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  • November 16, 2010
  • 09:39 PM
  • 1,418 views

A Brush with Madness

by Kristopher Hite in Tom Paine's Ghost







I'm giving myself ten minutes to do this. To write whatever storms into my mind then hit post.

I think the archaic revival might run into some barriers. Like starvation, no communication, and other electrical difficulties if it embraces the Abbey-esque Luddite philosophy entirely.

As much as I want to get onto that other boat I think I will just slip between the hulls and end up swimming by myself among the sea-monsters, bullets whizzing past my head with bubbles trailing behind in dark ........ Read more »

Sedel F, Baumann N, Turpin JC, Lyon-Caen O, Saudubray JM, & Cohen D. (2007) Psychiatric manifestations revealing inborn errors of metabolism in adolescents and adults. Journal of inherited metabolic disease, 30(5), 631-41. PMID: 17694356  

Rose FC. (2006) Van Gogh's madness. International review of neurobiology, 253-69. PMID: 16730519  

Altintoprak AE, Ersel M, & Bayrakci A. (2009) An unusual suicide attempt: a case with psychosis during an acute porphyric attack. European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 16(2), 106-8. PMID: 19262206  

Mandoki MW, & Sumner GS. (1994) Psychiatric manifestations of hereditary coproporphyria in a child. The Journal of nervous and mental disease, 182(2), 117-8. PMID: 8308532  

  • November 16, 2010
  • 10:50 AM
  • 1,204 views

Sometimes in cancer research there really is hope

by Sally Church in Pharma Strategy Blog

It’s easy to forget that oncologists (whether medical, radiation or surgical) and hematologists deal with death and dying every single day, it’s sadly an integral part of the daily job.  Sometimes though, something comes along that offers hope or perhaps … Continue reading →... Read more »

  • November 15, 2010
  • 01:04 PM
  • 1,563 views

Can obesity surgery for mothers prevent obesity in their children?

by Travis Saunders, MSc in Obesity Panacea

…And we’re back! After a month in exile from the blogging world my comprehensive exams are done!… for now. Assuming that my committee finds my answers satisfactory I will move on to an oral exam sometime between now and the holiday season. The good news is that I have read a ton of papers in the past few months (probably somewhere north of 200) so I’ve found plenty of interesting things to blog about well into the new year!... Read more »

  • November 10, 2010
  • 10:28 PM
  • 1,648 views

Glucosamine and Chondroitin Found to be Ineffective for Relief of Arthritis Pain

by Walter Jessen in Highlight HEALTH

A recent meta-analysis in the British Journal of Medicine (BMJ) concludes that chondroitin, glucosamine and their combination do not reduce joint pain or have an impact on narrowing of joint space.... Read more »

  • November 4, 2010
  • 10:45 AM
  • 1,186 views

Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

by Sally Church in Pharma Strategy Blog

This morning I was delighted to see that one of my favourite medical doctors on Twitter, Dr Anas Younes from MD Anderson, has published a paper in the New England Journal of Medicine on a clinical trial of a promising … Continue reading →... Read more »

Younes, A., Bartlett, N., Leonard, J., Kennedy, D., Lynch, C., Sievers, E., & Forero-Torres, A. (2010) Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas. New England Journal of Medicine, 363(19), 1812-1821. DOI: 10.1056/NEJMoa1002965  

  • November 3, 2010
  • 12:11 PM
  • 1,149 views

Metastatic melanoma – what’s new on the horizon?

by Sally Church in Pharma Strategy Blog

Metastatic melanoma is quite a hot topic right now with a rich pipeline of products in development after a decade of little or no progress.  Of course, it is a bit like three London buses coming along at once after … Continue reading →... Read more »

  • November 3, 2010
  • 08:08 AM
  • 1,345 views

How To Form A Habit

by Lorimer Moseley in BodyInMind

We’ve all wondered how to get our patients to change their life habits (to the better of course…in our minds). In fact, the behavioural and physical therapies depend on us being able to convince patients to develop new habits – to  bend and straighten their knees a few times before getting up from prolonged sitting [...]... Read more »

Lally, P., van Jaarsveld, C., Potts, H., & Wardle, J. (2009) How are habits formed: Modelling habit formation in the real world. European Journal of Social Psychology. DOI: 10.1002/ejsp.674  

  • November 2, 2010
  • 08:13 AM
  • 1,024 views

Dendritic Polyglycerol Sulfates for Inflammatory Diseases

by Michael Long in Phased

Rainer Haag (Freie Universitat Berlin) and coworkers have synthesized a branched polymer that potently inhibits L and P selectin activity in mice, and thus shows promise as a treatment for inflammatory diseases.... Read more »

Dernedde, J., Rausch, A., Weinhart, M., Enders, S., Tauber, R., Licha, K., Schirner, M., Zugel, U., von Bonin, A., & Haag, R. (2010) Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1003103107  

