Post List

  • October 25, 2014
  • 03:47 AM
  • 10 views

Autism and intolerance of uncertainty

by Paul Whiteley in Questioning Answers

Good morning, gentlemen, the temperature is 110 degrees'Change' is often mentioned as something potentially problematic for many on the autism spectrum, and how unexpected change can sometimes have profound effects in terms of those so-called 'challenging behaviours' or when it comes to the presentation of important comorbidity such as anxiety. Like many others from the outside looking in, I was always taught that change as a more general concept was the important issue in autism, but recently t........ Read more »

  • October 24, 2014
  • 05:20 PM
  • 16 views

The Genetics of Congenital Heart Defects Slowly Emerge from Down Syndrome Study

by Gabriel in Lunatic Laboratories

Down syndrome, of all the genetic defects people are born with, is the most common (as far as chromosomal abnormalities go). Down syndrome involves having a third copy of all or part of chromosome 21 (for those who do not recall we are typically born with 23 pairs of chromosomes). In addition to intellectual disability, individuals with Down syndrome have a high risk of congenital heart defects. However, not all people with Down syndrome have them – about half have structurally normal hearts.... Read more »

Ramachandran D, Mulle JG, Locke AE, Bean LJ, Rosser TC, Bose P, Dooley KJ, Cua CL, Capone GT, Reeves RH.... (2014) Contribution of copy-number variation to Down syndrome-associated atrioventricular septal defects. Genetics in medicine : official journal of the American College of Medical Genetics. PMID: 25341113  

  • October 24, 2014
  • 01:14 PM
  • 19 views

Fish Want to Play Too

by Elizabeth Preston in Inkfish

Yes, fish. These aquarium lap-swimmers and pursuers of flaked food aren’t known for their joie de vivre. Yet in one hobbyist’s tanks, scientists say they’ve captured a rare instance of fish playing around. James Murphy is a herpetologist at the Smithsonian National Zoological Park. Although he professionally studies reptiles and amphibians, he keeps fish as […]The post Fish Want to Play Too appeared first on Inkfish.... Read more »

  • October 24, 2014
  • 12:50 PM
  • 13 views

The Pig-like Aardvark

by beredim in Strange Animals

Adult and juvenile AardvarksCredit: By Scotto Bear from North Beach, MD, USA (aardvarks) [CC-BY-SA-2.], via Wikimedia CommonsKingdom: AnimaliaPhylum: ChordataClass: MammaliaSuperorder: AfrotheriaOrder: TubulidentataFamily: OrycteropodidaeGenus: OrycteropusSpecies: Orycteropus aferConservation Status: Least Concern (Not Threatened)Common Name(s): Aardvark, African antbear, Cape anteaterMeet the Aardvark, a medium-sized, burrowing, nocturnal mammal from Afri........ Read more »

Taylor, W., Lindsey, P., & Skinner, J. (2002) The feeding ecology of the aardvark Orycteropus afer. Journal of Arid Environments, 50(1), 135-152. DOI: 10.1006/jare.2001.0854  

Mutlow AG, & Mutlow H. (2008) Caesarian section and neonatal care in the aardvark (Orycteropus afer). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 39(2), 260-2. PMID: 18634220  

Tabuce, R., Asher, R., & Lehmann, T. (2008) Afrotherian mammals: a review of current data. mammalia, 72(1). DOI: 10.1515/MAMM.2008.004  

White, J., Williams, G., Samour, J., Drury, P., & Cheeseman, P. (1985) The composition of milk from captive aardvark (Orycteropus afer). Zoo Biology, 4(3), 245-251. DOI: 10.1002/zoo.1430040305  

  • October 24, 2014
  • 11:23 AM
  • 22 views

Publication bias afflicts the whole of psychology

by BPS Research Digest in BPS Research Digest

In the last few years the social sciences, including psychology, have been taking a good look at themselves. While incidences of fraud hit the headlines, pervasive issues are just as important to address, such as publication bias, the phenomenon where non-significant results never see the light of day thanks to editors rejecting them or savvy researchers recasting their experiments around unexpected results and not reporting the disappointments. Statistical research has shown the extent of this ........ Read more »

