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  • October 2, 2014
  • 08:03 AM
  • 0 views

Coeliac disease risk not affected by early feeding practices

by Paul Whiteley in Questioning Answers

I'd like to bring three papers to your attention, all united by their discussion of coeliac (celiac) disease, that most classic of autoimmune conditions in the most part managed by the use of a lifelong gluten-free diet.First up are the papers by Elena Lionetti and colleagues [1] and Sabine Vriezinga and colleagues [2] which unfortunately pour cold water on the notion that the risk of developing coeliac disease (CD) can be somehow mitigated via the use of either the early or delayed in........ Read more »

Lionetti E, Castellaneta S, Francavilla R, Pulvirenti A, Tonutti E, Amarri S, Barbato M, Barbera C, Barera G, Bellantoni A.... (2014) Introduction of Gluten, HLA Status, and the Risk of Celiac Disease in Children. The New England journal of medicine, 371(14), 1295-1303. PMID: 25271602  

Vriezinga SL, Auricchio R, Bravi E, Castillejo G, Chmielewska A, Crespo Escobar P, Kolaček S, Koletzko S, Korponay-Szabo IR, Mummert E.... (2014) Randomized Feeding Intervention in Infants at High Risk for Celiac Disease. The New England journal of medicine, 371(14), 1304-1315. PMID: 25271603  

  • October 2, 2014
  • 04:57 AM
  • 9 views

Volatile organic compounds and autism

by Paul Whiteley in Questioning Answers

As harsh as the phrase volatile organic compounds (VOCs) might appear at first glance, all this refers to is a class of compounds containing carbon which have a tendency to evaporate at room temperature assuming normal air pressure. VOCs have been associated with pollutants as per their inclusion in various literature on the topic of things like indoor air pollution (see here) and the fact that just about everything around us in the modern home or office is likely to release VOCs. Whilst not try........ Read more »

  • October 2, 2014
  • 04:52 AM
  • 11 views

JUST PUBLISHED: A Trial to Evaluate the Efficacy of an Integrated Smoking Cessation Intervention among Mental Health Patients

by Mark Rubin in The University of Newcastle's School of Psychology Newsline

Depending on diagnosis and setting, between 33 and 90 per cent of people with mental illness smoke tobacco, both in Australia and worldwide. As a result, tobacco-related diseases are one of the leading causes of mortality among this population subgroup. A paucity of research to date has examined the efficacy of cessation strategies to assist people with mental illness to quit smoking. However, limited findings have suggested that aids that have been found to be effective for the general populati........ Read more »

  • October 1, 2014
  • 01:41 PM
  • 29 views

The Ever Plastic Brain and Intellectual Disabilities

by Gabriel in Lunatic Laboratories

The plasticity of the brain is always somewhat of a shock. It's near incredible what the brain can achieve, look at people who have strokes, or any other sort of brain injury and yet still somehow manage to get up and move, or perform tasks. So I guess it should be no surprise, but still amazing that studying mice with a genetic change similar to what is found in Kabuki syndrome (an inherited disease of humans) researchers report they have used an anticancer drug to improve mental function......... Read more »

Hans T. Bjornsson, Joel S. Benjamin, Li Zhang, Jacqueline Weissman, Elizabeth E. Gerber, Yi-Chun Chen, Rebecca G. Vaurio, Michelle C. Potter, Kasper D. Hansen, & Harry C. Dietz. (2014) Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome. Science Translational Medicine. info:/10.1126/scitranslmed.3009278

  • October 1, 2014
  • 05:11 AM
  • 37 views

Maternal complement C1q and offspring psychosis

by Paul Whiteley in Questioning Answers

"In conclusion, exposure to maternal C1q activity during pregnancy may be a risk factor for the development of schizophrenia and psychosis in offspring". That was the primary observation made by Emily Severance and colleagues [1] at Johns Hopkins, extending their scientific interest in immune system involvement being potentially linked to psychiatry [2]."Serve the public trust, protect the innocent, uphold the law"I've already talked about Dr Severance's previous research forays into complement ........ Read more »

Emily G. Severance, Kristin L. Gressitt, Stephen L. Buka, Tyrone D. Cannon, & Robert H. Yolken. (2014) Maternal complement C1q and increased odds for psychosis in adult offspring. Schizophrenia Research. info:/10.1016/j.schres.2014.07.053

  • September 30, 2014
  • 06:10 PM
  • 52 views

New Immune System Discovery

by Gabriel in Lunatic Laboratories

The immune system is sort of this big enigma, we know how pieces of it work, but we don’t know it as well as we would like or we wouldn’t have autoimmunity to contend with. Well new research reveals new information about how our immune system functions, shedding light on a vital process that determines how the body’s ability to fight infection develops. Which brings us one step closer to the big picture of the immune system.... Read more »

