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  • May 13, 2014
  • 03:59 PM
  • 1,005 views

Gabapentin abuse

by DJMac in Recovery Review

Gabapentin can be addictive. Search for gabapentin abuse or pregabalin abuse on Google Scholar and you’ll turn up 18,000 entries in less than a second. Pubmed is a little more specific finding 249 papers related to the subject. Vaults of Erowid has over 100 gabapentin and pregabalin ‘experiences’ detailed by users. I wrote a while back [...]
The post Gabapentin abuse appeared first on Recovery Review.
... Read more »

Smith, B., Higgins, C., Baldacchino, A., Kidd, B., & Bannister, J. (2012) Substance misuse of gabapentin. British Journal of General Practice, 62(601), 406-407. DOI: 10.3399/bjgp12X653516  

  • May 13, 2014
  • 11:05 AM
  • 527 views

Sleep Manipulation to Enhance Cognition

by William Yates, M.D. in Brain Posts

In the next series of posts, I will focus on research related to learning, learning disabilities and education.Sleep is known to play a key role in consolidation of memories and and learning.However, there has been relatively little discussion of how the effect of sleep on learning might be enhanced.Susanne Diekelmann reviewed this issue in a recent manuscript published in the journal Frontiers in Systems Neuroscience.In this review, two theories for sleep enhancement of memories are proposed:Ac........ Read more »

Diekelmann, S. (2014) Sleep for cognitive enhancement. Frontiers in Systems Neuroscience. DOI: 10.3389/fnsys.2014.00046  

  • May 13, 2014
  • 10:06 AM
  • 537 views

Our Frenemy, Schistosoma haematobium

by Michael Hsieh in Hsieh Lab Blog

Helminths, parasitic worms, have co-evolved with us for millennia, and, given their ability to often live in relative equilibrium with their hosts, have even been called "old friends". ... Read more »

  • May 13, 2014
  • 08:14 AM
  • 396 views

New study on iPSCs points to early indicators of schizophrenia

by beredim in Stem Cells Freak

These images show the movement of patient-derived neural progenitor cells from a sphere of neurons in a migration assay. How far and quickly the neurons move indicates whether they may behave atypically in the brainCredit:  Salk Institute for Biological StudiesUsing human induced pluripotent stem cells, researchers at the Salk Institute have shown that neurons generated from the skin cells of people with schizophrenia behave strangely in early developmental stages, providing a hint as to ways t........ Read more »

Brennand K, Savas JN, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont KG, Kim HJ, Topol A, Ladran I.... (2014) Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular psychiatry. PMID: 24686136  

  • May 13, 2014
  • 03:32 AM
  • 361 views

Gluten sensitivity and psychiatry reviewed

by Paul Whiteley in Questioning Answers

It's Coeliac Awareness Week here in the UK (see here) from 12-18 May 2014. With the rate of coeliac (celiac) disease going up according to the BBC website I thought it pertinent to talk today about something relevant to these issues.So...The review article by Genuis and Lobo [1] (open-access here) is the source material for today's short and quite descriptive post and their focus on how the protein gluten may be doing so much more than that currently recognised with the autoimmune condition........ Read more »

Genuis SJ, & Lobo RA. (2014) Gluten Sensitivity Presenting as a Neuropsychiatric Disorder. Gastroenterology research and practice, 293206. PMID: 24693281  

  • May 13, 2014
  • 01:00 AM
  • 97 views

Journal club summary on Changes in gene expression foreshadow diet-induced obesity in genetically identical mice.

by Bridges Lab in Bridges Lab Commentaries

We recently discussed the paper Changes in Gene Expression Foreshadow Diet-Induced Obesity in Genetically Identical Mice. We were interested in this paper because our lab is searching for new, effective ways to describe patients who are at-risk obesity. Koza et al. placed C57BL/6J mice on a 60% high fat diet and analyzed gene expression regarding adiposity in the top 10% of weight gainers and the bottom 10% of weight gainers. The group concluded that mice within the “high gainer” category we........ Read more »

Koza Robert A., Nikonova Larissa, Hogan Jessica, Rim Jong-Seop, Mendoza Tamra, Faulk Christopher, Skaf Jihad, & Kozak Leslie P. (2006) Changes in Gene Expression Foreshadow Diet-Induced Obesity in Genetically Identical Mice. PLoS Genetics, 2(5). DOI: 10.1371/journal.pgen.0020081.st001  

