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  • November 28, 2014
  • 12:11 PM
  • 1 view

Packing on the Pounds: Let the Holiday Eating Season Begin

by Melissa Chernick in Science Storiented

Here in the U.S., yesterday was Thanksgiving. A time of family, thanks, and lots and lots of food. Be honest, how much did you eat yesterday? Me, I watched a lot of football while I ate appetizers followed by turkey with gravy, mashed potatoes, green bean casserole, cranberry sauce, and cake. Then I entered a food coma for a few hours. It was glorious.I typically approach a holiday with a journal article, but this time I am going to use the holiday as a jumping off point: Thanksgiving as the sta........ Read more »

  • November 28, 2014
  • 11:56 AM
  • 1 view

New discovery sheds light on the forming brain

by Gabriel in Lunatic Laboratories

The cerebral cortex, which controls higher processes such as perception, thought and cognition, is the most complex structure in the mammalian central nervous system. Although much is known about the intricate structure of this brain region, the processes governing its formation remain uncertain. Research has now uncovered how feedback between cells, as well as molecular factors, helps shape cortical development during mouse embryogenesis.... Read more »

  • November 28, 2014
  • 02:34 AM
  • 8 views

The Autism-Spectrum Quotient: overlap between Asperger syndrome and schizophrenia

by Paul Whiteley in Questioning Answers

The paper by Tove Lugnegård and colleagues [1], including mention of one Maria Unenge Hallerbäck who has appeared on this blog previously, is fodder for today's discussions and their finding that a: "significant overlap of AQ [Autism-Spectrum Quotient] scores across the two diagnostic groups clearly reduces the discriminating power of the AQ in the separation of schizophrenia from AS [Asperger syndrome]."They say you're judged by the strength of your enemies.As per that link to ........ Read more »

  • November 27, 2014
  • 07:37 PM
  • 29 views

Does hot cocoa delay brain aging?

by Shelly Fan in Neurorexia

Image credits: downloaded from http://www.wallpapermania.eu/, artist unknown. One of the most enjoyable things about the holidays is curling up with a good book and a cup of...... Read more »

Brickman AM, Khan UA, Provenzano FA, Yeung LK, Suzuki W, Schroeter H, Wall M, Sloan RP, & Small SA. (2014) Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nature neuroscience, 17(12), 1798-803. PMID: 25344629  

  • November 27, 2014
  • 12:40 PM
  • 30 views

Fragile X and a new autism treatment

by Gabriel in Lunatic Laboratories

There are many roads to autism, none of them involve vaccination. I get tired of saying that, but it’s simple science, vaccines do not cause autism. Thankfully science knows this and is looking at not only what actually causes autism (Since again there are many different ways to develop on the spectrum). Well they may have found a new treatment for people affected by a common inherited form of autism by using a drug that is being tested as a treatment for cancer.... Read more »

Gkogkas, C., Khoutorsky, A., Cao, R., Jafarnejad, S., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T.... (2014) Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes. Cell Reports. DOI: 10.1016/j.celrep.2014.10.064  

  • November 27, 2014
  • 11:30 AM
  • 24 views

Potential New Roles for Bacteria and B Cells in Promoting the Stomach Flu

by Geoffrey Hannigan in Prophage

We are all unfortunately familiar with the notorious stomach flu. Most of us have experienced that awful nausea, vomiting, diarrhea, and tiredness associated with catching some stomach bug. While there are many viral causes of the stomach flu (also called gastroenteritis), one of the most common is the Norovirus. The Norovirus is a common and contagious virus that is currently the leading cause of viral gastroenteritis...... Read more »

Jones, M., Watanabe, M., Zhu, S., Graves, C., Keyes, L., Grau, K., Gonzalez-Hernandez, M., Iovine, N., Wobus, C., Vinje, J.... (2014) Enteric bacteria promote human and mouse norovirus infection of B cells. Science, 346(6210), 755-759. DOI: 10.1126/science.1257147  

  • November 27, 2014
  • 04:55 AM
  • 43 views

FC is a technique that has no validity

by Paul Whiteley in Questioning Answers

FC, by the way, refers to Facilitated Communication, a controversial technique which as the name suggests relies on a facilitator to support "the hand or arm of a communicatively impaired individual while using a keyboard or other devices with the aim of helping the individual to point and thereby to communicate." The quote for the title of this post comes from the paper by Ralf Schlosser and colleagues [1] who following systematic review, found "unequivocal evidence for facilitator co........ Read more »