  • September 30, 2014
  • 12:34 PM
  • 48 views

This Month in Blastocystis Research (SEP 2014)

by Christen Rune Stensvold in Blastocystis Parasite Blog

Do companion animals contribute to human Blastocystis? Do IBS patients have a higher prevalence of Blastocystis and Dientamoeba fragilis than healthy invididuals? Check out this issue of 'This Month in Blastocystis Research'.... Read more »

Krogsgaard LR, Engsbro AL, Stensvold CR, Vedel Nielsen H, & Bytzer P. (2014) The Prevalence of Intestinal Parasites is not Greater Among Individuals with IBS: a Population-Based Case-Control Study. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. PMID: 25229421  

Wang W, Cuttell L, Bielefeldt-Ohmann H, Inpankaew T, Owen H, & Traub RJ. (2013) Diversity of Blastocystis subtypes in dogs in different geographical settings. Parasites , 215. PMID: 23883734  

Wawrzyniak I, Poirier P, Viscogliosi E, Dionigia M, Texier C, Delbac F, & Alaoui HE. (2013) Blastocystis, an unrecognized parasite: an overview of pathogenesis and diagnosis. Therapeutic advances in infectious disease, 1(5), 167-78. PMID: 25165551  

  • September 30, 2014
  • 09:28 AM
  • 54 views

The Playing Ground Part One

by Rodney Steadman in Gravity's Pull

How parent and peer support in preadolescent and adolescent girls influences their engagement in physical activity across ages nine to 15 years.... Read more »

  • September 30, 2014
  • 05:06 AM
  • 59 views

Autoimmune thyroiditis and depressive disorder

by Paul Whiteley in Questioning Answers

"Our study demonstrates a strong association between anti-TPO levels, which are considered to be of diagnostic value for autoimmune thyroiditis... with uni- or bipolar depression.""Beware the bad cat bearing a grudge"So said the study published by Detlef Degner and colleagues [1]. Anti-TPO antibodies by the way, refers to anti-thyroid peroxidase antibodies which, as the name suggests, are antibodies against thyroid peroxidase, an important step in the production of thyroid hormone........ Read more »

Degner D, Haust M, Meller J, Rüther E, & Reulbach U. (2014) Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients. European archives of psychiatry and clinical neuroscience. PMID: 25193677  

  • September 29, 2014
  • 06:07 PM
  • 69 views

Cat and Dogs: seeking solutions with sniffing canines and science

by Cobb & Hecht in Do You Believe In Dog?

Hi Mia and Julie,  First of all, I LOVE your blog! After meeting at SPARCS this past summer (summer for us in North America.. I take it summer is just beginning in Australia!), I’ve followed it closely.  You do amazing things for the promotion of  canine science. Serious love. A bit of background for the readers: I’m currently doing my PhD at Dalhousie University in Halifax, Nova Scotia in Canada, under the supervision of Dr. Simon Gadbois. Dr. Gadbois........ Read more »

  • September 29, 2014
  • 05:12 PM
  • 64 views

New Protein Implicated in Alzheimer’s

by Gabriel in Lunatic Laboratories

Alzheimer's prevention has made some strides in recent years. We've even identified some new causes, and in some cases we can do both. In fact, researchers have now shown that low levels of the protein progranulin in the brain can increase the formation of amyloid-beta plaques (a hallmark of Alzheimer's disease). These plaques can cause neuroinflammation, and worsen memory deficits in a mouse model of this condition. Conversely, by using a gene therapy approach to elevate progranulin levels, sci........ Read more »

Minami, S., Min, S., Krabbe, G., Wang, C., Zhou, Y., Asgarov, R., Li, Y., Martens, L., Elia, L., Ward, M.... (2014) Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. Nature Medicine. DOI: 10.1038/nm.3672  

  • September 29, 2014
  • 10:32 AM
  • 66 views

Family Attachment and the Brain Cingulate Cortex

by William Yates, M.D. in Brain Posts

Healthy family attachment provides a key element for social support and successful interpersonal relationships.Several brain regions as well as hormonal factors appear to modulate positive emotional responses to family members.I have previously reviewed several studies involving the prosocial effects of the hormone oxytocin and the related hormone vasopressin.Nicolas Rusch from the Department of Psychiatry at Ulm University in Germany along with colleagues in Brazil and London recently published........ Read more »

