The title of this post should also have included the word 'glutathione' too based on the results reported by Richard Frye and colleagues* (open-access) describing behavioural and biochemical data from a 3-month open trial of methylcobalamin, a vitamin B12 'vitamer', and folinic acid with a group of children diagnosed with an autism spectrum disorder (ASD).Dr Frye and his various research are no stranger to this blog; ranging from mitochondrial dysfunction linked to cases of autism (see here........ Read more »
Richard Frye, Stepan Melnyk, George Fuchs, Tyra Reid, Stefanie Jernigan, Oleksandra Pavliv, Amanda Hubanks, David W. Gaylor, Laura Walters, S. Jill James. (2013) Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status. Autism Research and Treatment. DOI: 10.1155/2013/609705
Overreaching endurance athletes may be more likely to develop abnormal sleep quality and quantity as well as upper respiratory infections.... Read more »
Hausswirth C, Louis J, Aubry A, Bonnet G, Duffield R, & Le Meur Y. (2013) Evidence of Disturbed Sleep and Increased Illness in Overreached Endurance Athletes. Medicine and Science in Sports and Exercise. PMID: 24091995
Researchers have found the reason for the increased chances of cancer caused by antioxidants and green tea drinkers should be very cautious in consuming tea.
About lung and skin cancer:
Lung cancer is the leading cause of cancer death in men and women in U.S. while skin cancer is found to have the highest incidence rate that is rising at an increment of 3% per year.
Antioxidants are the chemicals tha........ Read more »
Linda Y. Lu et al. (2013) Antioxidant Induces DNA Damage, Cell Death and Mutagenicity in Human Lung and Skin Normal Cells. Scientific Reports. DOI: 10.1038/srep03169
Illustration of parvalbumin-expressing interneurons delivering lifesaving chemical messengers to newborn neurons via tentacle-like synapses.A specialized type of brain cell that tamps down stem cell activity ironically, perhaps, encourages the survival of the stem cells' progeny, Johns Hopkins researchers report.Understanding how these new brain cells "decide" whether to live or die and how to behave is of special interest because changes in their activity are linked to neurodege........ Read more »
Juan Song, Jiaqi Sun, Jonathan Moss, Zhexing Wen, Gerald J Sun, Derek Hsu, Chun Zhong, Heydar Davoudi, Kimberly M Christian, Nicolas Toni, Guo-li Ming . (2013) Parvalbumin interneurons mediate neuronal circuitry–neurogenesis coupling in the adult hippocampus. Nature Neuroscience. DOI: 10.1038/nn.3572
A recent study by researchers at the Ostrow School of Dentistry of USC shows how changes in cell signaling can cause ordinary stem cells in the jaw to start forming benign but potentially harmful tumors.Principal investigator Songtao Shi, professor at the Ostrow School's Center for Craniofacial Molecular Biology, said that ossifying fibromas, the type of tumors they focused on in this study, are benign but can grow aggressively and cause progressive enlargement of the jaw.Read More... Read more »
Haiyan Qin, Cunye Qu, Takayoshi Yamaza, Ruili Yang, Xia Lin, Xue-Yan Duan, Kentaro Akiyama, Yi Liu, Qunzhou Zhang, Chider Chen, Yibu Chen, Hank Heng Qi, Xin-Hua Feng, Anh D. Le, Songtao Shi. (2013) Ossifying Fibroma Tumor Stem Cells Are Maintained by Epigenetic Regulation of a TSP1/TGF-β/SMAD3 Autocrine Loop. Cell Stem Cell. DOI: 10.1016/j.stem.2013.08.010
All aboard the nanotrain network
Tiny self-assembling transport networks, powered by nano-scale motors and controlled by DNA, have been developed by scientists at Oxford University and Warwick University.
