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  • June 11, 2015
  • 05:41 PM
  • 42 views

Functional Status Is Important Predictor of Hospital Readmission

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Jeffrey C. Schneider, M.D. Medical Director, Trauma, Burn & Orthopedic Program Assistant Professor, Dept. of Physical Medicine and Rehabilitation Harvard Medical School Spaulding Rehabilitation Hospital Boston, MA 02129 Medical Research: What is the background for this study? … Continue reading →
The post Functional Status Is Important Predictor of Hospital Readmission appeared first on MedicalResearch.com Medical Research Interviews and News.
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Jeffrey C. Schneider, M.D., Medical Director, Trauma, Burn , Assistant Professor, Dept. of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, & Boston, MA 02129. (2015) Functional Status Is Important Predictor of Hospital Readmission. MedicalResearch.com. info:/

  • June 11, 2015
  • 05:32 PM
  • 36 views

New Borrelia Tick-Borne Disease Confirmed in Series of 51 Patients

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Dr. Philip Molloy, MD Imugen Medical Director Medical Research: What is the background for this study? What are the main findings? Response: There is a newly described tick-borne infection in the US, first case published in NEJM … Continue reading →
The post New Borrelia Tick-Borne Disease Confirmed in Series of 51 Patients appeared first on MedicalResearch.com Medical Research Interviews and News.
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Dr. Philip Molloy, MD, & Imugen Medical Director. (2015) New Borrelia Tick-Borne Disease Confirmed in Series of 51 Patients. MedicalResearch.com. info:/

  • June 11, 2015
  • 05:21 PM
  • 64 views

Lump Sum Payments To Long-term Care Hospitals May Have Created Incentive To Discharge Patients

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Yan S. Kim, MD PhD Delivery Science Fellow Division of Research Kaiser Permanente Northern California Oakland, CA 94612 Medical Research: What is the background for this study? What are the main findings? Dr. Kim: Long-term care hospitals … Continue reading →
The post Lump Sum Payments To Long-term Care Hospitals May Have Created Incentive To Discharge Patients appeared first on MedicalResearch.com Medical Research Interviews and News.
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MedicalResearch.com Interview with: Yan S. Kim, MD PhD, Delivery Science Fellow Division of Research, Kaiser Permanente Northern California, & Oakland, CA 94612. (2015) Lump Sum Payment To Long-term Care Hospitals May Have Created Incentive To Discharge Patients. MedicalResearch.com. info:/

  • June 11, 2015
  • 04:31 PM
  • 66 views

AKAP4 Is a Promising Blood Biomarker For Early Detection of Lung Cancer

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Qihong Huang, M.D., Ph.D. Associate professor in the Tumor Microenvironment and Metastasis Program The Wistar Institute Medical Research: What is the background for this study? What are the main findings? Dr. Huang: Lung cancer is the leading … Continue reading →
The post AKAP4 Is a Promising Blood Biomarker For Early Detection of Lung Cancer appeared first on MedicalResearch.com Medical Research Interviews and News.
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Qihong Huang, M.D., Ph.D., Associate professor in the Tumor Microenvironment and Metastasis Program, & The Wistar Institute. (2015) AKAP4 Is a Promising Blood Biomarker For Early Detection of Lung Cancer. MedicalResearch.com. info:/

  • June 11, 2015
  • 04:16 PM
  • 79 views

Noninvasive Prenatal Testing May Detect Maternal Cancer

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Prof. Joris Vermeesch Hoofd Moleculaire Cytogenetica Coordinator Genomics Core University of Leuven, University Hospitals Leuven, Belgium Medical Research: What is the background for this study? What are the main findings? Dr. Vermeesch: We developed a novel analysis … Continue reading →
The post Noninvasive Prenatal Testing May Detect Maternal Cancer appeared first on MedicalResearch.com Medical Research Interviews and News.
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Prof. Joris Vermeesch, Hoofd Moleculaire Cytogenetica, & Coordinator Genomics Core. (2015) Noninvasive Prenatal Testing May Detect Maternal Cancer. MedicalResearch.com. info:/

  • June 11, 2015
  • 03:12 PM
  • 106 views

Milk proteins may protect against cardiovascular disease

by Dr. Jekyll in Lunatic Laboratories

The Maillard reaction is a chemical reaction between amino acids and reducing sugars that results in browned foods like seared steaks and toasted bread. When proteins and sugars are mixed together and heated, new chemical compounds are formed. Some are responsible for new flavors and some, according to a new study, may protect us against cardiovascular disease.... Read more »