Schlosser RW, Balandin S, Hemsley B, Iacono T, Probst P, & von Tetzchner S. (2014) Facilitated Communication and Authorship: A Systematic Review. Augmentative and alternative communication (Baltimore, Md. : 1985), 1-10. PMID: 25384895  

  • November 26, 2014
  • 03:20 PM
  • 55 views

Need to turn off the pain? Well now we can!

by Gabriel in Lunatic Laboratories

My sister suffers from chronic pain issues. I’ve written several posts about how her autoimmune disease is a special brand of pain that you will thankfully (almost certainly) never have to feel. While great strides have been made in pain management, there are still relatively few options that do not carry the risk of being extremely addictive. Well thankfully there is some new research and it offers hope, not just for my sister, but for the millions of people suffering from chronic pain that ........ Read more »

Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S.... (2014) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a journal of neurology. PMID: 25414036  

  • November 26, 2014
  • 11:06 AM
  • 46 views

Treatment Resistance in Eating Disorders

by William Yates, M.D. in Brain Posts

Clinicians treating patients with eating disorders find the challenge great with many treatment-resistant cases.To some extent, this is true of any clinical disorder. Outpatient treatment rolls and inpatient samples are over-represented by those failing to respond to initial interventions.A medical example is helpful here. Endocrinologists specializing in diabetes see more complicated cases where glucose control is difficult and diabetic complications are common.Diabetics with easy glucose contr........ Read more »

  • November 26, 2014
  • 04:54 AM
  • 55 views

The gut microbiome in Down Syndrome

by Paul Whiteley in Questioning Answers

The recent preliminary findings from Elena Biagi and colleagues [1] (open-access) reporting on the constitution of the gut microbiome - the collected bacteria which reside in the deepest, darkest recesses of our gastrointestinal (GI) tract - in a small number of cases of Down's syndrome caught my eye recently.It's a funny feeling being taken under the wing of a dragonPerhaps a little bit unusually looking at the gut microbiome because of the link between premature ageing in Down's syndrome ........ Read more »

Biagi E, Candela M, Centanni M, Consolandi C, Rampelli S, Turroni S, Severgnini M, Peano C, Ghezzo A, Scurti M.... (2014) Gut Microbiome in Down Syndrome. PloS one, 9(11). PMID: 25386941  

  • November 25, 2014
  • 03:20 AM
  • 54 views

Serotonin - melatonin (and the in-betweeners) linked to autism

by Paul Whiteley in Questioning Answers

The paper by Pagan and colleagues [1] (open-access) looking at "serotonin, melatonin and the intermediate N-acetylserotonin (NAS) in a large cohort of patients with ASD [autism spectrum disorder] and their relatives" set the old grey-pink matter into action recently. Not only because I have some real interest in the starting material for these compounds - the aromatic amino acid known as tryptophan - but because this research group included some quite important analysis of the enz........ Read more »

Pagan C, Delorme R, Callebert J, Goubran-Botros H, Amsellem F, Drouot X, Boudebesse C, Le Dudal K, Ngo-Nguyen N, Laouamri H.... (2014) The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders. Translational psychiatry. PMID: 25386956  

  • November 24, 2014
  • 03:26 PM
  • 52 views

Hiding cells to prevent HIV transmission

by Gabriel in Lunatic Laboratories

The fight against HIV is ongoing and despite our rapid progression against the disease we still lack a cure or even adequate treatment for people infected. However, new research suggests that cloaking immune cells with antibodies that block T cell trafficking to the gut can substantially reduce the risk of viral transmission, at least in a non-human primate model of HIV infection. If it works out, this could help slow down the spread of HIV and give people a better shot at a normal life.... Read more »

  • November 24, 2014
  • 05:15 AM
  • 59 views

Helicobacter pylori and stem cells in the gastric crypt

by Artem Kaznatcheev in Evolutionary Games Group

Last Friday, the 4th Integrated Mathematical Oncology Workshop finished here at Moffitt. The event drew a variety of internal and external participants — you can see a blurry photo of many of them above — and was structured as a competition between four teams specializing in four different domains: Microbiome, Hepatitis C, Human papillomavirus, and […]... Read more »

Houghton, J., Stoicov, C., Nomura, S., Rogers, A.B., Carlson, J., Li, H., Cai, X., Fox, J.G., Goldenring, J.R., & Wang, T.C. (2004) Gastric cancer originating from bone marrow-derived cells. Science, 306(5701), 1568-71. PMID: 15567866  

