According to a new paper, mass shootings such as Sandy Hook and Aurora may be the result of Autism plus psychosis: A ‘one-two punch’ risk for tragic violence? The first thing to note about this paper is that it’s in Medical Hypotheses. I don’t normally take seriously anything that appears in this rather unique journal. [...]... Read more »
Wachtel LE, & Shorter E. (2013) Autism plus psychosis: A 'one-two punch' risk for tragic violence?. Medical hypotheses. PMID: 23786904
Half an hour after lunch, a 67 year old man passes out.
He regains consciousness, as often happens with syncope.
He is not quite back to normal, blood pressure is 80/60 mm Hg, heart rate is 110, respiratory rate is 25, oxygen saturation is 99% on room air, with a temperature of 96.8° Fahrenheit.
If we tilt him, we will probably get a worsening of his vital signs, but there is no need to actually obtain the numbers if the assessment is causing deterioration.... Read more »
Bourcier S, Mongardon N, Daviaud F, Moachon L, Arnould MA, Perruche F, Pène F, & Cariou A. (2013) Disulfiram ethanol reaction mimicking anaphylactic, cardiogenic, and septic shock. The American journal of emergency medicine, 31(1), 2700-3. PMID: 22809767
Senthilkumaran S, Menezes RG, Ravindra G, Jena NN, & Thirumalaikolundusubramanian P. (2013) Antabuse reaction due to occupational exposure-an another road on the map?. The American journal of emergency medicine. PMID: 23791458
Ehrlich RI, Woolf DC, Kibel DA. (2012) Disulfiram reaction in an artist exposed to solvents. Occup Med (Lond)., 62(1), 64-66. DOI: 10.1093/occmed/kqr172
How do junior doctors experience current working conditions? Pressures on public sector spending in many countries have put the squeeze on their health services, and this strata of the workforce - already renowned as being under pressure - seem to be feeling extra strain. This is the suggestion of a recent study that investigates the experiences of twenty junior doctors in the Irish medical system.The participants provided their experiences through qualitative interviews with the researchers, wo........ Read more »
McGowan, Yvonne, Humphries, Niamh, Burke, Helen, Conry, Mary, & Morgan, Karen. (2013) Through doctors’ eyes: A qualitative study of hospital doctor perspectives on their working conditions . British Journal of Health Psychology. DOI: 10.1111/bjhp.12037
Instead of creating scar tissue through an immune system response, extracellular matrix responds to injured areas by creating new cells that in turn divide and reproduce on top of themselves, creating a cellular foundation for new tissue to form.... Read more »
Stephen F Badylak. (2002) The extracellular matrix as a scaffold for tissue reconstruction. Seminars in Cell . DOI: 10.1016/S1084952102000940
We constantly grow new skin and slough off the old. Until now, scientists have never agreed on exactly how this works, but new research from the University of Sheffield may provide the answer.Engineers and biologists at the University have shown how a recent theory – that skin has ‘sleeping’ stem cells which can be woken up when required – best explains how our skin constantly regrows. The research – conducted in collaboration with The Procter & Gamble Company (P&G) and publish........ Read more »
Li X, Upadhyay AK, Bullock AJ, Dicolandrea T, Xu J, Binder RL, Robinson MK, Finlay DR, Mills KJ, Bascom CC.... (2013) Skin Stem Cell Hypotheses and Long Term Clone Survival - Explored Using Agent-based Modelling. Scientific reports, 1904. PMID: 23712735
Brain changes with age result in changes in sleep duration and architecture.In a previous post, I reviewed a study of the contribution of worry to sleep problems across the lifespan. This study found a trend for worry-related sleep problems to decrease in those over 60 years of age. However, sleep complaints rose throughout life affecting 25 to 30% of those in their 70s.Anderson and Bradley recently published a nice summary of the sleep problems in those with mental and neurodegenera........ Read more »
Anderson KN, & Bradley AJ. (2013) Sleep disturbance in mental health problems and neurodegenerative disease. Nature and science of sleep, 61-75. PMID: 23761983
Drugs lead to addiction, and addiction can lead people to a life of crime. Therefore, all drugs should be criminalized and users put in jail. That’s the general theory not only of drug laws in countries like the U.S., but also the way research on drugs is carried out, says Carl Hart, a psychologist at Columbia University in New York. According to Hall, that approach is totally wrong.... Read more »
Rowell TL, Wu E, Hart CL, Haile R, & El-Bassel N. (2012) Predictors of drug use in prison among incarcerated Black men. The American journal of drug and alcohol abuse, 38(6), 593-7. PMID: 22746253
Hart CL, Marvin CB, Silver R, & Smith EE. (2012) Is cognitive functioning impaired in methamphetamine users? A critical review. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(3), 586-608. PMID: 22089317