  • October 24, 2014
  • 11:22 AM
  • 11 views

October 24, 2014

by Erin Campbell in HighMag Blog

There is a party going on at the ends of microtubules, but I wasn’t invited. That won’t stop me, or countless cell biologists out there, from peeping in the window to check out all of the microtubule shenanigans. Today’s image is from a paper describing how Doublecortin binds to microtubule ends.The plus end of a microtubule is the primary site for growth and shrinkage, and interaction with several microtubule-associate proteins. Different microtubule end-binding proteins may interact with........ Read more »

  • October 24, 2014
  • 09:15 AM
  • 15 views

The Friday Five for 10/24/14

by Bill Sullivan in The 'Scope

A fun look at cool science news: making the blind see, the paralyzed walk, the first copulation sex, and fun with dry ice!... Read more »

  • October 24, 2014
  • 06:49 AM
  • 15 views

Blocking Key Gene To Stop Malaria Transmission

by Pieter Carrière in United Academics

Earlier this week Pieter wrote about a key gene in the transmission of Malaria. Now he explains more about blocking this gene to prevent spreading.... Read more »

Kafsack BF, Rovira-Graells N, Clark TG, Bancells C, Crowley VM, Campino SG, Williams AE, Drought LG, Kwiatkowski DP, Baker DA.... (2014) A transcriptional switch underlies commitment to sexual development in malaria parasites. Nature, 507(7491), 248-52. PMID: 24572369  

Kåhrström CT. (2014) Parasite development: master regulator of sex. Nature reviews. Microbiology, 12(4), 233. PMID: 24608336  

Rovira-Graells N, Gupta AP, Planet E, Crowley VM, Mok S, Ribas de Pouplana L, Preiser PR, Bozdech Z, & Cortés A. (2012) Transcriptional variation in the malaria parasite Plasmodium falciparum. Genome research, 22(5), 925-38. PMID: 22415456  

Gardner, M., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R., Carlton, J., Pain, A., Nelson, K., Bowman, S.... (2002) Genome sequence of the human malaria parasite Plasmodium falciparum. Nature, 419(6906), 498-511. DOI: 10.1038/nature01097  

  • October 24, 2014
  • 04:27 AM
  • 21 views

Collective Structures in Software Projects

by Jörg Friedrich in Software Engineering Economics

To understand the social dynamics of complex software development processes, it is necessary to analyze in which structures the persons involved and how this involvement affected their work. Damian Tamburri has in recent years identified the relevant social structures in a number of publications, analyzed and graded on their effect. He first distinguishes four basic […]... Read more »

Tamburri, D., Lago, P., & Vliet, H. (2013) Organizational social structures for software engineering. ACM Computing Surveys, 46(1), 1-35. DOI: 10.1145/2522968.2522971  

  • October 24, 2014
  • 03:00 AM
  • 14 views

Somatic mutations in FLCN can cause cancer

by Lizzie Perdeaux in BHD Research Blog

The majority of research on FLCN is within the context of BHD syndrome, which is caused by heterozygous germline mutations in the FLCN gene. However, two recent papers have reported that somatic FLCN mutations may be a factor in the … Continue reading →... Read more »

Wagle N, Grabiner BC, Van Allen EM, Amin-Mansour A, Taylor-Weiner A, Rosenberg M, Gray N, Barletta JA, Guo Y, Swanson SJ.... (2014) Response and acquired resistance to everolimus in anaplastic thyroid cancer. The New England journal of medicine, 371(15), 1426-33. PMID: 25295501  

  • October 24, 2014
  • 02:51 AM
  • 25 views

Autism, siblings and DSM-5 Social Communication Disorder

by Paul Whiteley in Questioning Answers

A quick post to bring to your attention the paper by Meghan Miller and colleagues [1] who concluded that: "Pragmatic language problems are present in some siblings of children with ASD [autism spectrum disorder] as early as 36 months of age". Further: "As the new DSM-5 diagnosis of Social (Pragmatic) Communication Disorder (SCD) is thought to occur more frequently in family members of individuals with ASD, it is possible that some of these siblings will meet criteria for SCD as th........ Read more »

  • October 24, 2014
  • 12:05 AM
  • 23 views

Who is at Risk for Medial Tibial Stress Syndrome?

