Post List

All posts; Tags Include "Behavioral Neuroscience"

(Modify Search »)

  • August 17, 2014
  • 09:00 PM
  • 1,553 views

Can psychopathy be treated?

by neurosci in Neuroscientifically Challenged

Some psychological conditions receive a disproportionate amount of attention in popular media relative to how frequently they actually occur in the population. One of those is psychopathy, a personality disorder that is characterized by antisocial behavior, impulsivity, and a lack of empathy. Psychopaths may be charming on the surface but tend towards pathological deception and indifferent manipulation of other people. And they are more likely to have behavioral problems or be involved in crimin........ Read more »

  • August 15, 2014
  • 06:49 PM
  • 1,012 views

A non-invasive system to replace EEG/EMG recording of sleep

by Allison in Dormivigilia

Researchers highlight a new system that is ideal for high-throughput (large numbers of animals) studies for recording sleep. A game changer for sure. ... Read more »

  • August 14, 2014
  • 11:17 AM
  • 979 views

FDA Approves Novel Insomnia Drug Suvorexant (Belsomra)

by William Yates, M.D. in Brain Posts

Regular readers of this blog had a heads up last year on the development of orexin receptor antagonists for the treatment of insomnia.I posted a review of an Italian clinical drug trial in humans with insomnia paired with polysomnography. This study used three different doses of a orexin receptor antagonist (10 mg 30 mg and 60 mg).In a second post, I reviewed a sleep lab study of the effects of an orexin antagonist drug compared to zolpidem (Ambien) on sleep architecture.This second study found ........ Read more »

  • August 11, 2014
  • 11:42 AM
  • 685 views

Clinical Drug Trials for Pathological Gambling

by William Yates, M.D. in Brain Posts

Several drug classes hold promise for reduction in pathological gambling behavior.However, there are very few published randomized and controlled clinical drug trials in gambling subjects.Searching clinical trials and gambling on PubMed yields only one small open-label proof of concept trial for the drug tolcapone within the last year.This study found evidence that this COMT inhibitor drug reduced gambling symptoms and was accompanied by fronto-parietal activation on fMRI imaging.However, on sea........ Read more »

Grant JE, Odlaug BL, Chamberlain SR, Hampshire A, Schreiber LR, & Kim SW. (2013) A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23(11), 1587-96. PMID: 23953269  

  • August 11, 2014
  • 09:38 AM
  • 899 views

Lithium For Aging Brain

by Vivek Misra in Uberbrain Research Frontier

Recent studies investigating Lithium, a drug commonly used for the treatment of mood disorders in humans, found its robust neurotrophic and neuroprotective effects which can help us exploring new novel, exciting, and promising targets. The molecular mechanism underlying lithium’s mood stabilizing effect is not yet unraveled. Suggested hypotheses include inositol-depletion via inhibition of inositol- monophosphatase and neuroprotection, via inhibition of GSK-3. Chronic lithium treatment inc........ Read more »

Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, & Manji HK. (2000) Enhancement of hippocampal neurogenesis by lithium. Journal of neurochemistry, 75(4), 1729-34. PMID: 10987856  

O'Brien WT, Harper AD, Jové F, Woodgett JR, Maretto S, Piccolo S, & Klein PS. (2004) Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(30), 6791-8. PMID: 15282284  

Berggren U, Tallstedt L, Ahlenius S, & Engel J. (1978) The effect of lithium on amphetamine-induced locomotor stimulation. Psychopharmacology, 59(1), 41-5. PMID: 100811  

Agam G, Bersudsky Y, Berry GT, Moechars D, Lavi-Avnon Y, & Belmaker RH. (2009) Knockout mice in understanding the mechanism of action of lithium. Biochemical Society transactions, 37(Pt 5), 1121-5. PMID: 19754464  

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS.... (2014) REST and stress resistance in ageing and Alzheimer's disease. Nature, 507(7493), 448-54. PMID: 24670762  

  • August 8, 2014
  • 09:52 AM
  • 1,553 views

Know your brain: Corpus callosum

by neurosci in Neuroscientifically Challenged







Corpus callosum (in red).CC image courtesy of Life Science Databases(LSDB).