The immune system is challenging to study. Different people may mount different responses to assaults on their system–and sometimes the systems go into overdrive on stuff they shouldn’t. Cracking the details of the functions of the immune system could help us to combat actual pathogens better, and might also help us to tune down inappropriate [...]... Read more »
Breuer, K., Foroushani, A., Laird, M., Chen, C., Sribnaia, A., Lo, R., Winsor, G., Hancock, R., Brinkman, F., & Lynn, D. (2012) InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curation. Nucleic Acids Research, 41(D1). DOI: 10.1093/nar/gks1147
A long, hard run is in the books and now it’s time to reward yourself. A nice, hot shower will hit the spot … or better yet – a long soak in the hot tub. You deserve it! “Not so fast, buddy! You do realize the havoc that heat will wreak on your already inflamed, … Continue reading »... Read more »
Versey NG, Halson SL, & Dawson BT. (2013) Water Immersion Recovery for Athletes: Effect on Exercise Performance and Practical Recommendations. Sports medicine (Auckland, N.Z.). PMID: 23743793
A new study by an international team led by Dana-Farber Cancer Institute scientists provides the first statistically-based guidelines for determining whether a stem cell transplant is appropriate for older patients with myelodysplastic syndromes (MDS) -- the most common blood disorders in people over 60 years of age, and frequently a precursor for leukemia.Using mathematical models to analyze hundreds of MDS cases from around the world, the researchers found reduced intensity transplants of dono........ Read more »
Koreth, J., Pidala, J., Perez, W., Deeg, H., Garcia-Manero, G., Malcovati, L., Cazzola, M., Park, S., Itzykson, R., Ades, L.... (2013) Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. Journal of Clinical Oncology. DOI: 10.1200/JCO.2012.46.8652
Summary: Today the only “cure” for permanent hair loss due to androgenetic alopecia (male/female pattern baldness) is hair restoration surgery. Recent research into how our ...... Read more »
Taylor G, Lehrer MS, Jensen PJ, Sun TT, & Lavker RM. (2000) Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell, 102(4), 451-61. PMID: 10966107
Aoi N, Inoue K, Chikanishi T, Fujiki R, Yamamoto H, Kato H, Eto H, Doi K, Itami S, Kato S.... (2012) 1α,25-dihydroxyvitamin D3 modulates the hair-inductive capacity of dermal papilla cells: therapeutic potential for hair regeneration. Stem cells translational medicine, 1(8), 615-26. PMID: 23197867
Foot strike pattern and ground-contact time – effect on economy of running... Read more »
Di Michele, R., & Merni, F. (2013) The concurrent effects of strike pattern and ground-contact time on running economy. Journal of Science and Medicine in Sport. DOI: 10.1016/j.jsams.2013.05.012
Ranging between 26% in UK and 65% in Poland an average of ONLY 48% of Primary Care physicians are using pain assessment tools. At the same time 81% of the same physicians believe that chronic pain and its impact on quality of life is underassessed in primary care.... Read more »
Kim Kristiansen, M.D. (2013) Pain is Underassessed According to Four Out of Five Physicians. Picture of Pain Blog. info:/
Anxiety contributes to risk of sleep impairment. The anxiety disorder known as generalized anxiety disorder includes description of worry that is out of control producing impairment through physical pain and insomnia.Sleep complaints including insomnia tend to increase with age. The mechanism for this effect is unclear but may relate to physiological changes associated with brain aging.Paula Salo and colleagues in Finland, the United Kingdom and France recently published an informati........ Read more »
Salo, P., Vahtera, J., Ferrie, J., Akbaraly, T., Goldberg, M., Zins, M., Pentti, J., Virtanen, M., Shipley, M., Singh-Manoux, A.... (2012) Trajectories of Sleep Complaints From Early Midlife to Old Age: Longitudinal Modeling Study. SLEEP. DOI: 10.5665/sleep.2210
It’s been said that hormonal young men with high levels of testosterone are constantly thinking about sex. Certainly, as we age, our libido decreases. Whether this is a result of a natural decline in testosterone or of cognitive maturity is open to debate. It’s also been reported that hypogonadal men are more depressed and perhaps not as sharp cognitively speaking. Some studies even show a benefit to testosterone replacement in such men with low testosterone levels.... Read more »
Davis S, et al. (2013) ransdermal testosterone improves verbal learning and memory in postmenopausal women not on estrogen therapy: a randomized placebo-controlled trial over 26 weeks. ENDO . info:/
More and more women are requesting surgery to replace their hymens, in an effort to “fake” virginity. But virginity is a psychological state, and a hymen is no reliable indicator it exists.