  • May 12, 2014
  • 03:30 PM
  • 945 views

Dientamoeba: To encyst or Not to Encyst?

by Christen Rune Stensvold in Christen Rune Stensvold

There is an interesting discussion going on at the moment on Dientamoeba fragilis transmission. There are bits of evidence that D. fragilis may be passed on to an individual by pinworm. But is it also possible that an unrecognised cyst stage may be a vehicle of transmission?... Read more »

Stark D, Garcia LS, Barratt JL, Phillips O, Roberts T, Marriott D, Harkness J, & Ellis JT. (2014) Description of Dientamoeba fragilis cyst and precystic forms from human samples. Journal of clinical microbiology. PMID: 24808242  

Clark CG, Röser D, & Stensvold CR. (2014) Transmission of Dientamoeba fragilis: pinworm or cysts?. Trends in parasitology, 30(3), 136-40. PMID: 24492020  

  • May 12, 2014
  • 01:14 PM
  • 480 views

Awake: The disturbed Brain

by Teodora Stoica in CuriousCortex

How did you feel when you woke up today? Did you get up slowly, felt refreshed and had enough time to eat breakfast and plan your day? Or did you throw your alarm against the wall, curse at everything in your path until you felt alive enough to make a cup of coffee? If you are like the 1 in 5 Americans that get less than 6 hours of sleep, you might have trouble remembering simple things, be ill-prepared to deal with everyday stressors and be on edge - leading to unnecessary arguments with friend........ Read more »

Deliens, G., Gilson, M., & Peigneux, P. (2014) Sleep and the processing of emotions. Experimental Brain Research, 232(5), 1403-1414. DOI: 10.1007/s00221-014-3832-1  

  • May 12, 2014
  • 12:47 PM
  • 649 views

Do AA & NA fit with methadone maintenance?

by DJMac in Recovery Review

  Given the dearth of research on NA populations this study from Bill White and colleagues is welcome. Knowing what we do already from the research on mutual aid groups, the researchers made the reasonable assumption that clients on ORT (opiate replacement therapy) attending 12-step mutual aid were likely to achieve to higher levels of abstinence (no [...]
The post Do AA & NA fit with methadone maintenance? appeared first on Recovery Review.
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  • May 12, 2014
  • 12:05 AM
  • 928 views

Don’t Be Quick to Use Simple Reaction Time Test on Concussed High School Athletes

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

The clinical reaction time test is a cost efficient, simple test to perform; however, further validation of this clinical measure is warranted before incorporation into the concussion protocol.
... Read more »

  • May 11, 2014
  • 09:11 AM
  • 550 views

Will the Worm Turn on Mother's Day?

by Michael Hsieh in Hsieh Lab Blog

The old English phrase "tread on a worm and it will turn" has been interpreted to mean that even the humblest worm (or person) will resent being badly treated and eventually revolt. What does this have to do with Mother's Day? A literal worm, Schistosoma haematobium, can be argued to ruin the lives of many mothers and potential mothers throughout large swaths of sub-Saharan Africa. ... Read more »

Richardson, M., Fu, C., Pennington, L., Honeycutt, J., Odegaard, J., Hsieh, Y., Hammam, O., Conti, S., & Hsieh, M. (2014) A New Mouse Model for Female Genital Schistosomiasis. PLoS Neglected Tropical Diseases, 8(5). DOI: 10.1371/journal.pntd.0002825  

  • May 11, 2014
  • 03:59 AM
  • 425 views

Neonatal jaundice and risk of autism?

by Paul Whiteley in Questioning Answers

The research of Mu-Hong Chen and colleagues from Taiwan appears on this blog quite a bit. Regular readers may already have read about the work of this group looking at various aspects on and around autism including the association with allergic and autoimmune conditions (see here) and the possibility of a link between asthma and ADHD (see here). Much of the strength of the data and results produced by this group lies in their examination of the National Health Insurance Research Database&nb........ Read more »

