Enhancing Running Performance by Coupling Cadence with the Right Beats... Read more »
ood RJ, Nijssen M, van der Kamp J, Roerdink M. (2013) The Power of Auditory-Motor Synchronization in Sports: Enhancing Running Performance by Coupling Cadence with the Right Beats . PLoS ONE. DOI: 10.1371/journal.pone.0070758
It is a long held belief that healthy brain cells, once damaged by radiation designed to kill brain tumours, cannot regenerate.However, a new study on mice by researchers at Johns Hopkins indicates that neural stem cells, from which new brain cells are created, are resistant to radiation, and can be roused from a hibernation-like state to reproduce and generate new cells able to migrate, replace injured cells and potentially restore lost function.Read More... Read more »
Vivian Capilla-Gonzalez1, Hugo Guerrero-Cazares1, Janice M. Bonsu1, Oscar Gonzalez-Perez2, Pragathi Achanta1, John Wong3, Jose Manuel Garcia-Verdugo4, Alfredo Quiñones-Hinojosa1,*. (2013) The Subventricular Zone is Able to Respond to a Demyelinating Lesion after Localized Radiation. Stem Cells. DOI: 10.1002/stem.1519
Neuroblastoma in a 2 year oldA missing gene required for stem cells in the brain to turn into neurons may underlie the most severe forms of neuroblastoma, a deadly childhood cancer of the nervous system, according to a Ludwig Cancer Research study that was published in Developmental Cell. The findings may also provide clues about how to improve the treatment of this often-deadly tumour.Neuroblastoma can appear in nervous tissue in the abdomen, chest and spine, among other regions of the body, an........ Read more »
Chris M. Egan, Ulrika Nyman, Julie Skotte, Gundula Streubel, Siobhán Turner, David J. O’Connell, Vilma Rraklli, Michael J. Dolan, Naomi Chadderton, Klaus Hansen, Gwyneth Jane Farrar, Kristian Helin, Johan Holmberg, Adrian P. Bracken. (2013) CHD5 Is Required for Neurogenesis and Has a Dual Role in Facilitating Gene Expression and Polycomb Gene Repression. Developmental Cell. DOI: 10.1016/j.devcel.2013.07.008
Some people are born football players, others are made for basketball: Yi Zhang, PhD, reaches often for this metaphor as he explains his research with stem cell differentiation, recently published in Stem Cell Reports. Stem cells are well-known for their ability to differentiate, or transform, into different types of cells. Two types of stem cells—embryonic [...]... Read more »
Wei Jiang, Donghui Zhang, Nenad Bursac and Yi Zhang. (2014) WNT3 Is a Biomarker Capable of Predicting the Definitive Endoderm Differentiation Potential of hESCs. Stem Cell Reports. DOI: 10.1016/j.stemcr.2013.03.003
In a new study, researchers at the Memorial Sloan-Kettering Cancer Centre have shown how stem cell technology can be used to mass-produce cancer-killing immune cells designed to target different kinds of cancers and tumours, with their research opening up the prospect of immunotherapy treatments that may one day help a lot of patients.In theory cancer can be tackled by elements of the body's own immune defences, especially white blood cells called T-cells.Read More... Read more »
Maria Themeli, Christopher C Kloss, Giovanni Ciriello, Victor D Fedorov, Fabiana Perna, Mithat Gonen . (2013) Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy. Nature Biotechnology. DOI: 10.1038/nbt.2678
Ten years ago, gene expression seemed to be relatively straightforward: genes were either switched on or off. Not both. Then in 2006, a blockbuster finding reported that developmentally regulated genes in mouse embryonic stem cells can have marks associated with both active and repressed genes, and that such genes, which were referred to as "bivalently marked genes," can be committed to one way or another during development and differentiation.This paradoxical state -- similar to figur........ Read more »
Deqing Hu, Alexander S Garruss, Xin Gao, Marc A Morgan, Malcolm Cook, Edwin R Smith, Ali Shilatifard. (2013) The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells. Nature Structural . DOI: 10.1038/nsmb.2653
Researchers have found that endophytes having mutualistic relationship with Digitalis lanata (foxglove) can be used as a novel source of digoxin.
