Last year, I discussed the controvery over the proposed new childhood syndrome of "Temper Disregulation Disorder with Dysphoria" (TDDD). It may be included in the upcoming revision of the psychiatric bible, DSM-V.Back then, I said:TDDD has been proposed in order to reduce the number of children being diagnosed with pediatric bipolar disorder... many people agree that pediatric bipolar is being over-diagnosed.So we can all sympathize with the sentiment behind TDDD - but this is fighting fire wit........ Read more »
Van Meter AR, Moreira AL, & Youngstrom EA. (2011) Meta-analysis of epidemiologic studies of pediatric bipolar disorder. The Journal of clinical psychiatry. PMID: 21672501
Axelson DA, Birmaher B, Findling RL, Fristad MA, Kowatch RA, Youngstrom EA, Arnold EL, Goldstein BI, Goldstein TR, Chang KD.... (2011) Concerns regarding the inclusion of temper dysregulation disorder with dysphoria in the DSM-V. The Journal of clinical psychiatry. PMID: 21672494
by Brian McMichael, M.D. in Pallimed: a Hospice & Palliative Medicine Blog
In this month's issue of the Mayo Clinic Proceedings is the first article reporting on a case series with inclusion of palliative medicine (PM) consultations as a routine, integrated part of pre-op or early post-op care for patients receiving ventricular assist device (VAD) as destination therapy (DT). Both Drew and Holly have posted previously on Pallimed about VAD DT.
The Mayo Clinic is a nationally and internationally recognized tertiary and quaternary referral center. As such, beyond the ........ Read more »
Swetz KM, Freeman MR, Abouezzeddine OF, Carter KA, Boilson BA, Ottenberg AL, Park SJ, & Mueller PS. (2011) Palliative medicine consultation for preparedness planning in patients receiving left ventricular assist devices as destination therapy. Mayo Clinic proceedings. Mayo Clinic, 86(6), 493-500. PMID: 21628614
Sometimes anger gets the better of you. A morning trip to the supermarket left me enraged (and no, it wasn’t anything to do with the queues, car parking or customer service). The source of my fury was what I had seen for sale in the aisles. Were my eyes deceiving me or had I really … Continue reading »... Read more »
AAP. (2011) Sports Drinks and Energy Drinks for Children and Adolescents: Are They Appropriate?. PEDIATRICS, 127(6), 1182-1189. DOI: 10.1542/peds.2011-0965
Real-time killing E coli by LL-37 and how to kill bacterial persisters.... Read more »
Sochacki KA, Barns KJ, Bucki R, & Weisshaar JC. (2011) Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37. Proceedings of the National Academy of Sciences of the United States of America, 108(16). PMID: 21464330
Allison KR, Brynildsen MP, & Collins JJ. (2011) Metabolite-enabled eradication of bacterial persisters by aminoglycosides. Nature, 473(7346), 216-20. PMID: 21562562
Over the last five years I’ve been involved in quite a bit of market research relating to chronic lymphocytic leukemia (CLL) and have been struck how the core therapies are still largely chemotherapy based. CLL is an indolent disease of the … Continue reading →
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Fabbri, G., Rasi, S., Rossi, D., Trifonov, V., Khiabanian, H., Ma, J., Grunn, A., Fangazio, M., Capello, D., Monti, S.... (2011) Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. Journal of Experimental Medicine. DOI: 10.1084/jem.20110921
Readers will recall a post earlier this week on the importance of sleep for weight management.
Researchers and clinicians, wanting to know more about the underlying biology and mechanisms on how lack of sleep, disruption of circadian rhythm (e.g. through shift work, jet lag, or having a baby), and alterations in light/dark cycles can impact ingestive [...]... Read more »
Reiter RJ, Tan DX, Korkmaz A, & Ma S. (2011) Obesity and metabolic syndrome: Association with chronodisruption, sleep deprivation, and melatonin suppression. Annals of medicine. PMID: 21668294
What the emergency department needs to treat, EMS also needs to treat.
We can pretend otherwise.
We can pretend that just driving fast while wrestling with a patient is in some way safe.
These are delusions just as much as what is going on in the head of the patient with acute behavioural disturbance.
