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  • April 28, 2014
  • 12:05 AM

Are Concussion Apps Ready For the General Public?

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

The SCAT2-1.0.0, SCAT2-1.3.0, and Concussion-1.2.0 are comprehensive apps for trained medical personnel to use for concussion diagnosis and monitoring.... Read more »

Lee H, Sullivan SJ, Schneiders AG, Ahmed OH, Balasundaram AP, Williams D, Meeuwisse WH, & McCrory P. (2014) Smartphone and tablet apps for concussion road warriors (team clinicians): a systematic review for practical users. British Journal of Sports Medicine. PMID: 24668048  

  • April 27, 2014
  • 03:04 AM

MMP-9 and symptom severity of ADHD

by Paul Whiteley in Questioning Answers

"The statistical regression analysis revealed a correlation between increased serum MMP-9 levels and severity of symptoms in the ADHD". That was the sentence that caught my eye taken from the paper by Halina Kadziela-Olech and colleagues [1] (open-access here) looking at serum matrix metalloproteinase-9 (MMP-9) levels in children with hyperkinetic disorder (HKD) [2] "a severe form of a syndrome which is referred to in DSM-IV... and the American literature as attention deficit........ Read more »

  • April 26, 2014
  • 12:56 PM

Belief vs. Research-based Decisions

by Rodney Steadman in Gravity's Pull

In Canada, the Harper government has have used belief and not research to inform their decisions. This has been disastrous for proven social programs.... Read more »

McDonald M. (2006) Stephen Harper and the Theo-cons: The rising clout of Canada’s religious right. The Walrus. info:/

Wood E, Tyndall MW, Zhang R, Stoltz JA, Lai C, Montaner JS, & Kerr T. (2006) Attendance at supervised injecting facilities and use of detoxification services. The New England journal of medicine, 354(23), 2512-4. PMID: 16760459  

  • April 26, 2014
  • 10:00 AM

Could a Vaccine for Cancer be a Reality?

by Dr. Jekyll in Lunatic Laboratories

The new advances that show there might be a new vaccine for some of the most common types of cancers.... Read more »

Facciponte John G., Ugel Stefano, De Sanctis Francesco, Li Chunsheng, Wang Liping, Nair Gautham, Sehgal Sandy, Raj Arjun, Matthaiou Efthymia, & Coukos George. (2014) Tumor endothelial marker 1–specific DNA vaccination targets tumor vasculature. Journal of Clinical Investigation, 124(4), 1497-1511. DOI: 10.1172/JCI67382DS1  

  • April 26, 2014
  • 03:49 AM

Reduction in Ground Reaction Forces with Barefoot Running

by Craig Payne in Running Research Junkie

Reduction in Ground Reaction Forces with Barefoot Running... Read more »

  • April 26, 2014
  • 03:14 AM

Methadone, Suboxone and Recovery: what really happened?

by DJMac in Recovery Review

Recently I found a paper I wanted to read about the policy shift from harm reduction to recovery in the UK and the impact on attitudes to methadone. It’s a fascinating subject. As I say, I really wanted to read it, but I kept getting distracted by a persistent question: what’s the difference between recovery [...]... Read more »

  • April 25, 2014
  • 04:59 AM

Maternal thyroid dysfunction and autism or ADHD?

by Paul Whiteley in Questioning Answers

The paper by Anderson and colleagues [1] talking about the risk of offspring attention deficit hyperactivity disorder (ADHD) and/or autism spectrum disorder (ASD) where mothers presented with "maternal thyroid disease" is the source material for this post.The Circus @ Wikipedia Based on data derived from Denmark, and those very useful Danish health registries which seem to be producing all-manner of potentially important information (see here), researchers repo........ Read more »

  • April 25, 2014
  • 04:28 AM

Epidermis grown from human stem cells could replace animals in drug and cosmetics testing

by beredim in Stem Cells Freak

Human SkinAn international team ofresearchers led by King's College London and the San Francisco Veteran Affairs Medical Center (SFVAMC) has developed the first lab-grown epidermis -- the outermost skin layer -- with a functional permeability barrier akin to real skin.The new epidermis, grown using  human pluripotent stem cells, offers a cost-effective alternative lab model for testing drugs and cosmetics, and could also help to develop new therapies for rare and common skin disorders.The e........ Read more »

  • April 25, 2014
  • 04:19 AM

Scientists reprogram blood cells into hematopoietic stem cells

by beredim in Stem Cells Freak

Derrick J. Rossi, Ph.D., of Boston Children's HospitalCredit: Boston Children's HospitalResearchers at Boston Children's Hospital have reprogrammed mature blood cells from mice into blood-forming hematopoietic stem cells (HSCs), using a cocktail of eight genetic switches called transcription factors. The reprogrammed cells, which the researchers have dubbed induced HSCs (iHSCs), have the functional hallmarks of HSCs, are able to self-renew like HSCs, and can give rise to all of the c........ Read more »

