Anterior cruciate ligament (ACL) ruptures often coincide with meniscal and cartilaginous injuries. These ruptures are generally treated with surgical reconstruction or non-surgical treatment. Patients who chose to delay surgical treatment may be at greater risk for increasing the severity of the associated injuries; however, this has not been demonstrated in the literature. Therefore, Fok and Yau completed a retrospective, comparative study investigating (1) if delaying ACL reconstruction is ass........ Read more »
Fok AW, & Yau WP. (2012) Delay in ACL reconstruction is associated with more severe and painful meniscal and chondral injuries. Knee Surgery, Sports Traumatology, Arthroscopy. PMID: 22552616
Given the popularity of my post on how the media portrays eating disorders, I thought I’d do a follow-up post about a more recent and comprehensive study on media reporting of eating disorders. Shepherd & Seale (2010) wanted to build up on the findings of O’Hara & Clegg-Smith, but focusing on UK newspapers.... Read more »
Shepherd, E., & Seale, C. (2010) Eating disorders in the media: The changing nature of UK newspaper reports. European Eating Disorders Review, 18(6), 486-495. DOI: 10.1002/erv.1006
The current Annals of Emergency Medicine has a pair of editorials on the article I wrote about in This is the Way to Bad Medicine back in January. Dr. Radecki also was critical of this paper. There is another study that refers to the same question published in this issue, but I will write about that paper later.
"These data raise the real question, Do such findings matter? By admitting more patients and ordering more CTs, do we improve outcomes? Or do we simply find more things tha........ Read more »
Menditto, V., Lucci, M., Polonara, S., Pomponio, G., & Gabrielli, A. (2012) Management of Minor Head Injury in Patients Receiving Oral Anticoagulant Therapy: A Prospective Study of a 24-Hour Observation Protocol. Annals of Emergency Medicine. DOI: 10.1016/j.annemergmed.2011.12.003
In this installment, I will discuss why it is difficult to discover, design and develop a drug, in view of our current knowledge of physiology.With numerous, intertwined reactions happening, our body is a complex clockwork of biomachinery gears. What do you do, then, if some gears fail—that is, if you got sick? On one hand, it is a consolation that many gears are what biologists call 'redundant', which means that it's alright that a certain gear fails, because there are other gears that can ta........ Read more »
Eckert, D., & Kim, P. (2001) Mechanisms of Viral Membrane Fusion and Its Inhibition. Annual Review of Biochemistry, 70(1), 777-810. DOI: 10.1146/annurev.biochem.70.1.777
Welsch, M., Snyder, S., & Stockwell, B. (2010) Privileged scaffolds for library design and drug discovery. Current Opinion in Chemical Biology, 14(3), 347-361. DOI: 10.1016/j.cbpa.2010.02.018
Marusyk A, Almendro V, & Polyak K. (2012) Intra-tumour heterogeneity: a looking glass for cancer?. Nature reviews. Cancer, 12(5), 323-34. PMID: 22513401
The liquorice root is full of surprises. Chewed as a breath freshener in Italy and a sweet in Sweden (and the north of England), this little brown stick has also been used as a remedy for mouth ulcers for thousands of years.
New research has identified a natural chemical extracted from the liquorice root that could be used to treat Type II diabetes.... Read more »
Weidner, C., de Groot, J., Prasad, A., Freiwald, A., Quedenau, C., Kliem, M., Witzke, A., Kodelja, V., Han, C., Giegold, S.... (2012) From the Cover: Amorfrutins are potent antidiabetic dietary natural products. Proceedings of the National Academy of Sciences, 109(19), 7257-7262. DOI: 10.1073/pnas.1116971109
There were always two types of cholesterol, the good and the
bad. Until now. A large new study tells us that good cholesterol might have
been an impostor. That's food for the media types. For those who think before
they type, the real news is that we are finally getting closer to uncovering
the impostors. Thanks to the genetics revolution which seems to be paying off
in an unexpected area.