  • May 10, 2014
  • 07:40 PM
  • 541 views

Folate, Anti-Oxidants and the Physical Stress of Depression

by AB Kirk in Stiff Competition

Depression is a brain disorder that interferes with many aspects of function.  The evidence for genetic susceptibility to depression is strong, although it may take a traumatic event, or even a series of traumatic events, to trigger it. The brains of people with depression differ from those of people who are not depressed.  Brain imagery studies […]
The post Folate, Anti-Oxidants and the Physical Stress of Depression appeared first on WODMasters.
... Read more »

  • May 10, 2014
  • 07:40 PM
  • 406 views

Depression Brain. Folate and Anti-Oxidants can help protect against damage

by AB Kirk in Stiff Competition

Depression brain.  Depression damages the brain and contributes to memory problems Depression is a brain disorder that interferes with many aspects of function.  The evidence for genetic susceptibility to depression is strong, although it may take a traumatic event, or even a series of traumatic events, to trigger it. The brains of people with depression differ […]
The post Depression Brain. Folate and Anti-Oxidants can help protect against damage appeared first on WODMasters: Stiff Com........ Read more »

  • May 10, 2014
  • 03:00 PM
  • 519 views

Using Genes to Boost Brain Power: Live Longer, Think Better

by Dr. Jekyll in Lunatic Laboratories

Does your family have a history of living to a ripe old age? That may bode well for you! Not only does a gene linked to longevity seem to help […]... Read more »

Dubal Dena B., Yokoyama Jennifer S., Zhu Lei, Broestl Lauren, Worden Kurtresha, Wang Dan, Sturm Virginia E., Kim Daniel, Klein Eric, & Yu Gui-Qiu. (2014) Life Extension Factor Klotho Enhances Cognition. Cell Reports. DOI: 10.1016/j.celrep.2014.03.076  

  • May 10, 2014
  • 08:12 AM
  • 1,198 views

Parasite-Microbiota-Host Interactions

by Christen Rune Stensvold in Blastocystis Parasite Blog

In order to identify the role of Blastocystis in human health and disease, it's important to explore and recognise the potential spectrum of parasite-microbiota-host interactions.... Read more »

  • May 10, 2014
  • 04:50 AM
  • 415 views

Scientists decode epigenetic mechanisms distinguishing hematopoietic stem cell function and blood cancer

by beredim in Stem Cells Freak

Patricia ErnstResearchers at Dartmouth's Norris Cotton Cancer Center have published results from a study in Cell Reports that discovers a new mechanism that distinguishes regular hematopoietic stem cells (blood stem cells) from blood cancers."These findings constitute a significant advance toward the goal of killing leukemia cells without harming the body's normal blood stem cells which are often damaged by chemotherapy." said Patricia Ernst, PhD, co-director of the Cancer Mec........ Read more »

  • May 10, 2014
  • 02:36 AM
  • 526 views

What are the Main Risk Factors for Running-Related Injuries?

by Craig Payne in Running Research Junkie

What are the Main Risk Factors for Running-Related Injuries?... Read more »

Saragiotto BT, Yamato TP, Hespanhol Junior LC, Rainbow MJ, Davis IS, & Lopes AD. (2014) What are the Main Risk Factors for Running-Related Injuries?. Sports medicine (Auckland, N.Z.). PMID: 24809248  

  • May 9, 2014
  • 02:00 PM
  • 440 views

New Study Explains why MS Affects more Women

by Dr. Jekyll in Lunatic Laboratories

MS affects women almost four times more often than it affects men.  The reasons are unclear, but a new study is the first to associate a sex difference in the brain with […]... Read more »

Cruz-Orengo Lillian, Daniels Brian P., Dorsey Denise, Basak Sarah Alison, Grajales-Reyes José G., McCandless Erin E., Piccio Laura, Schmidt Robert E., Cross Anne H., & Crosby Seth D. (2014) Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility. Journal of Clinical Investigation. DOI: 10.1172/JCI73408DS1  

  • May 9, 2014
  • 08:36 AM
  • 1,092 views

THE GAY GENE AND THE ETHICS OF GENETIC TESTING

by Robb Hollis in Antisense Science

Over 20 years ago, Dean Hamer – an American geneticist – and his colleagues published an investigation into the possible genetic basis of sexual orientation. The paper, which analysed genetic data from 114 families containing homosexual men, reported an association between genetic markers on the q arm of the X chromosome (chromosomal region Xq28) and male homosexuality: and so the ‘gay gene’ was born.... Read more »

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