Oral films have gained interest in the last couple of years. Films for oral application offer an interesting new approach for drug administration. Active pharmaceutical ingredients (API) can be implemented in thin-sheeted polymer film matrices. These dosage forms are intended to be placed in mouth to dissolve in the saliva without the need of additional liquid and without swallowing of a solid dosage form.... Read more »
Preis, M., Pein, M., & Breitkreutz, J. (2012) Development of a Taste-Masked Orodispersible Film Containing Dimenhydrinate. Pharmaceutics, 4(4), 551-562. DOI: 10.3390/pharmaceutics4040551
Garsuch V, & Breitkreutz J. (2010) Comparative investigations on different polymers for the preparation of fast-dissolving oral films. The Journal of pharmacy and pharmacology, 62(4), 539-45. PMID: 20604845
Hoffmann EM, Breitenbach A, & Breitkreutz J. (2011) Advances in orodispersible films for drug delivery. Expert opinion on drug delivery, 8(3), 299-316. PMID: 21284577
Janßen E.M., Schliephacke R,, Breitenbach A,, & Breitkreutz J. (2013) Drug-printing by flexographic printing technology—A new manufacturing process for orodispersible films. International Journal of Pharmaceutics, 441(1-2), 818-825. info:/10.1016/j.ijpharm.2012.12.023
Garsuch V, & Breitkreutz J. (2009) Novel analytical methods for the characterization of oral wafers. European Journal of Pharmaceutics and Biopharmaceutics, 73(1), 195-201. PMID: 19482082
Woertz K, Tissen C, Kleinebudde P, & Breitkreutz J. (2011) Taste sensing systems (electronic tongues) for pharmaceutical applications. International journal of pharmaceutics, 417(1-2), 256-71. PMID: 21094230
A new highly sensitive method of measurement allowed physicists form Helmholtz-Zentrum Berlin for Materials and Energy to directly detect defects in solar cells with atomic resolution. This findings can be used to optimize solar cells’ efficiency and decrease production costs.
HZB physicists have managed to localize defects in amorphous/crystalline silicon heterojunction solar cells. Now, for the first time ever, using computer simulations at Paderborn University, the scientists were able to determine the defects’ exact locations and assign them to certain structures within the interface between the amorphous and crystalline phases.... Read more »
George, B., Behrends, J., Schnegg, A., Schulze, T., Fehr, M., Korte, L., Rech, B., Lips, K., Rohrmüller, M., Rauls, E.... (2013) Atomic Structure of Interface States in Silicon Heterojunction Solar Cells. Physical Review Letters, 110(13). DOI: 10.1103/PhysRevLett.110.136803
Stampede, the newest supercomputer at the Texas Advanced Computing Center (TACC) and one of the most advanced scientific research instruments in the world, fills aisle after aisle of a new 11,000-square-foot data center on the J.J. Pickle Research Campus. Through the glass machine room doors, you can see 182 racks holding more than 500,000 interconnected computer processors. Inside, wind whips from in-row coolers, wires snake over the racks and chilled water courses below the floor as Stampede performs calculations on behalf of scientists and engineers nationwide.... Read more »
Aaron Dubrow. (2013) Texas Unleashes Stampede for Science. UT - Texas Advanced Computing Center. info:/
This week’s video tip of the week introduces you to Enzyme Portal, an interface to explore data about these important proteins, from the EBI. In the video, Jenny Cham–one of the authors of the paper below–takes you through the main features of their newly designed resource. I learned about the new effort from this blog [...]... Read more »
de Matos, P., Cham, J., Cao, H., Alcántara, R., Rowland, F., Lopez, R., & Steinbeck, C. (2013) The Enzyme Portal: A case study in applying user-centred design methods in bioinformatics. BMC Bioinformatics, 14(1), 103. DOI: 10.1186/1471-2105-14-103
Most people in the world now live in a city, feeling pretty anonymous. An even bigger number of people don’t have to defocate out in the open anymore, but have access to a toilet. And then there’s this growing amount of people that can talk in private on their cells. But beware, these are false senses of privacy.... Read more »
de Montjoye YA, Hidalgo CA, Verleysen M, & Blondel VD. (2013) Unique in the Crowd: The privacy bounds of human mobility. Scientific reports, 1376. PMID: 23524645
The ultrafast, ultrabright X-ray pulses of the Linac Coherent Light Source (LCLS) have enabled unprecedented views of a catalyst in action, an important step in the effort to develop cleaner and more efficient energy sources.
Scientists at the U.S. Department of Energy’s (DOE) SLAC National Accelerator Laboratory used LCLS, together with computerized simulations, to reveal surprising details of a short-lived early state in a chemical reaction occurring at the surface of a catalyst sample. The study offers important clues about how catalysts work and launches a new era in probing surface chemistry as it happens.... Read more »
Andy Freeberg. (2013) Breakthrough Research Shows Chemical Reaction in Real Time. SLAC National Accelerator Laboratory News. info:/
Using laser light to read and write magnetic data by quickly flipping tiny magnetic domains could help keep pace with the demand for faster computing devices.