by Hallie Labrador MD, MS in Sports Medicine Research (SMR): In the Lab & In the Field

Risk of medial tibial stress syndrome (MTSS) is associated with increased body mass index, navicular drop, ankle plantarflexion range of motion (ROM) and hip external rotation ROM.... Read more »

  • October 23, 2014
  • 05:58 PM
  • 33 views

The Genes Responsible for Immune System Reset after Infection

by Gabriel in Lunatic Laboratories

We’ve all been sick before, the aches and pains that come with it– most of the time including a fever — are all responses to our immune system kicking into high gear. But what if your body didn’t reverse course and go back to a, let’s call it” relaxed state.” Once the battle is won, the body’s efforts would be wasted on energy costing defense. A bad thing when the body really should be focusing on repairing the damage done by the foreign invaders.... Read more »

Brian Head,, & Alejandro Aballay. (2014) Recovery from an Acute Infection in C. elegans Requires the GATA Transcription Factor ELT-2. PLoS Genetics. info:/10.1371/journal.pgen.1004609

  • October 23, 2014
  • 10:20 AM
  • 42 views

Smartphone App Boosts Alcoholism Treatment Outcome

by William Yates, M.D. in Brain Posts

Smartphone apps and other mobile technology are emerging as promising tools in medical treatment.A recent randomized study published in JAMA Psychiatry found evidence that a smartphone app improves alcoholism treatment outcomes.David Gustafson and colleagues conducted a study funded by the National Institute of Alcohol Abuse and Alcoholism.A series of 349 adults with DSM-IV alcohol dependence were enrolled as they entered a alcoholism residential treatment program.Approximately half of the subje........ Read more »

Gustafson DH, McTavish FM, Chih MY, Atwood AK, Johnson RA, Boyle MG, Levy MS, Driscoll H, Chisholm SM, Dillenburg L.... (2014) A smartphone application to support recovery from alcoholism: a randomized clinical trial. JAMA psychiatry, 71(5), 566-72. PMID: 24671165  

  • October 23, 2014
  • 09:05 AM
  • 60 views

The Monster Mash – Diseases That May Have Spawned Monster Legends

by Bill Sullivan in The 'Scope

Creepy diseases that produce symptoms that mimic characteristics associated with legendary monsters!... Read more »

Schulenburg-Brand D, Katugampola R, Anstey AV, & Badminton MN. (2014) The cutaneous porphyrias. Dermatologic clinics, 32(3), 369. PMID: 24891059  

Deshmukh S, & Prashanth S. (2012) Ectodermal dysplasia: a genetic review. International journal of clinical pediatric dentistry, 5(3), 197-202. PMID: 25206167  

Ramirez-Bermudez J, Aguilar-Venegas LC, Crail-Melendez D, Espinola-Nadurille M, Nente F, & Mendez MF. (2010) Cotard syndrome in neurological and psychiatric patients. The Journal of neuropsychiatry and clinical neurosciences, 22(4), 409-16. PMID: 21037126  

  • October 23, 2014
  • 07:38 AM
  • 61 views

Four Solar-Powered Animals

by beredim in Strange Animals

Photosynthesis, a process used by plants and some bacteria to convert light from the sun into chemical energy which can be later released to fuel their activities. Animals on the other hand, have to consume other organisms in order to cover their energy needs. But every rule has an exception.In recent years, researchers have discovered a small number of animals that much like plants have found a way to directly harness and feed off the Sun’s energy.1# Oriental Hornet (Vespa orientalis)Typicall........ Read more »

Rumpho ME, Worful JM, Lee J, Kannan K, Tyler MS, Bhattacharya D, Moustafa A, & Manhart JR. (2008) Horizontal gene transfer of the algal nuclear gene psbO to the photosynthetic sea slug Elysia chlorotica. Proceedings of the National Academy of Sciences of the United States of America, 105(46), 17867-71. PMID: 19004808  

Plotkin M, Hod I, Zaban A, Boden SA, Bagnall DM, Galushko D, & Bergman DJ. (2010) Solar energy harvesting in the epicuticle of the oriental hornet (Vespa orientalis). Die Naturwissenschaften, 97(12), 1067-76. PMID: 21052618  