  • November 1, 2010
  • 01:42 PM
  • 1,171 views

Crizotinib in ALK-rearranged cancer mutations

by Sally Church in Pharma Strategy Blog






While reading the latest New England Journal of Medicine, it was hard not to notice the focus on ALK mutations and crizotinib (Pfizer), with four articles in all on the topic, including a full original article, two brief reports and [...]... Read more »

Morris, S., Kirstein, M., Valentine, M., Dittmer, K., Shapiro, D., Saltman, D., & Look, A. (1994) Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science, 263(5151), 1281-1284. DOI: 10.1126/science.8122112  

Soda, M., Choi, Y., Enomoto, M., Takada, S., Yamashita, Y., Ishikawa, S., Fujiwara, S., Watanabe, H., Kurashina, K., Hatanaka, H.... (2007) Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer. Nature, 448(7153), 561-566. DOI: 10.1038/nature05945  

Kwak, E., Bang, Y., Camidge, D., Shaw, A., Solomon, B., Maki, R., Ou, S., Dezube, B., Jänne, P., Costa, D.... (2010) Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer. New England Journal of Medicine, 363(18), 1693-1703. DOI: 10.1056/NEJMoa1006448  

Hallberg, B., & Palmer, R. (2010) Crizotinib — Latest Champion in the Cancer Wars?. New England Journal of Medicine, 363(18), 1760-1762. DOI: 10.1056/NEJMe1010404  

Butrynski, J., D'Adamo, D., Hornick, J., Dal Cin, P., Antonescu, C., Jhanwar, S., Ladanyi, M., Capelletti, M., Rodig, S., Ramaiya, N.... (2010) Crizotinib in -Rearranged Inflammatory Myofibroblastic Tumor . New England Journal of Medicine, 363(18), 1727-1733. DOI: 10.1056/NEJMoa1007056  

  • October 29, 2010
  • 09:00 AM
  • 913 views

What's in a placebo? Mike Adams certainly doesn't know. [Respectful Insolence]

by Orac none@example.com in Food Matters

If there's one thing that confounds advocates of so-called "complementary and alternative medicine" (CAM), it's the placebo effect. That's because, whenever most such remedies are studied using rigorous clinical trial design using properly constituted placebo controls, they almost always end up showing effects no greater than placebo effects. That's the main reason why they frequently suggest that, you know, all those rigorous, carefully constructed randomized placebo-controlled clinical trials ........ Read more »

Golomb BA, Erickson LC, Koperski S, Sack D, Enkin M, & Howick J. (2010) What's in placebos: who knows? Analysis of randomized, controlled trials. Annals of internal medicine, 153(8), 532-5. PMID: 20956710  

  • October 29, 2010
  • 08:44 AM
  • 2,201 views

Weight-loss variability in response to the same diet

by Peter Janiszewski, Ph.D. in Obesity Panacea

Whoever said weight loss was a straightforward process has probably never tried to go from a BMI of 40 down to 24 kg/m2. I must admit that only a few years back, in the early stages of my graduate training, I was equally naive. I thought: it’s a case of simple math – once your energy expenditure exceeds your energy intake, you lose weight.
It certainly sounds simple, and yet it rarely is that simple in practice.
Take for example a recent study published in the November issue of Obesi........ Read more »

  • October 29, 2010
  • 08:31 AM
  • 2,096 views

What's in a placebo? Mike Adams certainly doesn't know.

by Orac in Respectful Insolence

If there's one thing that confounds advocates of so-called "complementary and alternative medicine" (CAM), it's the placebo effect. That's because, whenever most such remedies are studied using rigorous clinical trial design using properly constituted placebo controls, they almost always end up showing effects no greater than placebo effects. That's the main reason why they frequently suggest that, you know, all those rigorous, carefully constructed randomized placebo-controlled clinical trials ........ Read more »

Golomb BA, Erickson LC, Koperski S, Sack D, Enkin M, & Howick J. (2010) What's in placebos: who knows? Analysis of randomized, controlled trials. Annals of internal medicine, 153(8), 532-5. PMID: 20956710  

  • July 9, 2010
  • 01:37 AM
  • 930 views

Friday Weird Science: The Human Penis Bone

by Evil Monkey in Neurotopia

Today's post is some seriously OLD science. Old science and WEIRD science, coming to you courtesy of Mt. Sinai hospital in NYC, 1913.

And it's also the WEIRDEST conjunction of this:



And this:



That Sci has ever seen.

Gerster AG, Mandlebaum FS. "XI. On the Formation of Bone in the Human Penis." Annals of Surgery, 1913.

