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  • June 21, 2011
  • 06:43 AM

Autism diagnosis and hyper-systemizing parents: Nottingham vs. Eindhoven

by Dorothy Bishop in bishopblog

A recent paper found higher rates of autism diagnoses in Eindhoven compared to 2 other cities in the Netherlands, and suggested this related to hyper-systemizing in parents in the IT industry. Analogous data from the UK suggest that such diagnostic data may be too inconsistent to give meaningful prevalence comparisons.... Read more »

  • June 21, 2011
  • 03:00 AM

Guns in the home provide a greater risk than benefit

by SAGE Insight in SAGE Insight

Risks and benefits of a gun in the home From American Journal of Lifestyle Medicine  Despite the fact that nearly one-third of American households have a firearm, studies show that having a gun in the home poses a household a greater health risk than a potential benefit. This study examined scientific research on both sides [...]... Read more »

Hemenway, D. (2011) Risks and Benefits of a Gun in the Home. American Journal of Lifestyle Medicine. DOI: 10.1177/1559827610396294  

  • June 21, 2011
  • 02:58 AM

Animal research is helping us beat cancer

by Cancer Research UK in Cancer Research UK - Science Update

More people are surviving cancer than ever before. Thanks to decades of research, survival from cancer has doubled in the last 40 years, giving thousands of people more time with their loved ones. But this progress simply wouldn’t have been possible without animal research. At Cancer Research UK, research using animals is an unavoidable part [...]... Read more »

Chinwalla, A., Cook, L., Delehaunty, K., Fewell, G., Fulton, L., Fulton, R., Graves, T., Hillier, L., Mardis, E., McPherson, J.... (2002) Initial sequencing and comparative analysis of the mouse genome. Nature, 420(6915), 520-562. DOI: 10.1038/nature01262  

Gambacorti-Passerini C, Antolini L, Mahon FX, Guilhot F, Deininger M, Fava C, Nagler A, Della Casa CM, Morra E, Abruzzese E.... (2011) Multicenter independent assessment of outcomes in chronic myeloid leukemia patients treated with imatinib. Journal of the National Cancer Institute, 103(7), 553-61. PMID: 21422402  

Druker, B., Tamura, S., Buchdunger, E., Ohno, S., Segal, G., Fanning, S., Zimmermann, J., & Lydon, N. (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells. Nature Medicine, 2(5), 561-566. DOI: 10.1038/nm0596-561  

  • June 20, 2011
  • 09:00 AM

Why Diet and Exercise is Not a Treatment for Obesity

by Arya M. Sharma in Dr. Sharma's Obesity Notes

If going on a diet or starting an exercise program resulted in persistent weight loss,  we would not have an obesity epidemic.
Unfortunately, as anyone who has tried this knows, maintaining a significant degree of weight loss requires daily dedication, motivation and a limitless supply of will power - nothing short of developing a compulsive obsession.
As [...]... Read more »

Maclean PS, Bergouignan A, Cornier MA, & Jackman MR. (2011) Biology's Response to Dieting: the Impetus for Weight Regain. American journal of physiology. Regulatory, integrative and comparative physiology. PMID: 21677272  

  • June 20, 2011
  • 08:00 AM

Is Charity Bad For Your Health?

by Shaheen Lakhan in Brain Blogger

Since 2000, there has been a massive flow of funding from the West into health care in developing African countries. Some of this has come from governmental sources in response to G8 initiatives such as the 2000 Millenium Fund and a significant amount has come from charitable organizations. One of the largest of these, the Bill [...]... Read more »

  • June 20, 2011
  • 07:33 AM

Update on emerging therapies in ALK lung cancer

by Sally Church in Pharma Strategy Blog

Last week’s post on FGFR1 mutations in squamous cell lung cancer and the new EGFR/ALK combination agent, AP26113 (Ariad) drew a lot of attention from readers, with many writing in for more details or correctly suggesting an update in squamous … Continue reading →
... Read more »

Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, Ou SH, Dezube BJ, Jänne PA, Costa DB.... (2010) Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. The New England journal of medicine, 363(18), 1693-703. PMID: 20979469  

  • June 20, 2011
  • 05:30 AM

Obesity's contagious, or is it? A sober second look at obesity and social networks.

by Yoni Freedhoff in Weighty Matters

Right off the top let me say I'm not well versed enough in statistics to know who's right.On one side of the fence are the findings of Christakis and Fowler, famously published in the New England Journal of Medicine that posited obesity is socially contagious. Non-statistically, their paper didn't sit right with me, but as far as stats go, I'm no maven.On the other side of the fence is a new paper published by Russel Lyons who posits that Christakis' and Fowler's work is a great example of stat........ Read more »

