Interest in Peer Review of Biomedical Research Funding Studied

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Stephen Gallo, Ph.D. Technical Operations Manager American Institute of Biological Sciences Scientific Peer Advisory and Review Services Reston, VA  20191 Medical Research: What is the background for this study? What are the main findings? Dr. Gallo: Peer … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Stephen Gallo, Ph.D. (2015) Conflicts of Interest in Peer Review of Biomedical Research Funding Studied. MedicalResearch.com. info:/

  • March 11, 2015
  • 08:13 AM
  • 71 views

Breath Test for Drug Testing In the Pipeline

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Niclas Stephanson, PhD Leg. Apotekare, Analytisk kemist Karolinska Universitetssjukhuset Stockholm Medical Research: What is the background for this study? What are the main findings? Dr. Stephanson: Drug testing is most commonly performed using urine samples, which is … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Niclas Stephanson, PhD. (2015) Breath Test for Drug Testing In the Pipeline. MedicalResearch.com. info:/

  • March 11, 2015
  • 08:01 AM
  • 49 views

Inhaled Nitric Oxide Still Used Off-Label In Preterm Infants

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Marc Ellsworth, M.D Neonatology fellow at the Mayo Clinic Children’s Center MedicalResearch: What is the background for this study? Dr. Ellsworth: Inhaled Nitric Oxide (iNO) is a drug that has FDA approval for use in neonates >34 … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Marc Ellsworth, M.D. (2015) Inhaled Nitric Oxide Still Used Off-Label In Preterm Infants. MedicalResearch.com. info:/

  • March 11, 2015
  • 07:50 AM
  • 54 views

Personalized Risk Calculations May Reduce Readmissions Of Sepsis Survivors

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Hallie Prescott, MD, MSc Clinical Lecturer, Internal Medicine Division of Pulmonary & Critical Care Medicine University of Michigan Health System Ann Arbor, MI 48109-2800   Medical Research: What is the background for this study? What are the … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Hallie Prescott, MD, MSc. (2015) Personalized Risk Calculations May Reduce Readmissions Of Sepsis Survivors. MedicalResearch.com. info:/

  • March 11, 2015
  • 07:38 AM
  • 52 views

‘Traffic Light’ Nutrition Labels Help Consumers Make Healthier Choices

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Professor Dr. Bernd Weber Heisenberg Professor Department of Epileptology Head – NeuroCognition | Imaging Life&Brain Center  Board of Directors Center for Economics and Neuroscience Bonn Medical Research: What is the background for this study? What are the … Continue reading →... Read more »

MedicalResearch.com Interview with:, & Professor Dr. Bernd Weber. (2015) 'Traffic Light' Nutrition Labels Help Consumers Make Healthier Choices. MedicalResearch.com. info:/

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