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All posts; Tags Include "osteoarthritis"

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  • July 24, 2013
  • 01:05 AM
  • 956 views

Potentially Modifiable Osteoarthritis Risk Factors

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Take Home Message: Osteoarthritis prevention programs could focus on certain risk factors, such as joint injury, obesity, and occupational activities.

Osteoarthritis (OA), a degenerative joint disease, affects millions of adults worldwide. There are many potential risk factors for OA, including several of interest in sports medicine: obesity, repetitive tasks (physical or occupational activity), and joint injury. It is important to understand what modifiable risk factors may exist so that w........ Read more »

  • May 20, 2013
  • 01:04 AM
  • 879 views

Do Hyaluronic Acid Injections Reduce Biomarkers of Collagen Degradation?

by Stephen Thomas in Sports Medicine Research (SMR): In the Lab & In the Field

Take Home Message: Hyaluronic acid injections decrease factors related to collagen degradation. Some blood tests may differentiate responders and nonresponders to these injections.

Knee osteoarthritis, one of the leading causes of disability, has no cure and current treatments commonly involve medications to decrease inflammation and pain. Hyaluronic acid (HA) injections have become a popular form of treatment for knee osteoarthritis. However, the mechanism of action has yet to be determ........ Read more »

  • May 15, 2013
  • 01:04 AM
  • 1,190 views

Elite Soccer Players Have High Rates of Osteoarthritis

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Take Home Message: Elite soccer athletes may be at an increased risk for knee and ankle osteoarthritis compared with the general population. This group should be identified as high risk and preventative measures should be taken.

While participation in elite-level sports is often viewed as a good thing, there is an established increased risk of short-term injuries (e.g., sprains, strains). This increased injury risk may leave athletes at an increased risk for long-term disability (e.g., oste........ Read more »

  • May 8, 2013
  • 05:04 AM
  • 762 views

Scaffold made of silk and cellulose effective for cartilage regeneration

by beredim in Stem Cells Freak

Osteoarthritis (OA) is a joint disease affecting more than 27 million people in the U. S, globally causing moderate to severe disability in more than 40 million people. In the past decade, stem cells have shown great promise in treating OA. Yesterday, researchers at the University of Bristol announced that they have created a 'smart material', composed of silk and cellulose, that according to them paves the wave for both affordable and effective cell based treatments for cartilage regene........ Read more »

Singh, N., Rahatekar, S., Koziol, K., Ng, T., Patil, A., Mann, S., Hollander, A., & Kafienah, W. (2013) Directing Chondrogenesis of Stem Cells with Specific Blends of Cellulose and Silk. Biomacromolecules, 2147483647. DOI: 10.1021/bm301762p  

  • May 1, 2013
  • 01:02 AM
  • 947 views

Early Degenerative Changes After an ACL Injury

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Take Home Message: Knees with a recent history of an anterior cruciate ligament injury have radiographic and biochemical differences from healthy knees.

An anterior cruciate ligament (ACL) injury predisposes a knee to osteoarthritis. Little is known about the causes and characteristics of the path from injury to osteoarthritis. Without these fundamental concepts it is challenging to determine who will develop knee osteoarthritis, optimal interventions, and how to measure if the treatments a........ Read more »

  • February 11, 2013
  • 12:30 PM
  • 1,253 views

Cheap plastic materials and embryonic stem cells for bone regeneration

by beredim in Stem Cells Freak

Researchers from the University of Southampton and in collaboration with the University of Glasgow just announced a new method for generating bone cells from human embryonic stem cells. The study has implications for people in need of hip replacement due to osteoporosis and/or osteoarthritis and for people with severe bone loss due to trauma or disease. It should be noted that this is the second study coming from the same university in the field of bone regeneration, in less than a week. You can........ Read more »

