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  • August 13, 2014
  • 08:00 AM
  • 989 views

Getting High On Life

by Mark Lasbury in As Many Exceptions As Rules

Living organisms can survive and thrive in all kinds of rough environments. This would include the edges of space. There are bird species that can fly at almost 40,000 ft., as high as the highest clouds. New research is showing just how the bar headed goose is able to fly when the air is thin and the oxygen is scarce. But more impressive are the bacteria. They can actually live their whole lives in the air, dividing and growing nearly 25 miles (41 km) above the surface of the Earth. A study from........ Read more »

Pawar SP, Dhotre DP, Shetty SA, Chowdhury SP, Chaudhari BL, & Shouche YS. (2012) Genome sequence of Janibacter hoylei MTCC8307, isolated from the stratospheric air. Journal of bacteriology, 194(23), 6629-30. PMID: 23144385  

Hawkes LA, Balachandran S, Batbayar N, Butler PJ, Chua B, Douglas DC, Frappell PB, Hou Y, Milsom WK, Newman SH.... (2013) The paradox of extreme high-altitude migration in bar-headed geese Anser indicus. Proceedings. Biological sciences / The Royal Society, 280(1750), 20122114. PMID: 23118436  

  • August 13, 2014
  • 04:11 AM
  • 396 views

Neonatal intensive care unit (NICU) survivors and greater risk of autism?

by Paul Whiteley in Questioning Answers

"In term NICU [neonatal intensive care unit] survivors, ASD [autism spectrum disorder] occurs with a greater frequency than in the general population and often develops alongside comorbid conditions". That was the conclusion from the study by Alexander Winkler-Schwartz and colleagues [1] looking at term at-risk infants who survived NICU."You were only meant to blow the bloody doors off"'Surviving' their earliest days spent in NICU brings a bit of lump to my throat. As a paren........ Read more »

  • August 13, 2014
  • 12:05 AM
  • 681 views

Make Sure You Charge That Phone Before Measuring Anterior Tibial Translation

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

A mobile phone arthrometer application may be a reliable alternative to the KT-1000 when measuring anterior tibial translation following an anterior cruciate ligament injury.... Read more »

Andrea, F., Luigi, V., Daniele, M., Luca, M., Paolo, I., Giovanni, G., Fabio, C., & Raffaele, I. (2014) Smartphone versus knee ligament arthrometer when size does not matter. International Orthopaedics. DOI: 10.1007/s00264-014-2432-9  

  • August 12, 2014
  • 02:07 PM
  • 701 views

Treatment and Prevention of PTSD

by Dr. Jekyll in Lunatic Laboratories

It’s no secret for anyone who follows me that I am a Marine veteran. It’s also no secret for anyone who follows me that I’ve had my own ups and downs in life because of my experiences. PTSD is a nightmare, one that you can’t quite shake no matter how hard you try. Then again, not everyone reacts the same way to the trauma that typically causes PTSD, not everyone walks away from war with it. The big question that scientists set out to answer was, why? And now they might just have an answe........ Read more »

Nikolaos P. Daskalakis, Hagit Cohen, Guiqing Caia, Joseph D. Buxbaum, & Rachel Yehuda. (2014) Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes. Proceedings of the National Academy of Sciences of the United States of America, 111(32). info:/10.1073/pnas.1401660111

  • August 12, 2014
  • 04:04 AM
  • 525 views

Neonatal jaundice and increased risk of ADHD

by Paul Whiteley in Questioning Answers

The findings from Chang-Ching Wei and colleagues [1] suggesting an over-representation of the diagnosis of attention-deficit hyperactivity disorder (ADHD) following a history of neonatal jaundice provides fodder for today's brief post. Based in Taiwan, one of the most impressive countries when it comes to the use and analysis of 'big data' (see here), researchers were able to identify some 25,000 participants diagnosed with neonatal jaundice and compare them with almost 70,000 non-jaundiced........ Read more »

  • August 11, 2014
  • 01:30 PM
  • 926 views

New Hope for Autoimmune Diseases

by Dr. Jekyll in Lunatic Laboratories

Autoimmune diseases are on the rise. Since I have a history of over sharing, my Uncle suffered from a form of lupus. It caused him intense and — in my opinion — unbearable pain although he shouldered it like the incredible man he was and never complained. My sister unfortunately is suffering from a rare disease that has yet to be diagnosed, which in my opinion has autoimmune dysfunction as the root cause. If you or anyone you know suffers in a similar fashion then you know that the treatment........ Read more »

Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK.... (2014) Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. PMID: 24891519  

  • August 11, 2014
  • 12:00 PM
  • 829 views

IT’S NEVER LUPUS? THINK AGAIN…

by Robb Hollis in Antisense Science

Those of you familiar with a certain misanthropic maverick MD will no doubt be familiar with the phrase “it’s never lupus”. Unfortunately, in the real world, it IS sometimes lupus – but what is lupus and how does it arise?
... Read more »

  • August 11, 2014
  • 12:00 PM
  • 771 views

It's Never Lupus? Think Again...

