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  • May 30, 2017
  • 03:57 AM
  • 8 views

Healthcare use before, during and after a diagnosis of CFS/ME

by Paul Whiteley in Questioning Answers

"Adults and children with CFS/ME [chronic fatigue syndrome / myalgic encephalomyelitis] have greater health care needs than the rest of the population for at least ten years before their diagnosis, and these higher levels of health care resource use continue for at least ten years after diagnosis."So concluded the study published by Simon Collin and colleagues [1] (open-access available here) who once again (see here) relied on data derived from the "Clinical Practice Research Datalink........ Read more »

  • May 29, 2017
  • 04:08 AM
  • 33 views

Assisted reproductive technology and risk of offspring autism meta-analysed

by Paul Whiteley in Questioning Answers

"Our study indicated that the use of ART [assisted reproductive technology] may [be] associated with higher risk of ASD [autism spectrum disorder] in the offspring. However, further prospective, large, and high-quality studies are still required."So said the results of the meta-analysis published by Liang Lui and colleagues [1] (open-access) surveying the peer-reviewed research literature - "11 records (3 cohort studies and 8 case-control studies)" - between 2006 and 201........ Read more »

  • May 27, 2017
  • 03:59 AM
  • 79 views

Low dose suramin and autism: a small RCT with potentially big results

by Paul Whiteley in Questioning Answers

'Low dose' has been a feature of my autism research reading this week; first starting with the results from Dan Quintana and colleagues [1] talking about some important effects following intranasal delivery of low dose oxytocin and then moving on to the primary reason for this entry with results from Robert Naviaux and colleagues [2] (open-access) continuing a research theme looking at suramin and autism (see here for some background).For those interested in the oxytocin-autism research bas........ Read more »

Naviaux, R., Curtis, B., Li, K., Naviaux, J., Bright, A., Reiner, G., Westerfield, M., Goh, S., Alaynick, W., Wang, L.... (2017) Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial. Annals of Clinical and Translational Neurology. DOI: 10.1002/acn3.424  

  • May 26, 2017
  • 11:42 AM
  • 80 views

Adolescent Brain Development

by William Yates, M.D. in Brain Posts

Functional magnetic resonance imaging yields improvement in our understanding of brain development.A recent study out of the University of Pennsylvania is a good example. This study examined the relationship between brain connectivity and the development of cognitive executive function.The researchers imaged a group of 882 subjects between the ages of 8 and 22.Brain connectivity patterns were compared with a neurocognitive assessment of executive function. Executive function increases with age t........ Read more »

Graham L. Baum, Rastko Ciric, David R. Roalf, Richard F. Betzel, Tyler M. Moore, Russel T. Shinohara, Ari E. Kahn, Megan Quarmley, Philip A. Cook, Mark A. Elliot.... (2016) Modular Segregation of Structural Brain Networks Supports the Development of Executive Function in Youth. Current Biology. arXiv: 1608.03619v1

  • May 26, 2017
  • 05:08 AM
  • 77 views

The PI3K/mTOR inhibitor GSK2126458 is effective for treating TSC solid renal tumours

by Joana Guedes in BHD Research Blog

Tuberous sclerosis (TSC) is an inherited tumour syndrome that shares clinical similarities with Birt-Hogg-Dube Syndrome. It is caused by mutations in TSC1 or TSC2 that lead to aberrant activation of mTOR, affecting multiple organs, including the kidney and lung. In the kidney, lesions such as multiple renal cysts and renal cell carcinoma (RCC) can occur. Tumour reduction in TSC patients after treatment with rapamycin, an inhibitor of mTOR, is partial and reversible probably due to feedback activ........ Read more »

  • May 26, 2017
  • 03:06 AM
  • 88 views

On ADHD medication and motor vehicle crashes

by Paul Whiteley in Questioning Answers

"Among patients with ADHD [attention-deficit hyperactivity disorder], rates of MVCs [motor vehicle crashes] were lower during periods when they received ADHD medication."That was the research bottom-line discussed by Zheng Chang and colleagues [1] who continue a theme on how managing/treating the symptoms of ADHD can often have some profound effects on those diagnosed with ADHD and also the wider population.The outcome measure on this occasion was MVCs; in particular: "E........ Read more »