Endophytes are the microorganisms living inside another plant, i.e. host plant. They usually have a mutualistic relationship, i.e. advantageous relationship, with the host plant.
They are beneficial for the host plant by either giving them protection from a variety of s........ Read more »
Sanjana Kaul, Maroof Ahmed, Khalid Zargar, Pooja Sharma, Manoj K. Dhar. (2013) Prospecting endophytic fungal assemblage of Digitalis lanata Ehrh. (foxglove) as a novel source of digoxin: a cardiac glycoside. 3 Biotech. DOI: 10.1007/s13205-012-0106-0
Migraine headaches are recurrent, painful and debilitating headaches. Estimates from the World Health Organization (WHO) suggest that ~47% of the world’s adult population suffers from headaches. Women are more prone to migraine attacks as compared to men.... Read more »
Cucchiara, B, Wolf, RL, Nagae, L, Zhang, Q, Kasner, S, Datta, R, Aguirre, GK, & Detre, JA. (2013) Migraine with Aura Is Associated with an Incomplete Circle of Willis: Results of a Prospective Observational Study. PLoS ONE. DOI: 10.1371/journal.pone.0071007
Take Home Message: Elevated body mass index and percent body fat predict for the presence of several cardiovascular risk factors for metabolic syndrome in college and high school football players. Increased activity levels in these athletes does not necessarily protect against these risk factors.... Read more »
Steffes GD, Megura AE, Adams J, Claytor RP, Ward RM, Horn TS, & Potteiger JA. (2013) Prevalence of Metabolic Syndrome Risk Factors in High School and NCAA Division I Football Players. Journal of Strength and Conditioning Research, 27(7), 1749-57. PMID: 22996023
The day before the child’s death was not a pleasant one, because it was not a sudden injury that killed the 10-13 year old child who was buried in the medieval town of Ribe in Denmark 800 years ago. The day before death was full of suffering because the child had been given a large dose of mercury in an attempt to cure a severe illness.... Read more »
Birgitte Svennevig. (2013) The day before death: A new archaeological technique gives insight into the day before death. Eurekalert. info:/
Grounding: Going barefoot to prevent cardiovascular disease!... Read more »
Chevalier G, Sinatra ST, Oschman JL, & Delany RM. (2013) Earthing (grounding) the human body reduces blood viscosity-a major factor in cardiovascular disease. Journal of alternative and complementary medicine (New York, N.Y.), 19(2), 102-10. PMID: 22757749
Although now only available to subscribers, a short while back I was very peripherally involved in helping to write an article on the science of lipidomics (see here). The crux of that overview article was that the science of biological lipids - lipidomics (yes, another one of those -omics) - is really starting to make some waves when it comes to health and wellbeing. Also that one should not be too hasty in making snap judgements about fats; not all fats are equal and without the........ Read more »
Montgomery P, Burton JR, Sewell RP, Spreckelsen TF, & Richardson AJ. (2013) Low Blood Long Chain Omega-3 Fatty Acids in UK Children Are Associated with Poor Cognitive Performance and Behavior: A Cross-Sectional Analysis from the DOLAB Study. PloS one, 8(6). PMID: 23826114
Kissing is the second most common form of physical intimacy among United States adolescents (after holding hands), and that about 85% of 15 to 16-year-old adolescents in the US have experienced it. Kissing another person's lips has become a common expression of affection in many cultures worldwide. Being stereotype, its our nature to classify each and everything thing around us. So as “Kissing” into First Kiss, Last Kiss, Best Kiss and Worst Kiss and so on. Well, I am not going to talk........ Read more »
Halpern CT, Joyner K, Udry JR, & Suchindran C. (2000) Smart teens don't have sex (or kiss much either). The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 26(3), 213-25. PMID: 10706169
Rashid H, & Booy R. (2012) Passive smoking, invasive meningococcal disease and preventive measures: a commentary. BMC medicine, 160. PMID: 23228079
Coen PG, Tully J, Stuart JM, Ashby D, Viner RM, & Booy R. (2006) Is it exposure to cigarette smoke or to smokers which increases the risk of meningococcal disease in teenagers?. International journal of epidemiology, 35(2), 330-6. PMID: 16394119
Researchers have found that furazolidone - an antibacterial drug - can effectively be used for the treatment of acute myeloid leukemia (AML), i.e. a form of cancer.
