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  • February 3, 2015
  • 08:30 AM

Liver Fibrosis Starts Early After Hepatitis C Infection

by Marie Benz in Medical Research Interviews and News Interview with: Adeel A. Butt, MD, MS, FACP, FIDSA Adjunct Associate Professor of Medicine and Clinical and Translational Science University of Pittsburgh School of Medicine   MedicalResearch: What is the background for this study? What are the main findings? … Continue reading →
The post Liver Fibrosis Starts Early After Hepatitis C Infection appeared first on Medical Research Inte........ Read more » Interview with:, & Adeel A. Butt, MD, MS, FACP, FIDSA. (2015) Liver Fibrosis Starts Early After Hepatitis C Infection. MedicalResearch.comm. info:/

  • February 2, 2015
  • 12:39 PM

Exercise in the Prevention of Alzheimer's Disease

by William Yates, M.D. in Brain Posts

Growing evidence links physical activity to improved cognitive outcome in elderly individuals.Few studies have examined effects of exercise on those at highest risk for Alzheimer's disease.J Carson Smith and colleagues recently published a prospective study of a cohort of older adults using structural magnetic resonance imaging.The key elements of the design of their study included the following elements:Participants: 97 adults between the ages of 65 and 89Physical activity level: Frequency and ........ Read more »

Smith JC, Nielson KA, Woodard JL, Seidenberg M, Durgerian S, Hazlett KE, Figueroa CM, Kandah CC, Kay CD, Matthews MA.... (2014) Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease. Frontiers in aging neuroscience, 61. PMID: 24795624  

  • January 28, 2015
  • 01:24 PM

Carotid Atherosclerosis Predicted by Cholesterol-Overloaded HDL Particles

by Marie Benz in Medical Research Interviews and News Interview with: Dong Zhao MD.PhD Deputy Director & Professor Beijing Institute of Heart,Lung & Blood Vessel Diseases Capital Medical University Beijing Anzhen Hospital Medical Research: What is the background for this study? What are the main findings? Dr. Dong … Continue reading →
The post Carotid Atherosclerosis Predicted by Cholesterol-Overloaded HDL Particles appeared first on Read more »

Interview with Dong Zhao MD.PhD. (2015) Carotid Atherosclerosis Predicted by Cholesterol-Overloaded HDL Particles. info:/

  • January 26, 2015
  • 11:02 AM

Obesity, Inflammation and Cognitive Decline

by William Yates, M.D. in Brain Posts

The rate of cognitive decline with aging is quite variable. Identifying important components of this process is needed for developing interventions to reduce the burden of Alzheimer's and other dementias.Excess inflammation has been linked to obesity as well as aging-related cognitive decline.Archana Singh-Manoux and colleagues recently published a study of the association between blood markers of inflammation and cognitive decline.This study used data from the U.K. Whitehall II cohort, a g........ Read more »

Singh-Manoux A, Dugravot A, Brunner E, Kumari M, Shipley M, Elbaz A, & Kivimaki M. (2014) Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife. Neurology, 83(6), 486-93. PMID: 24991031  

  • January 23, 2015
  • 04:25 PM

Exotic Pets: Emerging Risk Factor for Salmonellosis in Children

by Pranab Chatterjee in Scepticemia

The increasing trend of having exotic reptiles as pets may lead to an increase in reptile associated infections such as Salmonellosis, especially in the children in the household. ... Read more »

  • January 23, 2015
  • 02:53 PM

First Partially Successful Vaccine Developed Against Prion Disease in Deer

by Pranab Chatterjee in Scepticemia

The first partially successful vaccine against a prion disease (Chronic Wasting Disease in white tailed deer) is good news, but the journey has just begun. ... Read more »

  • January 19, 2015
  • 11:09 AM

Mediterranean Diet and Aging

by William Yates, M.D. in Brain Posts

There is a growing research body of evidence to support beneficial effects of a Mediterranean diet on brain health.In previous posts I have reviewed research on the Mediterranean diet and:Cognitive DeclineAlzheimer's Disease PreventionA recent study adds an important element in potential mechanisms for the beneficial effects of the Mediterranean diet.Marta Crous-Bou and colleauges from Harvard University and the University of Washington published a study of the Mediterranean diet and chromosome ........ Read more »

