The neurotransmitter deficiency in Parkinson's disease interacts with important sleep mechanisms. Patients with Parkinson's disease report increased rates of a variety of sleep problems. REM sleep behavior disorder is a disorder commonly linked to Parkinson's disease as well as Lewy body dementia. I have previously posted commentary on a study describing the value of using REM sleep behavior disorder is the differential diagnosis of dementia here.A new study has further examine........ Read more »
Svensson E, Beiske AG, Loge JH, Beiske KK, & Sivertsen B. (2012) Sleep problems in Parkinson¿s disease: a community-based study in Norway. BMC neurology, 12(1), 71. PMID: 22883600
Over the last ten years, participation rates have increased in baseball and softball (3.9% and 8.4% at the interscholastic level, respectively). Despite this rise in popularity, a dearth of knowledge exists concerning the incidence of injuries sustained by high school baseball and softball players. Therefore, the authors conducted a prospective cohort study of high school athletes (247 athletes; 103 female, 144 male) to determine initial and subsequent injury rates; compare injury rates between ........ Read more »
Shanley E, Rauh MJ, Michener LA, & Ellenbecker TS. (2011) Incidence of injuries in high school softball and baseball players. Journal of Athletic Training, 46(6), 648-54. PMID: 22488191
Periodontitis is an infectious inflammatory disease that destroys the tooth-supporting (periodontal) tissues. Porphyromonas gingivalis is an oral pathogen highly implicated in the pathogenesis of this disease. It can exert its effects to a number of cells, including osteogenic bone marrow stromal cells which are important for homeostastic capacity of the tissues. By employing gene microarray technology, this study aimed to describe the overall transcriptional events (2-fold regulation) elicited ........ Read more »
Durga Reddi, & Georgios N. Belibasakis. (2012) Transcriptional Profiling of Bone Marrow Stromal Cells in Response to Porphyromonas gingivalis Secreted Products. PLoS ONE. DOI: 10.1371/journal.pone.0043899
The current Annals of Emergency Medicine has an editorial and two studies of pain management in older adults.
One study is a 10-year prospective, observational study of a convenience sample of patients who had pain on presentation to the ED. Over 10 years any Hawthorne effect can be expected to wear off. Over a decade a lot can change, especially with the ways that pain management has progressed.... Read more »
Cinar O, Ernst R, Fosnocht D, Carey J, Rogers L, Carey A, Horne B, & Madsen T. (2012) Geriatric patients may not experience increased risk of oligoanalgesia in the emergency department. Annals of emergency medicine, 60(2), 207-11. PMID: 22818367
There is more than one type of genetic material within the cell. As well as DNA, which stores the code for making cellular protiens, there is also RNA, which contains similar snatches of code but is less stable and more mobile than DNA. If DNA is a library of books which are not allowed to be removed, then RNA is little buts of paper containing copies of pages that are spread around for people to read.... Read more »
Mann B, van Opijnen T, Wang J, Obert C, Wang YD, Carter R, McGoldrick DJ, Ridout G, Camilli A, Tuomanen EI.... (2012) Control of Virulence by Small RNAs in Streptococcus pneumoniae. PLoS pathogens, 8(7). PMID: 22807675
Hi all, Gina here, again. This article is short and sweet, as is my post. I’m becoming increasingly interested in some of the more cognitive aspects of eating disorders and seeing as my background on the subject is pretty limited (re: none, although I’m taking a cognitive science class this term), I was hoping to generate some discussion /or references from readers that I could incorporate into further posts. Cheers!
It has long been suggested that people with eating disorders (in th........ Read more »
Tokley M, & Kemps E. (2007) Preoccupation with detail contributes to poor abstraction in women with anorexia nervosa. Journal of clinical and experimental neuropsychology, 29(7), 734-41. PMID: 17896199
In a recent post, SMR discussed the utilization of vertical traction to restore lumbar curvature as an effective way to reduce low back pain (LBP). Traction was compared to conservative generalized exercise measures, but was a generalized plan of exercise more appropriate than a clinically prescribed exercise regimen? Wajswelner et al. hypothesized that LBP will be significantly reduced in a patient population that undergoes a clinically prescribed and individualized Pilates exercise regimen ........ Read more »
Wajswelner H, Metcalf B, & Bennell K. (2012) Clinical Pilates versus general exercise for chronic low back pain: randomized trial. Medicine and Science in Sports and Exercise, 44(7), 1197-205. PMID: 22246216
First thoughts...Hey Julie! I hope you had a great weekend. Can I tell you more about assessing welfare? Hell to the yeah I can! (By the way, who gave you that photo of me working at 3:17am?!) I could probably blog every day until the next Canine Science Forum about measuring animal welfare - but there are so many other things I want to discuss with you, that simply won’t do.In thinking how to respond to your question, I popped out to my bookcase (technically, it’s more of a book wall) ........ Read more »
Dreschel Nancy A., & Granger Douglas A. (2009) Methods of collection for salivary cortisol measurement in dogs. Hormones and Behavior, 55(1), 168. DOI: 10.1016/j.yhbeh.2008.09.010
This study looks at the "efficacy and safety" of adenosine as a diagnostic tool for WCT (Wide Complex Tachycardia) WCT is a fast rhythm with prolonged ventricular conduction that has not had its cause diagnosed, yet. The W in WCT is its Width on an ECG (ElectroCardioGram), which is a measure of time.
