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  • January 31, 2012
  • 05:36 AM

Neil harbisson, the world's first cyborg.

by United Academics in United Academics

Neil Harbisson, aged 29, considers himself a cyborg. Affected from birth by achromatopsia, he is unable to perceive colours, just black and white. Since 2004, he wears an eyeborg, a device that allows him to recognize colours through sound waves... Read more »

Warwick, K. (2011) Future Issues with Robots and Cyborgs. Studies in Ethics, Law, and Technology, 4(3). DOI: 10.2202/1941-6008.1127  

  • January 31, 2012
  • 12:08 AM

Social Interactions may Influence Inflammation

by Jeffrey B. Driban in Sports Medicine Research (SMR): In the Lab & In the Field

Chiang et al evaluated if daily social interactions among 122 healthy young adults to determine if these interactions relate to systematic concentrations of proinflammatory mediators (measured via oral collection) at rest and after acute stress. Social interactions were classified into 3 categories: negative (e.g., conflict with another person), competitive (e.g., competing for attention, academic competition, games) and positive (e.g., time with friends, support from partner) daily interactions........ Read more »

  • January 30, 2012
  • 11:57 PM

Taking back Epigenetics

by zacharoo in Lawn Chair Anthropology

If I'm good at anything, it's looking into one topic and then getting distracted by something else during my search. In a recent case, I was scouring the literature on growth and life history. One ribald thing led to another, and next thing I know I've stumbled upon Gunter Wagner's recent review of the book Epigenetics: Linking Genotype and Phenotype in Development and Evolution. WTF is epigenetics, you ask? That's actually a pretty good question (see here). In the past ........ Read more »

  • January 30, 2012
  • 08:36 PM

3D look at protein family with a long Sanford-Burnham history

by Sanford- Burnham in Beaker

Structural biologists Stefan Riedl, Ph.D. and Peter Mace, Ph.D. recently answered several perplexing questions about the Cas proteins--a family of cancer-related proteins that's long been studied at Sanford-Burnham.... Read more »

Mace PD, Wallez Y, Dobaczewska MK, Lee JJ, Robinson H, Pasquale EB, & Riedl SJ. (2011) NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural , 18(12), 1381-7. PMID: 22081014  

  • January 30, 2012
  • 11:35 AM

Childhood Pneumonia – What’s the Problem?

by Jason in Views From Beyond the OR

An article caught my eye in last week’s Lancet. Soofi and colleagues conducted a cluster-randomised controlled trial of community case management of severe pneumonia in children aged 2-59 months in a rural district of Pakistan to try and understand how … Continue reading →... Read more »

  • January 30, 2012
  • 08:11 AM

The wondrous mitochondrion and its proteome

by EE Giorgi in CHIMERAS

The sequencing of human mitochondrial DNA, a circular DNA molecule contained in mitochondria, was completed in 1981, and, since then, roughly 150 mutations have been found that are associated with maternally inherited diseases (if you don't remember why mtDNA is inherited from the mother and not the father, check out this earlier post of mine). Despite this, the majority of human mitochondrial syndromes are actually caused by defects in the nuclear genome. This is sort of obvious if you think ab........ Read more »

Calvo, S., & Mootha, V. (2010) The Mitochondrial Proteome and Human Disease. Annual Review of Genomics and Human Genetics, 11(1), 25-44. DOI: 10.1146/annurev-genom-082509-141720  

  • January 30, 2012
  • 07:33 AM

Absence of evidence is, er, well, absence of evidence — even for agrobiodiversity and health

by Jeremy in Agricultural Biodiversity Weblog

It has been a bit of a rough week for people who prefer their grand policy pronouncements backed with a teeny bit of evidence. Like us. Two big papers, in important journals, have concluded that there is very little evidence that agriculturally improving dietary diversity feeds into better nutrition and health. In the British Medical [...]... Read more »

  • January 30, 2012
  • 05:33 AM

Do we really need a new measles vaccine?

by Connor Bamford in The Rule of 6ix

Measles, that deadly childhood infectious disease is almost a distant memory to most people nowadays, that is except for a few isolated outbreaks across the US and Europe. This is all because of a really amazing preventative therapy: the vaccine.