The system can construct its own network of tracks spanning tens of micrometres in length, transport cargo across the network and even dismantle the tracks.___ The University of Oxford
Transport and self-organization across different length scales powered by m........ Read more »
Adam J. M. Wollman, Carlos Sanchez-Cano, Helen M. J. Carstairs, Robert A. Cross, & Andrew J. Turberfield. (2013) Transport and self-organization across different length scales powered by motor proteins and programmed by DNA. Nature Nanotechnology. DOI: 10.1038/nnano.2013.230
How zinc starves lethal bacteria to stop infection
“This work spans fields from chemistry and biochemistry to microbiology and immunology to see, at an atomic level of detail, how this transport protein is responsible for keeping the bacteria alive by scavenging one essential metal (manganese), but at the same time also makes the bacteria vulnerable to being killed by another metal (zinc),”
says Professor Bostjan Kobe, Professor of Structural Biology at The University of........ Read more »
Rafael M Couñago,, Miranda P Ween,, Stephanie L Begg,, Megha Bajaj,, Johannes Zuegg,, Megan L O'Mara,, Matthew A Cooper,, Alastair G McEwan,, James C Paton,, Bostjan Kobe,.... (2013) Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology. DOI: 10.1038/nchembio.1382
Human growth hormone stimulates collagen expression in skeletal muscle and tendon and abolishes the normal decline seen during inactivity and rehabilitation.
... Read more »
Boesen AP, Dideriksen K, Couppé C, Magnusson P, Schjerling P, Boesen M, Kjaer M, & Langberg H. (2013) Tendon and skeletal muscle matrix gene expression and functional responses to immobilisation and rehabilitation in young males: Effect of growth hormone administration. The Journal of Physiology. PMID: 24081158
What happens during the swing phase related to impact load?... Read more »
Anne Schmitz, Michael B. Pohl, Kaitlin Woods, Brian Noehren. (2013) Variables during swing associated with decreased impact peak and loading rate in running. Journal of Biomechanics. DOI: 10.1016/j.jbiomech.2013.10.026
We humans love a good story. We even love a bad story (evidence: Hollyoaks is still on television). We all have them; we all tell them. Storytelling is like magic, according to Esquire writer Chris Jones.
Can stories make us better too?... Read more »
Hartling L, Scott SD, Johnson DW, Bishop T, & Klassen TP. (2013) A randomized controlled trial of storytelling as a communication tool. PloS one, 8(10). PMID: 24204974
Last year the reputed science magazine Scientific American ranked Singapore as the world’s third most innovative country for biotechnology, beaten only by the United States and Denmark. The magazine's report cited government investment and a stable and predictable regulatory regime ..... Read more »
Axel Gelfert. (2013) Before Biopolis: Representations of the Biotechnology Discourse in Singapore. East Asian Science, Technology and Society , 7(1), 103-123. DOI: 10.1215/18752160-2075527
Scientists have developed a new way to regrow missing or damaged bones with the help of “Bio-Patch”.
The patch has been shown to nearly fully regrow missing skull, seen in the image above. (Image credit: Satheesh Elangovan/The University of Iowa)Scientists, in the present study, put DNA (having genetic information for a platelet-derived growth factor called PDGF-B) into nano-sized particles on a collagen platform on........ Read more »
Satheesh Elangovan et al. (2013) The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor. Biomaterials. DOI: 10.1016/j.biomaterials.2013.10.021
Researchers have found that “July effect” has nothing to do with mortality of low risk heart patients in teaching hospital.
