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  • May 3, 2013
  • 05:23 AM

New Insight into Meat vs Fish Debate

by Mark Fonseca Rendeiro in United Academics

The benefits of taking fish oil and the harm caused by eating red meat, these two nutritional nuggets of wisdom have been passed around so much over the past few decades, we rarely stop to ask if they really do what people claim they do.

This month, two new papers on the subject of fish and meat have come forward from the University of Western Australia. The first examines the real impact of taking fish oil supplements on the diets of obese people.... Read more »

  • May 3, 2013
  • 02:19 AM

The Specter of Rising Cancer Deaths in Latin America and Caribbean

by Ajay Malik in Mission Tumor

Latin America and the Caribbean are the next hotspots of cancer-related deaths in the world and countries in this region are woefully ill-prepared to face this growing epidemic. A report by Latin American Cooperative Oncology Group (LACOG) presented at the LACOG Conference 2013 on April 26-27, 2013, at Sao Paulo, Brazil, put these facts in depressing hard numbers: currently 13 people of 22 diagnosed with cancer die in Latin America and the Caribbean in contrast to 13 of 37 in US or 13 of 30 i........ Read more »

Goss, P., Lee, B., Badovinac-Crnjevic, T., Strasser-Weippl, K., Chavarri-Guerra, Y., Louis, J., Villarreal-Garza, C., Unger-Saldaña, K., Ferreyra, M., Debiasi, M.... (2013) Planning cancer control in Latin America and the Caribbean. The Lancet Oncology, 14(5), 391-436. DOI: 10.1016/S1470-2045(13)70048-2  

  • May 2, 2013
  • 11:35 PM

Red meat, cardiovascular risk and gut bacteria

by Aurelie in Coffee break Science

In a study published in April in Nature Medicine, US researchers show that the intestinal microflora can process L-carnitine, a nutrient abundant in red meat, to produce a compound linked to the risk of developing cardiovascular disease. Nowadays, many people … Continue reading →... Read more »

  • May 2, 2013
  • 04:30 PM

Will IV Oxygen Save Lives?

by Rogue Medic in Rogue Medic

Intravenous oxygen delivery that works?

Maybe temporary oxygenation, but not yet.

Will this change the approach to CICV (Can’t Intubate, Can’t Ventilate) patients?

No, but it may change the approach to CICO (Can’t Intubate, Can’t Oxygenate) patients.

The distinction is important. ... Read more »

Kheir, J., Scharp, L., Borden, M., Swanson, E., Loxley, A., Reese, J., Black, K., Velazquez, L., Thomson, L., Walsh, B.... (2012) Oxygen Gas-Filled Microparticles Provide Intravenous Oxygen Delivery. Science Translational Medicine, 4(140), 140-140. DOI: 10.1126/scitranslmed.3003679  

  • May 2, 2013
  • 03:24 PM

The woman who couldn't find her way

by zstansfi in Neuroautomaton

In 2009, researchers from the University of British Columbia reported on a case of developmental topographical disorientation. The woman, referred to only as patient 1 (Pt1), is the first reported individual to demonstrate this profound and lifelong impairment in navigation. Throughout her school years, Pt1 was forced to follow her sisters or parents to school and friends to extracurricular activities. As an adult, she relies upon specific, stereotyped instructions to travel from work to home, u........ Read more »

Iaria G, Bogod N, Fox CJ, & Barton JJ. (2009) Developmental topographical disorientation: case one. Neuropsychologia, 47(1), 30-40. PMID: 18793658  

  • May 2, 2013
  • 02:48 PM

Sex, hormones, and the microbiome

by sedeer in Inspiring Science

The microbiome — the kilogram of microbes that each of us carries around — has been shown to be involved …Continue reading »... Read more »

Markle JG, Frank DN, Mortin-Toth S, Robertson CE, Feazel LM, Rolle-Kampczyk U, von Bergen M, McCoy KD, Macpherson AJ, & Danska JS. (2013) Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science (New York, N.Y.), 339(6123), 1084-8. PMID: 23328391  