HDL - The Knight in Shining Armor
In the cholesterol u........ Read more »
Voight, B., Peloso, G., Orho-Melander, M., Frikke-Schmidt, R., Barbalic, M., Jensen, M., Hindy, G., Hólm, H., Ding, E., Johnson, T.... (2012) Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. The Lancet. DOI: 10.1016/S0140-6736(12)60312-2
Journalists like to report on novel and exciting findings regardless of how likely they are to be replicated or how well they fit in with everything else we know about that topic. It is an all too common occurrence that a small pilot study which has favourable results, creates a buzz in and gets into our heads, only to produce negative or unfavourable results once the sample size is increased. But the latter, negative finding, rarely makes it to the printing press. So we are left thinking the re........ Read more »
Pietrini, F., Castellini, G., Ricca, V., Polito, C., Pupi, A., & Faravelli, C. (2011) Functional neuroimaging in anorexia nervosa: A clinical approach. European Psychiatry, 26(3), 176-182. DOI: 10.1016/j.eurpsy.2010.07.011
by Jason in Views From Beyond the OR
TweetIn the days and weeks following the January 2010 earthquake in Haiti, thousands of surgical procedures were performed to alleviate suffering, save lives, and hopefully allow patients to obtain rehabilitation and support in order to return to their lives. Surgery … Continue reading →... Read more »
Nickerson JW, Chackungal S, Knowlton L, McQueen K, & Burkle FM. (2012) Surgical Care during Humanitarian Crises: A Systematic Review of Published Surgical Caseload Data from Foreign Medical Teams. Prehospital and disaster medicine, 1-6. PMID: 22591739
Knowlton LM, Gosney JE, Chackungal S, Altschuler E, Black L, Burkle FM, Casey K, Crandell D, Demey D, Di Giacomo L.... (2011) Consensus statements regarding the multidisciplinary care of limb amputation patients in disasters or humanitarian emergencies: report of the 2011 humanitarian action summit surgical working group on amputations following disasters or conflict. Prehospital and disaster medicine, 26(6), 438-48. PMID: 22559308
Chackungal S, Nickerson JW, Knowlton LM, Black L, Burkle FM, Casey K, Crandell D, Demey D, Di Giacomo L, Dohlman L.... (2011) Best Practice Guidelines on Surgical Response in Disasters and Humanitarian Emergencies: Report of the 2011 Humanitarian Action Summit Working Group on Surgical Issues within the Humanitarian Space. Prehospital and disaster medicine, 26(6), 429-37. PMID: 22475370
Redmond AD, Mardel S, Taithe B, Calvot T, Gosney J, Duttine A, & Girois S. (2011) A qualitative and quantitative study of the surgical and rehabilitation response to the earthquake in haiti, january 2010. Prehospital and disaster medicine, 26(6), 449-56. PMID: 22469020
In today’s tip I am linking to a YouTube video from NCBI that briefly explains the new Filters Sidebar feature that has been added to PubMed. We first saw a tweet that the change was coming back on May 2nd, just as I was completing a total update to our full PubMed tutorial*. I struggled with [...]... Read more »
Sayers E. W., Barrett T., Benson D. A., Bolton E., Bryant S. H., Canese K., Chetvernin V., Church D. M., DiCuccio M., & Federhen S. (2011) Database resources of the National Center for Biotechnology Information. Nucleic Acids Research, 40(D1). DOI: 10.1093/nar/gkr1184
One of the main goals of pre-participation screening (PPS) is to identify unknown cardiac alterations in asymptomatic athletes with the intent to prevent sudden death in athletes. In Italy, it is mandatory by law that all children entering competitive activity must receive screening that includes physical examination and electrocardiogram (ECG), which is usually first done between the ages of 8 to 12 years of age. This mandatory screening has been shown to be effective in preventing sudden car........ Read more »
Rizzo, M., Spataro, A., Cecchetelli, C., Quaranta, F., Livrieri, S., Sperandii, F., Cifra, B., Borrione, P., & Pigozzi, F. (2011) Structural cardiac disease diagnosed by echocardiography in asymptomatic young male soccer players: implications for pre-participation screening. British Journal of Sports Medicine, 46(5), 371-373. DOI: 10.1136/bjsm.2011.085696
At Resus.ME, Dr. Reid suggests that one benefit of nebulized naloxone is its diagnostic value. He asks –
"Do you ever use naloxone diagnostically, and if so, do you think it’s worth knowing that the nebulised route is an option?"
This has been studied.... Read more »
Hoffman JR, Schriger DL, & Luo JS. (1991) The empiric use of naloxone in patients with altered mental status: a reappraisal. Annals of emergency medicine, 20(3), 246-52. PMID: 1996818
Regular exercise appears to moderate the severity of anxiety and depression symptoms. However there are few studies that examine the effectiveness of community-based exercise intervention programs for anxiety and depression.One of the largest research studies of this type was recently published in the Journal of Epidemiology and Community Health. This study from Wales examined the effect of an exercise program intervention in a group of inactive community subjects with coronary heart........ Read more »
Murphy, S., Edwards, R., Williams, N., Raisanen, L., Moore, G., Linck, P., Hounsome, N., Din, N., & Moore, L. (2012) An evaluation of the effectiveness and cost effectiveness of the National Exercise Referral Scheme in Wales, UK: a randomised controlled trial of a public health policy initiative. Journal of Epidemiology . DOI: 10.1136/jech-2011-200689
The Simple Idea That Is Transforming Health Care... Read more »
Kim Kristiansen, M.D. (2012) Could This Improve Health Care?. Picture of Pain Blog. info:/
Well, ok, not quite yet. But he thinks it’s coming. Have a look (and hang on to the end for you on a chip): [YouTube TEDMED talk here].
At a recent TEDMED session, Francis Collins gave a short talk about some ways forward in drug development. It’s just taking too long, and there are many hazards that affect the process today. He had a nice illustration of the pipeline that takes us from a bucketload of promising compounds –pre-clinical testing – clinical trials &ndash........ Read more »
Collins, F. (2011) Reengineering Translational Science: The Time Is Right. Science Translational Medicine, 3(90), 90-90. DOI: 10.1126/scitranslmed.3002747
by Stephen Yang in ExerGame Lab
I just came across SciVee and thought it is a great way to make science and research understandable for the masses. Although the quality of the videos can really vary, it has great potential to...