  • May 25, 2017
  • 11:07 PM
  • 96 views

Gaslighting in the Medical Literature

by The Neurocritic in The Neurocritic

Have you felt that your sense of reality has been challenged lately? That the word “truth” has no meaning any more? Does the existence of alternative facts make you question your own sanity? In modern usage, the term gaslighting refers to “a form of psychological abuse in which false information is presented to the victim with the intent of making him/her doubt his/her own memory and perception”.Gaslighting is a form of manipulation that seeks to sow seeds of doubt in a targeted ........ Read more »

Barton R, & Whitehead JA. (1969) The gas-light phenomenon. Lancet (London, England), 1(7608), 1258-60. PMID: 4182427  

Kutcher SP. (1982) The gaslight syndrome. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 27(3), 224-7. PMID: 7093877  

Lund CA, & Gardiner AQ. (1977) The gaslight phenomenon--an institutional variant. The British journal of psychiatry : the journal of mental science, 533-4. PMID: 588872  

Smith CG, & Sinanan K. (1972) The "gaslight phenomenon" reappears. A modification of the Ganser syndrome. The British journal of psychiatry : the journal of mental science, 120(559), 685-6. PMID: 5043219  

  • May 25, 2017
  • 03:02 AM
  • 95 views

Blood heavy metal levels and autism (yet again)

by Paul Whiteley in Questioning Answers

"Data showed that the children with ASD [autism spectrum disorder] had significantly (p < 0.001) higher levels of mercury and arsenic and a lower level of cadmium."And... "It is desirable to continue future research into the relationship between ASD and heavy metal exposure."Those sentences come from the study by Huamei Li and colleagues [1] continuing a research theme regarding (generally) elevated levels of heavy metals being detected in those on the autism spectrum (see here). Ye........ Read more »

  • May 24, 2017
  • 04:33 AM
  • 104 views

Irritable bowel syndrome (IBS) as a risk factor for bipolar disorder

by Paul Whiteley in Questioning Answers

"Only irritable bowel syndrome (IBS) emerged as a risk factor for BD [bipolar disorder] supported by convincing evidence."So said the results of the umbrella review of systematic reviews and meta-analyses by Beatrice Bortolato and colleagues [1] looking at the various environmental risk factors potentially linked to the diagnosis of bipolar disorder. I might add that this is a topic that has been discussed before on this blog (see here and see here for examples).If the systematic ........ Read more »

  • May 23, 2017
  • 02:54 AM
  • 127 views

"there is no single way for a brain to be normal" (or how 'neurotypical' is a nonsense)

by Paul Whiteley in Questioning Answers

I'm not usually so forthright with my posts on this blog, but today I'm being a little more bullish as I talk about an editorial from Simon Baron-Cohen [1] titled: "Neurodiversity – a revolutionary concept for autism and psychiatry."The crux of the SBC paper is the suggestion that use of the term 'disorder' specifically with autism in mind might have certain connotations - "Disorder should be used when there is nothing positive about the condition" - and until the "biomedical mechanistic cause........ Read more »

  • May 22, 2017
  • 03:00 PM
  • 188 views

Unraveling the Mysteries of Mischievous Microbiome

by Aurametrix team in Aurametrix Blog

Science explains why some people smell worse than others despite keeping themselves squeaky clean. The body is crawling with bacteria increasing the risk for diseases for which we have unreserved levels of sympathy. It can also lead to ​unlikable conditions such as unpredictable and embarrassing outbursts of body odor - so bad it ruins social lives and careers.  But there is no cure for metabolic body odor ... Read more »

  • May 22, 2017
  • 05:13 AM
  • 111 views

"a gluten-related subgroup of schizophrenia"?

by Paul Whiteley in Questioning Answers

A quote to begin this post: "this preliminary study demonstrates that altered AGDA [antibodies against gliadin-derived antigen] levels in the circulation are associated with schizophrenia and could serve as biomarkers for the identification of a schizophrenia subgroup that may need an alternative therapy or precision treatment."So said the findings reported by McLean and colleagues [1] (open-access) looking at an area of some interest to this blog (see here) on how dietary gluten might........ Read more »

  • May 22, 2017
  • 04:30 AM
  • 161 views

Should Athletic Trainers Add Anxiety Surveys to Preseason Baseline Testing?

