Think you know what causes depression? Well unfortunately scientists don’t have the exact answer, surprised? That’s not the only problem, there is an ever growing concern that we live in an over medicated society and a newly released study doesn’t paint a better picture. About 15 percent of women in the United States suffer from anxiety disorders and depression during their pregnancies, and many are prescribed antidepressants. However little is known about how early exposure to these medic........ Read more »
Altieri SC, Yang H, O'Brien HJ, Redwine HM, Senturk D, Hensler JG, & Andrews AM. (2014) Perinatal vs. Genetic Programming of Serotonin States Associated with Anxiety. Neuropsychopharmacology. PMID: 25523893
"The relationship between JH/HDCT [joint hypermobility / heritable disorders of connective tissue] and mental disorders merits further attention in order to improve current knowledge and clarify a possible common etiology."There is nothing in the desert and no man needs nothing.That was the conclusion reached in the paper by Carolina Baeza-Velasco and colleagues  looking at the possibility of some interesting connections, outside of just physical presentation, when it come........ Read more »
Baeza-Velasco C, Pailhez G, Bulbena A, & Baghdadli A. (2014) Joint hypermobility and the heritable disorders of connective tissue: clinical and empirical evidence of links with psychiatry. General hospital psychiatry. PMID: 25459977
Thanks to the internet age we have lost touch with the fact that there is a human out there reading these words. Because of this, the golden rule –treat others the way you want to be treated — went out the window. Making fun of “fat” people now seems to be a internet hobby and that insensitivity can (and does) bleed over into “normal” non-internet life. Now a new study shows that women whose loved ones are critical of their weight tend to put on even more pounds, which is probably no........ Read more »
LOGEL, C., STINSON, D., GUNN, G., WOOD, J., HOLMES, J., & CAMERON, J. (2014) A little acceptance is good for your health: Interpersonal messages and weight change over time. Personal Relationships, 21(4), 583-598. DOI: 10.1111/pere.12050
Bipolar disorder appearing again on this blog this week? It's just the way that the papers fall...With a title like: 'Increased uric acid levels in bipolar disorder subjects during different phases of illness' I was hardly likely to pass up the opportunity to discuss the paper by Umberto Albert and colleagues  and their suggestion that there may be a lot more to see when it comes to "a purinergic dysfunction associated with BD [bipolar disorder]".I lost the defuser gun when I mispla........ Read more »
Albert U, De Cori D, Aguglia A, Barbaro F, Bogetto F, & Maina G. (2014) Increased uric acid levels in bipolar disorder subjects during different phases of illness. Journal of affective disorders, 170-175. PMID: 25462413
As December rolls into its second half, and the days warm up - or cool down - depending on where you are situated on the globe, we wanted to say thank you for joining us in 2014 - we are continually blown away with the popular and supportive community we have around us at Do You Believe in Dog? here on the blog, on Facebook and also on Twitter. Taking our lead from Companion Animal Psychology, we decided to jump into some statistics (because hey, we are scientists!) to see wh........ Read more »
Scanlon Eileen. (2013) Scholarship in the digital age: Open educational resources, publication and public engagement. British Journal of Educational Technology, 45(1), 12-23. DOI: http://dx.doi.org/10.1111/bjet.12010
Stilgoe J., & J. Wilsdon. (2014) Why should we promote public engagement with science?. Public Understanding of Science, 23(1), 4-15. DOI: http://dx.doi.org/10.1177/0963662513518154
While the anti-vaccine movement enjoys the simple (and very wrong) answer to the cause of autism, there are people who want the actual truth. This drive had lead to a slew of causes (and risk factors) for autism in recent times. Now scientists have found that very small segments of genes called “microexons” influence how proteins interact with each other in the nervous system. In turn, this opens up a new line of research into the cause of autism.... Read more »
Irimia, M., Weatheritt, R., Ellis, J., Parikshak, N., Gonatopoulos-Pournatzis, T., Babor, M., Quesnel-Vallières, M., Tapial, J., Raj, B., O’Hanlon, D.... (2014) A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains. Cell, 159(7), 1511-1523. DOI: 10.1016/j.cell.2014.11.035
"Increased autistic characteristics found in adults with epilepsy without an ASD [autism spectrum disorder] diagnosis suggest that epilepsy syndromes may incorporate behavioral aspects of autism in the absence of some of its core cognitive features."Contrariwise, if you think we're alive you ought to speak to us.That was the intriguing finding reported by Sally Ann Wakeford and colleagues  who examined test performance on the Autism Spectrum Quotient (AQ) and "systemizing ........ Read more »
Metabolic syndrome is linked with an increased frequency and severity of lower urinary tract symptoms, but weight loss surgery may lessen these symptoms. The findings, which come from two studies published in BJU International, indicate that urinary problems may be added to the list of issues that can improve with efforts that address altered metabolism.
