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  • December 13, 2011
  • 08:40 PM

What are the similarities between chronic pain and opioid addiction?

by Kim Kristiansen in Picture of Pain

This is the second blog post of three about challenges in pain management using opioids and how we can navigate between risk of addiction and helping the patient... Read more »

Henriette Poulsen, M.D. and Kim Kristiansen, M.D. (2011) What are the similarities between chronic pain and opioid addiction?. Picture of Pain Blog. info:/

  • December 13, 2011
  • 01:01 PM

Weight Suppression and Bulimia Recovery

by William Yates, M.D. in Brain Posts

Weight suppression is a variable that is defined as highest ever historical weight minus current weight.  It represents a measure of the level of weight lost since being at the highest weight over a lifetime.Although many individuals with bulimia nervosa are within normal weight ranges, these individuals tend to have higher levels of weight suppression than those without an eating disorder.Weight loss in bulimia may increase drive for binge eating.  Weight suppression may similarly be ........ Read more »

Lowe, M., Berner, L., Swanson, S., Clark, V., Eddy, K., Franko, D., Shaw, J., Ross, S., & Herzog, D. (2011) Weight suppression predicts time to remission from bulimia nervosa. Journal of Consulting and Clinical Psychology, 79(6), 772-776. DOI: 10.1037/a0025714  

  • December 13, 2011
  • 06:00 AM

A magic bullet for haemophilia B

by Suzanne Elvidge in Genome Engineering

Haemophilia B is an inherited bleeding disorder caused by a mutation to the gene for factor IX, a blood clotting factor. It is X-linked and recessive, so it generally affects males but can be carried silently by females and passed onto their male offspring. Haemophilia B can be life-threatening, shortens lifespan, and makes daily life complicated. Researchers at University College London and St Jude Children’s Research Hospital have created a gene therapy and shown it to be effective in ea........ Read more »

Nathwani, A., Tuddenham, E., Rangarajan, S., Rosales, C., McIntosh, J., Linch, D., Chowdary, P., Riddell, A., Pie, A., Harrington, C.... (2011) Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1108046  

BIGGS R, DOUGLAS AS, MACFARLANE RG, DACIE JV, PITNEY WR, & MERSKEY. (1952) Christmas disease: a condition previously mistaken for haemophilia. British medical journal, 2(4799), 1378-82. PMID: 12997790  

  • December 13, 2011
  • 12:08 AM

Long-Term Effect of Physical Training as Treatment for Overuse Injury

by Hallie Labrador in Sports Medicine Research (SMR): In the Lab & In the Field

The purpose of this follow-up trial was to revisit the original subjects of a randomized controlled trial studying the impact of a training program on adductor-related groin pain and test whether the effects were still statistically significant 8 to 12 years later.... Read more »

  • December 12, 2011
  • 07:16 PM

Another gene therapy success story

by EE Giorgi in CHIMERAS

Last October I reported an incredible story in which researchers used an HIV chimeric virus to cure leukemia. Here's another success story. Hemophilia B is a blood clotting disorder caused by spontaneous mutations in the Factor IX gene, leading to a deficiency of Factor IX, an enzyme essential in blood coagulation. The gene is expressed mostly in the liver, where the enzyme is produced and then sent into circulation in the blood. Less than 1% of normal levels of Factor IX lead to severe hemophil........ Read more »

Nathwani, A., Tuddenham, E., Rangarajan, S., Rosales, C., McIntosh, J., Linch, D., Chowdary, P., Riddell, A., Pie, A., Harrington, C.... (2011) Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1108046  

  • December 12, 2011
  • 04:22 PM

Midline Carcinoma, a Cancer Without a Cure: No More

by Ajay Malik in Mission Tumor

An extremely rare and "almost always" fatal midline carcinoma effects just 20-40 individuals per year and there are about 200 people with this cancer in the US.  It typically originates in the "midline" regions of the body, such as nose, mouth and sinuses in the head; trachea in the neck; upper airways, chest and thymus in the mediastinum.  It effects children and adults, alike.

Since midline carcinoma cells are undifferentiated or poorly differentiated, this cancer is often misdia........ Read more »

French CA. (2010) NUT midline carcinoma. Cancer genetics and cytogenetics, 203(1), 16-20. PMID: 20951314  

Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I.... (2010) Selective inhibition of BET bromodomains. Nature, 468(7327), 1067-73. PMID: 20871596  

Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M.... (2011) RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature, 478(7370), 524-8. PMID: 21814200  

Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J.... (2011) BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell, 146(6), 904-17. PMID: 21889194  

