A recent paper found higher rates of autism diagnoses in Eindhoven compared to 2 other cities in the Netherlands, and suggested this related to hyper-systemizing in parents in the IT industry. Analogous data from the UK suggest that such diagnostic data may be too inconsistent to give meaningful prevalence comparisons.... Read more »
Roelfsema, M., Hoekstra, R., Allison, C., Wheelwright, S., Brayne, C., Matthews, F., & Baron-Cohen, S. (2011) Are Autism Spectrum Conditions More Prevalent in an Information-Technology Region? A School-Based Study of Three Regions in the Netherlands. Journal of Autism and Developmental Disorders. DOI: 10.1007/s10803-011-1302-1
Risks and benefits of a gun in the home From American Journal of Lifestyle Medicine Despite the fact that nearly one-third of American households have a firearm, studies show that having a gun in the home poses a household a greater health risk than a potential benefit. This study examined scientific research on both sides [...]... Read more »
More people are surviving cancer than ever before. Thanks to decades of research, survival from cancer has doubled in the last 40 years, giving thousands of people more time with their loved ones. But this progress simply wouldn’t have been possible without animal research. At Cancer Research UK, research using animals is an unavoidable part [...]... Read more »
Chinwalla, A., Cook, L., Delehaunty, K., Fewell, G., Fulton, L., Fulton, R., Graves, T., Hillier, L., Mardis, E., McPherson, J.... (2002) Initial sequencing and comparative analysis of the mouse genome. Nature, 420(6915), 520-562. DOI: 10.1038/nature01262
KÖHLER, G., & MILSTEIN, C. (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 256(5517), 495-497. DOI: 10.1038/256495a0
Gambacorti-Passerini C, Antolini L, Mahon FX, Guilhot F, Deininger M, Fava C, Nagler A, Della Casa CM, Morra E, Abruzzese E.... (2011) Multicenter independent assessment of outcomes in chronic myeloid leukemia patients treated with imatinib. Journal of the National Cancer Institute, 103(7), 553-61. PMID: 21422402
Druker, B., Tamura, S., Buchdunger, E., Ohno, S., Segal, G., Fanning, S., Zimmermann, J., & Lydon, N. (1996) Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells. Nature Medicine, 2(5), 561-566. DOI: 10.1038/nm0596-561
Kerbl DC, McDougall EM, Clayman RV, & Mucksavage P. (2011) A history and evolution of laparoscopic nephrectomy: perspectives from the past and future directions in the surgical management of renal tumors. The Journal of urology, 185(3), 1150-4. PMID: 21255799
If going on a diet or starting an exercise program resulted in persistent weight loss, we would not have an obesity epidemic.
Unfortunately, as anyone who has tried this knows, maintaining a significant degree of weight loss requires daily dedication, motivation and a limitless supply of will power - nothing short of developing a compulsive obsession.
As [...]... Read more »
Maclean PS, Bergouignan A, Cornier MA, & Jackman MR. (2011) Biology's Response to Dieting: the Impetus for Weight Regain. American journal of physiology. Regulatory, integrative and comparative physiology. PMID: 21677272
Since 2000, there has been a massive flow of funding from the West into health care in developing African countries. Some of this has come from governmental sources in response to G8 initiatives such as the 2000 Millenium Fund and a significant amount has come from charitable organizations. One of the largest of these, the Bill [...]... Read more »
Kickbusch, I. (2004) From charity to rights: proposal for five action areas of global health. Journal of Epidemiology , 58(8), 630-631. DOI: 10.1136/jech.2004.021121
Muntaner C, Sridharan S, Solar O, & Benach J. (2009) Against unjust global distribution of power and money: the report of the WHO commission on the social determinants of health: global inequality and the future of public health policy. Journal of public health policy, 30(2), 163-75. PMID: 19597448
Last week’s post on FGFR1 mutations in squamous cell lung cancer and the new EGFR/ALK combination agent, AP26113 (Ariad) drew a lot of attention from readers, with many writing in for more details or correctly suggesting an update in squamous … Continue reading →
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Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, Ou SH, Dezube BJ, Jänne PA, Costa DB.... (2010) Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. The New England journal of medicine, 363(18), 1693-703. PMID: 20979469
Right off the top let me say I'm not well versed enough in statistics to know who's right.On one side of the fence are the findings of Christakis and Fowler, famously published in the New England Journal of Medicine that posited obesity is socially contagious. Non-statistically, their paper didn't sit right with me, but as far as stats go, I'm no maven.On the other side of the fence is a new paper published by Russel Lyons who posits that Christakis' and Fowler's work is a great example of stat........ Read more »
Lyons, R. (2011) The Spread of Evidence-Poor Medicine via Flawed Social-Network Analysis. Statistics, Politics, and Policy, 2(1). DOI: 10.2202/2151-7509.1024
Summarizes the discovery of HIV as described by Francoise Barre-Sinnousi (1) as part of the CDC's HIV/AIDS 30 year anniversary lecture series and (2) in her initial HIV isolation publication in Science.... Read more »
Barré-Sinoussi, F. (2010) HIV: A discovery opening the road to novel scientific knowledge and global health improvement☆. Virology, 397(2), 255-259. DOI: 10.1016/j.virol.2009.08.033
Barre-Sinoussi, F., Chermann, J., Rey, F., Nugeyre, M., Chamaret, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vezinet-Brun, F., Rouzioux, C.... (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science, 220(4599), 868-871. DOI: 10.1126/science.6189183
The theme of the Upcoming Grand Rounds held at June 21th (1st day of the Summer) at Shrink Rap is “hot”. A bit far-fetched, but aah you know….shrinks“. Of course they hope assume that we will express Weiner-like exhibitionism at our blogs. Or go into spicy details of hot sexpectations or other Penis Friday NCBI-ROFL posts. But no, not me, [...]... Read more »
Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, & Brown J. (2007) Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database of Systematic Reviews. info:/10.1002/14651858.CD001395.pub3.
