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  • June 17, 2011
  • 03:27 AM
  • 899 views

Bipolar Kids: You Read It Here First

by Neuroskeptic in Neuroskeptic

Last year, I discussed the controvery over the proposed new childhood syndrome of "Temper Disregulation Disorder with Dysphoria" (TDDD). It may be included in the upcoming revision of the psychiatric bible, DSM-V.Back then, I said:TDDD has been proposed in order to reduce the number of children being diagnosed with pediatric bipolar disorder... many people agree that pediatric bipolar is being over-diagnosed.So we can all sympathize with the sentiment behind TDDD - but this is fighting fire wit........ Read more »

Van Meter AR, Moreira AL, & Youngstrom EA. (2011) Meta-analysis of epidemiologic studies of pediatric bipolar disorder. The Journal of clinical psychiatry. PMID: 21672501  

Axelson DA, Birmaher B, Findling RL, Fristad MA, Kowatch RA, Youngstrom EA, Arnold EL, Goldstein BI, Goldstein TR, Chang KD.... (2011) Concerns regarding the inclusion of temper dysregulation disorder with dysphoria in the DSM-V. The Journal of clinical psychiatry. PMID: 21672494  

  • June 17, 2011
  • 01:02 AM
  • 1,464 views

Routine Palliative Medicine Consults for VAD Destination Therapy

by Brian McMichael, M.D. in Pallimed: a Hospice & Palliative Medicine Blog


In this month's issue of the Mayo Clinic Proceedings is the first article reporting on a case series with inclusion of palliative medicine (PM) consultations as a routine, integrated part of pre-op or early post-op care for patients receiving ventricular assist device (VAD) as destination therapy (DT). Both Drew and Holly have posted previously on Pallimed about VAD DT.

The Mayo Clinic is a nationally and internationally recognized tertiary and quaternary referral center. As such, beyond the ........ Read more »

  • June 16, 2011
  • 12:42 PM
  • 1,161 views

Surely not! Is this Energy Drink marketed at Children!?

by Stuart Farrimond in Dr Stu's Science Blog

Sometimes anger gets the better of you. A morning trip to the supermarket left me enraged (and no, it wasn’t anything to do with the queues, car parking or customer service). The source of my fury was what I had seen for sale in the aisles. Were my eyes deceiving me or had I really … Continue reading »... Read more »

  • June 16, 2011
  • 11:46 AM
  • 1,194 views

Science Highlights this week:

by Brooke N in Smaller Questions

Real-time killing E coli by LL-37 and how to kill bacterial persisters.... Read more »

Sochacki KA, Barns KJ, Bucki R, & Weisshaar JC. (2011) Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37. Proceedings of the National Academy of Sciences of the United States of America, 108(16). PMID: 21464330  

  • June 16, 2011
  • 10:28 AM
  • 1,128 views

Is NOTCH a new target in leukemia?

by Sally Church in Pharma Strategy Blog

Over the last five years I’ve been involved in quite a bit of market research relating to chronic lymphocytic leukemia (CLL) and have been struck how the core therapies are still largely chemotherapy based. CLL is an indolent disease of the … Continue reading →
... Read more »

Fabbri, G., Rasi, S., Rossi, D., Trifonov, V., Khiabanian, H., Ma, J., Grunn, A., Fangazio, M., Capello, D., Monti, S.... (2011) Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. Journal of Experimental Medicine. DOI: 10.1084/jem.20110921  

  • June 16, 2011
  • 09:00 AM
  • 1,456 views

Managing Your Weight in The Dark

by Arya M. Sharma in Dr. Sharma's Obesity Notes

Readers will recall a post earlier this week on the importance of sleep for weight management.
Researchers and clinicians, wanting to know more about the underlying biology and mechanisms on how lack of sleep, disruption of circadian rhythm (e.g. through shift work, jet lag, or having a baby), and alterations in light/dark cycles can impact ingestive [...]... Read more »

  • June 16, 2011
  • 06:30 AM
  • 1,134 views

The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department – Part I

by Rogue Medic in Rogue Medic

What the emergency department needs to treat, EMS also needs to treat.

We can pretend otherwise.

We can pretend that just driving fast while wrestling with a patient is in some way safe.