Now experiments with SLAC’s Linac Coherent Light Source (LCLS) X-ray laser have given scientists their first detailed look at how light controls the first trillionth of a second of this process, known as all-optical magnetic switching.... Read more »
Glenn Roberts Jr. (2013) X-ray Laser Explores How to Write Data with Light. SLAC National Accelerator Laboratory News. info:/
Sometimes even big project could start from a tweet.
Matteo Cantarelli - member of the OpenWorm team - says: "It was 2007 when Giovanni Idili and I started - naively - talking about simulating the worm. We were approaching the problem after having hit common limits of artificial intelligence. We never got to write any code for the worm at that time, we just had lengthy conversations and paper reading sessions together."
... Read more »
Varshney LR, Chen BL, Paniagua E, Hall DH, & Chklovskii DB. (2011) Structural properties of the Caenorhabditis elegans neuronal network. PLoS computational biology, 7(2). PMID: 21304930
Palyanov A, Khayrulin S, Larson SD, & Dibert A. (2011) Towards a virtual C. elegans: a framework for simulation and visualization of the neuromuscular system in a 3D physical environment. In silico biology, 11(3-4), 137-47. PMID: 22935967
Don’t venture too far on the internet: bad neighborhoods were located! Internet bad neighborhoods are those geographical areas where the majority of spam and phishing mails originate from. Interestingly, some regions specialize in spam, while others focus on phishing for your bank account. ... Read more »
Giovane C. M. Moura, Anna Sperotto, Ramin Sadre, & Aiko Pras. (2013) Evaluating Third-Party Bad Neighborhood Blacklists for Spam Detection. IFIP/IEEE International Symposium on Integrated Network Management. info:/
Plain-looking but inherently strange crystalline materials called 3D topological insulators (TIs) are all the rage in materials science. Even at room temperature, a single chunk of TI is a good insulator in the bulk, yet behaves like a metal on its surface.
Researchers find TIs exciting partly because the electrons that flow swiftly across their surfaces are “spin polarized”: the electron’s spin is locked to its momentum, perpendicular to the direction of travel. These interesting electronic states promise many uses – some exotic, like observing never-before-seen fundamental particles, but many practical, including building more versatile and efficient high-tech gadgets, or, further into the future, platforms for quantum computing.... Read more »
Paul Preuss. (2013) Surprising Control over Photoelectrons from a Topological Insulator. Berkeley Lab News Center. info:/
Being able to predict the pace of technological development could be quite useful for a lot of people. No surprise then, that several models (or ‘laws’) have been posited that aim to describe how technological progress will unfurl (the most famous one probably being Moore’s law, for those interested: original article here). However, these laws [...]... Read more »
Nagy, B., Farmer, J., Bui, Q., & Trancik, J. (2013) Statistical Basis for Predicting Technological Progress. PLoS ONE, 8(2). DOI: 10.1371/journal.pone.0052669
Scientists and researchers at the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL) are constantly innovating, integrating novel technologies, and “walking the talk.” Since 1982, NREL has won 52 R&D 100 Awards — known in the research and development community as “the Oscars of Innovation” — for its groundbreaking work.... Read more »
Heather Lammers. (2013) New Ultra-Efficient HPC Data Center Debuts. NREL Newsroom. info:/
It’s fairly easy to surmise how quantum computing will evolve in the future if/when it becomes a reality. Devices that are currently based around a system of electronic circuits would eventually die off. Quantum devices would ultimately become the new standard in computing. While Peter Shor’s research showed how quantum algorithms would speed up advanced [...]... Read more »
Benningshof OW, Mohebbi HR, Taminiau IA, Miao GX, & Cory DG. (2013) Superconducting microstrip resonator for pulsed ESR of thin films. Journal of magnetic resonance (San Diego, Calif. : 1997), 84-87. PMID: 23454577
Petersson KD, McFaul LW, Schroer MD, Jung M, Taylor JM, Houck AA, & Petta JR. (2012) Circuit quantum electrodynamics with a spin qubit. Nature, 490(7420), 380-3. PMID: 23075988
by Artem Kaznatcheev in Evolutionary Games Group
Intelligence is one of the most loaded terms that I encounter. A common association is the popular psychometric definition — IQ. For many psychologists, this definition is too restrictive and the g factor is preferred for getting at the ‘core’ of intelligence tests. Even geneticists have latched on to g for looking at heritability of [...]... Read more »
Strannegård, C., Amirghasemi, M., & Ulfsbäcker, S. (2013) An anthropomorphic method for number sequence problems. Cognitive Systems Research, 27-34. DOI: 10.1016/j.cogsys.2012.05.003
Researchers at Duke University recently took a major step toward better understanding how swamp sparrows use a combination of song and visual displays to communicate with one another. How they came about making this discovery, though, is what makes this story particularly newsworthy — they stuffed a deceased swamp sparrow with a miniature computer and some [...]... Read more »
