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  • November 30, -1
  • 12:00 AM

Cheap Cell-Phone Microscopes Might Make Distance Ed Science Labs Feasible

by Michael Windelspecht in RicochetScience

Review of recent advances in cell phone microscopes... Read more »

  • November 30, -1
  • 12:00 AM

Novel Approach for anti AIDS drug development.

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

HIV virus when it incorporates its DNA in human T-Lymphocytes , it integrates in a very controlled manner so that it takes care that our T-Lymphocytes cells do not get destroyed before they code and generate HIV virus proteins and genetic material and form enough new HIV viruses.
Professors Abraham Loyter, Assaf Friedler and their colleagues have reported that they have developed a peptide called as “MIX”

Peptide “MIX” is able to increase activity of HIV virus enzyme ........ Read more »

B V Waghmare. (2010) Developing a peptide that kills HIV virus. info:/

  • November 30, -1
  • 12:00 AM

HIV vaccine research: Protein which train B cells for production of antibodies against HIV which successfully neutralize HIV

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

HIV virus rapidly undergoes mutation, which is main hurdle in developing vaccine against HIV.There is a region on HIV virus which shows less variations, called as Cd4 binding site ,therefore a protein which stimulate antibody formation against this region can be developed and used as a vaccine.
Researchers at Vaccine Research Center (VRC) and the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health have studied genes which code for such proteins which can........ Read more »

B V Waghmare. (2011) HIV vaccine development : Proteins which trains B Cells for production of antibodies which successfully neutralize HIV by binding with it . info:/(DOI/arXiv/etc.)

  • November 30, -1
  • 12:00 AM

Using folate receptor alpha flurorescence imaging in ovarian cancer

by Sally Church in Pharma Strategy Blog

The idea behind this concept is that fluorescence technology can be used to help guide ovarian cancer surgery more effectively, since the tumors tend to be small and hard to see for surgeons performing the excision.... Read more »

van Dam, G., Themelis, G., Crane, L., Harlaar, N., Pleijhuis, R., Kelder, W., Sarantopoulos, A., de Jong, J., Arts, H., van der Zee, A.... (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nature Medicine. DOI: 10.1038/nm.2472  

  • November 30, -1
  • 12:00 AM

More evidence that antibiotics are over-prescribed - How should that change?

by Rogue Medic in Rogue Medic

Today Lancet Infectious Diseases posted an early release of an article that shows that the antibiotic amoxicillin still does not work on viruses.

Many doctors still routinely prescribe antibiotics for viral infections.

Bias, perhaps the biggest confounder in medical research, is controlled for very well.

What does the study show?... Read more »

  • November 30, -1
  • 12:00 AM

Interlukin 32 biomarker which predict relapse of mycobacterium tuberculosis

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

Interlukin 32 a protien which is found in people which do test positie for mycobacterium tuberculosis infection but do not develop pulmonary disease, it is found that interlukin is important in killing micobacterium, thereby protect them from TB disease, this interleukin 32 can be used therapeutically in patients suffering with TB along with chemotherapy, which will enhance efficacy of anti tuberculosis chemo therapy... Read more »

B V Waghmare. (2014) Interlukin 32 biomarker that will predict relapse of tuberculosis infection and will be used in treatment of TB. info:/

  • November 30, -1
  • 12:00 AM

‘Hotspots’ for DNA breakage in neurons may promote brain genetic diversity, disease

by Tom Ulrich in Vector, a Boston Children's Hospital blog

As organs go, the brain seems to harbor an abundance of somatic mutations — genetic variants that arise after conception and affect only some of our neurons. In one recent study, researchers found about 1,500 variants in each of neurons they sampled.

New research revealing the propensity of DNA to break in certain spots backs up the idea of a genetically diverse brain. Reported in Cell last month, it also suggests a new avenue for thinking about brain development, brain tumors and neuro........ Read more »

  • November 30, -1
  • 12:00 AM

The PROCAMIO Trial – IV Procainamide vs IV Amiodarone for the Acute Treatment of Stable Wide Complex Tachycardia

by Rogue Medic in Rogue Medic

This is a very interesting trial that may surprise the many outspoken amiodarone advocates, but it should not surprise anyone who pays attention to research.

ALPS showed that we should stop giving amiodarone for unwitnessed shockable cardiac arrest. The lead researcher is still trying to spin amiodarone for witnessed shockable cardiac arrest, even though the results do not show improvement in the one outcome that matters – leaving the hospital with a brain that still works.[1],[2],[3]... Read more »

Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. The New England journal of medicine, 374(18), 1711-22. PMID: 27043165  

Marill KA, deSouza IS, Nishijima DK, Senecal EL, Setnik GS, Stair TO, Ruskin JN, & Ellinor PT. (2010) Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(3), 297-306. PMID: 20370763  

Marill KA, deSouza IS, Nishijima DK, Stair TO, Setnik GS, & Ruskin JN. (2006) Amiodarone is poorly effective for the acute termination of ventricular tachycardia. Annals of emergency medicine, 47(3), 217-24. PMID: 16492484  

Kułakowski P, Karczmarewicz S, Karpiński G, Soszyńska M, & Ceremuzyński L. (2000) Effects of intravenous amiodarone on ventricular refractoriness, intraventricular conduction, and ventricular tachycardia induction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2(3), 207-15. PMID: 11227590  

Bonny A, De Sisti A, Márquez MF, Megbemado R, Hidden-Lucet F, & Fontaine G. (2012) Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia. World journal of cardiology, 4(10), 296-301. PMID: 23110246  

Kowey PR. (1988) The calamity of cardioversion of conscious patients. The American journal of cardiology, 61(13), 1106-7. PMID: 3364364  

  • November 30, -1
  • 12:00 AM

DHM attenuates obesity-induced slow-twitch-fiber decrease via FLCN/FNIP1/AMPK pathway

by Joana Guedes in BHD Research Blog

Obesity is often associated with decreases in the proportion of skeletal muscle slow-twitch fibers and insulin sensitivity. Slow-twitch fibers are rich in mitochondria and utilize fatty acid oxidative phosphorylation for energy production. In their new study, Zhou et al. (2017) explore the role of the FLCN/FNIP1/AMPK signalling pathway in obesity-induced reductions in slow-twitch fibers and insulin sensitivity in skeletal muscle using high-fat-diet-induced (HFD) obese mice, ob/ob mutant mice, an........ Read more »

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