The authors claim that a lack of response to adenosine will identify VT (V Tach - Ventricular Tachycardia). At least, that is what they claim that their study demonstrates.... Read more »
Marill KA, Wolfram S, Desouza IS, Nishijima DK, Kay D, Setnik GS, Stair TO, & Ellinor PT. (2009) Adenosine for wide-complex tachycardia: efficacy and safety. Critical care medicine, 37(9), 2512-8. PMID: 19623049
Monitoring changes in the incidence, prevalence and mortality rates in clinical neuroscience disorders represents an important role for research. Changes in rates of disorder over time may provide clues into diagnostic issues, key environmental factors and the effects of public health prevention interventions.Frederick Smink and colleagues from the Netherlands recently published a review of the epidemiology of anorexia nervosa, bulimia nervosa and binge eating disorder. The review co........ Read more »
Smink FR, van Hoeken D, & Hoek HW. (2012) Epidemiology of eating disorders: incidence, prevalence and mortality rates. Current psychiatry reports, 14(4), 406-14. PMID: 22644309
(The Shambulance is an occasional series in which I try to find the truth about overhyped health products. My Shambulance co-captains this week are Steven Swoap and Daniel Lynch, both of Williams College.)
It could almost be a Zen question: What do you call a food with no food in it? In Japan they're called shirataki noodles, and are made from the root of the konjac plant. In the United States they're called "Miracle Noodles" or a "healthier alternative to pasta" and promise "NO calories......... Read more »
Chen HL, Sheu WH, Tai TS, Liaw YP, & Chen YC. (2003) Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects--a randomized double-blind trial. Journal of the American College of Nutrition, 22(1), 36-42. PMID: 12569112
Treating an eating disorder can sometimes feel like walking on eggshells; it is easy to say or do the wrong thing. In my previous posts, I’ve written about situations in which clinicians end up doing more harm than good to eating disorder patients. In my first post, I talked about negative attitudes that health-care providers often have with regard to eating disorder patients and in my second post, I covered some ways in which caring clinicians that do work with ED patients may – us........ Read more »
Vandereycken, W. (2011) Can eating disorders become 'contagious' in group therapy and specialized inpatient care?. European Eating Disorders Review: The Journal of the Eating Disorders Association, 19(4), 289-95. PMID: 21394837
Prof. Dorothy Bishop outlines the major problems currently affecting the field of neuroscience.... Read more »
Weisberg, Deena Skolnick. (2008) The Seductive Allure of Neuroscience Explanations. Journal of Cognitive Neuroscience, 18(3), 229-477. DOI: 10.1162/jocn.2008.20040
Apparently, the people of Strasbourg, France suffered a "dancing plague" in 1518. Some actually danced themselves to death! What happened? Can we explain this any better now?... Read more »
Feinstein A. (2011) Conversion disorder: advances in our understanding. CMAJ : Canadian Medical Association journal , 183(8), 915-20. PMID: 21502352
Every now and then, somebody who doesn't like science claims that research is not important and uses the reference of the parachute study.
The parachute study authors make it clear that their paper is a satire. It appears in the Christmas issue, which is the most comedic of the BMJ (British Medical Journal) issues.... Read more »
Smith GC, & Pell JP. (2003) Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials. BMJ (Clinical research ed.), 327(7429), 1459-61. PMID: 14684649
Anterior cruciate ligament (ACL) injury prevention programs have been integrated into team sports in efforts to prevent or decrease the overall incidence of ACL injuries. A wide variety of programs have been studied on various populations. The purpose of this systematic review was to analyze the literature on ACL intervention programs in team sports to see where we currently stand.... Read more »
Stojanovic MD, & Ostojic SM. (2012) Preventing ACL Injuries in Team-Sport Athletes: A Systematic Review of Training Interventions. Research in Sports Medicine, 20(3-4), 223-38. PMID: 22742077
Commonly available clinical brain imaging techniques do not provide reliable or valid information in mild traumatic brain injury (TBI). This has led to increased research on evolving imaging techniques.Diffusion tensor imaging (DTI) hold promise as a potential future clinical brain imaging. DTI can assess microstructure changes in brain white matter. Aoki and colleagues from Japan recently summarized the current knowledge of DTI in mild traumatic brain injury.This review used ........ Read more »
Aoki Y, Inokuchi R, Gunshin M, Yahagi N, & Suwa H. (2012) Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis. Journal of neurology, neurosurgery, and psychiatry, 83(9), 870-6. PMID: 22797288
Reflections on the 2011 IOM paper about chronic pain... Read more »
Henriette Poulsen, M.D. (2012) Talking about a revolution – let not compassion die when facing the challenges of chronic pain management. Picture of Pain Blog. info:/
If you're trying to fight fire, should you use fire?This, pretty much, is the question asked by a group of psychiatrists in a new paper: Will disruptive mood dysregulation disorder reduce false diagnosis of bipolar disorder in children?The background here is that there's growing concern that bipolar disorder, previously thought to be extremely rare in prepubescent children, is now being diagnosed, inappropriately, in children - specifically in American children. This epidemic of so-called "pedia........ Read more »
Margulies DM, Weintraub S, Basile J, Grover PJ, & Carlson GA. (2012) Will disruptive mood dysregulation disorder reduce false diagnosis of bipolar disorder in children?. Bipolar disorders, 14(5), 488-96. PMID: 22713098
The real trouble with the pig parasite Taenia solium, aside from it's distressing appearance in your cerebral headquarters, is that you can acquire neurocysticercosis even if you don't consume pork products. This is the surprise kicker, the coal in your Christmas stocking.
This is understandably alarming for people who choose to not eat pork but what if your culture and religion prohibits its very consumption? What does it mean to those that belong to a group with strongly delineated food tab........ Read more »
Moore AC, Lutwick LI, Schantz PM, Pilcher JB, Wilson M, Hightower AW, Chapnick EK, Abter EI, Grossman JR, & Fried JA. (1995) Seroprevalence of cysticercosis in an Orthodox Jewish community. The American journal of tropical medicine and hygiene, 53(5), 439-42. PMID: 7485700
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