Anderson, R., DuBois, A., Piech, D., Searcy, W., & Nowicki, S. (2013) Male response to an aggressive visual signal, the wing wave display, in swamp sparrows. Behavioral Ecology and Sociobiology. DOI: 10.1007/s00265-013-1478-9
There are numerous filters to separate particles in liquid based on their size, which can be enough to isolate them; however, particle shape can be more important, as it distinguishes healthy red blood cells from those affected by sickle-cell disease or malaria. Shape can also be used to determine what stage a cell is in of the cell cycle, which would benefit researchers looking for dividing cells. Recent research by Dino Di Carlo of UCLA looks to separate particles of differing aspect ratios continuously, using inertial fluid-dynamics. His work, “Continuous Inertial Focusing and Separation of Particles by Shape,” featured in Physical Review X reminds me of his previous work to use inertial fluid-dynamics to continuously filter particles according to size.... Read more »
Masaeli, M., Sollier, E., Amini, H., Mao, W., Camacho, K., Doshi, N., Mitragotri, S., Alexeev, A., & Di Carlo, D. (2012) Continuous Inertial Focusing and Separation of Particles by Shape. Physical Review X, 2(3). DOI: 10.1103/PhysRevX.2.031017
Di Carlo, D., Irimia, D., Tompkins, R., & Toner, M. (2007) Continuous inertial focusing, ordering, and separation of particles in microchannels. Proceedings of the National Academy of Sciences, 104(48), 18892-18897. DOI: 10.1073/pnas.0704958104
Sugaya, S., Yamada, M., & Seki, M. (2011) Observation of nonspherical particle behaviors for continuous shape-based separation using hydrodynamic filtration. Biomicrofluidics, 5(2), 24103. DOI: 10.1063/1.3580757
The third (and final, at the moment) paper in the likelihood calculus series from Dr. Terrence Sanger is Distributed control of uncertain systems using superpositions of linear operators. Carrying the torch for the series right along, here Dr. Sanger continues investigating the development of an effective, general method of controlling systems operating under uncertainty. This is the paper that delivers on all the promises of building a controller out of a system described by the stochastic differential operators we’ve been learning about in the previous papers. In addition to describing the theory, there are examples of system simulation with code provided! Which is a wonderful, and sadly uncommon, thing in academic papers, so I’m excited. We’ll go through a comparison of Bayes’ rule and Markov processes (described by our stochastic differential equations), go quickly over the stochastic differential operator description, and then dive into the control of systems. The examples and code run-through I’m going to have to save for another post, though, just to keep the size of this post reasonable.... Read more »
Sanger, T. (2011) Distributed Control of Uncertain Systems Using Superpositions of Linear Operators. Neural Computation, 23(8), 1911-1934. DOI: 10.1162/NECO_a_00151
Update: Sebastian Dennerlein and I have written a paper entitled “Towards a Model of Interdisciplinary Teamwork for Web Science: What can Social Theory Contribute?” which includes the patterns vs. models problem. The paper has been accepted for the Web Science 2013 Workshop: “Harnessing the Power of Social Theory for Web Science”. You can download it …Read More... Read more »
Peter Kraker, & Sebastian Dennerlein. (2013) Towards a Model of Interdisciplinary Teamwork for Web Science: What can Social Theory Contribute?. Web Science 2013 Workshop: Harnessing the Power of Social Theory for Web Science. info:/
In the previous post, I’ve described the relationship between environmental factors and the public’s insights. Moreover, what would happen if we have more than an ideal “physical” environment? Will people embrace a brand new world in which virtual components are added to the physical ones?
We all know that more research should be carried out to create software which supports the most complex and time-consuming portions of the analytical process, so that analysts can respond to increasingly more complex questions.... Read more »
Gershon Dublon, & Joseph A. Paradiso. (2012) Tongueduino: hackable, high-bandwidth sensory augmentation. Proceeding CHI EA '12 CHI '12 Extended Abstracts on Human Factors in Computing Systems, 1453-1454. DOI: 10.1145/2212776.2212482
Flywheel energy storage devices could be looked at as a radical application of very traditional technology. They work by maintaining rotational energy by moving a flywheel. This same idea is used to keep a mechanical watch ticking. A majority of modern FES devices use electricity to put the flywheel in motion, but some researchers are [...]... Read more »
Zhang, C., & Tseng, K. (2007) A Novel Flywheel Energy Storage System With Partially-Self-Bearing Flywheel-Rotor. IEEE Transactions on Energy Conversion, 22(2), 477-487. DOI: 10.1109/TEC.2005.858088
MacIntosh BR, Rishaug P, & Svedahl K. (2003) Assessment of peak power and short-term work capacity. European journal of applied physiology, 88(6), 572-9. PMID: 12560957
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