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  • June 24, 2015
  • 11:02 AM
  • 855 views

Bipolar Disorder Link to Rheumatoid Arthritis

by William Yates, M.D. in Brain Posts

Finding links between disorders felt to be distinct is a helpful tool in understanding genetics and pathophysiology. An example would be the discovery that individuals with genetically determined elevated cholesterol levels had higher rates of cardiovascular disease. This led to drug development of cholesterol lowering agents leading to reduced rates of cardiovascular disease and mortality.A recent population-based study from a research team in Taiwan identified an increased risk of bipolar........ Read more »

  • June 23, 2015
  • 12:11 PM
  • 1,262 views

Bipolar Disorder Linked to Increased Dementia Risk

by William Yates, M.D. in Brain Posts

A variety of risk factors have been identified in Alzheimer's disease and other types of dementia.The risk for dementia following major psychiatric syndromes in mid-life is an important research area.Renate Zilkens and colleagues in Australia recently published an informative study of psychiatric disorders and later dementia risk. This study used a population-based case control methodology.The key elements in the design of this study included the following:Subjects: General population in Western........ Read more »

  • June 19, 2015
  • 12:23 PM
  • 633 views

6 Realities of Genomic Research

by Daniel Koboldt in Massgenomics

The rise of next-generation sequencing has worked wonders for the field of genetics and genomics. It’s also generated a considerable amount of hype about the power of genome sequencing, particularly the possibility of individualized medicine based on genetic information. The rapid advances in technology — most recently, the Illumina X Ten system — have made […]... Read more »

Rehm HL, Berg JS, Brooks LD, Bustamante CD, Evans JP, Landrum MJ, Ledbetter DH, Maglott DR, Martin CL, Nussbaum RL.... (2015) ClinGen--the Clinical Genome Resource. The New England journal of medicine, 372(23), 2235-42. PMID: 26014595  

  • June 10, 2015
  • 12:58 PM
  • 850 views

Brain Default Network in Psychotic Bipolar Disorder

by William Yates, M.D. in Brain Posts

In a previous post I reviewed a summary of research related to genetics and improved diagnosis in bipolar disorder.One key point in this review was a highlight of the promise for integrating genetic with imaging research in bipolar disorder and other neuropsychiatric disorders.An example of this type of integrated research has been recently published in PNAS by a group of Yale University, the University of New Mexico and the University of Texas Southwestern Medical Center.This study used functio........ Read more »

Meda SA, Ruaño G, Windemuth A, O'Neil K, Berwise C, Dunn SM, Boccaccio LE, Narayanan B, Kocherla M, Sprooten E.... (2014) Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 111(19). PMID: 24778245  

  • June 8, 2015
  • 01:10 PM
  • 809 views

Genetics Leading to Better Bipolar Disorder Diagnosis

by William Yates, M.D. in Brain Posts

I wanted to alert Brain Posts readers to an important new review of genetics and diagnosis in brain disorders including bipolar disorder.One hope for the emerging genetics research in mental disorders is a better diagnostic classification system.The current psychiatric diagnostic system is hampered by use of a primary symptoms and signs approach leading to messy heterogeneous groups of clinical conditions.Elliot Gerson has been a giant in neuroscience genetics for quite some time and recently pu........ Read more »

  • June 5, 2015
  • 11:04 AM
  • 748 views

Bipolar Disorder Guidelines: NICE Update

by William Yates, M.D. in Brain Posts

Clinicians treating bipolar disorder and patients with a bipolar disorder diagnosis are aided by the availability of expert opinion guidelines.In the last post, I reviewed a study that found decreased rates of suicidal behavior in bipolar patients treated with antidepressant drugs.This review prompted me to look for a recent consensus update on assessment and treatment of bipolar. One recent update came from the UK National Institute for Health and Care Excellence or NICE. This guideline is free........ Read more »

Kendall T, Morriss R, Mayo-Wilson E, Marcus E, & Guideline Development Group of the National Institute for Health and Care Excellence. (2014) Assessment and management of bipolar disorder: summary of updated NICE guidance. BMJ (Clinical research ed.). PMID: 25258392  

  • June 4, 2015
  • 10:58 AM
  • 1,038 views

Antidepressants Linked to Lower Suicide in Bipolar Disorder

by William Yates, M.D. in Brain Posts

Bipolar disorder is known to have a marked increased lifetime risk for suicide.There has been limited study of the effect of specific interventions in the risk of suicidal behavior and completed suicide.A recent study has added to our understanding of this topic using data from the Collaborative Depression Study or CDS.The CDS is a large longitudinal stud funded by the NIMH that enrolled a large sample of subjects with bipolar I disorder, bipolar II disorder and unipolar depression.Subject were ........ Read more »