The idea of virginity is firmly anchored in religion and influenced by a variety of social forces that have led to its circulation across cultures for centuries. It popularly refers to a state of sexual inexperience, but has historically been primarily associated with women.... Read more »
van Moorst, B., van Lunsen, R., van Dijken, D., & Salvatore, C. (2012) Backgrounds of women applying for hymen reconstruction, the effects of counselling on myths and misunderstandings about virginity, and the results of hymen reconstruction. The European Journal of Contraception and Reproductive Health Care, 17(2), 93-105. DOI: 10.3109/13625187.2011.649866
O'Connor M. (2008) Reconstructing the hymen: mutilation or restoration?. Journal of law and medicine, 16(1), 161-75. PMID: 18807803
OK you got me.Another case study of autism is being discussed in this post. It's not that I'm moving away from good ole' evidence-based medicine - double-blind, placebo-controlled group studies like this one if you please - but rather that as I've discussed before, there is often merit in looking at autism from the N=1 perspective. After all, it is a heterogeneous condition and we have all that 'autisms' chatter of late (see here) coupled with some elevated risk of comorbidity (see here). Indeed........ Read more »
Ramirez, P., Barnhill, K., Gutierrez, A., Schutte, C., & Hewitson, L. (2013) Improvements in Behavioral Symptoms following Antibiotic Therapy in a 14-Year-Old Male with Autism. Case Reports in Psychiatry, 1-2. DOI: 10.1155/2013/239034
Summary: In male pattern baldness, hair follicles stay “asleep,” in a dormant state, leading to permanent hair loss. Hair follicle death is another (far less ...... Read more »
Oda Y, Hu L, Bul V, Elalieh H, Reddy JK, & Bikle DD. (2012) Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations. The Journal of investigative dermatology, 132(4), 1075-83. PMID: 22189783
Luderer HF, Gori F, & Demay MB. (2011) Lymphoid enhancer-binding factor-1 (LEF1) interacts with the DNA-binding domain of the vitamin D receptor. The Journal of biological chemistry, 286(21), 18444-51. PMID: 21471213
by Liz in Science of Eating Disorders
I have been studying the neurobehavioral aspects of food and drug reinforcement for the past 5 years (read more about it on my profile page). This involves using rats to mimic basic human behaviors surrounding food and drug intake. I then manipulate various neurotransmitter systems by using drugs and observe the effects this manipulation has on the behaviors I am interested in.
What’s important to this type of research is that we constantly challenge and evaluate the valid........ Read more »
Cifani, C., Polidori, C., Melotto, S., Ciccocioppo, R., & Massi, M. (2009) A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam. Psychopharmacology, 204(1), 113-125. DOI: 10.1007/s00213-008-1442-y
Effect of fatigue on running kinematics... Read more »
Koblbauer, I., van Schooten, K., Verhagen, E., & van Dieën, J. (2013) Kinematic changes during running-induced fatigue and relations with core endurance in novice runners. Journal of Science and Medicine in Sport. DOI: 10.1016/j.jsams.2013.05.013
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