by Robb Hollis in Antisense Science

Those of you familiar with a certain misanthropic maverick MD will no doubt be familiar with the phrase “it’s never lupus”. Unfortunately, in the real world, it IS sometimes lupus – but what is lupus and how does it arise?... Read more »

  • August 11, 2014
  • 11:42 AM
  • 624 views

Clinical Drug Trials for Pathological Gambling

by William Yates, M.D. in Brain Posts

Several drug classes hold promise for reduction in pathological gambling behavior.However, there are very few published randomized and controlled clinical drug trials in gambling subjects.Searching clinical trials and gambling on PubMed yields only one small open-label proof of concept trial for the drug tolcapone within the last year.This study found evidence that this COMT inhibitor drug reduced gambling symptoms and was accompanied by fronto-parietal activation on fMRI imaging.However, on sea........ Read more »

Grant JE, Odlaug BL, Chamberlain SR, Hampshire A, Schreiber LR, & Kim SW. (2013) A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23(11), 1587-96. PMID: 23953269  

  • August 11, 2014
  • 09:38 AM
  • 796 views

Lithium For Aging Brain

by Vivek Misra in Uberbrain Research Frontier

Recent studies investigating Lithium, a drug commonly used for the treatment of mood disorders in humans, found its robust neurotrophic and neuroprotective effects which can help us exploring new novel, exciting, and promising targets. The molecular mechanism underlying lithium’s mood stabilizing effect is not yet unraveled. Suggested hypotheses include inositol-depletion via inhibition of inositol- monophosphatase and neuroprotection, via inhibition of GSK-3. Chronic lithium treatment inc........ Read more »

Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, & Manji HK. (2000) Enhancement of hippocampal neurogenesis by lithium. Journal of neurochemistry, 75(4), 1729-34. PMID: 10987856  

O'Brien WT, Harper AD, Jové F, Woodgett JR, Maretto S, Piccolo S, & Klein PS. (2004) Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(30), 6791-8. PMID: 15282284  

Berggren U, Tallstedt L, Ahlenius S, & Engel J. (1978) The effect of lithium on amphetamine-induced locomotor stimulation. Psychopharmacology, 59(1), 41-5. PMID: 100811  

Agam G, Bersudsky Y, Berry GT, Moechars D, Lavi-Avnon Y, & Belmaker RH. (2009) Knockout mice in understanding the mechanism of action of lithium. Biochemical Society transactions, 37(Pt 5), 1121-5. PMID: 19754464  

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS.... (2014) REST and stress resistance in ageing and Alzheimer's disease. Nature, 507(7493), 448-54. PMID: 24670762  

  • August 11, 2014
  • 03:43 AM
  • 645 views

Risk of neurodevelopmental disorder in cases of hypospadias

by Paul Whiteley in Questioning Answers

"This is the first study to identify an increased risk for neurodevelopmental disorders in patients with hypospadias, as well as an increased risk for ASD [autism spectrum disorders] in their brothers, suggesting a common familial (genetic and/or environmental) liability".Rainy days and Mondays... @ Wikipedia That was the conclusion reached in the study by Agnieszka Butwicka and colleagues [1] looking at various neurodevelopmental outcomes associated with a diagnosis of ........ Read more »

Butwicka A, Lichtenstein P, Landén M, Nordenvall AS, Nordenström A, Nordenskjöld A, & Frisén L. (2014) Hypospadias and increased risk for neurodevelopmental disorders. Journal of child psychology and psychiatry, and allied disciplines. PMID: 25048198  

  • August 11, 2014
  • 12:05 AM
  • 834 views

Emergency Room Visits for Sports Injuries

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Take Home Message: Sports-related injuries among teenagers accounts for over 430,000 emergency room visits in the United States in 2008 and represent a significant financial burden to the healthcare system.

Sports-related injuries in teenagers result in a significant number of emergency room visits, which can result in relatively large direct costs. However, little is known about national estimates of how many emergency room visits actually occur as well as the direct costs affiliated ........ Read more »

Nalliah RP, Anderson IM, Lee MK, Rampa S, Allareddy V, & Allareddy V. (2014) Epidemiology of Hospital-Based Emergency Department Visits Due to Sports Injuries. Pediatric Emergency Care, 30(8), 511-515. PMID: 25062295  

  • August 10, 2014
  • 12:03 PM
  • 696 views

Pregnancy and Antibacterial Soap a Potentially Dangerous Combination

by Dr. Jekyll in Lunatic Laboratories

My wife likes to sanitize everything with bleach. I don’t really approve, but I bite my tongue because it makes her feel better. Germs are everywhere and honestly there is […]... Read more »

Pycke BF, Geer LA, Dalloul M, Abulafia O, Jenck AM, & Halden RU. (2014) Human biomonitoring of prenatal exposure to triclosan and triclocarban in a multiethnic urban population from Brooklyn, New York. Environmental Science , 8831-8838. info:/10.1021/es501100w