  • May 2, 2013
  • 10:53 AM

UF researchers develop ‘nanotrain’ for targeted cancer drug transport

by Perikis Livas in Chilon

University of Florida researchers have developed a “DNA nanotrain” that fast-tracks its payload of cancer-fighting drugs and bioimaging agents to tumor cells deep within the body. The nanotrain’s ability to cost-effectively deliver high doses of drugs to precisely targeted cancers and other medical maladies without leaving behind toxic nano-clutter has been the elusive Holy Grail for scientists studying the teeny-tiny world of DNA nanotechnology.... Read more »

Lindy McCollum-Brounley. (2013) UF researchers develop ‘nanotrain’ for targeted cancer drug transport. University of Florida News. info:/

  • May 2, 2013
  • 10:38 AM

Redefining Mental Disorders as Brain Disorders: TED Talk of Thomas Insel

by William Yates, M.D. in Brain Posts

Components of Brain Limbic SystemAdvances in the diagnosis and treatment of brain disorders like bipolar disorder, schizophrenia and autism are a public health priority.Dr. Thomas Insel, director at NIMH recently presented a TED talk that emphasized the need to rethink how we conceptualize and study these types of disorders.  He argues for a need to redefine mental disorders as brain disorders.  Advances in brain research tools are likely to provide improvements in early diagnosis and ........ Read more »

  • May 2, 2013
  • 08:27 AM

Bodyweight loss – a new industry benchmark to improve animal welfare in preclinical safety assessment

by Dr Fiona Sewell in NC3Rs Blog

Evidence from a multinational pharmaceutical industry collaboration shows this week that upper limits of bodyweight loss of 10 per cent in rats and dogs are sufficient for setting the maximum-tolerated dose in short-term toxicity studies. Where there has been no previously accepted evidence-based assessment criteria before now, Dr Fiona Sewell, NC3Rs, describes how the new recommendations were developed to improve the welfare of thousands of animals used in regulatory studies each year.... Read more »

  • May 2, 2013
  • 03:53 AM

Treatments Still Aren’t the Right Dose for Kids

by Andrew Porterfield in United Academics

It was an unprecedented move: U.S. Health and Human Services Secretary Kathleen Sibelius overruled the FDA when she announced that Teva Pharmaceutical’s Plan B One Step contraceptive pill would not be available to women under 17 years of age. ... Read more »

Funk RS, Brown JT, & Abdel-Rahman SM. (2012) Pediatric pharmacokinetics: human development and drug disposition. Pediatric clinics of North America, 59(5), 1001-16. PMID: 23036241  

  • May 1, 2013
  • 03:38 PM

Growing new arteries, bypassing blocked ones

by Perikis Livas in Chilon

Scientific collaborators from Yale School of Medicine and University College London (UCL) have uncovered the molecular pathway by which new arteries may form after heart attacks, strokes and other acute illnesses — bypassing arteries that are blocked.... Read more »

Helen Dodson. (2013) Growing new arteries, bypassing blocked ones. Yale News. info:/

  • May 1, 2013
  • 03:03 PM

Researchers decode the molecular signals used by tumours to recruit mesenchymal stem cells

by beredim in Stem Cells Freak

Its been known for years that tumours have the ability to recruit mesenchymal stem cells (MSCs), which is why they are sometimes so persistent and difficult to deal with. Unfortunately, this process is poorly understood on the molecular level. Today, a research team from the University of Michigan, led by Professor Russell Taichman, announced that it has successfully decoded "the molecular chatter" between cancer cells and MSCs.Read More... Read more »

Jung, Y., Kim, J., Shiozawa, Y., Wang, J., Mishra, A., Joseph, J., Berry, J., McGee, S., Lee, E., Sun, H.... (2013) Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nature Communications, 1795. DOI: 10.1038/ncomms2766  

  • May 1, 2013
  • 12:29 PM

Pericytes can be used for muscle regeneration

by beredim in Stem Cells Freak

Researchers from the Wake Forest Baptist Medical Center (WFBMC) announced today that they may have unveiled some of the mechanisms involved in obesity, diabetes mellitus type 2, muscular dystrophy and other diseases associated with fat replacing muscle tissue, causing it to weaken and degenerate. Their findings have the potential to lead to new therapies for the aforementioned diseases, say the researchers.Read More... Read more »