Riddell, J., Gazit, R., Garrison, B., Guo, G., Saadatpour, A., Mandal, P., Ebina, W., Volchkov, P., Yuan, G., Orkin, S.... (2014) Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors. Cell, 157(3), 549-564. DOI: 10.1016/j.cell.2014.04.006  

  • April 25, 2014
  • 03:00 AM

The European Cancer Patient’s Bill of Rights: a catalyst for change

by Danielle Stevenson in BHD Research Blog

In 28 European countries, cancer is now the leading cause of premature death, having overtaken cardiovascular disease (WHO European health report, 2012), and in 2012 there were 1.75 million cancer-related deaths in Europe (Ferlay et al., 2013). Cancer survival rates … Continue reading →... Read more »

De Angelis R, Sant M, Coleman MP, Francisci S, Baili P, Pierannunzio D, Trama A, Visser O, Brenner H, Ardanaz E.... (2014) Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE--5-a population-based study. The lancet oncology, 15(1), 23-34. PMID: 24314615  

Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D, & Bray F. (2013) Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. European journal of cancer (Oxford, England : 1990), 49(6), 1374-403. PMID: 23485231  

Lawler M, Le Chevalier T, Murphy MJ Jr, Banks I, Conte P, De Lorenzo F, Meunier F, Pinedo HM, Selby P, Armand JP.... (2014) A Catalyst for Change: The European Cancer Patient's Bill of Rights. The oncologist, 19(3), 217-24. PMID: 24493667  

Luce BR, Mauskopf J, Sloan FA, Ostermann J, & Paramore LC. (2006) The return on investment in health care: from 1980 to 2000. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 9(3), 146-56. PMID: 16689708  

  • April 25, 2014
  • 01:36 AM

Barefoot/Minimalism Running and Heel Striking

by Craig Payne in Running Research Junkie

Barefoot/Minimalism Running and Heel Striking... Read more »

  • April 24, 2014
  • 05:01 AM

Autologous stem cell therapy improves motor function in stroke victims

by beredim in Stem Cells Freak

CT scan slice of the brain showing a right-hemispheric ischemic stroke.People who have had a stroke, often suffer motor deficits with little potential to restore neurological function. However, a new study conducted in Taiwan, has found that when one group of stroke victims had their own peripheral blood stem cells (PBSCs) injected directly into the brain and a similar group did not, those who received the PBSCs experienced some "improvement in stroke scales and functional outcome." ........ Read more »

  • April 24, 2014
  • 04:48 AM

What You Need To Know About The New Ebola Outbreak

by Rebekah Morrow in United Academics

Recent outbreaks of Ebola virus in Guinea have made international news. Ebola virus was first identified in 1976 in the region that is now the Democratic Republic of the Congo in central Africa. The virus was named after the river near where it was found. Since 1976, there have been multiple outbreaks in central Africa, but this year is the first time that an outbreak has occurred as far west as Guinea and Sierra Leone.... Read more »

Groseth, A., Feldmann, H., & Strong, J. (2007) The ecology of Ebola virus. Trends in Microbiology, 15(9), 408-416. DOI: 10.1016/j.tim.2007.08.001  

Pettitt, J., Zeitlin, L., Kim, D., Working, C., Johnson, J., Bohorov, O., Bratcher, B., Hiatt, E., Hume, S., Johnson, A.... (2013) Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail. Science Translational Medicine, 5(199), 199-199. DOI: 10.1126/scitranslmed.3006608  

  • April 24, 2014
  • 04:45 AM

Stem cells in circulating blood affect cardiovascular health

by beredim in Stem Cells Freak

Heart DiagramA new study suggests that attempts to isolate an elusive adult stem cell from blood to understand and potentially improve cardiovascular health – a task considered possible but very difficult – might not be necessary.Instead, scientists have found that multiple types of cells with primitive characteristics circulating in the blood appear to provide the same benefits expected from a stem cell, including the endothelial progenitor cell that is the subject of hot pursuit."Ther........ Read more »

  • April 24, 2014
  • 04:35 AM

As if you needed telling...

by Paul Whiteley in Questioning Answers

"GI [gastrointestinal] dysfunction was prevalent in this cohort of children with ASD [autism spectrum disorders], observations consistent with the reports of parents and other clinicians". That was one of the conclusions reached by Victor Kang and colleagues [1] in their study looking at GI issues in cases of autism.Of course we've been here before... many times in fact, as autism research delivers more evidence that bowel issues are quite frequently over-represented in cases of autism........ Read more »