Leon AC, Fiedorowicz JG, Solomon DA, Li C, Coryell WH, Endicott J, Fawcett J, & Keller MB. (2014) Risk of suicidal behavior with antidepressants in bipolar and unipolar disorders. The Journal of clinical psychiatry, 75(7), 720-7. PMID: 25093469  

  • June 3, 2015
  • 08:15 AM
  • 758 views

Clinical Sequencing Data Sharing Is Essential

by Daniel Koboldt in Massgenomics

The past few decades have seen rapid advances in our knowledge of genetic diseases, which affect an estimated 25 million Americans. These advances can be quantified in things like the growth of dbSNP (now contains about 90 million validated genetic variants) and the number of Mendelian disorders understood at the genetic level (over 5,000). Some of the […]... Read more »

Rehm HL, Berg JS, Brooks LD, Bustamante CD, Evans JP, Landrum MJ, Ledbetter DH, Maglott DR, Martin CL, Nussbaum RL.... (2015) ClinGen - The Clinical Genome Resource. The New England journal of medicine. PMID: 26014595  

  • June 2, 2015
  • 03:41 PM
  • 750 views

Neurobiology of Child Neglect/Abuse: Nemeroff Lecture Notes

by William Yates, M.D. in Brain Posts

I had the opportunity to attend the Warren Neuroscience Lecture presented by Dr. Charles Nemeroff in Tulsa, OK on June 2, 2015.Dr. Nemeroff has been an international leader in research in mood and anxiety disorders. His recent focus has been on the effects of adverse childhood environments on risk for adult mood and anxiety disorders. Here are my notes that summarize some of the key points from his lecture.Introduction:Stress is an important factor in understanding depressionEarly life stre........ Read more »

  • May 26, 2015
  • 10:18 AM
  • 772 views

Conduct Disorder as a Substance Abuse Risk Factor

by William Yates, M.D. in Brain Posts

In this series of research reviews on conduct disorder several important findings are evident.Conduct disorder (CD) commonly evolves into adult antisocial personality disorderConduct disorder in children often presents along with attention deficit hyperactivity disorder and learning problemsCD in childhood and adolescence raises risk for alcohol, drug and nicotine dependence.Margaret Sibley and colleagues recently published a study of CD and ADHD and later initiation and escalation of the use of........ Read more »

  • May 22, 2015
  • 04:07 AM
  • 769 views

Clinical trials for rare diseases – finding and keeping patients

by Joana Guedes in BHD Research Blog

International Clinical Trial day (May 20th) celebrates the medical advances as a result of clinical trials. Clinical trials are essential to ensure drug safety and efficacy, and the recent increase in the development of orphan drugs has led to an increase in rare disease clinical trials. The nature of rare diseases creates specific challenges for clinical trial design and patient recruitment.... Read more »

  • May 18, 2015
  • 10:45 AM
  • 809 views

Brain Imaging and Conduct Disorder: Temporal Lobe Abnormalities

by William Yates, M.D. in Brain Posts

Conduct disorder is a complex behavioral disorder with significant risk for later adult psychopathology.There is increasing evidence for a biological basis for conduct disorder.Twin studies show a significant genetic contribution to the disorder.Brain imaging studies also point to biological factors in conduct disorder.Gregory Wallace and colleagues recently published a structural MRI study of conduct disorder in 22 adolescents between the ages of 10 and 18. Conduct disorder subjects were compar........ Read more »

Wallace GL, White SF, Robustelli B, Sinclair S, Hwang S, Martin A, & Blair RJ. (2014) Cortical and subcortical abnormalities in youths with conduct disorder and elevated callous-unemotional traits. Journal of the American Academy of Child and Adolescent Psychiatry, 53(4), 456-650. PMID: 24655655  

  • May 14, 2015
  • 01:15 PM
  • 1,132 views

Mary-Claire King on Inherited Breast/Ovarian Cancer

by Daniel Koboldt in Massgenomics

It is a rare but delightful opportunity to learn about something from an acknowledged world expert. Such was the case last month when I heard Mary-Claire King give the Stanley J. Korsmeyer Memorial lecture, hands-down one of the best talks I’ve ever heard. She was a wonderful public speaker: funny, charming, and straight-shooting. Her topic, of […]... Read more »

Hall JM, Lee MK, Newman B, Morrow JE, Anderson LA, Huey B, & King MC. (1990) Linkage of early-onset familial breast cancer to chromosome 17q21. Science (New York, N.Y.), 250(4988), 1684-9. PMID: 2270482  

