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  • May 25, 2012
  • 12:07 AM

Delayed ACL Reconstructions may be Associated with More Severe Meniscal and Chondral Lesions

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Anterior cruciate ligament (ACL) ruptures often coincide with meniscal and cartilaginous injuries. These ruptures are generally treated with surgical reconstruction or non-surgical treatment. Patients who chose to delay surgical treatment may be at greater risk for increasing the severity of the associated injuries; however, this has not been demonstrated in the literature. Therefore, Fok and Yau completed a retrospective, comparative study investigating (1) if delaying ACL reconstruction is ass........ Read more »

  • May 24, 2012
  • 11:50 PM

UK vs. US in Media Reporting on Eating Disorders: Who Does it Better?

by Tetyana in Science of Eating Disorders

Given the popularity of my post on how the media portrays eating disorders, I thought I’d do a follow-up post about a more recent and comprehensive study on media reporting of eating disorders. Shepherd & Seale (2010) wanted to build up on the findings of O’Hara & Clegg-Smith, but focusing on UK newspapers.... Read more »

  • May 24, 2012
  • 02:35 PM

Validation of the Dime

by Rogue Medic in Rogue Medic

The current Annals of Emergency Medicine has a pair of editorials on the article I wrote about[1] in This is the Way to Bad Medicine back in January. Dr. Radecki also was critical of this paper.[2] There is another study that refers to the same question published in this issue, but I will write about that paper later.

"These data raise the real question, Do such findings matter? By admitting more patients and ordering more CTs, do we improve outcomes? Or do we simply find more things tha........ Read more »

  • May 24, 2012
  • 11:15 AM

Clockworks: The Story of Drugs — Part 1

by xylph in xylem || phloem

In this installment, I will discuss why it is difficult to discover, design and develop a drug, in view of our current knowledge of physiology.With numerous, intertwined reactions happening, our body is a complex clockwork of biomachinery gears. What do you do, then, if some gears fail—that is, if you got sick? On one hand, it is a consolation that many gears are what biologists call 'redundant', which means that it's alright that a certain gear fails, because there are other gears that can ta........ Read more »

Welsch, M., Snyder, S., & Stockwell, B. (2010) Privileged scaffolds for library design and drug discovery. Current Opinion in Chemical Biology, 14(3), 347-361. DOI: 10.1016/j.cbpa.2010.02.018  

Marusyk A, Almendro V, & Polyak K. (2012) Intra-tumour heterogeneity: a looking glass for cancer?. Nature reviews. Cancer, 12(5), 323-34. PMID: 22513401  

  • May 24, 2012
  • 04:34 AM

Getting to the root of Type II diabetes... with liquorice?

by John Ankers in Too Many Live Wires

The liquorice root is full of surprises. Chewed as a breath freshener in Italy and a sweet in Sweden (and the north of England), this little brown stick has also been used as a remedy for mouth ulcers for thousands of years.

New research has identified a natural chemical extracted from the liquorice root that could be used to treat Type II diabetes.... Read more »

Weidner, C., de Groot, J., Prasad, A., Freiwald, A., Quedenau, C., Kliem, M., Witzke, A., Kodelja, V., Han, C., Giegold, S.... (2012) From the Cover: Amorfrutins are potent antidiabetic dietary natural products. Proceedings of the National Academy of Sciences, 109(19), 7257-7262. DOI: 10.1073/pnas.1116971109  

  • May 24, 2012
  • 01:58 AM

The Death Of Good Cholesterol

by Lutz Kraushaar in Chronic Health


There were always two types of cholesterol, the good and the
bad. Until now. A large new study tells us that good cholesterol might have
been an impostor. That's food for the media types. For those who think before
they type, the real news is that we are finally getting closer to uncovering
the impostors. Thanks to the genetics revolution which seems to be paying off
in an unexpected area.  