  • June 11, 2015
  • 05:11 AM
  • 143 views

Higher vitamin D = reduced risk of depression?

by Paul Whiteley in Questioning Answers

"These results support the hypothesis that higher serum 25(OH)D concentrations protect against depression even after adjustment for a large number of sociodemographic, lifestyle and metabolic factors."That was the conclusion reached by Tuija Jääskeläinen and colleagues [1] who analysed data from several thousands of people (men and women aged between 30 -79 years old) included as part of the Finnish Health 2000 survey. Alongside assaying for serum levels of 25(OH)D - 25-hydroxy vitamin D being the metabolite of choice for measuring how much vitamin D a person has - researchers also collected information on whether or not a diagnosis of depression or anxiety had been reported and looked for any potential connections. Further: "sociodemographic and lifestyle variables as well as indicators of metabolic health" were included in the analyses as potential confounders.The results: "Individuals with higher serum 25(OH)D concentrations showed a reduced risk of depression." Indeed: "Higher serum 25(OH)D concentrations were associated with a lower prevalence of depressive disorder especially among men, younger, divorced and those who had an unhealthy lifestyle or suffered from the metabolic syndrome." Metabolic syndrome, by the way, refers to a combination of clinical findings including diabetes, high blood pressure and obesity and has independently been suggested to be associated with depression [2]. Vitamin D levels have also been mentioned with metabolic syndrome in mind [3].Authors also calculated something called the population attributable fraction (PAF) - "the proportional reduction in population disease or mortality that would occur if exposure to a risk factor were reduced to an alternative ideal exposure scenario" - and estimated that nearly a fifth of cases of depression might be 'reduced' "when serum 25(OH)D concentration was at least 50 nmol/l." I've talked about PAF before on this blog; coincidentally suggesting that a fifth of cases of schizophrenia might not be diagnosed if that old devil Toxoplasma gondii weren't present (see here).Whilst calling for: "Large-scale prospective studies... to confirm this finding" the authors are already aware that there is a sizeable volume of peer-reviewed research suggestive of a connection between vitamin D levels and the presentation of depression. I've covered some of that literature before on this blog (see here) accepting that the label 'depression' covers quite a lot of clinical ground and is, most likely the result of a combination of various 'individual' factors: genetic, biological, psychological and sociological, varying from person to person. I'd also suggest that the concept of resilience might come into play too [4].Regular readers of this blog might already know of my interest in all-things 'the sunshine vitamin' (see here for example) and how this vitamin/hormone seems to be involved in so much more than just avoiding rickets. The body of research looking at vitamin D and depression (even vitamin D and schizophrenia) leads me to ask whether there may be wider implications of the proposed link between vitamin D and behaviour/psychiatry specifically in cases where depression (and/or schizophrenia) may be associated with other labels. I'm of course thinking about autism and how the research on vitamin D and the autism spectrum is increasingly suggesting that there may be more to see (see here). Various types of depression do seem to be over-represented when it comes to autism as per the suggestion of a link between some types of autism and bipolar disorder (see here). One therefore wonders to what extent vitamin D deficiency/insufficiency linked to autism might also be part and parcel of the presentation of this other comorbidity...Oh, and if you're thinking about supplementation (with no medical or clinical advice given or intended) please do be careful [5] (3 million international units is a bit much)...Music: Elastica - Connection.----------[1] Jääskeläinen T. et al. Higher serum 25-hydroxyvitamin D concentrations are related to a reduced risk of depression. Br J Nutr. 2015 May;113(9):1418-26.[2] Dunbar JA. et al. Depression: an important comorbidity with metabolic syndrome in a general population. Diabetes Care. 2008 Dec;31(12):2368-73.[3] Awad AB. et al. Vitamin d and metabolic syndrome risk factors: evidence and mechanisms. Crit Rev Food Sci Nutr. 2012;52(2):103-12.[4] Southwick SM. et al. The psychobiology of depression and resilience to stress: implications for prevention and treatment. Annu Rev Clin Psychol. 2005;1:255-91.----------Jääskeläinen T, Knekt P, Suvisaari J, Männistö S, Partonen T, Sääksjärvi K, Kaartinen NE, Kanerva N, & Lindfors O (2015). Higher serum 25-hydroxyvitamin D concentrations are related to a reduced risk of depression. The British journal of nutrition, 113 (9), 1418-26 PMID: 25989997... Read more »