  • January 18, 2013
  • 01:03 AM
  • 1,595 views

Hyaluronic Acid vs PRP for Knee Osteoarthritis

by Kris Fayock in Sports Medicine Research (SMR): In the Lab & In the Field

Osteoarthritis (also known as gonarthrosis) is characterized by structural and biochemical changes throughout the entire joint. Unfortunately, osteoarthritis can be challenging to treat and no treatments have been demonstrated to slow, halt, or reverse osteoarthritis progression. Recently, it has been hypothesized that hyaluronic acid (HA), a key component of synovial fluid, or platelet-rich plasma (PRP), which contains various growth factors involved in the inflammatory/healing process, may be........ Read more »

Cerza F, Carnì S, Carcangiu A, Di Vavo I, Schiavilla V, Pecora A, De Biasi G, & Ciuffreda M. (2012) Comparison Between Hyaluronic Acid and Platelet-Rich Plasma, Intra-articular Infiltration in the Treatment of Gonarthrosis. The American Journal of Sports Medicine, 40(12), 2822-7. PMID: 23104611  

  • November 12, 2012
  • 01:04 AM
  • 1,565 views

Are We Doing Enough to Plan for How Injuries Affect Players Later in Life?

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

Australian football players are exposed to extreme physical demands, which cause disproportionately high number of injuries compared to other sports. Due to the magnitude of the physical and psychological strains most Australian Football League players have an average career of 4.7 years inevitably meaning a player pursues a second career, and there has been little research on how their football career affects the players later in life. Therefore, the authors investigated the long-term health (m........ Read more »

King T, Rosenberg M, Braham R, Ferguson R, & Dawson B. (2012) Life after the game - Injury profile of past elite Australian Football players. Journal of Science and Medicine in Sport. PMID: 23058879  

  • October 17, 2012
  • 01:04 AM
  • 1,309 views

How Long are Synovial Fluid Biomarkers Altered After Acute Knee Injury?

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

Acute knee injuries, including anterior cruciate ligament (ACL) tears, are known to increase an athlete’s risk of developing osteoarthritis (OA). Rate of OA incidence seems to be at an increased risk, despite whether an athlete gets ACL surgery or not. There are various biomechanical as well as biochemical theories as to why this may be. One biochemical theory being that the acute inflammatory process that follows a knee injury propagates OA. Therefore the purpose of this study was to i........ Read more »

  • June 11, 2012
  • 01:04 AM
  • 1,294 views

Physical Activity and Knee Osteoarthritis: Protective or Destructive?

by Hallie Labrador, Marc Harwood in Sports Medicine Research (SMR): In the Lab & In the Field

Osteoarthritis has often been described as “wear and tear” on the joint. However, previous research has shown that the pathogenesis is not this clear cut. Several studies demonstrate that increased physical activity can actually prevent osteoarthritis; however, other studies have shown just the opposite. These two papers by Teichtahl and Ageberg look to further characterize the effects of physical activity on osteoarthritis incidence.... Read more »

  • February 10, 2012
  • 01:02 AM
  • 1,432 views

The Benefits of Prehabilitation: Mobilizing Your Patient Before it’s too Late

by Joseph Zeni in Sports Medicine Research (SMR): In the Lab & In the Field

The authors in this paper evaluated the value of “prehabilitation” before knee replacement.... Read more »

  • February 6, 2012
  • 01:06 AM
  • 2,204 views

Loss of Normal Knee Motion After ACL Reconstruction is Associated with Degenerative Changes

by Jeffrey B. Driban in Sports Medicine Research (SMR): In the Lab & In the Field

Shelbourne et al. assessed whether the prevalence of radiographic knee osteoarthritis was higher in patients who had abnormal knee ROM after an ACL reconstruction compared to patients with normal knee ROM; even when controlling for meniscal or cartilage damage.... Read more »

  • January 25, 2012
  • 01:05 AM
  • 2,035 views

Autologous Chondrocyte Implantation for Treatment of Cartilage Defects of the Knee: What Predicts the Need for Reintervention?

