An opinion piece by veteran psychiatrist and antidepressant drug researcher Sheldon Preskorn contains a remarkable historical note -“A dangerous idea!” That was the response after a presentation I gave to a small group of academic leaders with an interest in psychopharmacology [over 15 years ago].What evoked such a response? The acknowledgment that most currently available antidepressants specifically treat only one out of four patients with major depression based on the bulk of clinical tri........ Read more »
Preskorn SH. (2011) What Do the Terms "Drug-Specific Response/Remission Rate" and "Placebo" Really Mean?. Journal of psychiatric practice, 17(6), 420-424. PMID: 22108399
Therefore, Abdel et al. aimed to determine the absolute and relative number of myofibroblasts in contracting joint capsules over time and compared to the contralateral limb and a non-operative control animal.... Read more »
Abdel MP, Morrey ME, Barlow JD, Kreofsky CR, An KN, Steinmann SP, Morrey BF, & Sanchez-Sotelo J. (2011) Myofibroblast cells are preferentially expressed early in a rabbit model of joint contracture. Journal of Orthopaedic Research. PMID: 22057979
I have skeptical confession to make. I was once a panacea-seeking antioxidant-taker. As background, I’m a marathon runner and occasional triathlete. Several years ago, I was training for an Ironman triathlon, and banking 20+ hours of intense exercise per week. That may sound absurd to many (it does to me, now that I have kids) [...]
You might also like...Health Care in the Media goes Wylde! In all seriousness, people will probably get sick from this.
Coughs, colds, and the “appealing b........ Read more »
Peternelj TT, & Coombes JS. (2011) Antioxidant Supplementation during Exercise Training: Beneficial or Detrimental?. Sports medicine (Auckland, N.Z.), 41(12), 1043-69. PMID: 22060178
Scientists like to warn you not to talk about "the gene for" a particular disease or trait.I've done so in previous posts e.g. this one or this one.But such scalding is not always very effective. We like simple explanations, so we like to find simple connections between genes and phenotypes.Which is why a new paper is important. The authors, a large Turkish-American collaboration, found that mutations in a gene, WDR62, are associated with severe brain malformations in 9 patients. But what's inte........ Read more »
Bilgüvar K, Oztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoğlu D, Tüysüz B, Cağlayan AO, Gökben S.... (2010) Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Nature, 467(7312), 207-10. PMID: 20729831
I have been living with allergies for 26 years now...
And yet after all of that time, I still have so much to learn about why my body reacts so violently to watermelons, cats, and dust-mites...
But what causes this apparent 'march' from one type of allergy to the next? Why do children with symptoms of eczema often grow into additional allergy symptoms, including hayfever and asthma? ... Read more »
Paige K Brown. (2011) Atopy: Marching with allergies. Nature. info:/10.1038/479S14a
3D Image of Heart Using Echocardiography-Details BelowThe physical manifestations due to extreme weight loss in anorexia nervosa include effects on the heart.Cardiac effects can contribute to the risk of death in anorexia nervosa. Electrolytye abnormalities increase the risk of cardiac conduction defects and increase the risk of potentially fatal cardiac arrhythmias.One tool to study the effects of weight loss on the heart in anorexia nervosa is echocardiography. Echocardiography is ........ Read more »
Kastner S, Salbach-Andrae H, Renneberg B, Pfeiffer E, Lehmkuhl U, & Schmitz L. (2011) Echocardiographic findings in adolescents with anorexia nervosa at beginning of treatment and after weight recovery. European child . PMID: 22086424
Researchers from Japan explore the brain at rest and find that higher gray and white matter cerebral blood flow during rest is associated with intelligence and higher white matter cerebral blood flow is associated with creativity.... Read more »
Buckner RL, Andrews-Hanna JR, & Schacter DL. (2008) The brain's default network: anatomy, function, and relevance to disease. Annals of the New York Academy of Sciences, 1-38. PMID: 18400922
Takeuchi H, Taki Y, Hashizume H, Sassa Y, Nagase T, Nouchi R, & Kawashima R. (2011) Cerebral blood flow during rest associates with general intelligence and creativity. PloS one, 6(9). PMID: 21980485
