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Critically discussing nutrition related research.

Colby
73 posts

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  • November 15, 2011
  • 06:00 PM
  • 578 views

Latest salt Cochrane review including non-blood pressure surrogates

by Colby Vorland in nutsci.org

A new Cochrane review on dietary salt interventions was published last week by Graudal et. al (1), an update to a 2003 review. The meta-analyses examined the effects of randomized interventions with high or low dietary salt on blood pressure (BP), hormones and lipids. The trials included consisted of subjects with normal or elevated BP, and sodium intake estimated via 24 hour sodium excretion. In total, 167 studies were included that compared dietary sodium intakes 150 mmol. In studies on subjec........ Read more »

  • November 2, 2011
  • 10:45 AM
  • 514 views

Dietary sulforaphane reduces oxidative stress in diabetes

by Colby Vorland in nutsci.org

Type 2 diabetes is characterized by increased oxidative stress, which may result in vascular pathologies (Bekyarova, Ivanova, and Madjova, 2007). Certain dietary phytochemicals may ameliorate oxidative stress and restore a more normal metabolic milieu. As reviewed by Angeloni, Leoncini, Malaguti, Angelini, Hrelia, and Hrelia (2009), one such phytochemical found in cruciferous vegetables such as broccoli sprouts, sulforaphane (SFN), induces phase-II enzymes and increases endogenous antioxidant ac........ Read more »

  • August 12, 2011
  • 10:30 AM
  • 1,127 views

Latest Cochrane review on dietary fats and cardiovascular disease

by Colby Vorland in nutsci.org

Right on the heels of the updated Cochrane review on “Reduced dietary salt for the prevention of cardiovascular disease,” (and the terrible reporting on it), another one is updated: “Reduced or modified dietary fat for preventing cardiovascular disease.” One of the authors (Lee Hooper) worked on the salt review as well.

Given that this is a Cochrane review, it uses only RCTs (and only studies that tracked morbidity and mortality, not just intermediate risk factors). Of........ Read more »

Hooper L, Summerbell CD, Thompson R, Sills D, Roberts FG, Moore H, & Davey Smith G. (2011) Reduced or modified dietary fat for preventing cardiovascular disease. Cochrane Database of Systematic Reviews. info:/10.1002/14651858.CD002137.pub2.

  • June 28, 2011
  • 05:00 PM
  • 980 views

Increase in number of eating occasions, more than increases in food portion sizes or energy density per meal responsible for increased energy intake at the population level?

by Colby in nutsci.org

We know by now that an increase in calorie consumption since the 1970s by about 500 Calories per day for Americans is primarily fueling obesity.  Physical activity decline at the population level is a lesser contributor (and it is contentious … Continue reading →... Read more »

Duffey KJ, & Popkin BM. (2011) Energy Density, Portion Size, and Eating Occasions: Contributions to Increased Energy Intake in the United States. PLoS Med. info:/10.1371/journal.pmed.1001050

  • May 13, 2011
  • 08:00 AM
  • 1,021 views

Generational increases in stochastic epigenetic variability to sustained methyl donor supplementation in mice

by Colby in nutsci.org

This recent paper in PLoS Genetics by Cheryl C. Y. Li and colleagues (from a group that did earlier work with the agouti mouse model) was really fascinating- they looked at changes in methylation variability in response to dietary supplementation … Continue reading →... Read more »

Li CC, Cropley JE, Cowley MJ, Preiss T, Martin DI, & Suter CM. (2011) A sustained dietary change increases epigenetic variation in isogenic mice. PLoS genetics, 7(4). PMID: 21541011  

  • May 13, 2011
  • 08:00 AM
  • 1,062 views

Generational increases in stochastic epigenetic variability to sustained methyl donor supplementation in mice

by Colby in nutsci.org

This recent paper in PLoS Genetics by Cheryl C. Y. Li and colleagues (from a group that did earlier work with the agouti mouse model) was really fascinating- they looked at changes in methylation variability in response to dietary supplementation … Continue reading →... Read more »

Li CC, Cropley JE, Cowley MJ, Preiss T, Martin DI, & Suter CM. (2011) A sustained dietary change increases epigenetic variation in isogenic mice. PLoS genetics, 7(4). PMID: 21541011  