Vaccines are great. They are by far the most effective means that we have to control - and hopefully eradicate - infectious diseases from a range of species. Measles is one of these diseases that, over the last half a decade or so, we have backed........ Read more »

  • January 30, 2012
  • 02:05 AM

Mutations linked to aggressive childhood brain tumours

by Suzanne Elvidge in Genome Engineering

Diffuse intrinsic pontine glioma (DIPG) is a rare and lethal childhood brain cancer, and researchers taking part in the Pediatric Cancer Genome Project (PCGP) have found a link with a gene not previously connected with cancer, in a paper published in Nature Genetics.... Read more »

  • January 30, 2012
  • 12:04 AM

Accelerated versus Nonaccelerated Rehabilitation after ACL Reconstruction

by Jeffrey B. Driban in Sports Medicine Research (SMR): In the Lab & In the Field

The purpose of this paper was to describe the influence of 2 rehabilitation programs (19-week accelerated or 32-week nonaccelerated) after a bone-patellar tendon-bone autograft reconstruction on 6-degrees of freedom laxity values (instead of the previous trial which only evaluated anterior-posterior laxity).... Read more »

  • January 29, 2012
  • 03:31 PM

8 Tips for Developing Preventive Interventions for Children Exposed to Acute Medical Events

by Eva Alisic in Trauma Recovery

As a field, we have made significant progress in developing models and identifying key risk factors associated with the development of post-traumatic stress disorder (PTSD) in children who experience acute medical traumatic events. Additionally, we have given much attention to the evaluation of preventive interventions. However, a standard process for the development of preventive interventions is less clear.
... Read more »

Kazak AE, Kassam-Adams N, Schneider S, Zelikovsky N, Alderfer MA, & Rourke M. (2006) An integrative model of pediatric medical traumatic stress. Journal of pediatric psychology, 31(4), 343-55. PMID: 16093522  

  • January 29, 2012
  • 02:46 PM

Reading the mind’s eye: Online detection of visuo-spatial working memory and visual imagery in the inferior temporal lobe

by Julien Colomb in neuro JC

Posted on behalf of Jaime Martinez:
The authors of the present work studied the extent to which visual brain regions participate in non-sensory cognitive processes of visual representation. To this end, they evaluated the role of ventral visual pathway areas in visual imagery and working memory by analyzing intracerebral EEG recordings from the left inferior temporal [...]... Read more »

  • January 29, 2012
  • 03:28 AM

2011 Orwellian Prize for Journalistic Misrepresentation

by Dorothy Bishop in bishopblog

The Orwellian Prize was set up to identify bad science journalism. The winner for 2011 contains a spectacular number of errors in reporting on a paper about cannabinoid receptors in rats.... Read more »

  • January 29, 2012
  • 01:56 AM

Drunken Escape Fuels Much Male Suicide

by ultimo167 in Strong Silent Types

Many men who commit suicide could be described as impulsive and in terms of what they seemingly, actually responded to, over the top. Shniedman (1993)called it 'psychache'. Here, Coleman et al. (2011) draw from Baumeister's 'escape theory' to jam together impulsivity, alcohol misuse and lots and lots of anger to conclude that many suicidal men get stuck on a thought, that is, the thought that they must die. Supposedly, this painted into a bad corner montage was inspired ........ Read more »

Coleman, D., Kaplan, M., & Casey, J. (2011) The Social Nature of Male Suicide: A New Analytic Model. International Journal of Men's Health, 10(3), 240-252. DOI: 10.3149/jmh.1003.240  

  • January 28, 2012
  • 05:38 PM

Epidemiology of Brain Cancer

by William Yates, M.D. in Brain Posts

A recent summary of the trends in cancer highlighted the epidemiology of brain and other nervous system tumors.  In the United States, 213,500 brain and other nervous system tumors were diagnosed during the four year period from 2004 through 2007.Brain and other nervous systems (ONS) tumors rank fourteenth in the top 15 cancers for men and fifteenth in the top 15 cancers for women in the United States.Overall rates for brain and ONS tumors during this period were 22.37 per 100,000 for men a........ Read more »

