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  • September 1, 2014
  • 03:32 AM
  • 8 views

Lithium for mood disorder symptoms in autism?

by Paul Whiteley in Questioning Answers

Modern classroom? @ Wikipedia The paper published by Matthew Siegel and colleagues [1] talking about some preliminary observations on the use of lithium where symptoms of mood disorder might be present in cases of autism spectrum disorder (ASD) caught my eye recently. Concluding that: "lithium may be a medication of interest for those who exhibit two or more mood disorder symptoms, particularly mania or euphoria/elevated mood" the sentiments of more research-to-do in this area presents........ Read more »

Siegel M, Beresford CA, Bunker M, Verdi M, Vishnevetsky D, Karlsson C, Teer O, Stedman A, & Smith KA. (2014) Preliminary Investigation of Lithium for Mood Disorder Symptoms in Children and Adolescents with Autism Spectrum Disorder. Journal of child and adolescent psychopharmacology. PMID: 25093602  

  • August 31, 2014
  • 11:31 PM
  • 13 views

August lives up to its definition: respected and impressive

by Cobb & Hecht in Do You Believe In Dog?

The things we noticed in and around canine science over the past two weeks, Storified in one neat location for your convenience:[View the story "Do You Believe in Dog? [16-31 August 2014]" on Storify] Further reading:Feuerbacher E.N. (2014). Shut up and pet me! Domestic dogs (Canis lupus familiaris) prefer petting to vocal praise in concurrent and single-alternative choice procedures, Behavioural Processes, DOI: http://dx.doi.org/10.1016/j.beproc.2014.08.019 Gygax L. (2014). The A to Z of sta........ Read more »

  • August 31, 2014
  • 06:28 PM
  • 19 views

Chikungunya Virus and NDP52: a deadly association?

by thelonevirologist in Virology Tidbits

Chikungunya virus (CHIKV) is the causative agent of an arthropod (mosquito) transmitted disease which is characterised by a high fever, rash, joint pain, and arthritis which was reported in 1952 in Tanzania but has spread since to Europe, the Americas, Asia, and Australia and currently epidemic in the Americas. In this post, the importance of p62/SQSTM1 and NDP52 is discussed in the light of apoptosis induction and viral assembly.... Read more »

Kujala P, Ikäheimonen A, Ehsani N, Vihinen H, Auvinen P, & Kääriäinen L. (2001) Biogenesis of the Semliki Forest virus RNA replication complex. Journal of virology, 75(8), 3873-84. PMID: 11264376  

Krejbich-Trotot P, Gay B, Li-Pat-Yuen G, Hoarau JJ, Jaffar-Bandjee MC, Briant L, Gasque P, & Denizot M. (2011) Chikungunya triggers an autophagic process which promotes viral replication. Virology journal, 432. PMID: 21902836  

Mostowy S, Sancho-Shimizu V, Hamon MA, Simeone R, Brosch R, Johansen T, & Cossart P. (2011) p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. The Journal of biological chemistry, 286(30), 26987-95. PMID: 21646350  

Xie Z, & Klionsky DJ. (2007) Autophagosome formation: core machinery and adaptations. Nature cell biology, 9(10), 1102-9. PMID: 17909521  

von Muhlinen N, Akutsu M, Ravenhill BJ, Foeglein Á, Bloor S, Rutherford TJ, Freund SM, Komander D, & Randow F. (2012) LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy. Molecular cell, 48(3), 329-42. PMID: 23022382  

Joubert PE, Werneke SW, de la Calle C, Guivel-Benhassine F, Giodini A, Peduto L, Levine B, Schwartz O, Lenschow DJ, & Albert ML. (2012) Chikungunya virus-induced autophagy delays caspase-dependent cell death. The Journal of experimental medicine, 209(5), 1029-47. PMID: 22508836  

Judith D, Mostowy S, Bourai M, Gangneux N, Lelek M, Lucas-Hourani M, Cayet N, Jacob Y, Prévost MC, Pierre P.... (2013) Species-specific impact of the autophagy machinery on Chikungunya virus infection. EMBO reports, 14(6), 534-44. PMID: 23619093  

  • August 31, 2014
  • 05:34 PM
  • 20 views

Mushroom extracts might prevent dental cavities

by Valerie Ashton in The Molecular Scribe

Recently published research suggests red camphor mushroom extracts might prevent the proliferation of bacteria that cause dental cavities and gum disease.... Read more »