  • June 20, 2011
  • 03:13 AM

The Discovery of HIV

by Jennifer Ring in Antiviral Immunity

Summarizes the discovery of HIV as described by Francoise Barre-Sinnousi (1) as part of the CDC's HIV/AIDS 30 year anniversary lecture series and (2) in her initial HIV isolation publication in Science.... Read more »

  • June 19, 2011
  • 07:37 PM

HOT TOPIC: Does Soy Relieve Hot Flashes?

by Laika in Laika's Medliblog

The theme of the Upcoming Grand Rounds held at June 21th (1st day of the Summer) at Shrink Rap is “hot”. A bit far-fetched, but aah you know….shrinks“. Of course they hope  assume  that we will express Weiner-like exhibitionism at our blogs. Or go into spicy details of hot sexpectations or other Penis Friday NCBI-ROFL posts. But no, not me, [...]... Read more »

Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, & Brown J. (2007) Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database of Systematic Reviews. info:/10.1002/14651858.CD001395.pub3.

  • June 19, 2011
  • 07:32 AM

2 liter bolus of fat: no hemodynamic changes

by CxLxMx in cxlxmxrx

I bring to your attention a case report of a patient who received an accidental overdose of 2 liters intravenous lipid infusion and apparently suffered no ill cardiac effects. That is, the patient received fat directly into the blood stream in a quantity equal to a family-sized bottle of soda and didn't have a "heart attack."Just as certain medications bind to proteins, which binding in the blood stream changes their availability to other tissues, certain medications have an affinity for lipids........ Read more »

Dix, S., Rosner, G., Nayar, M., Harris, J., Guglin, M., Winterfield, J., Xiong, Z., & Mudge, G. (2011) Intractable cardiac arrest due to lidocaine toxicity successfully resuscitated with lipid emulsion*. Critical Care Medicine, 39(4), 872-874. DOI: 10.1097/CCM.0b013e318208eddf  

Smollin, C. (2010) Toxicology: Pearls and Pitfalls in the Use of Antidotes. Emergency Medicine Clinics of North America, 28(1), 149-161. DOI: 10.1016/j.emc.2009.09.009  

  • June 19, 2011
  • 01:42 AM

Imaging Sciences Pathway Retreat - A Conference Covered

by Paige Brown in From The Lab Bench

Coverage of a recent conference on Medical Imaging in St. Louis. Not only are we increasingly being able to image the intricate inner workings of the human body, but we are beginning also to use medical imaging as a tool to monitor disease treatment and even to design and implement new drugs in the treatment of diseases such as cancer. ... Read more »

Tsien RY. (2003) Imagining imaging's future. Nature reviews. Molecular cell biology. PMID: 14587522  

  • June 18, 2011
  • 03:26 PM

Invasive Harlequin parasites

by Africa Gomez in BugBlog

Every day on the way back from work I walk next to this wall. The other day there were plenty of cannibal Harlequin ladybird larvae eating prepupae. Today there were many more pupae and a few prepupae. I have no idea how I noticed this tiny fly on the head of a prepupa. The ladybird pupa shook its body back and forth to no avail. Later I identified the fly as a scuttle fly, genus Phalacrotophora. Some species of this genus are endoparasites of ladybird pupae. The fly mounts guard on a prepupa an........ Read more »

Durska, E., Ceryngier, P., & Disney, H.L. (2003) Phalacrotophora beuki (Diptera: Phoridae), a parasitoid of ladybird pupae (Coleooptera: Coccinellidae). European Journal of Entomology, 627-630. info:other/1210-5759

  • June 18, 2011
  • 12:00 AM

Anti-cancer Fungi

by James Byrne in Disease Prone

Mycology, the study of fungi, is an often-overlooked member of the microbiology family. Having said that there are plenty of dedicated mycologists out there doing all sorts of cool stuff and plenty more fungal species doing all sorts of weird and wonderful things.... Read more »

King-Fai Cheng, & Ping-Chung Leung. (2008) General review of polysaccharopeptides (PSP) from C. versicolor: Pharmacological and clinical studies. Cancer Therapy. info:/

  • June 17, 2011
  • 04:03 PM

Fast Calculation of van der Waals Volume as a Sum of Atomic and Bond Contributions

by egonw in Chem-bla-ics

I was recently asked about a volume descriptor in Bioclipse, which is not yet available. Jmol can calculate surfaces, so that was my first thought. However, I then ran into a paper from 2003 by Zhao, called Fast Calculation of van der Waals Volume as a Sum of Atomic and Bond Contributions and Its Application to Drug Compounds (doi:10.1021/jo034808o).