Jääskeläinen T, Knekt P, Suvisaari J, Männistö S, Partonen T, Sääksjärvi K, Kaartinen NE, Kanerva N, & Lindfors O. (2015) Higher serum 25-hydroxyvitamin D concentrations are related to a reduced risk of depression. The British journal of nutrition, 113(9), 1418-26. PMID: 25989997  

  • June 10, 2015
  • 08:37 PM
  • 71 views

Treatment With TNF-α inhibitors Raises Short Term Risk Of Infection in Inflammatory Bowel Disease

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Nynne Nyboe Andersen, MD, PhD student Department of Epidemiology Research Statens Serum Institut Copenhagen, Denmark Medical Research: What is the background for this study? What are the main findings? Dr. Andersen: The use of TNF-α inhibitors, including … Continue reading →
The post Treatment With TNF-α inhibitors Raises Short Term Risk Of Infection in Inflammatory Bowel Disease appeared first on MedicalResearch.com Medical Research Interviews and News.
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Nynne Nyboe Andersen, MD, PhD student Department of Epidemiology Research, Statens Serum Institut, & Copenhagen, Denmark. (2015) Treatment With TNF-α inhibitors Raises Short Term Risk Of Infection in Inflammatory Bowel Disease. MedicalResearch.com. info:/

  • June 10, 2015
  • 08:10 PM
  • 70 views

Lack of Random Allocation of Participants May Make Observational Research Misleading

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Andrew Grey, MD Department of Medicine University of Auckland Auckland, New Zealand Medical Research: What is the background for this study? What are the main findings? Dr. Grey: Observational research is commonly conducted and often published in prominent medical … Continue reading →
The post Lack of Random Allocation of Participants May Make Observational Research Misleading appeared first on MedicalResearch.com Medical Research Interviews and News.
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Andrew Grey, MD, Department of Medicine, University of Auckland, & Auckland, New Zealand. (2015) Lack of Random Allocation of Participants May Make Observational Studies Misleading. MedicalResearch.com. info:/

  • June 10, 2015
  • 07:21 PM
  • 97 views

Most Patients With Atrial Fibrillation Are Symptomatic and Have Impaired Quality of Life

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: James V. Freeman MD, MPH, MS Yale University School of Medicine New Haven, CT Medical Research: What is the background for this study? What are the main findings? Dr. Freeman: Atrial fibrillation (AF) substantially increases the risk … Continue reading →
The post Most Patients With Atrial Fibrillation Are Symptomatic and Have Impaired Quality of Life appeared first on MedicalResearch.com Medical Research Interviews and News.
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James V. Freeman MD, MPH, MS, Yale University School of Medicine, & New Haven, CT. (2015) Most Patients With Atrial Fibrillation Symptomatic and Have Impaired Quality of Life. MedicalResearch.com. info:/

  • June 10, 2015
  • 06:15 PM
  • 113 views

New drug can clear all psoriasis symptoms

by Dr. Jekyll in Lunatic Laboratories

Good news for anyone who has psoriasis, a University of Manchester led trial of a new drug has resulted in 40 percent of people showing a complete clearance of psoriatic plaques after 12 weeks of treatment and over 90 percent showing improvement. The research tested 2,500 people with psoriasis. Half were given a new drug – ixekizumab – either once every two or four weeks. The other half were given a placebo or a widely used drug for psoriasis called etanercept.... Read more »

Prof Christopher E M, Griffiths, MD, Prof Kristian Reich, MD, Prof Mark Lebwohl, MD, Prof Peter van de Kerkhof, MD, Prof Carle Paul, MD, Alan Menter, MD, Gregory S Cameron, PhD, Janelle Erickson, PhD, Lu Zhang, MS.... (2015) Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials . Lancet. DOI: http://dx.org/10.1016/S0140-6736(15)60125-8  

  • June 10, 2015
  • 05:44 PM
  • 130 views

First functional, synthetic immune organ with controllable antibodies created by engineers

by Dr. Jekyll in Lunatic Laboratories

Cornell University engineers have created a functional, synthetic immune organ that produces antibodies and can be controlled in the lab, completely separate from a living organism. The engineered organ has implications for everything from rapid production of immune therapies to new frontiers in cancer or infectious disease research.... Read more »

Purwada, A., Jaiswal, M., Ahn, H., Nojima, T., Kitamura, D., Gaharwar, A., Cerchietti, L., & Singh, A. (2015) Ex vivo Engineered Immune Organoids for Controlled Germinal Center Reactions. Biomaterials. DOI: 10.1016/j.biomaterials.2015.06.002  