Bolaños R, Del Castillo A, & Francia J. (2010) Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and meta-analysis. Menopause (New York, N.Y.), 17(3), 660-6. PMID: 20464785
I bring to your attention a case report of a patient who received an accidental overdose of 2 liters intravenous lipid infusion and apparently suffered no ill cardiac effects. That is, the patient received fat directly into the blood stream in a quantity equal to a family-sized bottle of soda and didn't have a "heart attack."Just as certain medications bind to proteins, which binding in the blood stream changes their availability to other tissues, certain medications have an affinity for lipids........ Read more »
West, P., Mckeown, N., & Hendrickson, R. (2010) Iatrogenic lipid emulsion overdose in a case of amlodipine poisoning. Clinical Toxicology, 48(4), 393-396. DOI: 10.3109/15563651003670843
Dix, S., Rosner, G., Nayar, M., Harris, J., Guglin, M., Winterfield, J., Xiong, Z., & Mudge, G. (2011) Intractable cardiac arrest due to lidocaine toxicity successfully resuscitated with lipid emulsion*. Critical Care Medicine, 39(4), 872-874. DOI: 10.1097/CCM.0b013e318208eddf
Smollin, C. (2010) Toxicology: Pearls and Pitfalls in the Use of Antidotes. Emergency Medicine Clinics of North America, 28(1), 149-161. DOI: 10.1016/j.emc.2009.09.009
Coverage of a recent conference on Medical Imaging in St. Louis. Not only are we increasingly being able to image the intricate inner workings of the human body, but we are beginning also to use medical imaging as a tool to monitor disease treatment and even to design and implement new drugs in the treatment of diseases such as cancer. ... Read more »
Every day on the way back from work I walk next to this wall. The other day there were plenty of cannibal Harlequin ladybird larvae eating prepupae. Today there were many more pupae and a few prepupae. I have no idea how I noticed this tiny fly on the head of a prepupa. The ladybird pupa shook its body back and forth to no avail. Later I identified the fly as a scuttle fly, genus Phalacrotophora. Some species of this genus are endoparasites of ladybird pupae. The fly mounts guard on a prepupa an........ Read more »
Koyama, S., & Majerus, M. (2007) Interactions between the parasitoid wasp Dinocampus coccinellae and two species of coccinellid from Japan and Britain. BioControl, 53(1), 253-264. DOI: 10.1007/s10526-007-9138-5
Kenis, M., Roy, H., Zindel, R., & Majerus, M. (2007) Current and potential management strategies against Harmonia axyridis. BioControl, 53(1), 235-252. DOI: 10.1007/s10526-007-9136-7
Durska, E., Ceryngier, P., & Disney, H.L. (2003) Phalacrotophora beuki (Diptera: Phoridae), a parasitoid of ladybird pupae (Coleooptera: Coccinellidae). European Journal of Entomology, 627-630. info:other/1210-5759
Mycology, the study of fungi, is an often-overlooked member of the microbiology family. Having said that there are plenty of dedicated mycologists out there doing all sorts of cool stuff and plenty more fungal species doing all sorts of weird and wonderful things.... Read more »
King-Fai Cheng, & Ping-Chung Leung. (2008) General review of polysaccharopeptides (PSP) from C. versicolor: Pharmacological and clinical studies. Cancer Therapy. info:/
Luk SU, Lee TK, Liu J, Lee DT, Chiu YT, Ma S, Ng IO, Wong YC, Chan FL, & Ling MT. (2011) Correction: Chemopreventive Effect of PSP Through Targeting of Prostate Cancer Stem Cell-Like Population. PloS one, 6(6). PMID: 21674070
I was recently asked about a volume descriptor in Bioclipse, which is not yet available. Jmol can calculate surfaces, so that was my first thought. However, I then ran into a paper from 2003 by Zhao, called Fast Calculation of van der Waals Volume as a Sum of Atomic and Bond Contributions and Its Application to Drug Compounds (doi:10.1021/jo034808o).