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

The purpose of this study was to identify risk factors associated with the need for a second (corrective) surgery after ACI.... Read more »

  • January 12, 2012
  • 01:03 AM
  • 1,120 views

Five-Year Outcomes After Two Techniques to Repair Articular Cartilage Defects

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

he purpose of this randomized trial was to compare 5-year clinical outcomes between patients undergoing microfracture (MF; drilling into the subchondral bone to promote fibrosis into the lesion area) and characterized chondrocyte implantation (CCI; harvesting and growing of patient’s cartilage that is then placed into patch over lesion area) surgical techniques for femoral condyle articular cartilage defects. ... Read more »

  • December 14, 2011
  • 01:08 AM
  • 4,743 views

Risk Factors for Poor Long-Term Outcomes among Knees with ACL Reconstructions

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

The purpose of this study was to identify the incidence of osteoarthritis (OA) in patients that have undergone ACL reconstruction utilizing the bone-patellar tendon-bone autograft technique as well as to identify factors associated with poor radiographic and patient-centered outcomes.... Read more »

  • December 12, 2011
  • 01:08 AM
  • 4,399 views

Radiographic Prevalence of Femoroacetabular Impingement in Collegiate Football Players

by Meghan Miller in Sports Medicine Research (SMR): In the Lab & In the Field

The purpose of this study was to use radiographic imaging to quantify the prevalence of FAI in asymptomatic football players.... Read more »

Kapron AL, Anderson AE, Aoki SK, Phillips LG, Petron DJ, Toth R, & Peters CL. (2011) Radiographic prevalence of femoroacetabular impingement in collegiate football players: AAOS Exhibit Selection. The Journal of Bone and Joint Surgery. American volume, 93(19). PMID: 22005872  

  • December 9, 2011
  • 01:14 AM
  • 1,272 views

Former Male Elite Athletes May Have a Higher Prevalence of Hip and Knee Osteoarthritis

by Jeffrey B. Driban in Sports Medicine Research (SMR): In the Lab & In the Field

veit et al evaluated whether former 678 male elite athletes (internationally or nationally ranked) in both impact (n = 586) and nonimpact (n = 92) sports have a higher prevalence (frequency) of hip and knee OA than 1316 male controls.... Read more »

  • November 15, 2011
  • 01:01 AM
  • 1,324 views

Predictors of Knee Osteoarthritis After ACL Reconstruction

by Jeffrey B. Driban in Sports Medicine Research (SMR): In the Lab & In the Field

Over the past few months, SMR had several posts highlighting that individuals with a history of knee injury are at greater risk for knee osteoarthritis (OA) even if they undergo surgeries like anterior cruciate ligament (ACL) reconstructions (see below). As clinicians we must strive to reduce the risk of knee OA for our injured patients. Unfortunately, it is unclear which variables might predict individuals who will develop knee OA after an injury. Therefore, Li et al. tried to determine the pr........ Read more »

  • November 8, 2011
  • 01:09 AM
  • 1,868 views

Articular Cartilage Damage and Long-term Changes After an ACL Tear

by Chris Kuenze in Sports Medicine Research (SMR): In the Lab & In the Field

Anterior cruciate ligament (ACL) injury is common in the athletic population and has been shown to cause an immediate reduction in function and increase the risk for long term joint degeneration. In a recent review, it was reported that 0 to 39% of patients following isolated ACL injury and 40 to 90% patients with combined ACL and meniscus injury will develop knee osteoarthritis within 10 to 15 years. Currently, there is little information regarding the health of knee joint articular cartilage........ Read more »

  • November 2, 2011
  • 01:01 AM
  • 1,288 views

Patellar Tendon versus Hamstring Autografts: 11-year Follow-Up of a Randomized Clinical Trial

by Nicole Cattano in Sports Medicine Research (SMR): In the Lab & In the Field

The goals of anterior cruciate ligament (ACL) reconstruction surgery are to decrease symptoms, increase function, and to return to pre-injury activity status. There are numerous techniques and grafts utilized for ACL reconstruction, including autografts or allografts. Autografts are frequently selected, and can consist of patellar tendon (PT) or semitendinosus and gracilis (STG) tendons. Currently, there is no consensus as to which graft is the best option for optimal outcomes. Therefore, th........ Read more »

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