Crous-Bou M, Fung TT, Prescott J, Julin B, Du M, Sun Q, Rexrode KM, Hu FB, & De Vivo I. (2014) Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study. BMJ (Clinical research ed.). PMID: 25467028  

  • January 14, 2015
  • 11:51 AM

Obesity, Inflammation and the Brain

by William Yates, M.D. in Brain Posts

Brain inflammation produces a variety of emotional, behavior and cognitive symptoms.I remember clearly a patient I cared for with central nervous system lupus erythrematosis (SLE). With SLE flairs she developed flagrant psychotic symptoms including hallucinations requiring inpatient psychiatric care.Between flares she had no significant psychiatric symptoms.Nicole Castanon and two colleagues from France have published a review of the role of obesity-associated inflammation and brain dysfunction......... Read more »

  • January 12, 2015
  • 11:56 AM

Dietary Grains and Heart/Stroke Mortality

by William Yates, M.D. in Brain Posts

Dietary intake of whole grains and fiber shows consistent beneficial effects on a variety of health and mortality measures.In a post in 2011, I reviewed study results from the NIH-AARP cohort. That study reported reduced cardiovascular disease but not cancer in men and women with the highest fiber intake.A recent Harvard University study examined mortality risk in a group of U.S. health professionals grouped by level of whole grain intake.Participants in this study were over 118,000 men and wome........ Read more »

  • December 15, 2014
  • 09:42 AM

Who is Getting High in Europe (and Where)?

by William Yates, M.D. in Brain Posts

My research training is in psychiatric epidemiology. Alcohol and drug dependence have been two of my topic areas of research.So I found a recent novel study of the epidemiology of illicit drug use in Europe intriguing.Typical methods of looking for the prevalence of drug use in populations are direct diagnostic interviews and studies of emergency room attendees or autopsy cases with medical complications of drug use.However, Christopher Ort from Switzerland along with a host of European col........ Read more »

Ort C, van Nuijs AL, Berset JD, Bijlsma L, Castiglioni S, Covaci A, de Voogt P, Emke E, Fatta-Kassinos D, Griffiths P.... (2014) Spatial differences and temporal changes in illicit drug use in Europe quantified by wastewater analysis. Addiction (Abingdon, England), 109(8), 1338-52. PMID: 24861844  

  • December 10, 2014
  • 12:46 PM

Prescription Opiate Abuse: High-Risk Populations

by William Yates, M.D. in Brain Posts

Prescription opiate abuse is a significant problem in the United States.I have previously written about this issue in several previous posts.One important factor for clinicians and patients is the need to identify high-risk populations that may be more vulnerable to opiate abuse and dependence.One obvious group would be those with alcohol or another non-opiate abuse diagnosis. Additionally, some psychiatric disorders are associated with increased risk for substance abuse including opiate abuse.G........ Read more »

  • December 10, 2014
  • 12:06 PM

Incentives in the Treatment of Cocaine Dependence

by William Yates, M.D. in Brain Posts

Relapse rates are high in treatment samples of adults with cocaine dependence.Cognitive behavioral therapy (CBT) is a common standard of care for cocaine dependence.A recent clinical trial from Switzerland examined the use of financial prize incentives to augment standard CBT in the treatment of cocaine dependence.Sixty subjects participated in this trial with the following inclusion criteria: least 18 years of age, had a DSM-IV diagnosis of cocaine dependence with at least one po........ Read more »

Petitjean SA, Dürsteler-MacFarland KM, Krokar MC, Strasser J, Mueller SE, Degen B, Trombini MV, Vogel M, Walter M, Wiesbeck GA.... (2014) A randomized, controlled trial of combined cognitive-behavioral therapy plus prize-based contingency management for cocaine dependence. Drug and alcohol dependence, 94-100. PMID: 25456571  

  • November 29, 2014
  • 04:40 AM

This Month in Blastocystis Research (NOV 2014): Blasting Blastocystis Edition

by Christen Rune Stensvold in Blastocystis Parasite Blog

A few notes on deliberate and inadvertent attempts to eradicate Blastocystis.... Read more »