HDL - The Knight in Shining Armor

In the cholesterol u........ Read more »

Voight, B., Peloso, G., Orho-Melander, M., Frikke-Schmidt, R., Barbalic, M., Jensen, M., Hindy, G., Hólm, H., Ding, E., Johnson, T.... (2012) Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. The Lancet. DOI: 10.1016/S0140-6736(12)60312-2  

  • May 23, 2012
  • 08:16 PM

The Anorexic Brain: A Summary of Neuroimaging Studies - Part 1

by Tetyana in Science of Eating Disorders

Journalists like to report on novel and exciting findings regardless of how likely they are to be replicated or how well they fit in with everything else we know about that topic. It is an all too common occurrence that a small pilot study which has favourable results, creates a buzz in and gets into our heads, only to produce negative or unfavourable results once the sample size is increased. But the latter, negative finding, rarely makes it to the printing press. So we are left thinking the re........ Read more »

Pietrini, F., Castellini, G., Ricca, V., Polito, C., Pupi, A., & Faravelli, C. (2011) Functional neuroimaging in anorexia nervosa: A clinical approach. European Psychiatry, 26(3), 176-182. DOI: 10.1016/j.eurpsy.2010.07.011  

  • May 23, 2012
  • 02:27 PM

Surgery in Humanitarian Emergencies: Lessons Learned from Recent Disasters

by Jason in Views From Beyond the OR

TweetIn the days and weeks following the January 2010 earthquake in Haiti, thousands of surgical procedures were performed to alleviate suffering, save lives, and hopefully allow patients to obtain rehabilitation and support in order to return to their lives. Surgery … Continue reading →... Read more »

  • May 23, 2012
  • 08:49 AM

Video Tip of the Week: the New PubMed Filters Sidebar

by Jennifer in OpenHelix

In today’s tip I am linking to a YouTube video from NCBI that briefly explains the new Filters Sidebar feature that has been added to PubMed. We first saw a tweet that the change was coming back on May 2nd, just as I was completing a total update to our full PubMed tutorial*. I struggled with [...]... Read more »

Sayers E. W., Barrett T., Benson D. A., Bolton E., Bryant S. H., Canese K., Chetvernin V., Church D. M., DiCuccio M., & Federhen S. (2011) Database resources of the National Center for Biotechnology Information. Nucleic Acids Research, 40(D1). DOI: 10.1093/nar/gkr1184  

  • May 23, 2012
  • 12:06 AM

Adding Echocardiography to Pre-participation Screening

by Kris Fayock, MD and Marc Harwood, MD in Sports Medicine Research (SMR): In the Lab & In the Field

One of the main goals of pre-participation screening (PPS) is to identify unknown cardiac alterations in asymptomatic athletes with the intent to prevent sudden death in athletes. In Italy, it is mandatory by law that all children entering competitive activity must receive screening that includes physical examination and electrocardiogram (ECG), which is usually first done between the ages of 8 to 12 years of age. This mandatory screening has been shown to be effective in preventing sudden car........ Read more »

  • May 22, 2012
  • 01:00 PM

How Diagnostic is Narcan?

by Rogue Medic in Rogue Medic

At Resus.ME,[1] Dr. Reid suggests that one benefit of nebulized naloxone[2] is its diagnostic value. He asks –

"Do you ever use naloxone diagnostically, and if so, do you think it’s worth knowing that the nebulised route is an option?"

This has been studied.... Read more »

  • May 22, 2012
  • 12:27 PM

Exercise in the Treatment of Anxiety and Depression

by William Yates, M.D. in Brain Posts

Regular exercise appears to moderate the severity of anxiety and depression symptoms.  However there are few studies that examine the effectiveness of community-based exercise intervention programs for anxiety and depression.One of the largest research studies of this type was recently published in the Journal of Epidemiology and Community Health.  This study from Wales examined the effect of an exercise program intervention in a group of inactive community subjects with coronary heart........ Read more »

  • May 22, 2012
  • 09:14 AM

Could This Improve Health Care?

by Kim Kristiansen in Picture of Pain

The Simple Idea That Is Transforming Health Care... Read more »

Kim Kristiansen, M.D. (2012) Could This Improve Health Care?. Picture of Pain Blog. info:/

  • May 21, 2012
  • 04:50 PM

Francis Collins wants to put you on a chip.

by Mary in OpenHelix

Well, ok, not quite yet. But he thinks it’s coming. Have a look (and hang on to the end for you on a chip): [YouTube TEDMED talk here].

At a recent TEDMED session, Francis Collins gave a short talk about some ways forward in drug development. It’s just taking too long, and there are many hazards that affect the process today. He had a nice illustration of the pipeline that takes us from a bucketload of promising compounds –pre-clinical testing – clinical trials &ndash........ Read more »

  • May 21, 2012
  • 03:36 PM

#Exergame Benefits Review & Improved Body Comp Studies (SciVee)

by Stephen Yang in ExerGame Lab

I just came across SciVee and thought it is a great way to make science and research understandable for the masses. Although the quality of the videos can really vary, it has great potential to...

