All posts; Tags Include "Adult Neurogenesis"
- May 12, 2010
- 03:30 AM
- 123 views
What IS the dentate gyrus doing to CA3?
by Jason Snyder in Functional Neurogenesis
A fundamental property of the hippocampus is its ability to rapidly encode memories while simultaneously keeping them distinct. Recording from hippocampal neurons one can clearly see that different populations of neurons are active as a rat explores two environments. This is thought to be one mechanism by which information is kept distinct in the brain.
For [...]... Read more »
Leutgeb JK, Leutgeb S, Moser MB, & Moser EI. (2007) Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science, 315(5814), 961-6. PMID: 17303747
- May 3, 2010
- 03:39 AM
- 132 views
Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons
by Jason Snyder in Functional Neurogenesis
Dendrites are the extensions of neurons that receive incoming information. Neurons have primary dendrites that further split off into secondary and tertiary dendritic branches. On each of these branches are thousands of synaptic connections with axons of neurons carrying incoming information. The result is a dendritic tree that is capable of receiving and integrating a wide array [...]... Read more »
Tronel S, Fabre A, Charrier V, Oliet SH, Gage FH, & Abrous DN. (2010) Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America, 107(17), 7963-8. PMID: 20375283
- March 22, 2010
- 04:17 PM
- 143 views
The first example of functional neurogenesis?
by Jason Snyder in Functional Neurogenesis
I recently became re-acquainted with the neurogenesis literature while writing the last post, re-finding data in papers whose gist, but not details, I had remembered. I reached out a little bit, asking others if I had forgot any studies and indeed I had, including this study by Okano, Pfaff and Gibbs from 1993.
I’ve been [...]... Read more »
Okano HJ, Pfaff DW, & Gibbs RB. (1993) RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(7), 2930-8. PMID: 8331381
- February 4, 2010
- 04:06 PM
- 209 views
Adult neurogenesis in humans: Murine Features of Neurogenesis in the Human Hippocampus
by Jason Snyder in Functional Neurogenesis
Studies of adult neurogenesis often begin with the following sentence: “Adult neurogenesis occurs in all mammals examined, including humans.” More detail-oriented papers might say, “Adult neurogenesis occurs in all mammals examined, including humans…but not bats.” Here, the similarities between bats and humans become more evident than one might expect: it could be an equally long [...]... Read more »
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R., Horvat, V., Volk, B., & Kempermann, G. (2010) Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years. PLoS ONE, 5(1). DOI: 10.1371/journal.pone.0008809
- January 25, 2010
- 01:22 PM
- 93 views
Decade in review #1: the neurogenesis-depression hypothesis
by Jason Snyder in Functional Neurogenesis
A major theme in the field of adult neurogenesis is the neurogenesis-depression hypothesis, the idea that newborn neurons are protective against depression. ... Read more »
Malberg JE, Eisch AJ, Nestler EJ, & Duman RS. (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(24), 9104-10. PMID: 11124987
Santarelli, L. (2003) Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants. Science, 301(5634), 805-809. DOI: 10.1126/science.1083328
- December 22, 2009
- 11:42 AM
- 115 views
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory
by Jason Snyder in Functional Neurogenesis
A review of the Cell paper by Kitamura, Inokuchi and colleagues on the role of adult-born neurons in systems consolidation of memory.... Read more »
Kitamura T, Saitoh Y, Takashima N, Murayama A, Niibori Y, Ageta H, Sekiguchi M, Sugiyama H, & Inokuchi K. (2009) Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell, 139(4), 814-27. PMID: 19914173
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