A new study in mice shows such that nature has a way of replacing damaged or destroyed tissues in the body with stem cells. When a pregnant mouse has a heart attack, her fetus donates some of its stem cells to help rebuild the damaged heart tissue.... Read more »
Kara RJ, Bolli P, Karakikes I, Matsunaga I, Tripodi J, Tanweer O, Altman P, Shachter NS, Nakano A, Najfeld V.... (2011) Fetal Cells Traffic to Injured Maternal Myocardium and Undergo Cardiac Differentiation. Circulation research. PMID: 22082491
Antibiotic resistance is increasing worldwide. AvidBiotics is creating genetically-engineered Avidocin proteins as an alternative to antibiotics and has shown their potential efficacy in the prevention and treatment of serious bacterial infections such as E coli, which can have severe and fatal consequences, especially once resistance develops.... Read more »
Ritchie JM, Greenwich JL, Davis BM, Bronson RT, Gebhart D, Williams SR, Martin D, Scholl D, & Waldor MK. (2011) An Escherichia coli O157-Specific Engineered Pyocin Prevents and Ameliorates Infection by E. coli O157:H7 in an Animal Model of Diarrheal Disease. Antimicrobial agents and chemotherapy, 55(12), 5469-74. PMID: 21947394
herefore Clement and Shannon, completed a study to determine injured athlete’s perceptions regarding satisfaction, availability, and contribution for 8 types of social support (i.e., listening support, emotional support, emotional-challenges support, reality confirmation, task-appreciation support, task-challenge support, tangible support, and personal assistance) from coaches, athletic trainers, and teammates.... Read more »
Clement D, & Shannon VR. (2011) Injured athletes' perceptions about social support. Journal of Sport Rehabilitation, 20(4), 457-70. PMID: 22012499
Capsaicin, the active chemical in "pepper spray" appears to be lethal to individuals under the influence of certain stimulants with the majority of deaths reported occuring within one hour.... Read more »
Mendelson, J., Tolliver, B., Delucchi, K., Baggott, M., Flower, K., Harris, C., Galloway, G., & Berger, P. (2009) Capsaicin, an active ingredient in pepper sprays, increases the lethality of cocaine. Forensic Toxicology, 28(1), 33-37. DOI: 10.1007/s11419-009-0079-9
As usual, a Daily Mail article caught my attention with its first line, "A mummified elongated skull from Peru could finally prove the existence of aliens." The purpose of this kind of opener, of course, is to get people to read the tripe the Mail peddles. According to the article, "three anthropologists agree: it is not a human being." Well, if three unnamed Spanish and Russian anthropologists agree, then it must be an alien.
Alien? Uh, no. (Photo: The Nati........ Read more »
Biggs WS. (2003) Diagnosis and management of positional head deformity. American Family Physician, 67(9), 1953-6. PMID: 12751657
Gerszten PC, & Gerszten E. (1995) Intentional cranial deformation: a disappearing form of self-mutilation. Neurosurgery, 37(3), 374. PMID: 7501099
Sleep Stage Architecture Figure with REM Sleep in RedSleep contributes to brain function through a variety of mechanisms. Sleep functions change over the life cycle with older adults showing a greater amount of time in light sleep phases (stage 1 and stage 2 sleep). Less time is typically spent among older adults in restorative or deep sleep (slow-wave sleep) and rapid age movement sleep.Since dementia risk increases with age, it is natural to wonder how age-related sleep chang........ Read more »
Blackwell, T., Yaffe, K., Ancoli-Israel, S., Redline, S., Ensrud, K., Stefanick, M., Laffan, A., Stone, K., & , . (2011) Associations Between Sleep Architecture and Sleep-Disordered Breathing and Cognition in Older Community-Dwelling Men: The Osteoporotic Fractures in Men Sleep Study. Journal of the American Geriatrics Society. DOI: 10.1111/j.1532-5415.2011.03731.x
Angiogenesis inhibitors have seen a long and rather chequered history since Judah Folkman first propounded the concept that tumours grow by adding new blood vessels. Many of these inhibitors have ended up in the dog heaven scrap heap, so to … Continue reading →
... Read more »
Tobler, N. (2006) Tumor and lymph node lymphangiogenesis--impact on cancer metastasis. Journal of Leukocyte Biology, 80(4), 691-696. DOI: 10.1189/jlb.1105653
People who rely on protein-based drugs often have to endure IV hookups or frequent injections, sometimes several times a week. And protein drugs – like Factor VIII and Factor IX for patients with hemophilia, alpha interferon for hepatitis C, interferon beta for multiple sclerosis — are very expensive.