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Maddison, R., Foley, L., Ni Mhurchu, C., Jiang, Y., Jull, A., Prapavessis, H., Hohepa, M., & Rodgers, A. (2011) Effects of active video games on body composition: a randomized controlled trial. American Journal of Clinical Nutrition, 94(1), 156-163. DOI: 10.3945/ajcn.110.009142  

Primack, B., Carroll, M., McNamara, M., Klem, M., King, B., Rich, M., Chan, C., & Nayak, S. (2012) Role of Video Games in Improving Health-Related Outcomes : A Systematic Review. American Journal of Preventive Medicine , 42(6), 630-638. info:/10.1016/j.amepre.2012.02.023

  • May 21, 2012
  • 01:47 PM

Children with CP Benefit from #exergames

by Stephen Yang in ExerGame Lab

#Exergaming can one way to incorporate more physical activity into the day and hopefully reduce the amount of sedentary time (The irony is not lost as I'm sitting down to write this). Seventeen...

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  • May 21, 2012
  • 11:52 AM

First Panic Attack and Agoraphobia

by William Yates, M.D. in Brain Posts

Panic disorder commonly presents acutely with a first severe panic attack.  Many patients can distinctly remember their first attack even years after the onset of the disorder.Agoraphobia may complicate panic disorder.  The word agoraphobia stems from the Greek word "agora" meaning gathering place.  The Greek agora was the common area for public assembly. People with agoraphobia commonly fear situations where they may be in a crowd of people.  They often fear that in such sit........ Read more »

  • May 21, 2012
  • 08:08 AM

Repetitive brain injury from high impact sports generates similar pathophysiology to traumatic brain injury in soldiers blown up by IEDs

by Pieter Droppert in Biotech Strategy Blog

Several retired American Football stars have ended up with chronic traumatic encephalophy (CTE), previously known as dementia pugilistica. It’s similar to Alzheimer’s disease in that the brain ends up with neurofibrillary tangles. CTE has also been seen in soldiers who … Continue reading →

... Read more »

Goldstein, L., Fisher, A., Tagge, C., Zhang, X., Velisek, L., Sullivan, J., Upreti, C., Kracht, J., Ericsson, M., Wojnarowicz, M.... (2012) Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model. Science Translational Medicine, 4(134), 134-134. DOI: 10.1126/scitranslmed.3003716  

  • May 21, 2012
  • 04:12 AM

Individualized medicine, ignorant medics and an invitation to lose weight.

by Lutz Kraushaar in Chronic Health

Why individualized medicine will not be a reality anytime soon, how physicians often misinterpret published studies, and how individualized prevention is a clear and present benefit.

In my previous post I promised to talk about your
individualized way to achieving optimal health. If that made you think
about personalized medicine, you were right. Almost. Because personalized
medicine is still light-years away from us. That's the bad news. The good news,
personalized prev........ Read more »

Pammolli, F., Magazzini, L., & Riccaboni, M. (2011) The productivity crisis in pharmaceutical R. Nature Reviews Drug Discovery, 10(6), 428-438. DOI: 10.1038/nrd3405  

Yang Q, Cogswell ME, Flanders WD, Hong Y, Zhang Z, Loustalot F, Gillespie C, Merritt R, & Hu FB. (2012) Trends in cardiovascular health metrics and associations with all-cause and CVD mortality among US adults. JAMA : the journal of the American Medical Association, 307(12), 1273-83. PMID: 22427615  

  • May 21, 2012
  • 12:06 AM

Predictors of Failure After ACL Reconstructions

by Andrew Lynch in Sports Medicine Research (SMR): In the Lab & In the Field

Re-injury rates after ACL reconstruction (ACLR) are shockingly high, with up to 25% of patients suffering a re-injury. Surgical advancements abound in attempting to decrease re-injury rates and the development of osteoarthritis after ACL injury, but highly structured prospective analysis of re-injury rates for each type of ACLR are not currently available. Therefore, the purpose of this investigation was to systematically analyze the re-injury rate of patients undergoing an anatomic ACLR with ........ Read more »

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