... Read more »
Calver LA, Downes MA, Page CB, Bryant JL, & Isbister GK. (2010) The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department. BMC emergency medicine, 14. PMID: 20584282
A fascinating case report details a remarkable recovery from serious brain injury: Characterization of recovery and neuropsychological consequences of orbitofrontal lesion.The patient "M. S." was a previously healthy 29 year old Israeli graduate student who suffered injuries in a terrorist attack. As the MRI scans above show, she lost large parts of her orbitofrontal cortex and ventromedial prefrontal cortex, although the left side was only partially affected. She also lost her right eye.These a........ Read more »
Fisher T, Shamay-Tsoory SG, Eran A, & Aharon-Peretz J. (2011) Characterization of recovery and neuropsychological consequences of orbitofrontal lesion: A case study. Neurocase, 17(3), 285-93. PMID: 21667397
Since cellular stress due to misfolded proteins in the endoplasmic reticulum (ER) has been implicated in many human diseases, a new appreciation of the cell cycle’s role in this process might help improve our understanding of conditions ranging from Alzheimer’s disease to cancer.... Read more »
Chen M, Gutierrez GJ, & Ronai ZA. (2011) Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. Proceedings of the National Academy of Sciences of the United States of America, 108(22), 9119-24. PMID: 21571647
I can't seem to stop myself from writing about pee, and I'm not even a nephrologist. But I deal with pee every day, and many of my younger patients with urinary tract infections will tell me all of the home and herbal remedies they tried before they came to see me. One of the most [...]... Read more »
Barbosa-Cesnik, C., Brown, M., Buxton, M., Zhang, L., DeBusscher, J., & Foxman, B. (2011) Cranberry Juice Fails to Prevent Recurrent Urinary Tract Infection: Results From a Randomized Placebo-Controlled Trial. Clinical Infectious Diseases, 52(1), 23-30. DOI: 10.1093/cid/ciq073
Two articles published last month in the American Journal of Physical Anthropology are starting to greatly complicate bioarchaeologists' use and interpretation of stable oxygen isotope ratios in an attempt to understand migration and mobility in the past. Science is constantly progressing, and it can be challenging to keep up with the latest research. The real challenge for me, though, is in interpreting the isotope analyses I have done on populations from Imperial Rome - first becau........ Read more »
Bianucci, R., Mattutino, G., Lallo, R., Charlier, P., Jouin-Spriet, H., Peluso, A., Higham, T., Torre, C., & Rabino Massa, E. (2008) Immunological evidence of Plasmodium falciparum infection in an Egyptian child mummy from the Early Dynastic Period. Journal of Archaeological Science, 35(7), 1880-1885. DOI: 10.1016/j.jas.2007.11.019
Pollard AM, Pellegrini M, & Lee-Thorp JA. (2011) Technical note: Some observations on the conversion of dental enamel δ(18) o(p) values to δ(18) o(w) to determine human mobility. American journal of physical anthropology. PMID: 21541927
Prowse TL, Schwarcz HP, Garnsey P, Knyf M, Macchiarelli R, & Bondioli L. (2007) Isotopic evidence for age-related immigration to imperial Rome. American Journal of Physical Anthropology, 132(4), 510-9. PMID: 17205550
Reitsema LJ, & Crews DE. (2011) Brief communication: Oxygen isotopes as a biomarker for sickle-cell disease? Results from transgenic mice expressing human hemoglobin S genes. American journal of physical anthropology. PMID: 21541922
The patient advocacy session at the recent 16th Congress of the European Hematology Association in London focused on adherence to cancer treatments, and was filled to capacity, with the many attendees having to watch it from an overflow area.
Dr David Marin, Reader in Onco-Haematology at Imperial College, London presented research published last year in the Journal of Clinical Oncology that dramatically demonstrated how adherence to chronic myeloid leukemia (CML) therapy is the critical fact........ Read more »
Marin, D., Bazeos, A., Mahon, F., Eliasson, L., Milojkovic, D., Bua, M., Apperley, J., Szydlo, R., Desai, R., Kozlowski, K.... (2010) Adherence Is the Critical Factor for Achieving Molecular Responses in Patients With Chronic Myeloid Leukemia Who Achieve Complete Cytogenetic Responses on Imatinib. Journal of Clinical Oncology, 28(14), 2381-2388. DOI: 10.1200/JCO.2009.26.3087
Athletes are not spared from the risk of developmental disorders like learning disabilities and attention deficit hyperactivity disorder (ADHD). Once an athlete is diagnosed with ADHD, the effect of this disorder and it's treatment on athletic performance becomes important. Dr. J. W. Parr recently published a comprehensive review of recent research and understanding of ADHD in the athlete. The review includes a look at diagnostic issues as well as a summary of the neurobi........ Read more »
Parr JW. (2011) Attention-deficit hyperactivity disorder and the athlete: new advances and understanding. Clinics in sports medicine, 30(3), 591-610. PMID: 21658550
We all know and love dbSNP, and DGV, and 1000 Genomes, and HapMap, and OMIM, and the couple of other dozen variation databases I can think of off the top of my head. But–even though there’s a lot of stuff out there–you never know what you aren’t seeing. What *isn’t* yet stored in those resources? [...]... Read more »
Bale, S., Devisscher, M., Criekinge, W., Rehm, H., Decouttere, F., Nussbaum, R., Dunnen, J., & Willems, P. (2011) MutaDATABASE: a centralized and standardized DNA variation database. Nature Biotechnology, 29(2), 117-118. DOI: 10.1038/nbt.1772
The idea of using electrical stimulation to affect gastric motility and emptying as a means to increase satiety and reduce appetite has received a considerable amount of attention.