Valmalette, J., Dombrovsky, A., Brat, P., Mertz, C., Capovilla, M., & Robichon, A. (2012) Light- induced electron transfer and ATP synthesis in a carotene synthesizing insect. Scientific Reports. DOI: 10.1038/srep00579  

Kerney, R., Kim, E., Hangarter, R., Heiss, A., Bishop, C., & Hall, B. (2011) Intracellular invasion of green algae in a salamander host. Proceedings of the National Academy of Sciences, 108(16), 6497-6502. DOI: 10.1073/pnas.1018259108  

  • October 23, 2014
  • 07:02 AM
  • 60 views

How reminders of money affect people's expression and perception of emotion

by BPS Research Digest in BPS Research Digest

Bank robbers and gamblers will tell you what people are prepared to do for the sake of money. But money also has more subtle influences. Back in 2006, researchers showed that mere reminders of money made people more selfish (although note a later attempt failed to replicate this result).In the latest research in this field, a team led by Yuwei Jiang have shown that exposing people to pictures of money, or to money-related words, reduces their emotional expressivity and makes them more sensitive ........ Read more »

Jiang, Y., Chen, Z., & Wyer, R. (2014) Impact of money on emotional expression. Journal of Experimental Social Psychology, 228-233. DOI: 10.1016/j.jesp.2014.07.013  

  • October 23, 2014
  • 04:46 AM
  • 57 views

Postpartum depression and the broader autism phenotype?

by Paul Whiteley in Questioning Answers

"The findings suggest that pregnant women with BAP [broader autism phenotype] have an elevated risk for PPD [postpartum depression]".That was the conclusion reached by Ryosuke Asano and colleagues [1] based on their analysis of data derived from the Hamamatsu Birth Cohort (HBC) Study [2]. The idea being that the more subtle presentation of issues linked to a diagnosis of autism spectrum disorder (the BAP) might predispose to a great likelihood of other behavioural or psychiat........ Read more »

Asano, R., Tsuchiya, K., Takei, N., Harada, T., Kugizaki, Y., Nakahara, R., Nakayasu, C., Okumura, A., Suzuki, Y., Takagai, S.... (2014) Broader autism phenotype as a risk factor for postpartum depression: Hamamatsu Birth Cohort (HBC) Study. Research in Autism Spectrum Disorders, 8(12), 1672-1678. DOI: 10.1016/j.rasd.2014.08.010  

  • October 22, 2014
  • 11:05 PM
  • 50 views

Microscopic observation in live tissue, awesome! But don’t ignore the methods

by Austin Bouck in Animal Science Review

The NIH sent me an email this week (via the various government listservs I’m enrolled in) that was proudly declaring that the mysteries of the cell were being solved right now, so I took the clickbait. In it was a cool study where we were able to actively watch mitochondria oscillate inside a living animal...... Read more »

Natalie Porat-Shliom, Yun Chen, Muhibullah Tora, Akiko Shitara, Andrius Masedunskas, & Roberto Weigertemail. (2014) In Vivo Tissue-wide Synchronization of Mitochondrial Metabolic Oscillations. Cell Reports. info:/http://dx.doi.org/10.1016/j.celrep.2014.09.022

Weigert R, Porat-Shliom N, & Amornphimoltham P. (2013) Imaging cell biology in live animals: ready for prime time. The Journal of cell biology, 201(7), 969-79. PMID: 23798727  

  • October 22, 2014
  • 03:55 PM
  • 52 views

Converting Skin Cells to Neurons: A Fight Against Huntington’s

by Gabriel in Lunatic Laboratories

Neurological diseases are some of the hardest to fight against (in my opinion). The big reason is the brain, we still know so little about it and treatment for anything effecting it can be difficult to say the least. Take Huntington’s disease, an ultimately fatal neurodegenerative disorder. There is no cure and no real treatment, but that might change relatively soon thanks to a new discovery.... Read more »

Victor, M., Richner, M., Hermanstyne, T., Ransdell, J., Sobieski, C., Deng, P., Klyachko, V., Nerbonne, J., & Yoo, A. (2014) Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts. Neuron, 84(2), 311-323. DOI: 10.1016/j.neuron.2014.10.016  

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