  • May 4, 2011
  • 08:00 AM
  • 581 views

The Great Fat Debate

by Colby in nutsci.org

At the FNCE last November in Boston, there was a debate titled “The Great Fat Debate – Is There Validity in the Age Old Dietary Guidance?” The scientist participants were Walter Willett (Harvard), Dariush Mozaffarian (Harvard), Alice Lichtenstein (Tufts), and … Continue reading →... Read more »

  • May 4, 2011
  • 08:00 AM
  • 524 views

The Great Fat Debate

by Colby in nutsci.org

At the FNCE last November in Boston, there was a debate titled “The Great Fat Debate – Is There Validity in the Age Old Dietary Guidance?” The scientist participants were Walter Willett (Harvard), Dariush Mozaffarian (Harvard), Alice Lichtenstein (Tufts), and … Continue reading →... Read more »

  • May 4, 2011
  • 08:00 AM
  • 553 views

The Great Fat Debate

by Colby in nutsci.org

At the FNCE last November in Boston, there was a debate titled “The Great Fat Debate – Is There Validity in the Age Old Dietary Guidance?” The scientist participants were Walter Willett (Harvard), Dariush Mozaffarian (Harvard), Alice Lichtenstein (Tufts), and … Continue reading →... Read more »

  • April 14, 2011
  • 08:00 AM
  • 1,106 views

A consensus paper on dietary fats and cardiovascular disease

by Colby in nutsci.org

The AJCN has a nice short “consensus” paper from many of the top researchers examining the supposed link between saturated fat and cardiovascular disease, which is open access here. Arne Astrup and Walter Willett organized an invitation-only symposium last year … Continue reading →... Read more »

Arne Astrup, Jørn Dyerberg, Peter Elwood, Kjeld Hermansen, Frank B Hu, Marianne Uhre Jakobsen, Frans J Kok, Ronald M Krauss, Jean Michel Lecerf, Philippe LeGrand.... (2011) The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?. The American Journal of Clinical Nutrition. info:/10.3945/​ajcn.110.004622

  • April 12, 2011
  • 05:00 PM
  • 1,703 views

Private nonprofit foundations & Public Health: Potential conflicts of interest in corporate links

by Colby in nutsci.org

Corporate involvement in public health is a sensitive topic, but one I am largely against.  It is pretty clear that corporations usually get the benefit of bettering their brand image (which is often largely unhealthy processed products) at a low … Continue reading →... Read more »

David Stuckler, Sanjay Basu, & Martin McKee. (2011) Global Health Philanthropy and Institutional Relationships: How Should Conflicts of Interest Be Addressed?. PLoS Medicine. info:/10.1371/journal.pmed.1001020

  • March 29, 2011
  • 10:32 PM
  • 1,044 views

Evidence-based nutrition: is proof of efficacy for nutrients too high?

by Colby in nutsci.org

…evidence-based nutrition (EBN), has seemingly swallowed EBM [evidence-based medicine] whole without either asking how well it might fit, or adapting it to the unique features of the nutrition context evidence-based nutrition (EBN), has seemingly swallowed EBM whole without either asking how well it might … Continue reading →... Read more »

Robert P. Heaney, Connie M. Weaver, & Jeffrey Blumberg. (2011) EBN (Evidence-Based Nutrition)Ver. 2.0. Nutrition Today. info:/10.1097/NT.0b013e3182076fdf

Blumberg J, Heaney RP, Huncharek M, Scholl T, Stampfer M, Vieth R, Weaver CM, & Zeisel SH. (2010) Evidence-based criteria in the nutritional context. Nutrition reviews, 68(8), 478-84. PMID: 20646225  

  • March 24, 2011
  • 10:30 PM
  • 1,123 views

Human serum metabolome (better) quantified

by Colby in nutsci.org

An important paper in PLoS One was published last month by Psychogios et al. that details a huge effort that yielded the most comprehensive characterization of the human serum metabolome yet.  I recommend reading the paper if you are casually … Continue reading →... Read more »

Psychogios N, Hau DD, Peng J, Guo AC, Mandal R, Bouatra S, Sinelnikov I, Krishnamurthy R, Eisner R, Gautam B.... (2011) The human serum metabolome. PloS one, 6(2). PMID: 21359215  