  • November 26, 2014
  • 12:06 PM

Treatment Resistance in Eating Disorders

by William Yates, M.D. in Brain Posts

Clinicians treating patients with eating disorders find the challenge great with many treatment-resistant cases.To some extent, this is true of any clinical disorder. Outpatient treatment rolls and inpatient samples are over-represented by those failing to respond to initial interventions.A medical example is helpful here. Endocrinologists specializing in diabetes see more complicated cases where glucose control is difficult and diabetic complications are common.Diabetics with easy glucose contr........ Read more »

  • November 18, 2014
  • 09:00 AM

This Is Your TV On Drugs

by Mark E. Lasbury in The 'Scope

There are more than 100 drug commercials on TV every hour of every day. Why? Because they work. Research shows that advertised drugs are prescribed 9x more than comparable drugs that aren’t advertised. And all those side effect notices? The drug companies like them because research says that all you remember is that they were “honest” with you.... Read more »

  • November 18, 2014
  • 08:02 AM

Feel like I-dosing? [Part 2]

by Henkjan Honing in Music Matters

"Digital drugs," otherwise known as binaural beats, have sparked an outcry in Lebanon, with the Justice Minister Ashraf Rifi calling Thursday for legal measures to be taken against the product...... Read more »

  • November 17, 2014
  • 11:55 AM

Eating Disorders in Obesity: DSM-IV and DSM-5

by William Yates, M.D. in Brain Posts

The recent revision of the American Psychiatric Associations Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (DSM-5) altered several eating disorder diagnostic criteria.Some have expressed concern that these revisions are overly broad and may result in over diagnosis in some clinical populations. One clinical population where this is a concern is obesity.A research study has been recently published addressing this issue.Jennifer Thomas and colleagues at Harvard University a........ Read more »

  • November 12, 2014
  • 12:14 PM

Binge Eating Linked to Risk for Irritable Bowel Syndrome

by William Yates, M.D. in Brain Posts

Binge eating is defined as the recurrent rapid consumption of high calorie meals accompanied by a feeling that eating is out of control.Bulimia nervosa is an eating disorder characterized by binge eating paired with a purging behavior such as self-induced vomiting.Binge eating without purging is receiving increased clinical and research attention.Binge eating is a relative common component in elevated body mass index and obesity. Successful behavior and drug treatment for obesity often includes ........ Read more »

Peat CM, Huang L, Thornton LM, Von Holle AF, Trace SE, Lichtenstein P, Pedersen NL, Overby DW, & Bulik CM. (2013) Binge eating, body mass index, and gastrointestinal symptoms. Journal of psychosomatic research, 75(5), 456-61. PMID: 24182635  

  • November 11, 2014
  • 12:13 PM

Anorexia Nervosa: Brain Connectivity Abnormalities

by William Yates, M.D. in Brain Posts

Functional magnetic resonance imaging is providing a new tool for understanding brain circuitry in normal brain development and in brain disorders. Anorexia nervosa is an restrictive calorie eating disorder often resistant to treatment.No effective drug treatment for anorexia nervosa currently exists and psychotherapy is often only partially effective. A better understanding of the brain pathophysiology in anorexia nervosa is needed to aid in treatment development.Stephanie Kullman along wi........ Read more »

  • November 10, 2014
  • 11:05 AM

Eating Disorders Linked to Higher Autoimmune Disease Rates

by William Yates, M.D. in Brain Posts

There is increasing evidence for inflammation contributing to risk for a variety of psychiatric disorders.I previously summarized research supporting use of anti-inflammatory drugs in the treatment of depression.A recent study from Finland supports an inflammation link to the eating disorder categories.The key elements of the design of this study included:Subjects: 2342 subjects admitted for treatment in the Eating Disorders Unit at the central hospital in Finland. Four controls were identified ........ Read more »

Raevuori A, Haukka J, Vaarala O, Suvisaari JM, Gissler M, Grainger M, Linna MS, & Suokas JT. (2014) The increased risk for autoimmune diseases in patients with eating disorders. PloS one, 9(8). PMID: 25147950  

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