  • August 31, 2014
  • 02:38 PM
  • 30 views

New Synthetic Amino Acid for a New Class of Drugs

by Gabriel in Lunatic Laboratories

Creating new drug molecules is challenging, developing drugs that are highly effective against a target, but with minimal (or no) toxicity and side-effects to the patient can be an exercise in futility. These drug properties are directly conferred by the 3D structure of the drug molecule. So ideally, the drug should have a shape that is perfectly complementary to a disease-causing target, so that it binds it with high specificity.With that, scientists have developed a synthetic amino acid that c........ Read more »

Chen S. Gopalakrishnan R, Schaer T, Marger F, Hovius R, Bertrand D, Pojer F, Heinis C. (2014) Di-thiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides. Nature Chemistry. info:/10.1038/nchem.2043

  • August 30, 2014
  • 02:23 PM
  • 36 views

Predictor of Sudden Death helps identify ICD candidates

by Gabriel in Lunatic Laboratories

New guidelines for patients with hypertrophic cardiomyopathy (HCM) identify candidates for implantable cardioverter defibrillators (ICDs). These devices help protect patients from arrhythmias (an irregular heartbeat) which can limit blood flow to vital organs, like the brain for example. Identifying which pacents would benefit from an ICD has been difficult. But the new guidelines, which were recently published, will help determine the patients most likely to benefit from ICDs by testing to see ........ Read more »

Perry M. Elliott, (Chairperson) (UK)*, Aris Anastasakis, (Greece), Michael A. Borger, (Germany), Martin Borggrefe, (Germany), Franco Cecchi, (Italy), Philippe Charron, (France), Albert Alain Hagege, (France), Antoine Lafont, (France), Giuseppe Limongelli,. (2014) 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). European Heart Journal . info:/10.1093/eurheartj/ehu284

  • August 30, 2014
  • 08:12 AM
  • 45 views

The Myth Of “Roid Rage”?

by Neuroskeptic in Neuroskeptic_Discover

Are men who inject testosterone and other anabolic steroids at risk of entering a violent “roid rage“? Many people think so. Whenever a professional athlete commits a violent crime, it’s not long before someone suggests that steroids may have been involved. The most recent example of this is the case of Jonathan “War Machine” Koppenhaver. […]The post The Myth Of “Roid Rage”? appeared first on Neuroskeptic.... Read more »

  • August 30, 2014
  • 03:34 AM
  • 46 views

Under-recognised co-occurring conditions in autism

by Paul Whiteley in Questioning Answers

A brief post to direct you to the paper by Nicolaidis and colleagues [1] talking about primary care for adults on the autism spectrum and mention of an issue quite important to this blog: "the recognition of associated conditions"."When 900 years old you reach, look as good you will not".Alongside the announcement of what seems like an interesting workshop organised by the US IACC (Interagency Autism Coordinating Committee) titled: "IACC Workshop on Under-Recognized Co-Occurring Condit........ Read more »

Nicolaidis C, Kripke CC, & Raymaker D. (2014) Primary Care for Adults on the Autism Spectrum. The Medical clinics of North America, 98(5), 1169-1191. PMID: 25134878  

  • August 29, 2014
  • 03:10 PM
  • 50 views

The Ever Mutating Ebola Virus

by Gabriel in Lunatic Laboratories

Ebola has a nasty reputation for the way it damages the body. It's rightfully earned when you look at the death rate. But when you look at the actual details of an Ebola infection, a surprising fact surfaces: The virus isn't what ends up killing you, it's your own immune system. Sure they are trying different ways to outsmart the virus, but it's mutating... quickly. In fact, scientists have rapidly sequenced and analyzed more than 99 Ebola virus genomes. The hope it to better understand the enem........ Read more »

Gire, S., Goba, A., Andersen, K., Sealfon, R., Park, D., Kanneh, L., Jalloh, S., Momoh, M., Fullah, M., Dudas, G.... (2014) Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science. DOI: 10.1126/science.1259657  

  • August 29, 2014
  • 01:31 PM
  • 39 views

August 29, 2014

by Erin Campbell in HighMag Blog

Stem cells in adults are responsible for tissue renewal and many cancers. So, the hunt for stem cells is important and has already been successful, with stem cell populations identified in countless types of tissues. Stem cells in the ovary, however, were shy to show themselves until a recent study using a marker for the Wnt protein Lgr5.In adults, stem cells are responsible for maintaining homeostasis during normal wear and tear of a tissue. The ovary and its ovary surface epithelium (OSE) expe........ Read more »

Ng, A., Tan, S., Singh, G., Rizk, P., Swathi, Y., Tan, T., Huang, R., Leushacke, M., & Barker, N. (2014) Lgr5 marks stem/progenitor cells in ovary and tubal epithelia. Nature Cell Biology, 16(8), 745-757. DOI: 10.1038/ncb3000  