  • August 9, 2014
  • 01:45 PM
  • 1,086 views

Marijuana and the Developing Brain

by Dr. Jekyll in Lunatic Laboratories

You can’t get away from it, the big marijuana debate here in the US. Is it good? Is it bad? What are other countries doing? There are also a lot of claims made about marijuana, most of which aren’t true, namely the big medical claims. Then there is the other side of that fence, what about some of the health issues that are claimed, where does science sit on that?[…]... Read more »

Giedd JN, Blumenthal J, Jeffries NO, Rajapakse JC, Vaituzis AC, Liu H, Berry YC, Tobin M, Nelson J, & Castellanos FX. (1999) Development of the human corpus callosum during childhood and adolescence: a longitudinal MRI study. Progress in neuro-psychopharmacology , 23(4), 571-88. PMID: 10390717  

Giedd, J. N. (2004) Structural magnetic resonance imaging of the adolescent brain. Adolescent Brain Development: Vulnerabilities and Opportunities. info:/

Choo EK, Benz M, Zaller N, Warren O, Rising KL, & McConnell KJ. (2014) The impact of state medical marijuana legislation on adolescent marijuana use. The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 55(2), 160-6. PMID: 24742758  

Joffe A, American Academy of Pediatrics Committee on Substance Abuse, & American Academy of Pediatrics Committee on Adolescence. (2004) Legalization of marijuana: potential impact on youth. Pediatrics, 113(6), 1825-6. PMID: 15173518  

  • August 9, 2014
  • 12:46 PM
  • 896 views

Terminal Lucidity: Myth, Mystery or Miracle?

by Neuroskeptic in Neuroskeptic_Discover

Can sick people gain mental clarity just before they die? University of Virginia researchers Michael Nahm and Bruce Greyson explore this issue in a gripping (if macabre) paper published in the journal Omega: The death of Anna Katharina Ehmer: a case study in terminal lucidity.The authors discuss the case of Anna Katharina Ehmer, a German […]The post Terminal Lucidity: Myth, Mystery or Miracle? appeared first on Neuroskeptic.... Read more »

  • August 8, 2014
  • 06:00 PM
  • 457 views

Psychiatry and inflammation (again)

by Paul Whiteley in Questioning Answers

I'd like to bring two papers to your attention in today's very quick post."The Death Star plans are not in the main computer"First up is the article by Kahn & Sommer [1] (open-access) titled: 'The neurobiology and treatment of first-episode schizophrenia'. It's about as good a read as we have so far on the topic of "brain changes in the first phase of schizophrenia" and the various management options for first-episode schizophrenia. Outside of the very important fact that "It is highly unlik........ Read more »

  • August 8, 2014
  • 03:36 PM
  • 581 views

The Self Assembling Brain

by Dr. Jekyll in Lunatic Laboratories

Let’s face it, if the brain were a lego set I would still be staring at the box wondering what I got myself into. So I guess we can just […]... Read more »

Lorenzo I. Finci et. al. (2014) The Crystal Structure of Netrin-1 in Complex with DCC Reveals the Bifunctionality of Netrin-1 As a Guidance Cue. Neuron. info:/http://dx.doi.org/10.1016/j.neuron.2014.07.010

  • August 8, 2014
  • 12:13 PM
  • 634 views

Melanoma, UV radiation, and TP53

by Aurelie in Coffee break Science

It’s summer, and time to get some tan. Many people flock to beaches and parks and expose as much skin as possible, bathing in sunlight – and ultraviolet (UV) radiation. Over the past decades, public health campaigns have rather successfully … Continue reading →... Read more »

Viros A, Sanchez-Laorden B, Pedersen M, Furney SJ, Rae J, Hogan K, Ejiama S, Girotti MR, Cook M, Dhomen N.... (2014) Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53. Nature, 511(7510), 478-82. PMID: 24919155  

  • August 8, 2014
  • 09:13 AM
  • 853 views

Translational Findings: How fruit fly research has already contributed to human health

by Bethany Christmann in Fly on the Wall

How have fruit flies already contributed to human health? I review four landmark fly papers that won their authors Nobel Prizes in Physiology or Medicine. ... Read more »

  • August 8, 2014
  • 08:01 AM
  • 665 views

Researchers Uncover Stem Cell Behaviour of Human Bowel

by beredim in Stem Cells Freak

For the first time, researchers say they have uncovered new information on how stem cells in the human bowel behave, revealing vital clues about the earliest stages in bowel cancer development and how we may begin to prevent it.The research, led by Queen May University of London (QMUL) and published yesterday the journal Cell Reports, discovered how many stem cells exist within the human bowel and how they behave and evolve over time.Read More... Read more »

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon. (2014) Ann-Marie Baker, Biancastella Cereser, Samuel Melton, Alexander G. Fletcher, Manuel Rodriguez-Justo, Paul J. Tadrous, Adam Humphries, George Elia, Stuart A.C. McDonald, Nicholas A. Wright, Benjamin D. Simons, Marnix Jansen, Trevor A. Graham. Cell Reports. info:/10.1016/j.celrep.2014.07.019

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