What if they could be made by people’s own bodies?
Combining tissue engineering with gene therapy, researchers at Children’s Hospital Boston showed that it’s pos........ Read more »
Fliesler, Nancy. (2011) Avoiding the needle: Engineering blood vessels to secrete drugs. Vector, A Children's Hospital Boston Blog. info:/
Mouse lemurs develop a disease that is strikingly similar to Alzheimer’s disease.
Advantages over current AD models:
- Short lifespan (6 – 8 yrs)
- Mimics sporadic AD
... Read more »
Languille, S., Blanc, S., Blin, O., Canale, C., Dal-Pan, A., Devau, G., Dhenain, M., Dorieux, O., Epelbaum, J., Gomez, D.... (2011) The grey mouse lemur: A non-human primate model for ageing studies. Ageing Research Reviews. DOI: 10.1016/j.arr.2011.07.001
Bons, N., Rieger, F., Prudhomme, D., Fisher, A., & Krause, K. (2006) Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease?. Genes, Brain and Behavior, 5(2), 120-130. DOI: 10.1111/j.1601-183X.2005.00149.x
Eva Peron, or Evita, is perhaps the most famous woman in Latin American history. As the wife of Argentinian leader Juan Peron she was immensely popular. But she died at the age of just 33 from cervical cancer, after a two year struggle with the disease.A new paper makes the startling claim that Eva Peron may have received a prefrontal lobotomy in the months before her death. The lobotomy is best known as a treatment for mental disorders such as schizophrenia, but according to Nijensohn et al, Pe........ Read more »
Nijensohn DE, Savastano LE, Kaplan AD, & Laws ER Jr. (2011) New Evidence of Prefrontal Lobotomy in the Last Months of the Illness of Eva Perón. World neurosurgery. PMID: 22079825
The goal of this investigation was to determine if any of the 4 typically utilized hop tests (single hop for distance, crossover hop for distance, triple hop for distance, or 6-m timed hop), which are used to provide objective measures of functional status, could predict knee reported function one-year post injury in 91 patients that elected nonoperative treatment (link to hop test descriptions). ... Read more »
Grindem H, Logerstedt D, Eitzen I, Moksnes H, Axe MJ, Snyder-Mackler L, Engebretsen L, & Risberg MA. (2011) Single-legged hop tests as predictors of self-reported knee function in nonoperatively treated individuals with anterior cruciate ligament injury. The American Journal of Sports Medicine, 39(11), 2347-54. PMID: 21828364
Last week I had an enjoyable time at the AACR-EORTC-NCI Molecular Targets meeting but gippy wifi in San Francisco followed by my blog hosting and RSS feed going haywire meant that reviews of the meeting were delayed until now. There … Continue reading →
... Read more »
Perez-Pinera, P., Garcia-Suarez, O., Menendez-Rodriguez, P., Mortimer, J., Chang, Y., Astudillo, A., & Deuel, T. (2007) The receptor protein tyrosine phosphatase (RPTP)β/ζ is expressed in different subtypes of human breast cancer. Biochemical and Biophysical Research Communications, 362(1), 5-10. DOI: 10.1016/j.bbrc.2007.06.050
Krishnan, C., Moline, S., Anders, K., & Warnke, R. (2009) Intravascular ALK-Positive Anaplastic Large-Cell Lymphoma Mimicking Inflammatory Breast Carcinoma. Journal of Clinical Oncology, 27(15), 2563-2565. DOI: 10.1200/JCO.2008.20.3984
Basal Ganglia Including Substantia Nigra Key In Parkinson's DiseaseEarly identification of neurodegenerative disorders plays a key role in prompt intervention and surveillance. A great deal of research is being conducted in the early identification of Alzheimer's disease. Less attention has been placed on early identification of Parkinson's disease. Early Parkinson's disease identification may be more valuable given the spectrum of pharmacological options for treatment.One clinical f........ Read more »
Rolheiser TM, Fulton HG, Good KP, Fisk JD, McKelvey JR, Scherfler C, Khan NM, Leslie RA, & Robertson HA. (2011) Diffusion tensor imaging and olfactory identification testing in early-stage Parkinson's disease. Journal of neurology, 258(7), 1254-60. PMID: 21287185
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