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  • May 24, 2016
  • 10:44 AM
  • 620 views

Does Flu Vaccination Reduce Dementia Risk?

by William Yates, M.D. in Brain Posts

In my daily review of neuroscience news I ran across an article flu vaccination and dementia risk in heart failure.This study was reported at the 3rd World Congress on Acute Heart Failure by Dr. Ju-Chi Liu from Taipei Medical University.So how might influenza vaccination be related to dementia risk?  We do know acute influenza infection reaches the brain causing headache and increasing brain inflammation, at least temporarily. We also know brain inflammation may be involved in the mechanism........ Read more »

  • May 21, 2016
  • 10:21 AM
  • 687 views

Quick Aspirin Use Reduces Stroke Risk in TIA

by William Yates, M.D. in Brain Posts

A free full-text commentary in the Lancet summarizes recent evidence of the benefit of aspirin in stroke prevention.This commentary focused on what is called secondary prevention. Secondary prevention is defined as prevention following events related to the disease in question.So secondary prevention in stroke would be reduction in stroke risk in those who have had a stroke or pre-stroke syndromes such as transient ischemic attacks (TIA).The key take-home message from the commentary by Graeme Ha........ Read more »

  • May 19, 2016
  • 11:33 AM
  • 514 views

Language Disorder in Preschoolers

by William Yates, M.D. in Brain Posts

Well-designed large population-based studies of the prevalence and correlates of learning disabilities in preschool children are rare.A research group working out of University College London has address that issues with a large study of language disorder in a group of over 7000 4 and 5 year olds in England.A stratified group of 529 children received a comprehensive assessment of language along with assessment of IQ, social, emotional and behavior function.The study found the following important........ Read more »

  • May 17, 2016
  • 02:35 PM
  • 570 views

Nurses Frequently Attending Church Live Longer

by William Yates, M.D. in Brain Posts

The Harvard-based Nurses' Health Study has been a remarkably productive longitudinal health study.My wife has been a subject in this study and frequently completes interval questionnaires regarding her health status.A recent publication looked at the relationship between religious service attendance and mortality in the Nurses's Health Study cohort.This manuscript tried to provide a more valid look at the relationship between religiosity/spirituality and health. Previous studies have found a lin........ Read more »

  • May 16, 2016
  • 03:34 PM
  • 865 views

Novel Borrelia Species Causes Lyme Disease with High Spirochetemia

by Pranab Chatterjee in Zoonoticus

In a recent paper in the Lancet Infectious Diseases, Pritt et al  have identified a new genospecies of Borrelia which is attributed to have caused several cases of Lyme disease, marked by a high degree of spirochetemia. In their research article abstract, they state: Methods At the Mayo clinic, from 2003 to 2014, we tested […]... Read more »

  • May 11, 2016
  • 01:00 PM
  • 427 views

How to Solve Homicide Crimes

by William Yates, M.D. in Brain Posts

Homicide rates in the U.S. represent a significant public health challenge. Homicide is a top ten leading cause of death in many groups in the U.S.One method to reduce homicide rates is to quickly identify and arrest individuals who have committed homicide. This is due to the fact that individuals committing homicide have a high rate of future homicide.A recent study from Michigan State University and Indiana University examined characteristics of U.S. police departments that have high rates of ........ Read more »

  • May 10, 2016
  • 12:54 PM
  • 428 views

Smartphones and Sleep Data: Data Mining

by William Yates, M.D. in Brain Posts

Smartphones contribute a treasure trove of data that is likely to expand our knowledge of a variety of human behaviors.An example of this is a recent study published in Science Advances by a research team from the University of Michigan.The University of Michigan team developed a smartphone app called ENTRAIN and then used the app to collect sleep data on subjects from around the world.They came up with some very interesting findings including the following:The time of going to sleep appears mor........ Read more »

  • May 5, 2016
  • 02:26 PM
  • 649 views

Ketamine Metabolite Linked to Rapid Antidepressant Effect

by William Yates, M.D. in Brain Posts

Model of crytalized ketamine moleculeStandard antidepressant therapies typically take two weeks or more to begin to act.Ketamine is an anesthetic drug recently demonstrated to have a rapid antidepressant effect.The mechanism for this effect is unknown. A recent mouse study of ketamine and metabolites of ketamine show some potentially groundbreaking insight for the treatment of depression.This study found these significant findings:Ketamine like most organic compounds is made of boty an R an........ Read more »

Zanos, P., Moaddel, R., Morris, P., Georgiou, P., Fischell, J., Elmer, G., Alkondon, M., Yuan, P., Pribut, H., Singh, N.... (2016) NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature. DOI: 10.1038/nature17998  