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

An athlete with anxiety symptoms during preseason was more likely to get injured during a season than an athlete without symptoms.... Read more »

  • May 20, 2017
  • 06:12 AM
  • 115 views

Gastrin-releasing peptide and autism continued

by Paul Whiteley in Questioning Answers

Yet another 'continued' or 'part 2' short post for you today, building on some previous - very preliminary research - talking about the use of gastrin-releasing peptide (GRP) and autism (see here).The authors included on the paper by Josemar Marchezan and colleagues [1] are familiar ones to this part of the autism research landscape as per the other occasions that members of this group have looked at / talked about GRP and autism in the peer-reviewed domain.GRP is all about a compound that 'does........ Read more »

Marchezan, J., Becker, M., Schwartsmann, G., Ohlweiler, L., Roesler, R., Renck, L., Gonçalves, M., Ranzan, J., & Riesgo, R. (2017) A Placebo-Controlled Crossover Trial of Gastrin-Releasing Peptide in Childhood Autism. Clinical Neuropharmacology, 1. DOI: 10.1097/WNF.0000000000000213  

  • May 19, 2017
  • 07:00 AM
  • 99 views

Friday Fellow: Common Stinkhorn

by Piter Boll in Earthling Nature

by Piter Kehoma Boll Today things are getting sort of pornographic again. Some time ago I introduced a plant whose flowers resemble a woman’s vulva, the asian pigeonwing, and now is time to look at something of the other sex. … Continue reading →... Read more »

  • May 19, 2017
  • 05:13 AM
  • 113 views

Characterization of a FLCN mutation associated with RCC

by Joana Guedes in BHD Research Blog

Mutations in the FLCN gene are the cause of Birt-Hogg-Dubé (BHD) syndrome, a rare disease characterized by renal cell carcinoma (RCC), pneumothorax and fibrofolliculomas. In their new study, Bartram et al. (2017) identify a heterozygous mutation in the FLCN gene in a patient with RCC. DNA from tumour and a metastasis was analysed and the authors demonstrated skipping of exon 11 as the consequence of this mutation leading to a shift in the reading frame and the insertion of a premature sto........ Read more »

Bartram MP, Mishra T, Reintjes N, Fabretti F, Gharbi H, Adam AC, Göbel H, Franke M, Schermer B, Haneder S.... (2017) Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer. BMC medical genetics, 18(1), 53. PMID: 28499369  

  • May 19, 2017
  • 04:26 AM
  • 103 views

Injury risk and ADHD: part 2

by Paul Whiteley in Questioning Answers

Consider this short post a sort of follow-on to a previous entry on this blog concerning the elevated risk of injury following a diagnosis of attention-deficit hyperactivity disorder (ADHD). The paper in question today is that by Wu-Chien Chien and colleagues [1] who yet again [2], brought the quite significant scientific weight of the "National Health Insurance Research Database in Taiwan" to bear on this topic.In this latest paper, Chien et al relied on data from a 'subset' of the main in........ Read more »

  • May 18, 2017
  • 04:40 AM
  • 115 views

On vaccinated and un-vaccinated homeschooled children: the disappearing-reappearing-disappearing-reappearing studies

by Paul Whiteley in Questioning Answers

I originally began writing this post in the last week of November 2016 following first sight of the study abstract by Anthony Mawson and colleagues [1] and their journey into a topic that has had its fair share of discussion/argument* (*delete as appropriate) with autism in mind down the years: are vaccines or immunisation patterns potentially linked to [some] autism?As it happened, this post was shelved for some time because (a) only an abstract appeared despite a publication date accompan........ Read more »

Anthony R Mawson, Brian D Ray, Azad R Bhuiyan, & Binu Jacob. (2017) Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year-old U.S. children. Journal of Translational Science. info:/10.15761/JTS.1000186

  • May 17, 2017
  • 11:24 AM
  • 119 views

Dad's Impact in Infant Development

by William Yates, M.D. in Brain Posts

Mother's interaction with their infants play a key role in infant development.The independent role of fathers in infant development is less well known and studied.A recent study from the United Kingdom supports a important role for father-child interactions in infant development.Here are the main elements of the design of this study:Subjects: Families of infants with typical deliveries were recruited from maternity wards in two hospitals in the United Kingdom.Design: Home assessments were comple........ Read more »

  • May 17, 2017
  • 04:30 AM
  • 109 views

Another Feather in the Cap of the FIFA 11 Injury Prevention Program

by Kyle Harris in Sports Medicine Research (SMR): In the Lab & In the Field

Implementing the FIFA 11 injury prevention program decreases the risk of injury among collegiate male soccer players.... Read more »

Silvers-Granelli HJ, Bizzini M, Arundale A, Mandelbaum BR, & Snyder-Mackler L. (2017) Does the FIFA 11  Injury Prevention Program Reduce the Incidence of ACL Injury in Male Soccer Players?. Clinical orthopaedics and related research. PMID: 28389864  

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