  • June 10, 2015
  • 05:12 PM
  • 58 views

Early Autism Intervention Produces Long Term Benefits

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Annette Estes, Ph.D. Research Associate Professor of Speech and Hearing Sciences Adjunct Research Associate Professor of Psychology Director, University of Washington Autism Center Susan & Richard Fade Endowed Chair Center on Human Development and Disability University of … Continue reading →
The post Early Autism Intervention Produces Long Term Benefits appeared first on MedicalResearch.com Medical Research Interviews and News.
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MedicalResearch.com Interview with: Annette Estes, Ph.D., Research Associate Professor of Speech and Hearing Sciences, Adjunct Research Associate Professor of Psychology, Director, University of Washington Autism Center, Susan , Center on Human Development and Disability, & University of Washington. (2015) Early Autism Intervention Produces Long Term Benefits . MedicalResearch.com. info:/

  • June 10, 2015
  • 04:56 PM
  • 70 views

Social Support From Friends and Family Linked To Lower Mortality

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Katie Becofsky Ph.D. Weight Control and Diabetes Research Center The Miriam Hospital Providence, RI Medical Research: What is the background for this study? What are the main findings? Dr. Becofsky: Previous research has provided clear evidence of … Continue reading →
The post Social Support From Friends and Family Linked To Lower Mortality appeared first on MedicalResearch.com Medical Research Interviews and News.
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Katie Becofsky Ph.D., Weight Control and Diabetes Research Center, The Miriam Hospital, & Providence, RI. (2015) Social Support From Friends and Family Linked To Lower Mortality. MedicalResearch.com. info:/

  • June 10, 2015
  • 02:26 PM
  • 64 views

Blood Pressure Medication ARBs Should Be Resumed As Soon As Possible After Surgery

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Susan Ming Lee, MD, FRCPC, MAS (Clinical Research) Clinical Instructor, Dept. of Anesthesia and Perioperative Care University of California, San Francisco Medical Research: What are the main findings? Dr. Lee: Angiotensin receptor blockers (often referred to as … Continue reading →
The post Blood Pressure Medication ARBs Should Be Resumed As Soon As Possible After Surgery appeared first on MedicalResearch.com Medical Research Interviews and News.
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Susan Ming Lee, MD, FRCPC, MAS (Clinical Research), Clinical Instructor, Dept. of Anesthesia and Perioperative Care, & University of California, San Francisco. (2015) Blood Pressure Medication ARBs Should Be Resumed As Soon As Possible After Surgery. MedicalResearch.com. info:/

  • June 10, 2015
  • 01:38 PM
  • 58 views

Pediatric Hospitalizations For Children Dropped Almost 90% After Rotavirus Vaccine Implemented

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Eyal Leshem, MD Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia Medical Research: What is the background for this study? What are the main findings? Response: Routine vaccination of US children to protect against … Continue reading →
The post Pediatric Hospitalizations For Children Dropped Almost 90% After Rotavirus Vaccine Implemented appeared first on MedicalResearch.com Medical Research Interviews and News.
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Eyal Leshem, MD, Division of Viral Diseases,, US Centers for Disease Control and Prevention,, & Atlanta, Georgia. (2015) Pediatric Hospitalizations For Children Dropped Almost 90% After Rotavirus Vaccine Implemented. MedicalResearch.com. info:/