These are delusions just as much as what is going on in the head of the patient with acute behavioural disturbance.
... Read more »

  • June 16, 2011
  • 03:43 AM
  • 931 views

Neuroplasticity Revisited

by Neuroskeptic in Neuroskeptic

A fascinating case report details a remarkable recovery from serious brain injury: Characterization of recovery and neuropsychological consequences of orbitofrontal lesion.The patient "M. S." was a previously healthy 29 year old Israeli graduate student who suffered injuries in a terrorist attack. As the MRI scans above show, she lost large parts of her orbitofrontal cortex and ventromedial prefrontal cortex, although the left side was only partially affected. She also lost her right eye.These a........ Read more »

  • June 15, 2011
  • 06:33 PM
  • 1,172 views

Cleaning the Cellular House

by Sanford- Burnham in Beaker

Since cellular stress due to misfolded proteins in the endoplasmic reticulum (ER) has been implicated in many human diseases, a new appreciation of the cell cycle’s role in this process might help improve our understanding of conditions ranging from Alzheimer’s disease to cancer.... Read more »

Chen M, Gutierrez GJ, & Ronai ZA. (2011) Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. Proceedings of the National Academy of Sciences of the United States of America, 108(22), 9119-24. PMID: 21571647  

  • June 15, 2011
  • 06:09 PM
  • 1,237 views

by PalMD in White Coat Underground

I can't seem to stop myself from writing about pee, and I'm not even a nephrologist.  But I deal with pee every day, and many of my younger patients with urinary tract infections will tell me all of the home and herbal remedies they tried before they came to see me.  One of the most [...]... Read more »

Raz, R., Chazan, B., & Dan, M. (2004) Cranberry Juice and Urinary Tract Infection. Clinical Infectious Diseases, 38(10), 1413-1419. DOI: 10.1086/386328  

  • June 15, 2011
  • 01:35 PM
  • 1,395 views

Sickle-Cell Disease, Oxygen Isotopes, and Malarial Romans

by Kristina Killgrove in Powered By Osteons

Two articles published last month in the American Journal of Physical Anthropology are starting to greatly complicate bioarchaeologists' use and interpretation of stable oxygen isotope ratios in an attempt to understand migration and mobility in the past.  Science is constantly progressing, and it can be challenging to keep up with the latest research.  The real challenge for me, though, is in interpreting the isotope analyses I have done on populations from Imperial Rome - first becau........ Read more »

Bianucci, R., Mattutino, G., Lallo, R., Charlier, P., Jouin-Spriet, H., Peluso, A., Higham, T., Torre, C., & Rabino Massa, E. (2008) Immunological evidence of Plasmodium falciparum infection in an Egyptian child mummy from the Early Dynastic Period. Journal of Archaeological Science, 35(7), 1880-1885. DOI: 10.1016/j.jas.2007.11.019  

Prowse TL, Schwarcz HP, Garnsey P, Knyf M, Macchiarelli R, & Bondioli L. (2007) Isotopic evidence for age-related immigration to imperial Rome. American Journal of Physical Anthropology, 132(4), 510-9. PMID: 17205550  

  • June 15, 2011
  • 01:20 PM
  • 1,027 views

Patient advocacy session at European Hematology Association EHA 2011 shows impact of drug adherence on outcome

by Pieter Droppert in Biotech Strategy Blog

The patient advocacy session at the recent 16th Congress of the European Hematology Association in London focused on adherence to cancer treatments, and was filled to capacity, with the many attendees having to watch it from an overflow area.

Dr David Marin, Reader in Onco-Haematology at Imperial College, London presented research published last year in the Journal of Clinical Oncology that dramatically demonstrated how adherence to chronic myeloid leukemia (CML) therapy is the critical fact........ Read more »

  • June 15, 2011
  • 09:34 AM
  • 1,494 views

ADHD and the Athlete

by William Yates, M.D. in Brain Posts

Athletes are not spared from the risk of developmental disorders like learning disabilities and attention deficit hyperactivity disorder (ADHD).  Once an athlete is diagnosed with ADHD, the effect of this disorder and it's treatment on athletic performance becomes important.  Dr. J. W. Parr recently published a comprehensive review of recent research and understanding of ADHD in the athlete.   The review includes a look at diagnostic issues as well as a summary of the neurobi........ Read more »

  • June 15, 2011
  • 09:19 AM
  • 1,365 views

Tip of the Week: MutaDATABASE, a centralized and standardized DNA variation database

by Mary in OpenHelix

We all know and love dbSNP, and DGV, and 1000 Genomes, and HapMap, and OMIM, and the couple of other dozen variation databases I can think of off the top of my head. But–even though there’s a lot of stuff out there–you never know what you aren’t seeing. What *isn’t* yet stored in those resources?  [...]... Read more »