Lower urinary tract symptoms related to urinary frequency and urgency, bladder leakage, the need to urinate at night, and incomplete bladder........ Read more »
Pashootan, P., Ploussard, G., Cocaul, A., de Gouvello, A., & Desgrandchamps, F. (2014) Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort. BJU International. DOI: 10.1111/bju.12931
Despite what you may think, the supposed “explosion” of children diagnosed with autism can directly attributed to better diagnosing techniques and — more importantly — the change of definition to make Autism spectrum disorders more broad. Thankfully more causes of autism have been found, none of them remotely related to vaccines and now scientists have found that chemical modifications to DNA’s packaging—known as epigenetic changes—can activate or repress genes involved in autism s........ Read more »
Gao, Z., Lee, P., Stafford, J., von Schimmelmann, M., Schaefer, A., & Reinberg, D. (2014) An AUTS2–Polycomb complex activates gene expression in the CNS. Nature, 516(7531), 349-354. DOI: 10.1038/nature13921
Ntziachristos, P., Tsirigos, A., Welstead, G., Trimarchi, T., Bakogianni, S., Xu, L., Loizou, E., Holmfeldt, L., Strikoudis, A., King, B.... (2014) Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia. Nature, 514(7523), 513-517. DOI: 10.1038/nature13605
I am the league's director, Silas Ramsbottom.Upon reading the paper published by Ramaekers and colleagues  talking about the use of folinic acid in cases of schizophrenia as a function of the presence of "Auto-antibodies against folate receptor alpha (FRα)", I raised a little smile. Not only because the authors suggested that there may be quite a lot more to see in this area on top of some already interesting discussions about the folate cycle and schizophrenia, but also because of the ........ Read more »
Ramaekers VT, Thöny B, Sequeira JM, Ansseau M, Philippe P, Boemer F, Bours V, & Quadros EV. (2014) Folinic acid treatment for schizophrenia associated with folate receptor autoantibodies. Molecular genetics and metabolism. PMID: 25456743
We’ve all seen the PSA’s trying to show the effects of meth use and in particular, what it does to your teeth. Typically, when it comes to drug use, people will not look at the long term side effects from their addiction instead thinking in the short term. This is unfortunate because as it turns out, methamphetamine users are three times more at risk for getting Parkinson’s disease than non-illicit drug users with even worse news for women, new research shows.... Read more »
Curtin K, Fleckenstein AE, Robison RJ, Crookston MJ, Smith KR, & Hanson GR. (2014) Methamphetamine/amphetamine abuse and risk of Parkinson's disease in Utah: A population-based assessment. Drug and alcohol dependence. PMID: 25479916
Rory Wilson recalls some nervous waterbirds.
"I've seen pelicans in Galapagos, in the port," the Swansea University biologist says. One set of birds was standing by the fish-gutting area and waiting for scraps, while another group stood out of the fray in some nearby bushes. Although both sets of pelicans acted the same, a closer look at the birds waiting for fish scraps revealed that they were quaking slightly. The tips of their wings trembled.