  • May 3, 2016
  • 12:00 PM
  • 470 views

"The Biggest Loser": Long-term Effects

by William Yates, M.D. in Brain Posts

Yesterday I posted a link to a New York Times article that posted a summary outcome in fourteen participants in TV's "The Biggest Loser" show.The study found a trend towards post-show weight gain for 13/14 of the participants.Four participants actually gained so much weight that after six years they weighed more than before participating in the show.A key finding from the study was this weight gain could be explained by a metabolic response resulting in up to 800 calories less burned daily ........ Read more »

Fothergill, E., Guo, J., Howard, L., Kerns, J., Knuth, N., Brychta, R., Chen, K., Skarulis, M., Walter, M., Walter, P.... (2016) Persistent metabolic adaptation 6 years after “The Biggest Loser” competition. Obesity. DOI: 10.1002/oby.21538  

  • May 3, 2016
  • 11:36 AM
  • 411 views

Delirium and Aortic Valve Surgery Outcome

by William Yates, M.D. in Brain Posts

Delirium is an acute confusional state that is common in elderly hospitalized patients.I think of it light a sign of acute brain failure requiring aggressive attentional for detection and treatment of any reversible underlying causes.Delirium in elderly hospitalized patients is a marker for poor outcome in a variety of medical and surgical subjects.A recent study published by a Norwegian team found effects on outcome for delirium following surgical aortic valve replacement. The key findings from........ Read more »

Eide LS, Ranhoff AH, Fridlund B, Haaverstad R, Hufthammer KO, Kuiper KK, Nordrehaug JE, Norekvål TM, & Delirium in Octogenarians Undergoing Cardiac Surgery or Intervention-CARDELIR Investigators. (2016) Delirium as a Predictor of Physical and Cognitive Function in Individuals Aged 80 and Older After Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement. Journal of the American Geriatrics Society. PMID: 27106745  

  • April 23, 2016
  • 11:37 PM
  • 603 views

Long-term antibiotics for those with chronic symptoms that may or may not be related to Lyme disease

by Microbe Fan in Spirochetes Unwound

A Lyme disease study published a few weeks ago in the New England Journal of Medicine has received a lot of coverage in the press.  According to the abstract of the study, Berende and colleagues conducted a randomized placebo-controlled clinical trial to test the effectiveness of long-term antibiotics in treating "longer-term" symptoms "attributed" to Lyme disease.As many readers of this blog know, treatment of Lyme disease is a controversial topic.  Antibiotics are effective in treati........ Read more »

Berende A, ter Hofstede HJ, Vos FJ, van Middendorp H, Vogelaar ML, Tromp M, van den Hoogen FH, Donders AR, Evers AW, & Kullberg BJ. (2016) Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease. The New England Journal of Medicine, 374(13), 1209-20. PMID: 27028911  

Melia MT, & Auwaerter PG. (2016) Time for a Different Approach to Lyme Disease and Long-Term Symptoms. The New England Journal of Medicine, 374(13), 1277-8. PMID: 27028918  

  • April 23, 2016
  • 12:41 PM
  • 580 views

Does E. ewingii Cause More Cases of Ehrlichiosis Than Previously Thought?

by Pranab Chatterjee in Zoonoticus

This figure shows the incidence of ehrlichicosis cases by state in 2010 per million persons. Ehrlichiosis was not notifiable in Alaska, Colorado, the District of Columbia, Hawaii, Idaho, Iowa, Nevada, New Mexico, North Dakota or Montana. The incidence rate was zero for Arizona, Connecticut, Indiana, Massachusetts, Oregon, South Dakota, Utah, Vermont, Washington, and Wyoming. Incidence […]... Read more »

Harris, R., Couturier, B., Sample, S., Coulter, K., Casey, K., & Schlaberg, R. (2016) Expanded Geographic Distribution and Clinical Characteristics of Infections, United States . Emerging Infectious Diseases, 22(5), 862-865. DOI: 10.3201/eid2205.152009  

  • April 12, 2016
  • 05:00 PM
  • 780 views

Dr. Kudenchuk is Misrepresenting ALPS as 'Significant'

by Rogue Medic in Rogue Medic

This study was very well done, but it was not designed to provide valid information about the effects of amiodarone or lidocaine on witnessed arrests or on EMS Witnessed arrests. Maybe the authors were overconfident.