New medical graduate (Copyright ReSurge International, Flickr.com)July effect:
July effect is found to be an increased risk of medical errors and surgical complications that may result in mortality. It is the time of year, when new medical school graduates start working and the others in the ........ Read more »
Anupam B. Jena et al. (2013) Mortality among High Risk Patients with Acute Myocardial Infarction Admitted to U.S. Teaching-Intensive Hospitals in July: A Retrospective Observational Study. Circulation. DOI: 10.1161/CIRCULATIONAHA.113.004074
Controlling the activty of specific neurons with light gives neuroscientists a new way to study neural circuitry and the interactions that shape movement behaviour and thought. ... Read more »
Zhang F, Wang LP, Brauner M, Liewald JF, Kay K, Watzke N, Wood PG, Bamberg E, Nagel G, Gottschalk A.... (2007) Multimodal fast optical interrogation of neural circuitry. Nature, 446(7136), 633-9. PMID: 17410168
I’m dreading the day I get knocked up, since I know that my incredibly low pain threshold will have trouble dealing with the crazy horror that is childbirth. That’s why I was overjoyed to hear of some new research from … Continue reading →... Read more »
Yang S, Xiao Y, Kang D, Liu J, Li Y, Undheim EA, Klint JK, Rong M, Lai R, & King GF. (2013) Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proceedings of the National Academy of Sciences of the United States of America, 110(43), 17534-9. PMID: 24082113
Breast cells with reduced mtDNA (right) became structurally disorganized compared to unmodified cells (left)For a long time now, researchers have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA. But, until now, no one was able to explain how this characteristic influenced disease progression.Today, researchers at the University of Pennsylvania have revealed how a reduction in mitochondrial DNA content le........ Read more »
Guha M, Srinivasan S, Ruthel G, Kashina AK, Carstens RP, Mendoza A, Khanna C, Van Winkle T, & Avadhani NG. (2013) Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells. Oncogene. PMID: 24186204
If there is anything we’ve learned over the many years of eating disorder research, it is that eating disorders are extremely complex. Often, this complexity is intensified by comorbidities, including post-traumatic stress disorder, depression, and “personality disorders.” Unfortunately, individuals whose disorders are labeled persistent, chronic, or “difficult to treat” may be even less likely to receive the treatment and support they require, deserve, and de........ Read more »
Federici A, & Wisniewski L. (2013) An intensive DBT program for patients with multidiagnostic eating disorder presentations: a case series analysis. The International Journal of Eating Disorders, 46(4), 322-31. PMID: 23381784
Whilst quite a lot of attention is currently being paid to the study by Warren Jones and Ami Klin* on 'Autism signs being present in first months of life' I'm heading off in a slightly different direction in this post. It's not that I don't find the possibility that the eyes may be more than just the windows to the soul, or at least "a decline in gazing at eyes [might] accurately predict the development of autism" an exciting prospect, it's just that I'm waiting for some more confirmatory eviden........ Read more »
Lv Wang, Claus T Christophersen, Michael J Sorich, Jacobus P Gerber, Manya T Angley, Michael A Conlon. (2013) Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder. Molecular Autism. DOI: 10.1186/2040-2392-4-42
George DaleyYoung animals are known to repair their tissues with little effort, but can this capacity be recaptured in adult individuals? A new study by researchers at the Stem Cell Program at Boston Children's Hospital suggests that it can.By reactivating a dormant gene called Lin28a, which is active in embryonic stem cells, researchers were able to regrow hair and repair cartilage, bone, skin and other soft tissues in a mouse model.The study also found that Lin28a promotes tissue repair in........ Read more »
Ng Shyh-Chang, Hao Zhu, T. Yvanka de Soysa, Gen Shinoda, Marc T. Seligson, Kaloyan M. Tsanov, Liem Nguyen, John M. Asara, Lewis C. Cantley, George Q. Daley. (2013) Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism. . Cell. DOI: 10.1016/j.cell.2013.09.059
Leonard ZonSkeletal muscle tissue has proved to be quite difficult to grow in patients with muscular dystrophy and other disorders that degrade and weaken muscle.Today, researchers at Boston Children's Hospital's Stem Cell Program reported that boosting muscle mass and reversing disease in a mouse model of Duchenne muscular dystrophy, using a "cocktail" of three compounds identified through a new rapid culture system.Adding the same compounds to induced pluripotent stem cells d........ Read more »
Cong Xu, Mohammadsharif Tabebordbar, Salvatore Iovino, Christie Ciarlo, Jingxia Liu, Alessandra Castiglioni, Emily Price, Min Liu, Elisabeth R. Barton, C. Ronald Kahn, Amy J. Wagers. (2013) A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species. Cell. DOI: 10.1016/j.cell.2013.10.023
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