Where is it?The corpus callosum is a large, C-shaped nerve fiber bundle found beneath the cerebral cortex. It stretches across the midline of the brain, connecting the left and right cerebral hemispheres. It makes up the largest collection of white matter tissue found in the brain.What is it and what does it do?To understand the role of the corpus callosum, it is first importan........ Read more »

  • August 6, 2014
  • 12:01 PM
  • 1,276 views

Brain Striatum and Loss-Chasing in Gambling

by William Yates, M.D. in Brain Posts

Pathological gambling (PG) is a pattern of gambling characterized by loss of control and large gambling debts.The near-miss phenomenon in gambling is the gaming scenario where gamblers sense they were very close to winning.This near-miss phenomenon can be programmed into slot machines. For example, a gambler might be presented frequently with four cherries when five cherries would result in a huge payout.The response to the near-miss in PG is often a sense that a big win is just around the corne........ Read more »

  • August 6, 2014
  • 12:03 AM
  • 839 views

Galen may have been (partly) right.

by Allison in Dormivigilia

Research in California has re-opened the ancient medical texts by identifying factors in the blood of young adult mice that may slow the rate of neurodegeneration in aged mice. Even Steven Colbert digs it. ... Read more »

Villeda, S., Plambeck, K., Middeldorp, J., Castellano, J., Mosher, K., Luo, J., Smith, L., Bieri, G., Lin, K., Berdnik, D.... (2014) Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine, 20(6), 659-663. DOI: 10.1038/nm.3569  

  • July 30, 2014
  • 11:24 AM
  • 1,049 views

Violent Death Rates Increased After Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Anecdotal reports have linked traumatic brain injury with later violent death including death by suicide.Few large epidemiological studies have been published on this association.However, a recent Swedish population study published in JAMA Psychiatry provides valuable insight into this issue.Seena Fazel and colleagues from the University of Oxford, University College London and the Karolinksa Institute examined a large database of over 200,000 patients with TBI.Cases of TBI were identified from ........ Read more »

  • July 29, 2014
  • 11:17 AM
  • 894 views

Treating Sleep Problems Following Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Sleep problems are common following traumatic brain injury (TBI).In a previous post, I reviewed a study of the risk factors for sleep disorders following TBI.The most severe TBI is a risk factor for hypersomnia. Anxiety and depression following TBI increase risk for insomnia complaints.Few large studies of treatment for sleep problems after TBI exist. However, a recent manuscript outlined the potential benefit of treatment of sleep disorders in a series of 12 subjects.Catherine Wiseman-Hake........ Read more »

  • July 25, 2014
  • 11:02 AM
  • 795 views

Risk Factors For Sleep Disturbance After Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Sleep disturbance following traumatic brain injury (TBI) is a common clinical challenge.Hypersomnia and insomnia can both been seen in the TBI population.The risk factors related to TBI-related sleep disturbance are not well known. Identification of risk factors can provide insight into clinical assessment and management.Lijun Hou and colleagues recently examined risk factors related to subjective sleep complaints in a series of 98 TBI subjects.The study sample include adults admitted to a ........ Read more »

  • July 17, 2014
  • 06:07 AM
  • 870 views

Profiling Risk: Predicting Alcoholism In Adolescents

by Agnese Mariotti in United Academics

It appears that certain personality traits and traumatic early life events are typically associated with binge drinking in teenage years. However, the predictive power of each type of factors by itself (personality or individual history for example) is not absolute. A new study evaluated not only one single factor, but a series of psychological, genetic, and neurological elements for their ability to determine, when combined, current and future alcohol misuse in a large group of youngsters. ... Read more »

Whelan, R., Watts, R., Orr, C., Althoff, R., Artiges, E., Banaschewski, T., Barker, G., Bokde, A., Büchel, C., Carvalho, F.... (2014) Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature. DOI: 10.1038/nature13402  

