It was a bit of a breath of fresh air to read the paper by Lauren Singer  (open-access) published in the journal Molecular Autism recently. Detailing the personal experiences of a sibling with a sister with autism who has "gone to walks, raised money via lemonade stands, volunteered in respite programs for families with kids with autism, and participated in autism research studies at the Yale Child Study Center", her very personal account is an important read in amongst the huge peer-rev........ Read more »
Singer L. (2015) Thoughts about sex and gender differences from the next generation of autism scientists. Molecular autism, 52. PMID: 26388981
Chronic pain results from disease or trauma to the nervous system. Damaged nerve fibres with heightened responses to normal stimuli send incorrect messages to pain centres in the brain. This phenomenon, called “peripheral and central sensitization” is one of the key mechanisms involved in the condition which touches people with diabetes, cancer, and those suffering from multiple sclerosis, among others.... Read more »
Cordeiro Matos, S., Zhang, Z., & Seguela, P. (2015) Peripheral Neuropathy Induces HCN Channel Dysfunction in Pyramidal Neurons of the Medial Prefrontal Cortex. Journal of Neuroscience, 35(38), 13244-13256. DOI: 10.1523/JNEUROSCI.0799-15.2015
"Children with ADHD [attention-deficit hyperactivity disorder] have a higher prevalence of asthma than the general Quebec pediatric population."So said the findings of the study by Grizenko and colleagues  adding to quite a volume of research potentially connecting the two conditions. During this latest foray into this area of research, researchers also observed that: "Children with ADHD born prematurely and/or those whose mothers experienced stress during pregnancy have a significa........ Read more »
Grizenko N, Osmanlliu E, Fortier MÈ, & Joober R. (2015) Increased Risk of Asthma in Children with ADHD: Role of Prematurity and Maternal Stress during Pregnancy. Journal of the Canadian Academy of Child and Adolescent Psychiatry , 24(2), 109-115. PMID: 26379722
Hormonal treatments administered as part of the procedures for sex reassignment have well-known and well-documented effects on the secondary sexual characteristics of the adult body, shifting a recipient’s physical appearance to that of the opposite sex. New research indicates that these hormonal treatments also alter brain chemistry.... Read more »
Kranz, G., Wadsak, W., Kaufmann, U., Savli, M., Baldinger, P., Gryglewski, G., Haeusler, D., Spies, M., Mitterhauser, M., Kasper, S.... (2015) High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People. Biological Psychiatry, 78(8), 525-533. DOI: 10.1016/j.biopsych.2014.09.010
This study came out of our group here at Morehouse School of Medicine. It concerns a mouse model of disrupted sleep in Angelman Syndrome. Basically, was it the circadian or homeostatic system that is responsible, or both? It was the homeostatic. ... Read more »
Ehlen, J., Jones, K., Pinckney, L., Gray, C., Burette, S., Weinberg, R., Evans, J., Brager, A., Zylka, M., Paul, K.... (2015) Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact. Journal of Neuroscience, 35(40), 13587-13598. DOI: 10.1523/JNEUROSCI.2194-15.2015
Part II in our series looking at the scientific evidence behind sunscreen and skin cancer.... Read more »
van der Pols JC, Williams GM, Pandeya N, Logan V, & Green AC. (2006) Prolonged prevention of squamous cell carcinoma of the skin by regular sunscreen use. Cancer epidemiology, biomarkers , 15(12), 2546-8. PMID: 17132769
Lee TK, Rivers JK, & Gallagher RP. (2005) Site-specific protective effect of broad-spectrum sunscreen on nevus development among white schoolchildren in a randomized trial. Journal of the American Academy of Dermatology, 52(5), 786-92. PMID: 15858467
Koh HK, Geller AC, Miller DR, Grossbart TA, & Lew RA. (1996) Prevention and early detection strategies for melanoma and skin cancer. Current status. Archives of dermatology, 132(4), 436-43. PMID: 8629848
Leiter U, & Garbe C. (2008) Epidemiology of melanoma and nonmelanoma skin cancer--the role of sunlight. Advances in experimental medicine and biology, 89-103. PMID: 18348450
Brenner M, & Hearing VJ. (2008) The protective role of melanin against UV damage in human skin. Photochemistry and photobiology, 84(3), 539-49. PMID: 18435612