Birbrair, A., Zhang, T., Wang, Z., Messi, M., Enikolopov, G., Mintz, A., & Delbono, O. (2013) Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation. Stem Cells and Development, 2147483647. DOI: 10.1089/scd.2012.0647  

  • May 1, 2013
  • 12:17 PM

Patterned Hearts

by Perikis Livas in Chilon

A team of bioengineers at Brigham and Women’s Hospital (BWH) is the first to report creating artificial heart tissue that closely mimics the functions of natural heart tissue through the use of human-based materials. Their work will advance how clinicians treat the damaging effects caused by heart disease, the leading cause of death in the United States.... Read more »

BWH Media Relations. (2013) Patterned Hearts . Brigham and Women's Hospital. info:/

  • May 1, 2013
  • 11:54 AM

Advances In Parkinson's Disease Treatment: Part II

by William Yates, M.D. in Brain Posts

Globus Pallidus Region of Brain Targeted in DBS in YellowIn a previous post, I summarized some of the highlights of a recent review of Parkinson's disease management by the German neurologists Pedrosa and Timmerman.The first post can be located here and was limited to the drug treatment of the motor symptoms of Parkinson's disease.In part II, I want to focus on deep brain stimulation and the treatment of non-motor symptoms.The authors of the review note the following key points regarding deep br........ Read more »

Pedrosa, D., & Timmermann, . (2013) Review: management of Parkinson's disease. Neuropsychiatric Disease and Treatment, 321. DOI: 10.2147/NDT.S32302  

  • May 1, 2013
  • 09:45 AM

Autism risk spotted at birth in abnormal placentas

by Perikis Livas in Chilon

Researchers at the Yale School of Medicine have figured out how to measure an infant’s risk of developing autism by looking for abnormalities in his/her placenta at birth, allowing for earlier diagnosis and treatment for the developmental disorder.... Read more »

Karen N. Peart. (2013) Autism risk spotted at birth in abnormal placentas. Yale News. info:/

  • May 1, 2013
  • 09:17 AM

Video Tip of the Week: My Cancer Genome

by Mary in OpenHelix

There are a lot of cancer database resources out there. Most of the ones we’ve focused on have been the data repository types. TCGA, ICGC, CaBIG, COSMIC, Cancer Genome Workbench, UCSC Cancer Genomic Browser, and of course big repositories like GEO. Researchers will need these sources of data to locate key alterations in cancer cells [...]... Read more »

  • May 1, 2013
  • 08:59 AM

New gene therapy could treat devastating heart failure

by Perikis Livas in Chilon

Heart failure, when the heart is unable to pump blood adequately, affects more than 750,000 people in the UK, causing breathlessness and hindering day-to-day activities.

The therapy is designed to increase the levels of SERCA2a protein in heart muscle cells by using a harmless virus to insert extra genes into the cells.... Read more »

Sam Wong. (2013) New gene therapy could treat devastating heart failure. London Imperial College of London. info:/

  • May 1, 2013
  • 08:54 AM

Four APS Fellows Elected to NAS

by ebender in Daily Observations

Five psychological scientists, including four APS Fellows, are among the 84 new members and 21 foreign associates elected to the National Academy of Sciences, in recognition of their contributions and The post Four APS Fellows Elected to NAS appeared first on Association for Psychological Science.... Read more »

  • May 1, 2013
  • 08:10 AM

Venomous Plants – A Hairy Situation

by Mark Lasbury in As Many Exceptions As Rules

There are many thousands of poison plants, but not too many are venomous. The nettles and the dendrocnidaes have hollow spines that deliver neurotoxins when they stab you. Recent research has shown that nettle toxin is beneficial in liver regeneration. It stimulates cell proliferation and reduces apoptosis. In an opposite effect, the dendrocnidae toxin called moroidin is a mitotic spindle inhibitor. It may prove useful as an anticancer drug.... Read more »

Hammond-Tooke, G., Taylor, P., Punchihewa, S., & Beasley, M. (2007) Urtica ferox neuropathy. Muscle , 35(6), 804-807. DOI: 10.1002/mus.20730  

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