The paper presents a very simple mathematical model, which approximates the molecular volume by a sum of atomic contributions, and a three terms t........ Read more »
Zhao, Y., Abraham, M., & Zissimos, A. (2003) Fast Calculation of van der Waals Volume as a Sum of Atomic and Bond Contributions and Its Application to Drug Compounds. The Journal of Organic Chemistry, 68(19), 7368-7373. DOI: 10.1021/jo034808o
It works against mosquitoes... can it work against bedbugs? A study in Nat...... Read more »
A study in Nature this month reveals a promising new line of defense against disease-carrying, bloodthirsty critters, namely the mosquito. The new line of defense is based on smelly chemicals, or inhibitory odorants, that disrupt the mosquito's ability to detect and travel towards human breath. Mosquitoes, as well as other blood-feeding insects, are attracted towards the carbon dioxide that we exhale with every breathe cycle (oxygen in, carbon dioxide out).... Read more »
“Using SNP array analysis, we found that a region of chromosome segment 8p11-12 containing three genes–WHSC1L1, LETM2, and FGFR1–is amplified in 3% of lung adenocarcinomas and 21% of squamous cell lung carcinomas.” Dutt et al., (2011) This snippet from a … Continue reading →
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Dutt A, Ramos AH, Hammerman PS, Mermel C, Cho J, Sharifnia T, Chande A, Tanaka KE, Stransky N, Greulich H.... (2011) Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer. PloS one, 6(6). PMID: 21666749
The first in a series on hormonal contraception. This post explores why human women menstruate and how that may impact their contraceptive decisions.... Read more »
Jasienska, G., & Thune, I. (2001) Research pointers: Lifestyle, hormones, and risk of breast cancer. BMJ, 322(7286), 586-587. DOI: 10.1136/bmj.322.7286.586
Strassmann, B. (1997) The Biology of Menstruation in Homo Sapiens: Total Lifetime Menses, Fecundity, and Nonsynchrony in a Natural-Fertility Population. Current Anthropology, 38(1), 123. DOI: 10.1086/204592
Vitzthum VJ, Spielvogel H, Caceres E, & Miller A. (2001) Vaginal bleeding patterns among rural highland Bolivian women: relationship to fecundity and fetal loss. Contraception, 64(5), 319-25. PMID: 11777494
Vitzthum VJ, & Ringheim K. (2005) Hormonal contraception and physiology: a research-based theory of discontinuation due to side effects. Studies in family planning, 36(1), 13-32. PMID: 15828522
Brain overgrowth has been noted among children with autism spectrum disorder (ASD). Now, a new imaging study suggests that the accelerated brain growth appears before 2 years of life, offering new avenues for early identification and intervention of ASD. Investigators conducted a longitudinal magnetic resonance imaging (MRI) study of 59 children with ASD and 38 [...]... Read more »
Cheng Y, Chou KH, Fan YT, & Lin CP. (2011) ANS: Aberrant Neurodevelopment of the Social Cognition Network in Adolescents with Autism Spectrum Disorders. PloS one, 6(4). PMID: 21541322
Courchesne E, Campbell K, & Solso S. (2011) Brain growth across the life span in autism: age-specific changes in anatomical pathology. Brain research, 138-45. PMID: 20920490
Courchesne E, Carper R, & Akshoomoff N. (2003) Evidence of brain overgrowth in the first year of life in autism. JAMA : the journal of the American Medical Association, 290(3), 337-44. PMID: 12865374
Hazlett HC, Poe MD, Gerig G, Styner M, Chappell C, Smith RG, Vachet C, & Piven J. (2011) Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years. Archives of general psychiatry, 68(5), 467-76. PMID: 21536976
Redcay E, & Courchesne E. (2005) When is the brain enlarged in autism? A meta-analysis of all brain size reports. Biological psychiatry, 58(1), 1-9. PMID: 15935993
Last year, I discussed the controvery over the proposed new childhood syndrome of "Temper Disregulation Disorder with Dysphoria" (TDDD). It may be included in the upcoming revision of the psychiatric bible, DSM-V.Back then, I said:TDDD has been proposed in order to reduce the number of children being diagnosed with pediatric bipolar disorder... many people agree that pediatric bipolar is being over-diagnosed.So we can all sympathize with the sentiment behind TDDD - but this is fighting fire wit........ Read more »
Van Meter AR, Moreira AL, & Youngstrom EA. (2011) Meta-analysis of epidemiologic studies of pediatric bipolar disorder. The Journal of clinical psychiatry. PMID: 21672501
Axelson DA, Birmaher B, Findling RL, Fristad MA, Kowatch RA, Youngstrom EA, Arnold EL, Goldstein BI, Goldstein TR, Chang KD.... (2011) Concerns regarding the inclusion of temper dysregulation disorder with dysphoria in the DSM-V. The Journal of clinical psychiatry. PMID: 21672494
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