The benefits of taking fish oil and the harm caused by eating red meat, these two nutritional nuggets of wisdom have been passed around so much over the past few decades, we rarely stop to ask if they really do what people claim they do.
This month, two new papers on the subject of fish and meat have come forward from the University of Western Australia. The first examines the real impact of taking fish oil supplements on the diets of obese people.... Read more »
Wong, A., Chan, D., Ooi, E., Ng, T., Watts, G., & Barrett, P. (2013) Omega-3 fatty acid ethyl ester supplementation decreases very-low-density lipoprotein triacylglycerol secretion in obese men. Clinical Science, 125(1), 45-51. DOI: 10.1042/CS20120587
Koeth, R., Wang, Z., Levison, B., Buffa, J., Org, E., Sheehy, B., Britt, E., Fu, X., Wu, Y., Li, L.... (2013) Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine. DOI: 10.1038/nm.3145
Latin America and the Caribbean are the next hotspots of cancer-related deaths in the world and countries in this region are woefully ill-prepared to face this growing epidemic. A report by Latin American Cooperative Oncology Group (LACOG) presented at the LACOG Conference 2013 on April 26-27, 2013, at Sao Paulo, Brazil, put these facts in depressing hard numbers: currently 13 people of 22 diagnosed with cancer die in Latin America and the Caribbean in contrast to 13 of 37 in US or 13 of 30 i........ Read more »
Goss, P., Lee, B., Badovinac-Crnjevic, T., Strasser-Weippl, K., Chavarri-Guerra, Y., Louis, J., Villarreal-Garza, C., Unger-Saldaña, K., Ferreyra, M., Debiasi, M.... (2013) Planning cancer control in Latin America and the Caribbean. The Lancet Oncology, 14(5), 391-436. DOI: 10.1016/S1470-2045(13)70048-2
In a study published in April in Nature Medicine, US researchers show that the intestinal microflora can process L-carnitine, a nutrient abundant in red meat, to produce a compound linked to the risk of developing cardiovascular disease. Nowadays, many people … Continue reading →... Read more »
Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L.... (2013) Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature medicine. PMID: 23563705
Intravenous oxygen delivery that works?
Maybe temporary oxygenation, but not yet.
Will this change the approach to CICV (Can’t Intubate, Can’t Ventilate) patients?
No, but it may change the approach to CICO (Can’t Intubate, Can’t Oxygenate) patients.
The distinction is important. ... Read more »
Kheir, J., Scharp, L., Borden, M., Swanson, E., Loxley, A., Reese, J., Black, K., Velazquez, L., Thomson, L., Walsh, B.... (2012) Oxygen Gas-Filled Microparticles Provide Intravenous Oxygen Delivery. Science Translational Medicine, 4(140), 140-140. DOI: 10.1126/scitranslmed.3003679
In 2009, researchers from the University of British Columbia reported on a case of developmental topographical disorientation. The woman, referred to only as patient 1 (Pt1), is the first reported individual to demonstrate this profound and lifelong impairment in navigation. Throughout her school years, Pt1 was forced to follow her sisters or parents to school and friends to extracurricular activities. As an adult, she relies upon specific, stereotyped instructions to travel from work to home, u........ Read more »
Iaria G, Bogod N, Fox CJ, & Barton JJ. (2009) Developmental topographical disorientation: case one. Neuropsychologia, 47(1), 30-40. PMID: 18793658
The microbiome — the kilogram of microbes that each of us carries around — has been shown to be involved …Continue reading »... Read more »
Markle JG, Frank DN, Mortin-Toth S, Robertson CE, Feazel LM, Rolle-Kampczyk U, von Bergen M, McCoy KD, Macpherson AJ, & Danska JS. (2013) Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science (New York, N.Y.), 339(6123), 1084-8. PMID: 23328391
University of Florida researchers have developed a “DNA nanotrain” that fast-tracks its payload of cancer-fighting drugs and bioimaging agents to tumor cells deep within the body. The nanotrain’s ability to cost-effectively deliver high doses of drugs to precisely targeted cancers and other medical maladies without leaving behind toxic nano-clutter has been the elusive Holy Grail for scientists studying the teeny-tiny world of DNA nanotechnology.... Read more »
Lindy McCollum-Brounley. (2013) UF researchers develop ‘nanotrain’ for targeted cancer drug transport. University of Florida News. info:/
Components of Brain Limbic SystemAdvances in the diagnosis and treatment of brain disorders like bipolar disorder, schizophrenia and autism are a public health priority.Dr. Thomas Insel, director at NIMH recently presented a TED talk that emphasized the need to rethink how we conceptualize and study these types of disorders. He argues for a need to redefine mental disorders as brain disorders. Advances in brain research tools are likely to provide improvements in early diagnosis and ........ Read more »
Collins, P., Insel, T., Chockalingam, A., Daar, A., & Maddox, Y. (2013) Grand Challenges in Global Mental Health: Integration in Research, Policy, and Practice. PLoS Medicine, 10(4). DOI: 10.1371/journal.pmed.1001434
Evidence from a multinational pharmaceutical industry collaboration shows this week that upper limits of bodyweight loss of 10 per cent in rats and dogs are sufficient for setting the maximum-tolerated dose in short-term toxicity studies. Where there has been no previously accepted evidence-based assessment criteria before now, Dr Fiona Sewell, NC3Rs, describes how the new recommendations were developed to improve the welfare of thousands of animals used in regulatory studies each year.... Read more »
Chapman, K., Sewell, F., Allais, L., Delongeas, J., Donald, E., Festag, M., Kervyn, S., Ockert, D., Nogues, V., Palmer, H.... (2013) A global pharmaceutical company initiative: An evidence-based approach to define the upper limit of body weight loss in short term toxicity studies. Regulatory Toxicology and Pharmacology. DOI: 10.1016/j.yrtph.2013.04.003