Pine Cone and Peacocks from Vatican MuseumTestosterone displays effects on brain function in both males and females.Emanuela Mhillaj and colleagues recently published a nice summary of what is currently known about the effects of anabolic-androgen steroids (AAS) on the brain.Their review highlighted the potential for AAS to modulate brain reward function and potentially lead to a drug dependence type of abuse pattern.Here are some of my notes on their discussion of AAS and the brain reward syste........ Read more »
Mhillaj E, Morgese MG, Tucci P, Bove M, Schiavone S, & Trabace L. (2015) Effects of anabolic-androgens on brain reward function. Frontiers in neuroscience, 295. PMID: 26379484
Yates WR, Perry PJ, & Andersen KH. (1990) Illicit anabolic steroid use: a controlled personality study. Acta psychiatrica Scandinavica, 81(6), 548-50. PMID: 2378247
My attention was grabbed recently by the paper published by Jon Kaiser  (open-access available here) detailing the results of a 'proof-of-concept investigation' examining the use of something called KPAX002 on a small number of participants diagnosed with Chronic Fatigue Syndrome (CFS).Looking at how KPAX002 - "a combination of low-dose methylphenidate hydrochloride and mitochondrial support nutrients currently under development by K-PAX Pharmaceuticals" - impacted on fatigue symptoms and "co........ Read more »
Kaiser JD. (2015) A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome. International journal of clinical and experimental medicine, 8(7), 11064-74. PMID: 26379906
It is now well-established that social class is positively related to mental health. However, researchers remain unclear about the specific processes that underlie the relation between social class and depression. In some recent research, we investigated the potential roles of parenting style and friendship in explaining the relationship between social class and mental health.... Read more »
Rubin, M., & Kelly, B. (2015) A cross-sectional investigation of parenting style and friendship as mediators of the relation between social class and mental health in a university community. International Journal for Equity in Health, 14(1), 1-11. DOI: 10.1186/s12939-015-0227-2
Parents who are more anxious and emotional can impact the amount of violent video games their children play, according to new consumer research from Iowa State University. Russell Laczniak, a professor of marketing and the John and Connie Stafford Professor in Business, says given the harmful effects of violent video games, he and his colleagues wanted to better understand how parents influence children’s behavior.... Read more »
Walker, D., Laczniak, R., Carlson, L., & Brocato, E. (2015) Parenting Orientations as Antecedents of Children's Violent Videogame Play. Journal of Consumer Affairs. DOI: 10.1111/joca.12096
MedicalResearch.com Interview with: Prof. Peter JD Andrews Honorary Professor Department of Anaesthesia University of Edinburgh Medical Research: What is the background for this study? Prof. Andrews: Therapeutic hypothermia has shown considerable promise as a neuro-protective intervention in many species and … Continue reading →
The post Hypothermia Did Not Improve Outcomes After Traumatic Brain Injury appeared first on MedicalResearch.com.
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Prof. Peter JD Andrews. (2015) Hypothermia Did Not Improve Outcomes After Traumatic Brain Injury. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Michael M. McNeil, MD, MPH Centers for Disease Control and Prevention Atlanta, GA Medical Research: What is the background for this study? What are the main findings? Dr. McNeil : Anaphylaxis is an uncommon potentially life-threatening allergic reaction … Continue reading →
The post CDC Study Finds Anaphylaxis Rare After Vaccinations, With No Fatalities appeared first on MedicalResearch.com.
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Michael M. McNeil, MD, MPH. (2015) CDC Study Finds Anaphylaxis Rare After Vaccinations, With No Fatalities. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Mark DeBoer, MD Children’s Hospital’s Department of Pediatrics University of Virginia Medical Research: What is the background for this study? What are the main findings? Dr. DeBoer: We have been interested in how the severity of the … Continue reading →
The post Metabolic Syndrome In Youth Linked To Later Life Heart Disease appeared first on MedicalResearch.com.