  • July 14, 2014
  • 11:08 PM
  • 1,373 views

Post-traumatic amnesia: why Kramer can’t remember his play in the World Cup Final

by Shelly Fan in Neurorexia

Image: screamer.deadspin.com It was 17 minutes into his second World Cup appearance when German midfielder Christoph Kramer slammed brutally into his Argentine opponent. Kramer’s head swerved...... Read more »

  • July 10, 2014
  • 07:17 AM
  • 881 views

Can a Failed Schizophrenia Drug Prevent PTSD?

by The Neurocritic in The Neurocritic

In the 2000s, enthusiasm was high that a novel class of drugs would reach the market as blockbuster treatments for psychiatric disorders. These drugs act on receptors for a group of neuropeptides known as tachykinins (or neurokinins). These peptides — substance P (SP), neurokinin A (NkA), and neurokinin B (NkB) — function as neurotransmitters or neuromodulators in the central nervous system, but are quite different from the usual monoamines targeted by current psychotropic medications prescr........ Read more »

  • July 9, 2014
  • 11:00 AM
  • 1,005 views

Chimp Talk

by Viputheshwar Sitaraman in Draw Science

Learn how to speak chimp with the newly translated language of chimpanzee gestures in non-play context. [Infographic]... Read more »

Hobaiter C, & Byrne RW. (2014) The Meanings of Chimpanzee Gestures. Current biology : CB. PMID: 24998524  

  • July 7, 2014
  • 11:27 PM
  • 823 views

The Refs are Biased, Neurologically

by Allison in Dormivigilia

During the last World Cup, a study was published that outlined why the human eye and human perception is fatly at certain angles. ... Read more »

Kranjec A, Lehet M, Bromberger B, Chatterjee A. (2010) A Sinister Bias for Calling Fouls in Soccer. PLoS One, 5(7). info:/10.1371/journal.pone.0011667

  • July 2, 2014
  • 12:26 PM
  • 794 views

That Shiver Down My Spine: How We Experience Emotions

by Agnese Mariotti in United Academics

Researchers draw bodily maps of emotions associated with corresponding brain maps. In a paper published in PNAS, Nummenmaa and colleagues from the University of Aalto in Finland wondered whether common emotions consistently activate the same body areas in different individuals. Their goal was to understand if it is possible to draw bodily maps of emotions that could be associated with corresponding brain maps.... Read more »

Nummenmaa L, Glerean E, Hari R, & Hietanen JK. (2014) Bodily maps of emotions. Proceedings of the National Academy of Sciences of the United States of America, 111(2), 646-51. PMID: 24379370  

  • July 2, 2014
  • 12:33 AM
  • 990 views

Fire together, wire together: building a memory with long-term potentiation

by Shelly Fan in Neurorexia

When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place...... Read more »

Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, & Malinow R. (2014) Engineering a memory with LTD and LTP. Nature. PMID: 24896183  

  • June 26, 2014
  • 09:26 AM
  • 1,034 views

Why use fruit flies to study a gene involved in language?

by Björn Brembs in bjoern.brembs.blog

This is the story behind our work on the function of the FoxP gene in the fruit fly Drosophila (more background info). As so many good things, it started with beer. Troy Zars and I were having a beer on […] ↓ Read the rest of this entry...... Read more »

Mendoza, E., Colomb, J., Rybak, J., Pflüger, H., Zars, T., Scharff, C., & Brembs, B. (2014) Drosophila FoxP Mutants Are Deficient in Operant Self-Learning. PLoS ONE, 9(6). DOI: 10.1371/journal.pone.0100648  

  • June 25, 2014
  • 07:58 PM
  • 848 views

Time weaves memories into patterns

by Shelly Fan in Neurorexia

When I get a craving for Cote d’Or chocolate, I always hit up London Drugs. It’s not the only grocer around that carries the brand,...... Read more »

Richards BA, Xia F, Santoro A, Husse J, Woodin MA, Josselyn SA, & Frankland PW. (2014) Patterns across multiple memories are identified over time. Nature neuroscience. PMID: 24880213  

join us!

Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.

If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.

Register Now

Research Blogging is powered by SRI Technology.

To learn more, visit http://selfregulationinstitute.org/.