Bale, S., Devisscher, M., Criekinge, W., Rehm, H., Decouttere, F., Nussbaum, R., Dunnen, J., & Willems, P. (2011) MutaDATABASE: a centralized and standardized DNA variation database. Nature Biotechnology, 29(2), 117-118. DOI: 10.1038/nbt.1772  

  • June 15, 2011
  • 09:00 AM
  • 1,808 views

Electrical Stimulation of the Colon Can Suppress Appetite

by Arya M. Sharma in Dr. Sharma's Obesity Notes

The idea of using electrical stimulation to affect gastric motility and emptying as a means to increase satiety and reduce appetite has received a considerable amount of attention.
Regular Readers may recall that, although two gastric stimulators have now been approved for obesity treatment in Europe, US studies on gastric stimulators for the treatment of obesity, have [...]... Read more »

  • June 15, 2011
  • 06:22 AM
  • 1,395 views

Learning from survivors of childhood cancer

by Cancer Research UK in Cancer Research UK - Science Update

As our Little Star awards remind us every year, people living with and surviving childhood cancer are very special. And our researchers know that these survivors need special attention because they face a different set of problems compared to older cancer survivors. This month, new research by Cancer Research UK scientists has shown that survivors [...]... Read more »

Reulen RC, Frobisher C, Winter DL, Kelly J, Lancashire ER, Stiller CA, Pritchard-Jones K, Jenkinson HC, Hawkins MM, & British Childhood Cancer Survivor Study Steering Group. (2011) Long-term risks of subsequent primary neoplasms among survivors of childhood cancer. JAMA : the journal of the American Medical Association, 305(22), 2311-9. PMID: 21642683  

  • June 15, 2011
  • 03:28 AM
  • 1,982 views

Shock! The way you Walk reveals Your IQ!

by Stuart Farrimond in Dr Stu's Science Blog

So you think you’re pretty smart, huh? I bet you think walking is easy. Let’s put those assumptions to the test: Haul yourself away from the computer for a couple of minutes and try this simple little test. We’ll see just how clever you really are… Continue reading »... Read more »

Yogev-Seligmann, G., Hausdorff, J., & Giladi, N. (2008) The role of executive function and attention in gait. Movement Disorders, 23(3), 329-342. DOI: 10.1002/mds.21720  

Ble, A., Volpato, S., Zuliani, G., Guralnik, J., Bandinelli, S., Lauretani, F., Bartali, B., Maraldi, C., Fellin, R., & Ferrucci, L. (2005) Executive Function Correlates with Walking Speed in Older Persons: The InCHIANTI Study. Journal of the American Geriatrics Society, 53(3), 410-415. DOI: 10.1111/j.1532-5415.2005.53157.x  

van Iersel, M. (2006) Frail elderly patients with dementia go too fast. Journal of Neurology, Neurosurgery , 77(7), 874-876. DOI: 10.1136/jnnp.2005.084418  

  • June 14, 2011
  • 04:16 PM
  • 1,379 views

Friends, Romans, Countrymen... Lend Me Your Rears!

by Kristina Killgrove in Powered By Osteons

Recent excavations in a sewer at Herculaneum uncovered a massive deposit of, well, poop. What can feces tell us about the ancient Romans' diet, diseases, and medicine?... Read more »

S.C. Bisel. (1988) Nutrition in first-century Herculaneum. Anthropologie, 26(1), 61-66. info:/

  • June 14, 2011
  • 09:01 AM
  • 1,369 views

Mild Cognitive Impairment in the Elderly

by William Yates, M.D. in Brain Posts

 The presence of mild cognitive impairment (MCI) in elderly individuals is often a clinical challenge of uncertainly prognostic value.  Defined as cognitive function below the normal range but insufficient for a diagnosis of dementia, MCI is receiving increased research attention.  This week in the New England Journal of Medicine, Dr. Ronald Petersen, a neurologist from the Mayo Clinic in Rochester, Minnesota highlighted what is known about MCI.  His review summarizes some of........ Read more »

Petersen, RC. (2011) Mild Cognitive Impairment. New Engl J Med, 2227-2234. info:/

  • June 14, 2011
  • 09:00 AM
  • 1,465 views

Preventing Weight Gain in Your Sleep?

by Arya M. Sharma in Dr. Sharma's Obesity Notes

Regular readers of these pages will be well aware of the many studies that now show a close association between less sleep and weight gain.
In fact, a now often shown slide clearly documents, how steadily decreasing hours of sleep remarkably parallels the steady increase in obesity rates over the past decades.
In addition, substantial data from [...]... Read more »

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