  • March 8, 2011
  • 09:12 PM
  • 1,153 views

Gene-environment interaction database related to nutritional phenotypes

by Colby in nutsci.org

Larry Parnell (Twitter, Blog), Yu-Chi Lee, Chao-Qiang Lai, & Jose Ordovas (Twitter) took what must have been an enormous amount of time and put together a database of gene-environment interactions related to lipids, cardiovascular disease, and diabetes.  I had no idea this … Continue reading →... Read more »

Yu-Chi Lee, Chao-Qiang Lai, Jose M Ordovas, & Laurence D Parnell. (2011) A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes. Data Mining in Genomics . info:/10.4172/2153-0602.1000106

  • March 3, 2011
  • 08:00 AM
  • 1,239 views

Athletes: obey your thirst

by Colby in nutsci.org

Tim Noakes has a nice review paper in the Annals of Nutrition & Metabolism on hydration for athletes: Is Drinking to Thirst Optimum? It is open access at least for now.  In short, Noakes makes a convincing case that drinking … Continue reading →... Read more »

Timothy David Noakes . (2011) Is Drinking to Thirst Optimum? . Annals of Nutrition . info:/10.1159/000322697

  • February 14, 2011
  • 10:06 PM
  • 1,232 views

“Antioxidants” in chocolate (and fruit): don’t buy the hype

by Colby in nutsci.org

Last week, just in time for Valentine’s day (clever science marketing or lucky peer review speed?), Hershey announced that cocoa is a “super fruit” with a paper in the Chemistry Central Journal (open access). Here is a random sampling of … Continue reading →... Read more »

Crozier SJ, Preston AG, Hurst WJ, Payne MJ, Mann J, Hainly L, & Miller DL. (2011) Cacao seeds are a "Super Fruit": A comparative analysis of various fruit powders and products. Chemistry Central journal, 5(1), 5. PMID: 21299842  

  • February 11, 2011
  • 06:00 AM
  • 1,072 views

Mitochondrial membrane alpha-tocopherol/homologues: super scavengers or peroxidase inhibitors?

by Colby in nutsci.org

I love research that alters established dogma with new technology (hence Nutritional Blogma), so I felt compelled to highlight this one. Polyunsaturated fatty acids (PUFAs) are structurally important in cell and some organelle membranes.  For simplicity’s sake, we are often … Continue reading →... Read more »

  • February 9, 2011
  • 10:08 PM
  • 1,457 views

Epidemiological evidence that UV exposure & vitamin D independently may reduce multiple sclerosis risk

by Colby in nutsci.org

Last year, I wrote about a mouse study that suggested UVB exposure suppressed a model of multiple sclerosis (MS) independent of vitamin D production.  So I was excited to see media reports this week covering another study, this one epidemiological … Continue reading →... Read more »

Lucas RM, Ponsonby AL, Dear K, Valery PC, Pender MP, Taylor BV, Kilpatrick TJ, Dwyer T, Coulthard A, Chapman C.... (2011) Sun exposure and vitamin D are independent risk factors for CNS demyelination. Neurology, 76(6), 540-8. PMID: 21300969  

  • February 9, 2011
  • 12:47 AM
  • 961 views

Quercetin paradox in a complex antioxidant network

by Colby in nutsci.org

This is sort of a random post, but I remember coming across this paper from 2007 awhile back titled “The quercetin paradox” that shows how quercetin protects against some oxidative damage in a lung cell line but the oxidation product … Continue reading →... Read more »

  • February 7, 2011
  • 11:44 PM
  • 898 views

Super Bowl weight damage – are temporary indulgences ok?

by Colby in nutsci.org

Last night my Green Bay Packers won Super Bowl 45 (woo!).  Like many people in Wisconsin and throughout the country, I was watching the game with friends, surrounded by lots of food and drink.  I can’t imagine most people are … Continue reading →... Read more »

Ohlrich H, Leon JB, Zimmerer J, & Sehgal AR. (2006) The impact of Super Bowl parties on nutritional parameters among hemodialysis patients. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 16(1), 63-6. PMID: 16414444  

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