  • November 24, 2014
  • 05:00 AM
  • 51 views

Removable functional appliances do not change skeletal pattern to a clinically meaningful amount

by Kevin OBrien in Kevin OBrien's Orthodontic Blog

Functional appliances do not influence skeletal pattern… This post is on functional appliances, which is an area that I have covered several times. A few postings ago I mentioned that the journals are publishing more and more systematic reviews. I also made the point in a previous post, that we need to critically read these […]
The post Removable functional appliances do not change skeletal pattern to a clinically meaningful amount appeared first on Kevin O'Brien's Orthodon........ Read more »

  • November 24, 2014
  • 04:29 AM
  • 51 views

Finland, parental migration and offspring Asperger syndrome

by Paul Whiteley in Questioning Answers

A quote from the paper by Venla Lehti and colleagues [1] to start things off: "The study showed that children whose parents are both immigrants have a significantly lower likelihood of being diagnosed with Asperger's syndrome than those with two Finnish parents."Can I cook, or can't I?Based on an analysis of data derived from "the Finnish Hospital Discharge Register" and "the Finnish Medical Birth Register", researchers looked at the records of children with a diagnosis of Asperger syndrome (AS)........ Read more »

Lehti V, Cheslack-Postava K, Gissler M, Hinkka-Yli-Salomäki S, Brown AS, & Sourander A. (2014) Parental migration and Asperger's syndrome. European child . PMID: 25381114  

  • November 23, 2014
  • 02:09 PM
  • 80 views

Love, it’s in your genes

by Gabriel in Lunatic Laboratories

Most kids worry about passing tests, winning games, lost phones, fractured bones—and whether or not they will ever really fall in love. While the first few things are of relatively low value in the scientific pursuit, three Chinese researchers have focused on that last question. All in a bid to find out some of the more interesting questions about our genes: Why do some students stay single? What factors determine if a young adult falls in love?... Read more »

  • November 22, 2014
  • 02:45 PM
  • 63 views

Mental Health- The invisible barrier for women’s care

by Gabriel in Lunatic Laboratories

A while back I wrote a post about mental health and jail sentences, it seems like no one takes mental health seriously and that leads to lack of care for the individual. Well a new study offers even more bad news on the mental health front. Women with symptoms of serious mental illness are significantly less likely to receive three routine cancer screenings – Pap tests, mammograms and clinical breast exams – than women in the general population, despite being at elevated risk for medical com........ Read more »

  • November 22, 2014
  • 03:26 AM
  • 61 views

Children as research participants: assessing competence

by Paul Whiteley in Questioning Answers

I was brought to writing about this topic after reading an interesting post by Virginia Hughes titled: Personhood Week: Do Kids Count? Among the various points raised in that article was some discussion about minors having medical autonomy and how this might impinge on areas outside of just medical decision-making. It also reminded me about something which was raised on more than one occasion when I undertook a stint on a University Ethics committee...Most people involved in the medica........ Read more »

  • November 21, 2014
  • 06:39 PM
  • 83 views

Dogtober = Canine science in October

by Cobb & Hecht in Do You Believe In Dog?

What a BOOMING month for dogs and science October was! We've captured the links to all the latest blogs, research and news that caught out attention throughout Dog-tober.Thanks to Storify (click here if the you can't see the collection of links below) you can make sure you didn't miss out too.[View the story "Do You Believe in Dog? [01-31 October 2014]" on Storify] Further reading:Bradshaw J.W.S. & Nicola J. Rooney (2014). Why do adult dogs ‘play’?, Behavioural Processes, DOI: http:/........ Read more »

Bozkurt Alper, Barbara Sherman, Rita Brugarolas, Sean Mealin, John Majikes, Pu Yang, & Robert Loftin. (2014) Towards Cyber-Enhanced Working Dogs for Search and Rescue. IEEE Intelligent Systems, 1-1. DOI: http://dx.doi.org/10.1109/mis.2014.77  

  • November 21, 2014
  • 04:54 PM
  • 75 views

The impact of powered prosthetic failures on the user

by Gabriel in Lunatic Laboratories

Prosthetics have come a long way in a relatively short amount of time. With the ongoing wars in the middle east the need for better prosthetics technologies has become more apparent, to this end we now have prosthetics that will allow a person to "feel", we even have motorized prosthetics that will help allow a more fluid walk, but while powered lower limb prosthetics hold promise for improving the mobility of amputees, errors in the technology may also cause some users to stumble or fall. Becau........ Read more »

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