Wilson thinks the tremor in the pelicans... Read more »
Wilson, R., Grundy, E., Massy, R., Soltis, J., Tysse, B., Holton, M., Cai, Y., Parrott, A., Downey, L., Qasem, L.... (2014) Wild state secrets: ultra-sensitive measurement of micro-movement can reveal internal processes in animals. Frontiers in Ecology and the Environment, 12(10), 582-587. DOI: 10.1890/140068
My name's Buttercup. You've met Baron von Shush."Our study demonstrated that serum TRX [thioredoxin] levels were associated with ASD [autism spectrum disorder], and elevated levels could be considered as a novel, independent diagnosis indicator of ASD." So was the conclusion reported by Qing-biao Zhang and colleagues  looking at serum levels of TRX in 80 children diagnosed with an ASD compared against "100 sex and age matched typically developing children".I'll freely admi........ Read more »
Zhang QB, Gao SJ, & Zhao HX. (2014) Thioredoxin: A novel, independent diagnosis marker in children with autism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. PMID: 25433158
What’s that over there!? The next time you are around people, count how many people are on their phone? Distractions invade every aspect of our lives. Status updates, text messages, email notifications all threaten to steal our attention away from the moment. While we fight the urge to check the phone, our brains are making constant judgment calls about where to focus attention. The brain must continually filter important information from irrelevant interference.... Read more »
Ahrens, S., Jaramillo, S., Yu, K., Ghosh, S., Hwang, G., Paik, R., Lai, C., He, M., Huang, Z., & Li, B. (2014) ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection. Nature Neuroscience. DOI: 10.1038/nn.3897
My research training is in psychiatric epidemiology. Alcohol and drug dependence have been two of my topic areas of research.So I found a recent novel study of the epidemiology of illicit drug use in Europe intriguing.Typical methods of looking for the prevalence of drug use in populations are direct diagnostic interviews and studies of emergency room attendees or autopsy cases with medical complications of drug use.However, Christopher Ort from Switzerland along with a host of European col........ Read more »
Ort C, van Nuijs AL, Berset JD, Bijlsma L, Castiglioni S, Covaci A, de Voogt P, Emke E, Fatta-Kassinos D, Griffiths P.... (2014) Spatial differences and temporal changes in illicit drug use in Europe quantified by wastewater analysis. Addiction (Abingdon, England), 109(8), 1338-52. PMID: 24861844
Malocclusion, orthodontics and quality of life? One of the most important areas of orthodontic research that needs to be carried out is to clearly identify the effects of treatment. I have highlighted this in previous posts on the “the great unanswered questions” and “papers that have influenced me”. When we consider this area, I feel […]
The post Malocclusion, orthodontics and quality of life appeared first on Kevin O'Brien's Orthodontic Blog.
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Al-Omari, I., Al-Bitar, Z., Sonbol, H., Al-Ahmad, H., Cunningham, S., & Al-Omiri, M. (2014) Impact of bullying due to dentofacial features on oral health–related quality of life. American Journal of Orthodontics and Dentofacial Orthopedics, 146(6), 734-739. DOI: 10.1016/j.ajodo.2014.08.011
Benson, P., Da'as, T., Johal, A., Mandall, N., Williams, A., Baker, S., & Marshman, Z. (2014) Relationships between dental appearance, self-esteem, socio-economic status, and oral health-related quality of life in UK schoolchildren: A 3-year cohort study. The European Journal of Orthodontics. DOI: 10.1093/ejo/cju076
I've mentioned a few times on this blog that a diagnosis of autism or autism spectrum disorder (ASD) is by no means protective against any other diagnosis being received, be it based on a somatic illness or condition, or something more behaviourally defined.Reading through the paper by Liz Forty and colleagues  (open-access) it appears that a similar scenario might also pertain to other behaviourally-defined conditions as per the example of bipolar disorder (BD) and their conclusion: "Bi........ Read more »
A new analysis has found that while clinical trial data support omitting radiation treatments in elderly women with early stage breast cancer, nearly two-thirds of these women continue to receive it. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.
Results published in 2004 from a large, randomized clinical trial showed that adding radiation therapy to surgery plus tamoxifen does not reduce 5-year recurrence rates or prolong survival i........ Read more »
Palta, M., Palta, P., Bhavsar, N., Horton, J., & Blitzblau, R. (2014) The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: Changes in practice patterns after publication of Cancer and Leukemia Group B 9343. Cancer. DOI: 10.1002/cncr.28937
It seems like we’ve been on a weight loss campaign here at the labs, but there just has been so much new and interesting research on the subject to report on, this is no exception. Researchers have uncovered the mechanism by which white fat cells from humans (an important distinction) gets reprogrammed to become browner.... Read more »
Anne Loft, Isabel Forss, Majken Storm Siersbæk, Søren Fisker Schmidt, Ann-Sofie Bøgh Larsen, Jesper Grud Skat Madsen, Didier F. Pisani, Ronni Nielsen, Mads Malik Aagaard, Angela Mathison.... (2014) Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers. Genes . info:/10.1101/gad.250829.114
I'm not normally minded to post on a Sunday (day of rest and all that) but I did want to bring your attention to the results presented by Petroc Sumner and colleagues  (open-access) concluding that: "Exaggeration in news is strongly associated with exaggeration in press releases" when it comes to the media reporting of [some] health-related science news.The idea behind this particular study - which has been summarised pretty well in some of the accompanying media and in an editorial........ Read more »
Sumner, P., Vivian-Griffiths, S., Boivin, J., Williams, A., Venetis, C., Davies, A., Ogden, J., Whelan, L., Hughes, B., Dalton, B.... (2014) The association between exaggeration in health related science news and academic press releases: retrospective observational study. BMJ, 349(dec09 7). DOI: 10.1136/bmj.g7015
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