Kang V, Wagner GC, & Ming X. (2014) Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders. Autism research : official journal of the International Society for Autism Research. PMID: 24753336  

  • April 24, 2014
  • 04:34 AM

Study finds long-term survival of human neural stem cells transplanted into primates

by beredim in Stem Cells Freak

A team of researchers in Korea who transplanted human neural stem cells (hNSCs) into the brains of nonhuman primates and assessed cell survival and differentiation after 22 and 24 months found that the hNSCs had differentiated into neurons at 24 months and did not cause tumors.The hNSCs were labeled with magnetic nanoparticles to enable them to be followed by magnetic resonance imaging (MRI). They did not use immunosuppressants. According to the researchers, their study is the first to evaluate ........ Read more »

Lee, S-R.; Lee, H. J.; Cha, S-H.; Jeong, K-J.; Lee, Y. J.; Jeon, C-Y.; Yi, K. S.; Lim, I.; Cho, Z-H.; Chang, K-T.; Kim, S. U. (2014) Long-term survival and differentiation of human neural stem cells in nonhuman primate brain with no immunosuppression. Cell Transplantation. info:/

  • April 24, 2014
  • 12:29 AM

Effect of Pose/Chi type running instruction on running economy

by Craig Payne in Running Research Junkie

Effect of Pose/Chi type running instruction on running economy... Read more »

Craighead D, Lehecka N, & King DL. (2014) A novel running mechanic's class changes kinematics but not running economy. Journal of strength and conditioning research / National Strength . PMID: 24736769  

  • April 23, 2014
  • 08:25 AM

Chili Peppers Run Hot And Cold

by Mark Lasbury in As Many Exceptions As Rules

Hot peppers are hot because their capsaicin binds to the TRPV1 heat sensing ion channel. Agonists of TRPV1 can lead to a hypothermia, while antagonists result in a hyperthermia. Normally these would be poor outcomes, but there are particular instances that new researchs are showing to be beneficial. Brown adipose tissue is promoted by TRPV1 agonists, and studies are showing that capsaicin can hinder formation of white adipose tissue. Likewise, agonists of TRPV1 can induce a protective hypothermi........ Read more »

Yoneshiro T, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, & Saito M. (2013) Recruited brown adipose tissue as an antiobesity agent in humans. The Journal of clinical investigation, 123(8), 3404-8. PMID: 23867622  

Feng Z, Hai-Ning Y, Xiao-Man C, Zun-Chen W, Sheng-Rong S, & Das UN. (2014) Effect of yellow capsicum extract on proliferation and differentiation of 3T3-L1 preadipocytes. Nutrition (Burbank, Los Angeles County, Calif.), 30(3), 319-25. PMID: 24296036  

Muzzi M, Felici R, Cavone L, Gerace E, Minassi A, Appendino G, Moroni F, & Chiarugi A. (2012) Ischemic neuroprotection by TRPV1 receptor-induced hypothermia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 32(6), 978-82. PMID: 22434066  

  • April 23, 2014
  • 07:00 AM

How ginseng works against flu

by Patricia Pedro in United Academics

Not that long ago, I heard about ginseng in my Plants’ Diversity class, but it was not given that much relevance. Soon after that, ginseng teas and supplements and a panoply of ginseng-made products appeared in the market. Then I finally realized I may not have given ginseng the importance it deserves.... Read more »

Lee JS, Hwang HS, Ko EJ, Lee YN, Kwon YM, Kim MC, & Kang SM. (2014) Immunomodulatory activity of red ginseng against influenza A virus infection. Nutrients, 6(2), 517-29. PMID: 24473234  

  • April 23, 2014
  • 04:25 AM

Phenylalanine and schizophrenia: new directions for intervention?

by Paul Whiteley in Questioning Answers

As regular readers might already have noticed, amino acids are a bit of a obsession of mine on this blog. Out of all of them - and there are quite a few - I'm particularly interested in the aromatic amino acids and the their various connections to health and wellbeing. I've talked at length about some of the proposed connections made between amino acids such as tryptophan, tyrosine and phenylalanine to all manner of conditions but specifically with the autism spectrum in mind (see here).The conv........ Read more »

Olaoluwa Okusaga, Olesja Muravitskaja, Dietmar Fuchs, Ayesha Ashraf, Sarah Hinman, Ina Giegling, Annette M. Hartmann, Bettina Konte, Marion Friedl, Jason Schiffman.... (2014) Elevated Levels of Plasma Phenylalanine in Schizophrenia: A Guanosine Triphosphate Cyclohydrolase-1 Metabolic Pathway Abnormality?. PLoS ONE. DOI: 10.1371/journal.pone.0085945  

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