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Mark DeBoer, MD. (2015) Metabolic Syndrome In Youth Linked To Later Life Heart Disease. MedicalResearch.com. info:/
The manuscript in this post is two years old but I thought it was worthy of comment.The Global Burden of Disease study seeks to provide an estimate of the relative contribution of a variety of medical disorders on disability and death.I have summarized data with an original chart with data abstracted on the leading causes of early death in the U.S. This is provided by the chart in numbers (x1000). The most recent estimate rates heart disease as the continuing cause of years of life lost (2010 es........ Read more »
Murray CJ, Atkinson C, Bhalla K, Birbeck G, Burstein R, Chou D, Dellavalle R, Danaei G, Ezzati M, Fahimi A.... (2013) The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA, 310(6), 591-608. PMID: 23842577
MedicalResearch.com Interview with: Dr. Anne Moseley Senior Research Fellow, Musculoskeletal Division The George Institute for Global Health Sydney Australia Medical Research: What is the background for this study? What are the main findings? Dr. Moseley: Ankle fracture is a common … Continue reading →
The post Single Session Advice From Physical Therapist Sufficient After Uncomplicated Ankle Fracture appeared first on MedicalResearch.com.
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Dr. Anne Moseley. (2015) Single Session Advice From Physical Therapist Sufficient After Uncomplicated Ankle Fracture. MedicalResearch.com. info:/
Glyphosate use and autism rates - should I blog about it?Well, after some deliberation I decided it was a topic worthy of an entry. There is some peer-reviewed science discussions behind it and, as per other areas of controversy on the autism research landscape, the idea that 'science is about debate' (why else does everyone keep going on about open-access and transparency) should always prevail.I'm assuming most people have heard of the organophosphonate (that's phosphonate not p........ Read more »
Faria MA. (2015) Glyphosate, neurological diseases - and the scientific method. Surgical neurology international, 132. PMID: 26322242
MedicalResearch.com Interview with: Nynne Nyboe Andersen, MD Department of Epidemiology Research Statens Serum Institut Denmark Medical Research: What is the background for this study? Response: The use of TNF-α inhibitors, including infliximab, adalimumab and certolizumab pegol to treat people with inflammatory bowel … Continue reading →
The post Biologics Slightly Increase Risk of Demyelinating Disease In Patients with IBD appeared first on MedicalResearch.com.
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Nynne Nyboe Andersen, MD. (2015) Biologics Slightly Increase Risk of Demyelinating Disease In Patients with IBD. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Anja Bye, PhD, Senior Researcher Cardiac Exercise Research Group (CERG) K.G. Jebsen Center of Exercise in Medicine National Council of Cardiovascular Disease Department of Circulation and Medical Imaging Medical Faculty Norwegian University of Science and Technology Medical … Continue reading →
The post Pilot Study Tests High Intensity Exercise in Women With Rheumatic Disease appeared first on MedicalResearch.com.
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Anja Bye, PhD,. (2015) Pilot Study Tests High Intensity Exercise in Women With Rheumatic Disease. MedicalResearch.com. info:/
MedicalResearch.com Interview with: Susan Gray MD Division of Adolescent Medicine Boston Children’s Hospital Boston, MA Medical Research: What is the background for this study? What are the main findings? Dr. Gray: This is a study of the health care costs … Continue reading →
The post Mental Health, Obesity, Orphan Drugs Linked To High Cost Adolescent Care appeared first on MedicalResearch.com.
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Susan Gray MD. (2015) Mental Health, Obesity, Orphan Drugs Linked To High Cost Adolescent Care. MedicalResearch.com. info:/
A new study finds that rising placebo responses may play a part in the increasingly high failure rate for clinical trials of drugs designed to control chronic pain caused by nerve damage. Surprisingly, however, the analysis of clinical trials conducted since 1990 found that the increase in placebo responses occurred only in trials conducted wholly in the U.S.; trials conducted in Europe or Asia showed no changes in placebo responses over that period.... Read more »
Tuttle, A., Tohyama, S., Ramsay, T., Kimmelman, J., Schweinhardt, P., Bennett, G., & Mogil, J. (2015) Increasing placebo responses over time in U.S. clinical trials of neuropathic pain. PAIN, 1. DOI: 10.1097/j.pain.0000000000000333
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