The paper presents a very simple mathematical model, which approximates the molecular volume by a sum of atomic contributions, and a three terms t........ Read more »

  • June 17, 2011
  • 11:55 AM

Smelly Hangups for Mosquitoes... and Bedbugs?

by Nature Education in Student Voices

It works against mosquitoes... can it work against bedbugs? A study in Nat...... Read more »

Turner SL, Li N, Guda T, Githure J, Cardé RT, & Ray A. (2011) Ultra-prolonged activation of CO2-sensing neurons disorients mosquitoes. Nature, 474(7349), 87-91. PMID: 21637258  

  • June 17, 2011
  • 10:57 AM

Smelly Hangups for Mosquitoes... and Bedbugs?

by Paige Brown in From The Lab Bench

A study in Nature this month reveals a promising new line of defense against disease-carrying, bloodthirsty critters, namely the mosquito. The new line of defense is based on smelly chemicals, or inhibitory odorants, that disrupt the mosquito's ability to detect and travel towards human breath. Mosquitoes, as well as other blood-feeding insects, are attracted towards the carbon dioxide that we exhale with every breathe cycle (oxygen in, carbon dioxide out).... Read more »

Turner SL, Li N, Guda T, Githure J, Cardé RT, & Ray A. (2011) Ultra-prolonged activation of CO2-sensing neurons disorients mosquitoes. Nature, 474(7349), 87-91. PMID: 21637258  

  • June 17, 2011
  • 10:53 AM

FGFR1 mutations in squamous cell lung cancer

by Sally Church in Pharma Strategy Blog

“Using SNP array analysis, we found that a region of chromosome segment 8p11-12 containing three genes–WHSC1L1, LETM2, and FGFR1–is amplified in 3% of lung adenocarcinomas and 21% of squamous cell lung carcinomas.” Dutt et al., (2011) This snippet from a … Continue reading →
... Read more »

Dutt A, Ramos AH, Hammerman PS, Mermel C, Cho J, Sharifnia T, Chande A, Tanaka KE, Stransky N, Greulich H.... (2011) Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer. PloS one, 6(6). PMID: 21666749  

  • June 17, 2011
  • 09:00 AM

Summer of the pill: why do we menstruate?

by Kate Clancy in Context & Variation

The first in a series on hormonal contraception. This post explores why human women menstruate and how that may impact their contraceptive decisions.... Read more »

  • June 17, 2011
  • 08:00 AM

Brain Growth in Autism

by Shaheen Lakhan in Brain Blogger

Brain overgrowth has been noted among children with autism spectrum disorder (ASD). Now, a new imaging study suggests that the accelerated brain growth appears before 2 years of life, offering new avenues for early identification and intervention of ASD. Investigators conducted a longitudinal magnetic resonance imaging (MRI) study of 59 children with ASD and 38 [...]... Read more »

Courchesne E, Carper R, & Akshoomoff N. (2003) Evidence of brain overgrowth in the first year of life in autism. JAMA : the journal of the American Medical Association, 290(3), 337-44. PMID: 12865374  

Courchesne E, Redcay E, & Kennedy DP. (2004) The autistic brain: birth through adulthood. Current opinion in neurology, 17(4), 489-96. PMID: 15247547  

Hazlett HC, Poe MD, Gerig G, Styner M, Chappell C, Smith RG, Vachet C, & Piven J. (2011) Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years. Archives of general psychiatry, 68(5), 467-76. PMID: 21536976  

  • June 17, 2011
  • 03:27 AM

Bipolar Kids: You Read It Here First

by Neuroskeptic in Neuroskeptic

Last year, I discussed the controvery over the proposed new childhood syndrome of "Temper Disregulation Disorder with Dysphoria" (TDDD). It may be included in the upcoming revision of the psychiatric bible, DSM-V.Back then, I said:TDDD has been proposed in order to reduce the number of children being diagnosed with pediatric bipolar disorder... many people agree that pediatric bipolar is being over-diagnosed.So we can all sympathize with the sentiment behind TDDD - but this is fighting fire wit........ Read more »

Van Meter AR, Moreira AL, & Youngstrom EA. (2011) Meta-analysis of epidemiologic studies of pediatric bipolar disorder. The Journal of clinical psychiatry. PMID: 21672501  

Axelson DA, Birmaher B, Findling RL, Fristad MA, Kowatch RA, Youngstrom EA, Arnold EL, Goldstein BI, Goldstein TR, Chang KD.... (2011) Concerns regarding the inclusion of temper dysregulation disorder with dysphoria in the DSM-V. The Journal of clinical psychiatry. PMID: 21672494  

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