  • June 10, 2015
  • 12:58 PM
  • 120 views

Brain Default Network in Psychotic Bipolar Disorder

by William Yates, M.D. in Brain Posts

In a previous post I reviewed a summary of research related to genetics and improved diagnosis in bipolar disorder.One key point in this review was a highlight of the promise for integrating genetic with imaging research in bipolar disorder and other neuropsychiatric disorders.An example of this type of integrated research has been recently published in PNAS by a group of Yale University, the University of New Mexico and the University of Texas Southwestern Medical Center.This study used functional magnetic resonance imaging (fMRI) default mode network (DMN) across a group of subjects with psychotic bipolar disorder, schizophrenia and healthy controls. Additionally, study included imaging a group of unaffected relatives of the psychotic bipolar subjects and schizophrenia.Subjects also had genetic analyses available for comparison with any imaging results that would emerge in the study.The research team identified three circuit components in the DMN. The included the networks below (also identified by color as highlighted in group name):Anterior DMN--Medial prefrontal cortex-anterior cingulate caudate DMNInferior posterior DMN--posterior cingulate caudate, inferior parietal lobule, middle temporal gyrus, cuneus/pre-cuneusSuperior posterior DMN--cuneus/pre-cuneus, inferior parietal lobule, cingulateThe key findings from the study include the following:Measures of hypoconnectivity in all three networks were identified in the psychotic bipolar and schizophrenia groups compared to controls.Unaffected psychotic bipolar disorder relatives had normal DMN measures in the three networks while the unaffected schizophrenic relatives showed hypoconnectivity in on one of the three networks.Genetic analysis revealed five genetic links to a brain connectivity sub-DMNs.Genes identified in this brain mapping linkage had previously been linked to psychosis and mood disordersThe five genetic clusters identified in this study were related to specific brain developmental and neuronal processes:NMDA long-term potentiationProtein kinase A regulationImmune response signalingGuidance of axonal developmentSynaptogenesisThe authors note an important advance in their study is the ability to"dissect the underlying biological/molecular pathways and processes that might mediate genetic risk of psychosis via a valuable, noninvasive imaging marker."Default mode network imaging and analysis is advancing as a promising research and clinical tool. It holds the promise of improving diagnostic accuracy and potentially improvement in targeting best treatment interventions for many brain disorders.Readers with more interest in this topic can access the free full-text manuscript by clicking on the PMID link below.Image of the cingulate fiber connectivity anatomy is an iPad screen shot from the app Brain Tutor.Follow the author on Twitter WRY999Meda SA, Ruaño G, Windemuth A, O'Neil K, Berwise C, Dunn SM, Boccaccio LE, Narayanan B, Kocherla M, Sprooten E, Keshavan MS, Tamminga CA, Sweeney JA, Clementz BA, Calhoun VD, & Pearlson GD (2014). Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 111 (19) PMID: 24778245... Read more »

Meda SA, Ruaño G, Windemuth A, O'Neil K, Berwise C, Dunn SM, Boccaccio LE, Narayanan B, Kocherla M, Sprooten E.... (2014) Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 111(19). PMID: 24778245  

  • June 10, 2015
  • 12:26 PM
  • 58 views

Cognitive Therapy May Be Safe and Effective For Chronic Insomnia

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Dr David Cunnington Sleep Physician & Director Melbourne Sleep Disorders Centre East Melbourne Australia Medical Research: What is the background for this study? What are the main findings? Response: Insomnia is a very common problem with 15-20% … Continue reading →
The post Cognitive Therapy May Be Safe and Effective For Chronic Insomnia appeared first on MedicalResearch.com Medical Research Interviews and News.
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Dr David Cunnington Sleep Physician , Melbourne Sleep Disorders Centre, & East Melbourne Australia. (2015) Cognitive Therapy May Be Safe and Effective For Chronic Insomnia. MedicalResearch.com. info:/

  • June 10, 2015
  • 12:08 PM
  • 48 views

CDC Study Finds No Pattern Suggesting Vaccines Contributed To Or Caused Deaths

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Dr. Pedro Moro, MD, MPH Immunization Safety Office Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Atlanta, GA 3033 Medical Research: What is the background for this study? What are the main findings? Response: … Continue reading →
The post CDC Study Finds No Pattern Suggesting Vaccines Contributed To Or Caused Deaths appeared first on MedicalResearch.com Medical Research Interviews and News.
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Dr. Pedro Moro, MD, MPH, Immunization Safety Office, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, & Atlanta, GA 3033. (2015) CDC Study Finds No Pattern Suggesting Vaccines Contributed To Or Caused Deaths. MedicalResearch.com. info:/

  • June 10, 2015
  • 10:28 AM
  • 39 views

Research Into Many Dermatology Disorders Underfunded

by Marie Benz in MedicalResearch.com

MedicalResearch.com Medical Research Interviews and News
MedicalResearch.com Interview with: Chante Karimkhani MD Columbia University College of Physicians and Surgeons, New York, New York, Erika Hagstrom MD Loyola University of Chicago Stritch School of Medicine, Maywood, Illinois Robert Dellavalle MD, PhD, MPH Department of Dermatology, University of … Continue reading →
The post Research Into Many Dermatology Disorders Underfunded appeared first on MedicalResearch.com Medical Research Interviews and News.
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MedicalResearch.com Interview with:, Chante Karimkhani MD, & Columbia University College of Physicians and Surgeons, New York, New York,. (2015) Research Into Many Dermatology Disorders Underfunded. MedicalResearch.com. info:/

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