[[ This is a content summary only. Visit my website for full links, other content, and more! ]]
... Read more »
Maddison, R., Foley, L., Ni Mhurchu, C., Jiang, Y., Jull, A., Prapavessis, H., Hohepa, M., & Rodgers, A. (2011) Effects of active video games on body composition: a randomized controlled trial. American Journal of Clinical Nutrition, 94(1), 156-163. DOI: 10.3945/ajcn.110.009142
Primack, B., Carroll, M., McNamara, M., Klem, M., King, B., Rich, M., Chan, C., & Nayak, S. (2012) Role of Video Games in Improving Health-Related Outcomes : A Systematic Review. American Journal of Preventive Medicine , 42(6), 630-638. info:/10.1016/j.amepre.2012.02.023
by Stephen Yang in ExerGame Lab
#Exergaming can one way to incorporate more physical activity into the day and hopefully reduce the amount of sedentary time (The irony is not lost as I'm sitting down to write this). Seventeen...
[[ This is a content summary only. Visit my website for full links, other content, and more! ]]
... Read more »
Howcroft J, Klejman S, Fehlings D, Wright V, Zabjek K, Andrysek J, & Biddiss E. (2012) Active Video Game Play in Children With Cerebral Palsy: Potential for Physical Activity Promotion and Rehabilitation Therapies. Archives of Physical Medicine and Rehabilitation. PMID: 22571917
Panic disorder commonly presents acutely with a first severe panic attack. Many patients can distinctly remember their first attack even years after the onset of the disorder.Agoraphobia may complicate panic disorder. The word agoraphobia stems from the Greek word "agora" meaning gathering place. The Greek agora was the common area for public assembly. People with agoraphobia commonly fear situations where they may be in a crowd of people. They often fear that in such sit........ Read more »
Hara N, Nishimura Y, Yokoyama C, Inoue K, Nishida A, Tanii H, Okada M, Kaiya H, & Okazaki Y. (2012) The development of agoraphobia is associated with the symptoms and location of a patient's first panic attack. BioPsychoSocial medicine, 6(1), 12. PMID: 22494552
Several retired American Football stars have ended up with chronic traumatic encephalophy (CTE), previously known as dementia pugilistica. It’s similar to Alzheimer’s disease in that the brain ends up with neurofibrillary tangles. CTE has also been seen in soldiers who … Continue reading →
... Read more »
Goldstein, L., Fisher, A., Tagge, C., Zhang, X., Velisek, L., Sullivan, J., Upreti, C., Kracht, J., Ericsson, M., Wojnarowicz, M.... (2012) Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model. Science Translational Medicine, 4(134), 134-134. DOI: 10.1126/scitranslmed.3003716
Why individualized medicine will not be a reality anytime soon, how physicians often misinterpret published studies, and how individualized prevention is a clear and present benefit.
In my previous post I promised to talk about your
individualized way to achieving optimal health. If that made you think
about personalized medicine, you were right. Almost. Because personalized
medicine is still light-years away from us. That's the bad news. The good news,
personalized prev........ Read more »
Nicholson, J. (2006) Global systems biology, personalized medicine and molecular epidemiology. Molecular Systems Biology. DOI: 10.1038/msb4100095
Wegwarth O, Schwartz LM, Woloshin S, Gaissmaier W, & Gigerenzer G. (2012) Do physicians understand cancer screening statistics? A national survey of primary care physicians in the United States. Annals of internal medicine, 156(5), 340-9. PMID: 22393129
Loscalzo, J. (2012) Personalized Cardiovascular Medicine and Drug Development: Time for a New Paradigm. Circulation, 125(4), 638-645. DOI: 10.1161/CIRCULATIONAHA.111.089243
Yang, Q. (2012) Trends in Cardiovascular Health Metrics and Associations With All-Cause and CVD Mortality Among US Adults. JAMA: The Journal of the American Medical Association, 307(12), 1273. DOI: 10.1001/jama.2012.339
Yang Q, Cogswell ME, Flanders WD, Hong Y, Zhang Z, Loustalot F, Gillespie C, Merritt R, & Hu FB. (2012) Trends in cardiovascular health metrics and associations with all-cause and CVD mortality among US adults. JAMA : the journal of the American Medical Association, 307(12), 1273-83. PMID: 22427615
Re-injury rates after ACL reconstruction (ACLR) are shockingly high, with up to 25% of patients suffering a re-injury. Surgical advancements abound in attempting to decrease re-injury rates and the development of osteoarthritis after ACL injury, but highly structured prospective analysis of re-injury rates for each type of ACLR are not currently available. Therefore, the purpose of this investigation was to systematically analyze the re-injury rate of patients undergoing an anatomic ACLR with ........ Read more »
van Eck CF, Schkrohowsky JG, Working ZM, Irrgang JJ, & Fu FH. (2012) Prospective analysis of failure rate and predictors of failure after anatomic anterior cruciate ligament reconstruction with allograft. The American Journal of Sports Medicine, 40(4), 800-7. PMID: 22238055
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.