Regular Readers may recall that, although two gastric stimulators have now been approved for obesity treatment in Europe, US studies on gastric stimulators for the treatment of obesity, have [...]... Read more »
Sallam HS, & Chen JD. (2011) Colon Electrical Stimulation: Potential Use for Treatment of Obesity. Obesity (Silver Spring, Md.). PMID: 21660079
As our Little Star awards remind us every year, people living with and surviving childhood cancer are very special. And our researchers know that these survivors need special attention because they face a different set of problems compared to older cancer survivors. This month, new research by Cancer Research UK scientists has shown that survivors [...]... Read more »
Reulen RC, Frobisher C, Winter DL, Kelly J, Lancashire ER, Stiller CA, Pritchard-Jones K, Jenkinson HC, Hawkins MM, & British Childhood Cancer Survivor Study Steering Group. (2011) Long-term risks of subsequent primary neoplasms among survivors of childhood cancer. JAMA : the journal of the American Medical Association, 305(22), 2311-9. PMID: 21642683
So you think you’re pretty smart, huh? I bet you think walking is easy. Let’s put those assumptions to the test: Haul yourself away from the computer for a couple of minutes and try this simple little test. We’ll see just how clever you really are… Continue reading »... Read more »
Yogev-Seligmann, G., Hausdorff, J., & Giladi, N. (2008) The role of executive function and attention in gait. Movement Disorders, 23(3), 329-342. DOI: 10.1002/mds.21720
Heath, S. (1943) The military use of the rail-walking test as an index of locomotor coordination. Psychological Bulletin, 40(4), 282-284. DOI: 10.1037/h0061269
Ble, A., Volpato, S., Zuliani, G., Guralnik, J., Bandinelli, S., Lauretani, F., Bartali, B., Maraldi, C., Fellin, R., & Ferrucci, L. (2005) Executive Function Correlates with Walking Speed in Older Persons: The InCHIANTI Study. Journal of the American Geriatrics Society, 53(3), 410-415. DOI: 10.1111/j.1532-5415.2005.53157.x
Recent excavations in a sewer at Herculaneum uncovered a massive deposit of, well, poop. What can feces tell us about the ancient Romans' diet, diseases, and medicine?... Read more »
S.C. Bisel. (1988) Nutrition in first-century Herculaneum. Anthropologie, 26(1), 61-66. info:/
Capasso L. (2002) Bacteria in two-millennia-old cheese, and related epizoonoses in Roman populations. The Journal of infection, 45(2), 122-7. PMID: 12217720
Capasso, L. (2007) Infectious diseases and eating habits at Herculaneum (1st century AD, southern Italy). International Journal of Osteoarchaeology, 17(4), 350-357. DOI: 10.1002/oa.906
The presence of mild cognitive impairment (MCI) in elderly individuals is often a clinical challenge of uncertainly prognostic value. Defined as cognitive function below the normal range but insufficient for a diagnosis of dementia, MCI is receiving increased research attention. This week in the New England Journal of Medicine, Dr. Ronald Petersen, a neurologist from the Mayo Clinic in Rochester, Minnesota highlighted what is known about MCI. His review summarizes some of........ Read more »
Petersen, RC. (2011) Mild Cognitive Impairment. New Engl J Med, 2227-2234. info:/
Regular readers of these pages will be well aware of the many studies that now show a close association between less sleep and weight gain.
In fact, a now often shown slide clearly documents, how steadily decreasing hours of sleep remarkably parallels the steady increase in obesity rates over the past decades.
In addition, substantial data from [...]... Read more »
Chaput JP, Després JP, Bouchard C, & Tremblay A. (2011) Longer sleep duration associates with lower adiposity gain in adult short sleepers. International journal of obesity (2005). PMID: 21654631
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