King MC. (2014) "The race" to clone BRCA1. Science (New York, N.Y.), 343(6178), 1462-5. PMID: 24675952  

  • May 14, 2015
  • 10:31 AM
  • 763 views

Male Depression Risk Via Childhood Conduct Disorder

by William Yates, M.D. in Brain Posts

Conduct disorder represents an important childhood-onset condition that commonly persists into adulthood.Adult antisocial personality disorder and substance abuse are known risks associated with conduct disorder.A recent study by Kenneth Kendler and Charles Gardner identified male conduct disorder as a risk factor for adult major depression.Their study using the Virginia Twin Registry examined 20 developmental risk factors in male and female twins for presence of recent adult major depression.A ........ Read more »

  • May 8, 2015
  • 04:13 AM
  • 971 views

Advances in immunotherapy for renal cell carcinoma

by Joana Guedes in BHD Research Blog

In recent years there has been renewed interest in immunotherapies to treat of metastatic renal cell carcinoma (mRCC). Immunotherapies increase the body’s natural finely regulated multiple-step anti-tumour immune response (Figure 1). The balance of stimulatory and inhibitory signals (reviewed in Chen & Mellman, 2013) are important in maintaining self-tolerance and modulating normal immune responses to minimising health tissue damage. However, tumours can develop mechanisms to evade this im........ Read more »

  • May 7, 2015
  • 10:30 AM
  • 892 views

Conduct Disorder: Predictors, Gender and Genetics

by William Yates, M.D. in Brain Posts

Genetic factors contribute to risk for many childhood mental disorders.Gender issues in childhood psychopathology are also important factors.Boys show higher rates for conduct disorder (CD), oppositional defiant disorder (ODD) and attention deficit hyperactivity disorder (ADHD).Nora Kerekes and colleagues in Sweden and Australia examined a large twin study of childhood behavioral and neurobehavioral disorders. The aims of this study were to better understand the developmental and genetic feature........ Read more »

  • May 5, 2015
  • 11:12 AM
  • 619 views

Bad Boy. Bad Boy. Is It Conduct Disorder?

by William Yates, M.D. in Brain Posts

Defining the line between normal childhood behavior and more serious problems like conduct disorder (CD) is important.Conduct disorder is linked to a significant risk for a lifelong problem with aggression. Identifying CD early in life provides the hope that early intervention might reduce the later consequences of the disorder.The American Academy of Child and Adolescent Psychiatry has an excellent online resource center to understand conduct disorder. They note the condition is characteri........ Read more »

  • May 4, 2015
  • 09:00 AM
  • 866 views

this is your brain on cosmic rays

by Greg Fish in weird things

Back in the day, I argued that if we were going to get serious about space exploration, we also had to budget for large, luxury spacecraft rather than just capsules in which we would cram the brave men and women we’d be sending to other worlds with a pat on the back for agreeing to deal with the discomfort and damage to their bodies. Among the reasons listed were the basic physiological problems of spending many months in zero gravity, and mental health hazards of boredom and cabin fever. ........ Read more »

Vipan K. Parihar, Barrett Allen, Katherine K. Tran, Trisha G. Macaraeg, Esther M. Chu, Stephanie F. Kwok, Nicole N. Chmielewski, Brianna M. Craver, Janet E. Baulch, Munjal M. Acharya, Francis A. Cucinotta, & Charles L. Limoli. (2015) What happens to your brain on the way to Mars. Science Advances, 1(4). info:/10.1126/sciadv.1400256

  • April 30, 2015
  • 10:35 AM
  • 846 views

Bupropion: A Non-stimulant ADHD Drug Treatment

by William Yates, M.D. in Brain Posts

Stimulant drugs including dextroamphetamine (Adderall) and methylphenidate (Ritalin) remain among the most common and effective drug treatments for attention deficit hyperactivity disorder (ADHD).Alternative to stimulant drugs are needed to expand treatment options for clinicians and patients.One problem with the stimulants is the potential for misuse and diversion of prescription drugs to illicit drug use.One non-stimulant FDA approved drug (atomoxetine/Strattera) is available in the U.S.An add........ Read more »

  • April 27, 2015
  • 10:50 AM
  • 632 views

ADHD and Vehicular Accident Risk

by William Yates, M.D. in Brain Posts

Attention and impulsive behaviors found in attention deficit hyperactivity disorder (ADHD) can contribute to accident risk in children and adults.A recent study of adult drivers in France provides evidence for increased accident risk in adults with ADHD.Researchers at the Bordeaux University Hospital interviewed a series of adult drivers seen in the emergency department following a road traffic crash.A total of 777 eligible subjects completed assessments of accident information, distraction expo........ Read more »

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