Acute myeloid leukemia (AML):
AML is the cancer of myeloid line of blood cells i.e. blood cells related to or derived from bone marrow or the spinal cord. This cancer especially affects white blood cells called as myeloid cells and progresses rapidly.
Bone marrow a........ Read more »
Xueqing Jiang, Lin Sun, Jihui Julia Qiu, Xiujing Sun, Sen Li, Xiyin Wang, Chi Wai Eric So, Shuo Dong mail. (2013) A Novel Application of Furazolidone: Anti-Leukemic Activity in Acute Myeloid Leukemia. PLoS ONE. DOI: 10.1371/journal.pone.0072335
Life is so unfair. Trying to give up something you’re addicted to just makes you crave that thing even more, whether it’s cigarettes, alcohol or sugar. You’re caught in a Catch-22: you want to quit, but the more you try, the harder it gets to resist temptation. Perhaps the key is not to try so […]... Read more »
Yi-Yuan Tang, Rongxiang Tang, & Michael I. Posner. (2013) Brief meditation training induces smoking reduction. PNAS. DOI: 10.1073/pnas.1311887110
Foot Pronation and Leg Length Differences... Read more »
Bloedel PK, & Hauger B. (1995) The effects of limb length discrepancy on subtalar joint kinematics during running. The Journal of orthopaedic and sports physical therapy, 22(2), 60-4. PMID: 7581432
Cholecystokinin (CCK) is a digestive hormone that stimulates fat and protein digestion, and promotes the feeling of satiety. CCK is released after food consumption to promote digestion (by releasing digestive enzymes from the pancreas and stimulating bile secretion). In rats and monkeys, injection of CCK induces satiety, though it seems (from what I’ve skimmed), the extent to which CCK regulates food intake in humans is not well-established. Previous research on the role of CCK in a........ Read more »
Cuntz U, Enck P, Frühauf E, Lehnert P, Riepl RL, Fichter MM, & Otto B. (2013) Cholecystokinin revisited: CCK and the hunger trap in anorexia nervosa. PloS ONE, 8(1). PMID: 23349895
It was ten years ago whenscientists announced the end of the Human Genome Project, an international attempt to learn which combination of four nucleotides -- adenine, thymine, cytosine, and guanine -- is unique to the homo sapiens DNA. This biological alphabet helped scientists identify the approximately 25,000 genes coded in the human genome, but as time went on, questions arose about how all of these genes are controlled.Today, Harvard Stem Cell Institute Principal Faculty member Alexander Mei........ Read more »
Michael J. Ziller, Hongcang Gu, Fabian Müller, Julie Donaghey, Linus T.-Y. Tsai, Oliver Kohlbacher, Philip L. De Jager, Evan D. Rosen, David A. Bennett, Bradley E. Bernstein, Andreas Gnirke, Alexander Meissner. (2013) Charting a dynamic DNA methylation landscape of the human genome. Nature. DOI: 10.1038/nature12433
Joint contact loading in forefoot and rearfoot strike patterns during running... Read more »
Rooney BD, & Derrick TR. (2013) Joint contact loading in forefoot and rearfoot strike patterns during running. Journal of biomechanics. PMID: 23910541
A team of scientists from the Indiana University, the University of Michigan, the Fred Hutchinson Cancer Research Center and the Dana-Farber Cancer Institute have identified and validated a biomarker accessible in blood tests that could be used to predict which stem cell transplant patients are at highest risk for a potentially fatal immune response (graft-versus-host disease).Although transplant specialists have been able to reduce its impact, graft-versus-host disease still remains a leading c........ Read more »
Mark T. Vander Lugt, Thomas M. Braun, Samir Hanash, Jerome Ritz, Vincent T. Ho, Joseph H. Antin, Qing Zhang, Chee-Hong Wong, Hong Wang, Alice Chin, Aurélie Gomez, Andrew C. Harris, John E. Levine, Sung W. Choi, Daniel Couriel, Pavan Reddy, James L.M. Fer. (2013) ST2 as a Marker for Risk of Therapy-Resistant Graft-versus-Host Disease and Death. New England Journal of Medicine. DOI: 10.1056/NEJMoa1213299
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