All posts; Tags Include "mutation"
- August 18, 2010
- 09:52 AM
- 73 views
Is the cancer research paradigm changing?
by Sally Church in Pharma Strategy Blog
Over the weekend, a reader (a scientist in translational medicine) kindly sent me the link to a paper on PARP inhibition and asked: "Is this a sign of the new wave of oncology drug development? Rather than basing treatment on...... Read more »
Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, Friedlander M, Arun B, Loman N, Schmutzler RK.... (2010) Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet, 376(9737), 235-44. PMID: 20609467
- August 5, 2010
- 11:46 AM
- 100 views
Somatic mutations and pathway alterations in cancer
by Sally Church in Pharma Strategy Blog
"The systematic characterization of somatic mutations in cancer genomes is essential for understanding the disease and for developing targeted therapeutics." So began today's journal article from a letter to Nature (link below) from scientists at Genentech. They went on to...... Read more »
Kan, Z., Jaiswal, B., Stinson, J., Janakiraman, V., Bhatt, D., Stern, H., Yue, P., Haverty, P., Bourgon, R., Zheng, J.... (2010) Diverse somatic mutation patterns and pathway alterations in human cancers. Nature. DOI: 10.1038/nature09208
- February 3, 2010
- 10:53 AM
- 434 views
Story behind the science: #PLoS Genetics "Evolutionary mirages" paper
by Jonathan Eisen in The Tree of Life
So there is this cool new paper out in PLoS Genetics: Evolutionary Mirages: Selection on Binding Site Composition Creates the Illusion of Conserved Grammars in Drosophila Enhancers. and I have wanted to write about it for a week or so. You see, the paper is about something I have been interested in for most of my career - how the particular processes by which mutations occur can sometimes be biased (i.e., some types of mutations are more common than others) and that these biases can create high........ Read more »
Lusk, R., & Eisen, M. (2010) Evolutionary Mirages: Selection on Binding Site Composition Creates the Illusion of Conserved Grammars in Drosophila Enhancers. PLoS Genetics, 6(1). DOI: 10.1371/journal.pgen.1000829
- February 5, 2009
- 10:08 AM
- 567 views
Mutation Patterns in the Human Genome are More Variable Than Expected
by Greg Laden in Greg Laden's Blog
I want to bring your attention to a somewhat dense and possibly inconclusive (but important) paper accompanied by a very informative overview in PLoS Biology, concerning mutations in the human genome.
Mutation rates and patterns of mutation are important for a number of reasons. For one thing, the genome itself is a data set that is both broad and deep. There is a lot of information in a given individual genome (a haploid set of genes from a person, for instance) but there is a wide range of ........ Read more »
Alan Hodgkinson, Emmanuel Ladoukakis, & Adam Eyre-Walker. (2009) Cryptic Variation in the Human Mutation Rate. PLoS Biology, 7(2). DOI: 10.1371/journal.pbio.1000027
Laurent Duret. (2009) Mutation Patterns in the Human Genome: More Variable Than Expected. PLoS Biology, 7(2). DOI: 10.1371/journal.pbio.1000028
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