  • December 12, 2011
  • 12:16 PM

Best Test for Diagnosing Alzheimer's Dementia

by William Yates, M.D. in Brain Posts

PET Image Normal Definitive diagnosis of Alzheimer's disease (AD) from other forms of dementia is a complex clinical challenge.  Positron imaging tomography (PET) scans are widely available in the United States.  A more recent approach has used the estimation of brain amyloid levels using an amyloid ligand Pittsburgh Compound B (PiB).  PiB imaging is primarily a research tool at the present.I have previously summarized some of the research related to PiB imaging from a lectur........ Read more »

Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, Mormino EC, O'Neil JP, Janabi M, Karydas A.... (2011) Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD. Neurology, 77(23), 2034-42. PMID: 22131541  

  • December 12, 2011
  • 12:00 PM

Does Epinephrine Improve Survival from Cardiac Arrest

by Rogue Medic in Rogue Medic

Even though epinephrine (adrenaline) is used automatically in cardiac arrest, and there is evidence that epinephrine helps to produce a pulse (ROSC – Return Of Spontaneous Circulation), there is no evidence that epinephrine improves the only survival statistic that matters – discharge from the hospital with a brain that still works. There were so many deviations from assignment protocol in their 2009 study,[1] that the authors decided to examine the results based on what treatment pa........ Read more »

  • December 12, 2011
  • 08:00 AM

Cell Phones Still Not Linked to Brain Cancer

by Michael Kruse in Skeptic North

Enter cell phones. We are constantly reminded of the failure of society to recognize the dangers of tobacco, let alone do something about it, and the industry led effort to suppress information and increase uncertainty in the pubic is held up as proof that all industries will stop at no lengths to protect their investment, despite dangers to the public. In the face of this, we need a scientific outlook to unblinker us from determining an unbiased truth. A new systematic review published in Oct........ Read more »

Repacholi MH, Lerchl A, Röösli M, Sienkiewicz Z, Auvinen A, Breckenkamp J, d'Inzeo G, Elliott P, Frei P, Heinrich S.... (2011) Systematic review of wireless phone use and brain cancer and other head tumors. Bioelectromagnetics. PMID: 22021071  

  • December 12, 2011
  • 05:39 AM

Gene provides link between multiple sclerosis and vitamin D

by Suzanne Elvidge in Genome Engineering

Multiple sclerosis (MS) is a neurological disease where the protective coverings of the nerves (myelin sheaths) are damaged, causing damage to the nerves below. MS has been linked with vitamin D, and in a study published in Annals of Neurology, researchers have found a rare gene variant that leads people to have lower levels of vitamin D in their bodies.... Read more »

Ramagopalan, S., Dyment, D., Cader, M., Morrison, K., Disanto, G., Morahan, J., Berlanga-Taylor, A., Handel, A., De Luca, G., Sadovnick, A.... (2011) Rare variants in the CYP27B1 gene associated with multiple sclerosis. Annals of Neurology. DOI: 10.1002/ana.22678  

Hayes CE, Cantorna MT, & DeLuca HF. (1997) Vitamin D and multiple sclerosis. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 216(1), 21-7. PMID: 9316607  

Ramagopalan SV, Maugeri NJ, Handunnetthi L, Lincoln MR, Orton SM, Dyment DA, Deluca GC, Herrera BM, Chao MJ, Sadovnick AD.... (2009) Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS genetics, 5(2). PMID: 19197344  

  • December 12, 2011
  • 12:08 AM

Radiographic Prevalence of Femoroacetabular Impingement in Collegiate Football Players

by Meghan Miller in Sports Medicine Research (SMR): In the Lab & In the Field

The purpose of this study was to use radiographic imaging to quantify the prevalence of FAI in asymptomatic football players.... Read more »

Kapron AL, Anderson AE, Aoki SK, Phillips LG, Petron DJ, Toth R, & Peters CL. (2011) Radiographic prevalence of femoroacetabular impingement in collegiate football players: AAOS Exhibit Selection. The Journal of Bone and Joint Surgery. American volume, 93(19). PMID: 22005872  

  • December 11, 2011
  • 05:03 PM

The CSI Blowfly

by Africa Gomez in BugBlog

At this time of the year, when there has been a few frosts and the sun is weak, the most likely insect you are likely to see on the wing are bluebottles. I found this one yesterday enjoying the sun in my conservatory. It is the urban blowfly, Calliphora vicina, a very cold tolerant species which is the most common buebottle in the UK.  Calliphora vicina is one of the most important species in forensic entomology, especially in investigating human remains. Different fly species arrive a........ Read more »

Amendt, J., Krettek, R., & Zehner, R. (2004) Forensic entomology. Naturwissenschaften, 91(2), 51-65. DOI: 10.1007/s00114-003-0493-5  

  • December 11, 2011
  • 07:58 AM

Do Antidepressants Make Some People Worse?