It was an unprecedented move: U.S. Health and Human Services Secretary Kathleen Sibelius overruled the FDA when she announced that Teva Pharmaceutical’s Plan B One Step contraceptive pill would not be available to women under 17 years of age. ... Read more »
Funk RS, Brown JT, & Abdel-Rahman SM. (2012) Pediatric pharmacokinetics: human development and drug disposition. Pediatric clinics of North America, 59(5), 1001-16. PMID: 23036241
Scientific collaborators from Yale School of Medicine and University College London (UCL) have uncovered the molecular pathway by which new arteries may form after heart attacks, strokes and other acute illnesses — bypassing arteries that are blocked.... Read more »
Helen Dodson. (2013) Growing new arteries, bypassing blocked ones. Yale News. info:/
Its been known for years that tumours have the ability to recruit mesenchymal stem cells (MSCs), which is why they are sometimes so persistent and difficult to deal with. Unfortunately, this process is poorly understood on the molecular level. Today, a research team from the University of Michigan, led by Professor Russell Taichman, announced that it has successfully decoded "the molecular chatter" between cancer cells and MSCs.Read More... Read more »
Jung, Y., Kim, J., Shiozawa, Y., Wang, J., Mishra, A., Joseph, J., Berry, J., McGee, S., Lee, E., Sun, H.... (2013) Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nature Communications, 1795. DOI: 10.1038/ncomms2766
Researchers from the Wake Forest Baptist Medical Center (WFBMC) announced today that they may have unveiled some of the mechanisms involved in obesity, diabetes mellitus type 2, muscular dystrophy and other diseases associated with fat replacing muscle tissue, causing it to weaken and degenerate. Their findings have the potential to lead to new therapies for the aforementioned diseases, say the researchers.Read More... Read more »
Birbrair, A., Zhang, T., Wang, Z., Messi, M., Enikolopov, G., Mintz, A., & Delbono, O. (2013) Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation. Stem Cells and Development, 2147483647. DOI: 10.1089/scd.2012.0647
A team of bioengineers at Brigham and Women’s Hospital (BWH) is the first to report creating artificial heart tissue that closely mimics the functions of natural heart tissue through the use of human-based materials. Their work will advance how clinicians treat the damaging effects caused by heart disease, the leading cause of death in the United States.... Read more »
BWH Media Relations. (2013) Patterned Hearts . Brigham and Women's Hospital. info:/
Globus Pallidus Region of Brain Targeted in DBS in YellowIn a previous post, I summarized some of the highlights of a recent review of Parkinson's disease management by the German neurologists Pedrosa and Timmerman.The first post can be located here and was limited to the drug treatment of the motor symptoms of Parkinson's disease.In part II, I want to focus on deep brain stimulation and the treatment of non-motor symptoms.The authors of the review note the following key points regarding deep br........ Read more »
Researchers at the Yale School of Medicine have figured out how to measure an infant’s risk of developing autism by looking for abnormalities in his/her placenta at birth, allowing for earlier diagnosis and treatment for the developmental disorder.... Read more »
Karen N. Peart. (2013) Autism risk spotted at birth in abnormal placentas. Yale News. info:/
There are a lot of cancer database resources out there. Most of the ones we’ve focused on have been the data repository types. TCGA, ICGC, CaBIG, COSMIC, Cancer Genome Workbench, UCSC Cancer Genomic Browser, and of course big repositories like GEO. Researchers will need these sources of data to locate key alterations in cancer cells [...]... Read more »
Swanton, C. (2012) My Cancer Genome: a unified genomics and clinical trial portal. The Lancet Oncology, 13(7), 668-669. DOI: 10.1016/S1470-2045(12)70312-1
Yeh, P., Chen, H., Andrews, J., Naser, R., Pao, W., & Horn, L. (2013) DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): A Catalog of Clinically Relevant Cancer Mutations to Enable Genome-Directed Anticancer Therapy. Clinical Cancer Research, 19(7), 1894-1901. DOI: 10.1158/1078-0432.CCR-12-1894
Heart failure, when the heart is unable to pump blood adequately, affects more than 750,000 people in the UK, causing breathlessness and hindering day-to-day activities.
The therapy is designed to increase the levels of SERCA2a protein in heart muscle cells by using a harmless virus to insert extra genes into the cells.... Read more »
Sam Wong. (2013) New gene therapy could treat devastating heart failure. London Imperial College of London. info:/
by ebender in Daily Observations
Five psychological scientists, including four APS Fellows, are among the 84 new members and 21 foreign associates elected to the National Academy of Sciences, in recognition of their contributions and The post Four APS Fellows Elected to NAS appeared first on Association for Psychological Science.... Read more »
Aslin, R.N. (2012) Questioning the questions that have been asked about the infant brain using near-infrared spectroscopy. Cognitive Neuropsychology, 29(1-2), 7-33. PMID: 22329690
There are many thousands of poison plants, but not too many are venomous. The nettles and the dendrocnidaes have hollow spines that deliver neurotoxins when they stab you. Recent research has shown that nettle toxin is beneficial in liver regeneration. It stimulates cell proliferation and reduces apoptosis. In an opposite effect, the dendrocnidae toxin called moroidin is a mitotic spindle inhibitor. It may prove useful as an anticancer drug.... Read more »
Oguz, S., Kanter, M., Erboga, M., Toydemir, T., Sayhan, M., & Onur, H. (2013) Effects of Urtica dioica on oxidative stress, proliferation and apoptosis after partial hepatectomy in rats. Toxicology and Industrial Health. DOI: 10.1177/0748233713480211
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