The pictures below are curiously safe for work. I suppose that picture up there wasn't. oops. Read the rest of this post... | Read the comments on this post...... Read more »

GERSTER, A., & MANDLEBAUM, F. (1913) ON THE FORMATION OF BONE IN THE HUMAN PENIS. Annals of Surgery, 57(6), 896-901. DOI: 10.1097/00000658-191306000-00012  

  • November 2, 2009
  • 08:37 PM
  • 2,195 views

Hot News: Curry, Curcumin, Cancer & Cure

by Laika in Laika's Medliblog

*Hot* News via Twitter and various news media a few days ago. Big headlines tell the following in respectively The Sun, Herald, Ireland, BBC News / NHS Health and Reuters:
Curry is a ‘cure for cancer‘
Spices in curry may help cure cancer
Curry spice ‘kills cancer cells‘
Scientists say curry compound kills cancer cells
The message of these headlines [...]... Read more »

  • November 30, 1999
  • 12:00 AM
  • 2,450 views

genetically engineered stem cell treatment, gen therapy for HIV virus infection, AIDS.

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

Scientists have collected stem cells from patients own body , and engineered them , and induced in to them gens which expresses three RNA-based anti-HIV moieties as follows .
1.tat/rev short hairpin RNA,
2.TAR decoy,
3.CCR5 ribozyme.
Amongst these anti HIV moieties CCR5 ribozyme is capable of hampering production of CCR5 protein a essential protein which is responsible for HIV virus entry in to new host cell , there it can lower a viral load , in to patient and help anti retroviral drugs t........ Read more »

B V Waghmare. (2010) Information on genetically engineered stem cell treatment, gen therapy for HIV virus infection, AIDS. . bvwaghmare.blogspot.com. info:/

  • November 30, 1999
  • 12:00 AM
  • 2,161 views

Novel Approach for anti AIDS drug development.

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

HIV virus when it incorporates its DNA in human T-Lymphocytes , it integrates in a very controlled manner so that it takes care that our T-Lymphocytes cells do not get destroyed before they code and generate HIV virus proteins and genetic material and form enough new HIV viruses.
Professors Abraham Loyter, Assaf Friedler and their colleagues have reported that they have developed a peptide called as “MIX”

Peptide “MIX” is able to increase activity of HIV virus enzyme ........ Read more »

B V Waghmare. (2010) Developing a peptide that kills HIV virus. bvwaghmare.blogspot.com. info:/

  • November 30, 1999
  • 12:00 AM
  • 1,958 views

HIV vaccine research: Protein which train B cells for production of antibodies against HIV which successfully neutralize HIV

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

HIV virus rapidly undergoes mutation, which is main hurdle in developing vaccine against HIV.There is a region on HIV virus which shows less variations, called as Cd4 binding site ,therefore a protein which stimulate antibody formation against this region can be developed and used as a vaccine.
Researchers at Vaccine Research Center (VRC) and the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health have studied genes which code for such proteins which can........ Read more »

B V Waghmare. (2011) HIV vaccine development : Proteins which trains B Cells for production of antibodies which successfully neutralize HIV by binding with it . http://bvwaghmare.blogspot.com. info:/(DOI/arXiv/etc.)

  • November 30, 1999
  • 12:00 AM
  • 1,857 views

Using folate receptor alpha flurorescence imaging in ovarian cancer

by Sally Church in Pharma Strategy Blog

The idea behind this concept is that fluorescence technology can be used to help guide ovarian cancer surgery more effectively, since the tumors tend to be small and hard to see for surgeons performing the excision.... Read more »

van Dam, G., Themelis, G., Crane, L., Harlaar, N., Pleijhuis, R., Kelder, W., Sarantopoulos, A., de Jong, J., Arts, H., van der Zee, A.... (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nature Medicine. DOI: 10.1038/nm.2472  

  • November 30, 1999
  • 12:00 AM
  • 1,377 views

More evidence that antibiotics are over-prescribed - How should that change?

by Rogue Medic in Rogue Medic

Today Lancet Infectious Diseases posted an early release of an article that shows that the antibiotic amoxicillin still does not work on viruses.

Many doctors still routinely prescribe antibiotics for viral infections.

Bias, perhaps the biggest confounder in medical research, is controlled for very well.

What does the study show?... Read more »

  • November 30, 1999
  • 12:00 AM
  • 31 views

DHM attenuates obesity-induced slow-twitch-fiber decrease via FLCN/FNIP1/AMPK pathway

by Joana Guedes in BHD Research Blog

Obesity is often associated with decreases in the proportion of skeletal muscle slow-twitch fibers and insulin sensitivity. Slow-twitch fibers are rich in mitochondria and utilize fatty acid oxidative phosphorylation for energy production. In their new study, Zhou et al. (2017) explore the role of the FLCN/FNIP1/AMPK signalling pathway in obesity-induced reductions in slow-twitch fibers and insulin sensitivity in skeletal muscle using high-fat-diet-induced (HFD) obese mice, ob/ob mutant mice, an........ Read more »

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