by Neuroskeptic in Neuroskeptic

Antidepressants may help depression in some people but make it worse for others, according to a new paper.This is a tough one so bear with me.Gueorguieva, Mallinckrodt and Krystal re-analysed the data from a number of trials of duloxetine (Cymbalta) vs placebo. Most of the trials also had another antidepressant (an SSRI) as well. And the SSRIs and duloxetine seemed to be indistinguishable so from now on I'll just call it antidepressants vs. placebo as the authors did.People on placebo got, on av........ Read more »

  • December 10, 2011
  • 02:48 PM

What’s hot at SABCS – Update 2 – advanced breast cancer

by Sally Church in Pharma Strategy Blog

After a number of basic research and science sessions over the last two days (see the Update 1 post on the science that intrigued me for more details), but the last two days heralded some excellent clinical sessions, in both … Continue reading →
... Read more »

Baselga, J., Campone, M., Piccart, M., Burris, H., Rugo, H., Sahmoud, T., Noguchi, S., Gnant, M., Pritchard, K., Lebrun, F.... (2011) Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1109653  

Baselga, J., Cortés, J., Kim, S., Im, S., Hegg, R., Im, Y., Roman, L., Pedrini, J., Pienkowski, T., Knott, A.... (2011) Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1113216  

Gradishar, W. (2011) HER2 Therapy — An Abundance of Riches. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMe1113641  

  • December 10, 2011
  • 11:11 AM

Do Vaccines Contain Toxic Chemicals?

by Mutant Dragon in Puff the Mutant Dragon

The year 1900 marks the birth of an organization that would play a prominent role in British political life — the UK Labor Party. Their first manifest is a curious document.... Read more »

Dhareshwar, S., & Stella, V. (2008) Your prodrug releases formaldehyde: Should you be concerned? No!. Journal of Pharmaceutical Sciences, 97(10), 4184-4193. DOI: 10.1002/jps.21319  

  • December 10, 2011
  • 09:00 AM

Cursing soothes your pain

by United Academics in United Academics

No acces to painkillers after bumping your head? Just shout out all the bad, vulgair, and profane words you can think of. New research shows that swearing actually relieves your pain. But don’t curse to often, overuse of swearing decreases the beneficial effect.... Read more »

  • December 10, 2011
  • 07:27 AM

Risk Factors for Recurrence of Depression

by Jennifer Gibson, PharmD in Brain Blogger

Depression is a common mental health disorder that negatively affects daily functioning and quality of life. Unfortunately, depression is often a recurrent disorder. Current treatment guidelines are based on clinical features of the disease, but new evidence points to sociodemographic and psychosocial characteristics that influence the severity and prognosis of depression. Specifically, a study published [...]... Read more »

Colman I, Naicker K, Zeng Y, Ataullahjan A, Senthilselvan A, & Patten SB. (2011) Predictors of long-term prognosis of depression. CMAJ : Canadian Medical Association journal , 183(17), 1969-76. PMID: 22025655  

Howland RH, Wilson MG, Kornstein SG, Clayton AH, Trivedi MH, Wohlreich MM, & Fava M. (2008) Factors predicting reduced antidepressant response: experience with the SNRI duloxetine in patients with major depression. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 20(4), 209-18. PMID: 19034753  

  • December 9, 2011
  • 08:29 PM

Seeking Moby Dick Mo-99

by Ajay Malik in Mission Tumor

Technetium-99m (Tc-99m) is the most used radioactive tracer with over 30 million tests per year done all over the world. When tagged to a pharmaceutical or biological marker, it helps evaluate, diagnose or manage cancer spread, blood flow and cardiac function; brain activity and thyroid disease; and detect osseous metastasis, fractures and infections (bone scan). . . Tc-99m is a metastable isotope of molybdenum-99 (Mo-99). . . Lately, Tc-99m supply chain has come under stress.

(Read ........ Read more »

  • December 9, 2011
  • 08:29 PM

GNE Video: Understanding Biomarkers

by Ajay Malik in Mission Tumor

Friday Grand Rounds are back, a day early because Jeff just flew in and can't wait to tell us all about Biomarkers. 
So, please settle down in your uncomfortable conference room chairs (don't spill coffee) and let's listen to Jeff Settleman.  Jeff is the Senior Director of Discovery Oncology and Staff Scientist at Genentech, South San Francisco, Calif.  He is going to teach us about biomarkers and their potential for identifying which patients may benefit form certain treatme........ Read more »

  • December 9, 2011
  • 08:29 PM

Shaping Cancer Diagnosis: Looking at the Horizon of Next Generation Sequencing and Targeted Resequencing

by Ajay Malik in Mission Tumor

Two articles in this week's issue of Genetic Engineering & Biotechnology News reviewed recent trends in the next-generation sequencing and targeted resequencing technologies.  These advances are expected to further impact cancer diagnostics and treatment decision-making.

Harry Glorikain and Brian Clancy of Scientia Advisors described business trends in next-generation sequencing:

The shift of sequencing service (or activity) from small labs to large labs, companies and consorti........ Read more »

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