  • September 29, 2014
  • 04:35 AM
  • 68 views

Term vs. preterm birth and the presentation of autism

by Paul Whiteley in Questioning Answers

The paper by Katherine Bowers and colleagues [1] continues the interest in the concept of 'the autisms' with their observations on the presentation of autism (and its comorbidities) when looking at those "born preterm versus those born at term".We'd better get back, 'cause it'll be dark soon, and they mostly come at night... mostlyBased on an analysis of quite a healthy participant number heading up to 900 "males and females with autism spectrum disorder", authors reported on several phenotypic ........ Read more »

  • September 28, 2014
  • 03:37 PM
  • 82 views

The Genetic Evolutionary Arms Race

by Gabriel in Lunatic Laboratories

Genes are tricky little buggers, the stuff that makes us up has fought the test of time to make it to where we are today. It is thought that our genes changed in an attempt to outpace other life, albeit random changes.That might only be half right however, new findings suggest that there is an evolutionary arms race going on within the genome against, of all things, itself. This inherent competition of primates drove the evolution of complex regulatory networks that orchestrate the activity of ........ Read more »

Jacobs, Greenberg, Nguyen, Haeussler, Ewing, Katzman, Paten, Salama . (2014) An evolutionary arms race betweenKRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. Nature. info:/10.1038/nature13760

  • September 28, 2014
  • 12:00 PM
  • 83 views

Numbers on a scale: How bad did you say your pain was?

by Bronwyn Thompson in Healthskills: Skills for Healthy Living

Have you ever been asked to give your pain rating on a scale of 0 – 10 (where 0 = no pain at all and 10 = most extreme pain you can imagine)? Have you ever tried to work out whether today’s pain is worse than yesterdays? What does a pain rating tell us?... Read more »

  • September 27, 2014
  • 03:50 AM
  • 90 views

Yes, people with autism do have headaches

by Paul Whiteley in Questioning Answers

I don't mean to be haughty but a sentence included in the paper by Victorio [1] led to the title of today's very quick post. Based on a chart review of patients diagnosed with an autism spectrum disorder (ASD) attending a neurology clinic, the author concluded that "ASD patients, despite being known to have indifference to pain, can experience headaches".Pain is something which has cropped up quite a bit in the autism research arena and has appeared more than once on this blog (see here and see ........ Read more »

  • September 26, 2014
  • 02:15 PM
  • 111 views

“GMO” Foods (Once Again) Proven Safe

by Gabriel in Lunatic Laboratories

GMO, I shudder every time I hear someone talk about the “dangers”. It’s one of the new buzzwords that doesn’t actually mean anything, but still manages to scare people. Well a new scientific review reports that the performance and health of food-producing animals consuming genetically engineered feed, first introduced 18 years ago, has been comparable to that of animals consuming non-GE feed. Not that this will stop people from spreading fear, but it’s a start.... Read more »

  • September 26, 2014
  • 10:30 AM
  • 89 views

Walking Really Is Just Falling and Catching Yourself

by Elizabeth Preston in Inkfish

The flailing of a gymnast who’s missed a step on the balance beam might not be far off from what the rest of us experience every day. Each step we take is really a tiny fall, a mathematical model suggests. The random-looking variation in our footfalls is actually a series of corrections. Our strides are […]The post Walking Really Is Just Falling and Catching Yourself appeared first on Inkfish.... Read more »

  • September 26, 2014
  • 05:32 AM
  • 80 views

Schizophrenia after child and adolescent psychiatric disorders

by Paul Whiteley in Questioning Answers

More of a 'bring to your attention' post today, as I bring to your attention(!) the paper by Cecilie Frejstrup Maibing and colleagues [1] who concluded: "The risk of being diagnosed with schizophrenia spectrum disorders [SSD] after a child and adolescent psychiatric disorder was significantly increased particularly in the short term but also in the long-term period"."I coulda been a contender"The findings were based on an analysis of one of those very informative Scandinavian........ Read more »

  • September 25, 2014
  • 10:37 AM
  • 111 views

A New Discovery in the Treatment of Autoimmunity and Chronic Inflammation

by Gabriel in Lunatic Laboratories

Lupus, Type 1 diabetes, and multiple sclerosis are all diseases brought on by autoimmunity — the bodies inability to tell itself apart from foreign invaders. Finding a cure, or even a suitable treatment has been to put it gently a long, painful road, with little to show for it. On the forefront of the war against the body betrayal is immunosuppressants, which with them carry their own set of side effects and in most cases only off mild to moderate relief of symptoms. But that is all changing a........ Read more »

Dubiella C, Cui H, Gersch M, Brouwer AJ, Sieber SA, Krüger A, Liskamp RM, & Groll M. (2014) Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site. Angewandte Chemie (International ed. in English). PMID: 25244435  

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