Kohler, B., Ward, E., McCarthy, B., Schymura, M., Ries, L., Eheman, C., Jemal, A., Anderson, R., Ajani, U., & Edwards, B. (2011) Annual Report to the Nation on the Status of Cancer, 1975-2007, Featuring Tumors of the Brain and Other Nervous System. JNCI Journal of the National Cancer Institute, 103(9), 714-736. DOI: 10.1093/jnci/djr077  

  • January 27, 2012
  • 07:00 PM

Magic Mushrooms Found to Be Therapeutic

by United Academics in United Academics

As it turns out, magic mushrooms don’t actually expand your brain, they contract it. But that’s not a bad thing. In fact, two new studies from the UK have revealed that psilocybin, the active ingredient found in magic mushrooms, could actually help treat depression... Read more »

Carhart-Harris, R., Erritzoe, D., Williams, T., Stone, J., Reed, L., Colasanti, A., Tyacke, R., Leech, R., Malizia, A., Murphy, K.... (2012) Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1119598109  

  • January 27, 2012
  • 01:50 PM

Forensics to the Rescue: Prosecuting Endangered Snake Poachers

by Arielle D. Ross in Salamander Hours

This week, I was lucky enough to handle a few live Ontario snakes during my herpetology course. This was quite a treat for me because, for as long as I can remember, I have held a fierce fascination for all … Continue reading →... Read more »

Singh, C., Gaur, A., Sreenivas, A., & Singh, L. (2012) Species Identification from Dried Snake Venom*. Journal of Forensic Sciences. DOI: 10.1111/j.1556-4029.2011.02049.x  

  • January 27, 2012
  • 11:15 AM

The Whole Enchilada: New Method for High-Res Brain Images

by Karen Kreeger in Penn Medicine News Blog

Magnetic resonance imaging (MRI) provides exquisite structural detail of the brain, for example, to detect tumors or relative size of regions. However, current MRI methods are not capable of imaging the distribution of neurotransmitters – the brain’s chemical messengers -- across the whole brain. A new Nature Medicine paper out this week from Perelman School of Medicine researchers led by Ravinder Reddy, PhD, professor of Radiology, describes a first-of-its-kind MRI technique (GluCEST) to me........ Read more »

Cai, K., Haris, M., Singh, A., Kogan, F., Greenberg, J., Hariharan, H., Detre, J., & Reddy, R. (2012) Magnetic resonance imaging of glutamate. Nature Medicine. DOI: 10.1038/nm.2615  

  • January 27, 2012
  • 10:10 AM

Oxford University Censor First Broadcast of Lecture That Resulted in Censuring of Prof. Nutt, Former UK Government Drugs Advisor

by Neurobonkers in Neurobonkers

Watch the full video of the lecture and uncover what was in the slides censored for "copyright reasons"... Read more »

Nutt, D. (2009) Estimating drug harms: a risky business?. Centre for Crime and Justice Studies. info:/

Halpern JH, Sherwood AR, Hudson JI, Gruber S, Kozin D, & Pope HG Jr. (2011) Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs. Addiction (Abingdon, England), 106(4), 777-86. PMID: 21205042  

Carhart-Harris, R., Erritzoe, D., Williams, T., Stone, J., Reed, L., Colasanti, A., Tyacke, R., Leech, R., Malizia, A., Murphy, K.... (2012) Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1119598109  

Editorial team. (2010) The EMCDDA annual report 2010: the state of the drugs problem in Europe. The European Monitoring Centre for Drugs and Drug Addiction, also published in Euro surveillance :European communicable disease bulletin, 15(46). PMID: 21144426  

  • January 26, 2012
  • 11:25 PM

Speed Matters: Human Genome Sequencing with a Nano-Mechanical Twist

by Paige Brown in From The Lab Bench

Imagine genome sequencing technologies that approach the speed of that seen in the movies, in the futuristic film GATTACA, for example. In the future, a person need only wait a few minutes for important information to be retrieved from their genes for purposes of medical diagnosing and disease prevention. Nanotechnology, the science and technology of objects in the range of 1 billionth of a meter, may be just the key to upping the ante in DNA sequencing speed and accessible personalized medicine........ Read more »

Jiahao Wu, Rattikan Chantiwas,, & Alborz Amirsadeghi, Steven A. Soper, Sunggook Park. (2011) Complete plastic nanofluidic devices for DNA analysis via direct imprinting with polymer stamps. Lab on a Chip, 2984. info:/

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