Editor’s Selections: Sirtuins and marathon running, mutation, and a new treatment for sepsis

Editor's Selections 10 Comments
By Vincent Racaniello

Vincent RacanielloVincent Racaniello selects several notable posts each week from molecular and cellular biology and virology. He blogs at virology blog.

  • Is apoptosis is increased in cells of the immune system after running a marathon? It is not, because exercise increases expression of sirtuins, proteins that are part of a signaling system that enhances survival during times of stress.
  • Mutation is necessary for populations to change over time. Mutations comprise any change to the genetic code, whether caused by an external factor like radiation, or an error during DNA replication.
  • Sepsis is a serious illness because the body mounts a massive inflammatory response to infection. The cytokine interleukin (IL)-33 reduces sepsis in mice by enhancing neutrophil influx to the site of infection, suggesting that it could be used to treat this often fatal inflammatory condition.

I’ll be back next Friday with more selections.

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