In resuscitation research, we have abundant evidence that overconfidence is much more common than improvements in outcomes.... Read more »

Kudenchuk, P., Brown, S., Daya, M., Rea, T., Nichol, G., Morrison, L., Leroux, B., Vaillancourt, C., Wittwer, L., Callaway, C.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. New England Journal of Medicine. DOI: 10.1056/NEJMoa1514204  

Glover BM, Brown SP, Morrison L, Davis D, Kudenchuk PJ, Van Ottingham L, Vaillancourt C, Cheskes S, Atkins DL, Dorian P.... (2012) Wide variability in drug use in out-of-hospital cardiac arrest: A report from the resuscitation outcomes consortium. Resuscitation. PMID: 22858552  

  • April 6, 2016
  • 12:02 PM
  • 664 views

World Serology Bank: Key to a Better Understanding of Infectious Disease Dynamics?

by Pranab Chatterjee in Zoonoticus

An article published in The Lancet today has highlighted the possibility of establishing a World Serology Bank to better understand the dynamics of infectious disease dynamics, especially in an era where vaccinations against infectious diseases is becoming more and more prevalent. With rapid advance in diagnostic technologies, there has been impressive progress in what used […]... Read more »

  • April 4, 2016
  • 06:15 PM
  • 714 views

Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest

by Rogue Medic in Rogue Medic

I wrote about the start of the ALPS (Amiodarone, Lidocaine, Placebo Study) in 2012[1] and the results are now in.
... Read more »

Kudenchuk, P., Brown, S., Daya, M., Rea, T., Nichol, G., Morrison, L., Leroux, B., Vaillancourt, C., Wittwer, L., Callaway, C.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. New England Journal of Medicine. DOI: 10.1056/NEJMoa1514204  

  • March 11, 2016
  • 08:26 AM
  • 753 views

Kill "Bill" !!!

by AG McCluskey in Zongo's Cancer Diaries

Drug Discovery, Part I

How does Drug Discovery start? How are targets identified? Time for Epidemiology 101... Read more »

AG McCluskey. (2016) Kill "Bill". Zongo's Cancer Diaries. info:/

  • February 12, 2016
  • 04:16 AM
  • 639 views

Maintained disomic chromosome 17 as a diagnostic marker for BHD-associated chromophobe RCC

by Joana Guedes in BHD Research Blog

Renal cell carcinomas (RCCs) can be life-threatening and although mostly sporadic, approximately 5% are associated with genetic conditions such as BHD. Early identification of families carrying cancer-predisposing mutations enables access to regular screening and earlier treatment. However, it can be difficult to distinguish between sporadic and inherited RCC based on standard immunohistological analysis. New research from Kato et al. (2016) assessed whether variability in the chromosomal status........ Read more »

  • January 24, 2016
  • 02:45 PM
  • 789 views

Treat the pain... or treat the depression? Carpal Tunnel Syndrome management

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

Carpal tunnel syndrome is a very common pain disorder associated with compression of the median nerve at the carpal tunnel. Approximately 139 women and 67 males per 100,000 people will report this problem over the course of one year, although this depends on the definition used. The problem with CTS is not only that it is common, but also that it affects function - it is really difficult to carry out normal daily life with a numb or tingly hand, poor grip strength (particularly in the fingertips........ Read more »

Fernández-Muñoz, J., Palacios-Ceña, M., Cigarán-Méndez, M., Ortega-Santiago, R., de-la-Llave-Rincón, A., Salom-Moreno, J., & Fernández-de-las-Peñas, C. (2016) Pain is Associated to Clinical, Psychological, Physical, and Neurophysiological Variables in Women With Carpal Tunnel Syndrome. The Clinical Journal of Pain, 32(2), 122-129. DOI: 10.1097/AJP.0000000000000241  

  • January 15, 2016
  • 09:07 AM
  • 560 views

A Weighty Problem……

by anthony.mccluskey12 in Zongo's Cancer Diaries

Amid all of the hoopla that accompanied last week’s press reports about the new Alcohol Consumption Guidelines, something else slipped under the radar.  CRUK released a statement, which didn’t receive quite the same level of media hysteria.  Which is surprising, frankly, because it involved another popular subject.  One which, if it had been released at […]... Read more »

Pérez-Hernández,A.I., Catalán, V., Gómez-Ambrosi, J., AmaiaRodríguez, A., & Frühbeck, G. (2014) Mechanisms Linking Excess Adiposity and Carcinogenesis Promotion. Frontiers in Endocrinology. DOI: 10.3389/fendo.2014.00065  

Bhimjiyani, A., Knuchel-Takano, A., & Hunt, D. (2016) Tipping the scales: Why preventing obesity makes economic sense. CRUK. info:/

  • January 15, 2016
  • 09:04 AM
  • 583 views

A Weighty Problem....

by AG McCluskey in Zongo's Cancer Diaries

Obesity causes many medical conditions, such as Heart Disease, Stroke & Diabetes.
.....And cancer....?... Read more »

Pérez-Hernández,A.I., Catalán, V., Gómez-Ambrosi, J., AmaiaRodríguez, A., & Frühbeck, G. (2014) Mechanisms Linking Excess Adiposity and Carcinogenesis Promotion. Frontiers in Endocrinology. DOI: 10.3389/fendo.2014.00065  

Bhimjiyani, A., Knuchel-Takano, A., & Hunt, D. (2016) Tipping the scales: Why preventing obesity makes economic sense. CRUK. info:/

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