  • August 29, 2014
  • 09:25 AM
  • 57 views

The Friday Five for 8/29/14

by Bill Sullivan in The 'Scope

5 of the hottest science news stories this week include a lab-grown thymus, big Alzheimer’s news, and how to make the perfect pizza.... Read more »

  • August 29, 2014
  • 09:09 AM
  • 42 views

Folliculin function is highly cell-specific

by Lizzie Perdeaux in BHD Research Blog

Whilst trying to elucidate the role of FLCN, a number of studies have reported opposing results. FLCN has been shown to both activate and inhibit mTOR signalling, AMPK signalling and RhoA signalling and to both potentiate and abrogate cell-cell adhesion. … Continue reading →... Read more »

Khabibullin D, Medvetz DA, Pinilla M, Hariharan V, Li C, Hergrueter A, Laucho Contreras M, Zhang E, Parkhitko A, Yu JJ.... (2014) Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells. Physiological reports, 2(8). PMID: 25121506  

  • August 29, 2014
  • 06:38 AM
  • 66 views

Fish with Lungs Gives Clues to the Origin of Tetrapods

by beredim in Strange Animals

Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could she........ Read more »

  • August 29, 2014
  • 03:52 AM
  • 98 views

Oxytocin and autism: the hype?

by Paul Whiteley in Questioning Answers

Consider some excerpts from two recent papers looking at oxytocin (OXT) - the "love hormone"(!) - and the autism spectrum disorders (ASDs)...“It’s not the years, honey. It’s the mileage”"These findings indicate that dysregulated OXT biology is not uniquely associated with ASD social phenotypes as widely theorized, but instead variation in OXT biology contributes to important individual differences in human social functioning, including the severe social impairments which characterize ASD........ Read more »

Parker, K., Garner, J., Libove, R., Hyde, S., Hornbeak, K., Carson, D., Liao, C., Phillips, J., Hallmayer, J., & Hardan, A. (2014) Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1402236111  

Guastella AJ, Gray KM, Rinehart NJ, Alvares GA, Tonge BJ, Hickie IB, Keating CM, Cacciotti-Saija C, & Einfeld SL. (2014) The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial. Journal of child psychology and psychiatry, and allied disciplines. PMID: 25087908  

  • August 28, 2014
  • 11:48 PM
  • 94 views

A Map to Build Roads to a Better Future

by Yao-Hua Law in TORCH

When I learned that the pesticide DDT–widely toxic and now widely banned–has snaked its way into polar bears and beluga whales, I questioned if any environment remains pristine on terrestrial Earth. Perhaps, the thick, hostile and unyielding rainforests of Borneo might prove a bastion? Then in 2013, satellite images showed roads penetrating deep into Borneo. […]... Read more »

Laurance, W., Clements, G., Sloan, S., O’Connell, C., Mueller, N., Goosem, M., Venter, O., Edwards, D., Phalan, B., Balmford, A.... (2014) A global strategy for road building. Nature. DOI: 10.1038/nature13717  

  • August 28, 2014
  • 04:53 PM
  • 141 views

This is your Brain. This is your Brain on Drugs

by Gabriel in Lunatic Laboratories

Drugs are bad for the brain. That is (excuse the horrible pun) a no-brainer, but while scientists have seen the after effect drugs have on the brain, we have never seen how they affect the blood flow to the brain. That is of course, until now. A new method for measuring and imaging how quickly blood flows in the brain could help doctors and researchers better understand how drug abuse affects the brain and they are currently testing this new method as we speak.... Read more »

  • August 28, 2014
  • 12:52 PM
  • 133 views

The Things Living on your Toothbrush…

by Gabriel in Lunatic Laboratories

Did you remember to brush? I hope you did, but you may be throwing away your toothbrush soon. Get ready for your daily amount of gross, because have I got a scientific discovery that will make you rethink your dental hygiene. Researchers have found that “solid-head” power toothbrushes have up to 3,000 times less bacteria when compared to “hollow-head” toothbrushes.[…]... Read more »

Morris DW, Goldschmidt M, Keene H, & Cron SG. (2014) Microbial contamination of power toothbrushes: a comparison of solid-head versus hollow-head designs. Journal of dental hygiene : JDH / American Dental Hygienists' Association, 88(4), 237-42. PMID: 25134956  

  • August 28, 2014
  • 04:29 AM
  • 80 views

Minocycline for schizophrenia?

by Paul Whiteley in Questioning Answers

"Minocycline may improve the psychopathology of schizophrenia, especially the negative symptoms, and seems to be well tolerated".A Bachelors Drawer (apparently) @ Wikipedia That was the finding from the systematic review and meta-analysis undertaken by Oya and colleagues [1] looking at the collected literature on the use of "minocycline augmentation therapy in patients with schizophrenia receiving antipsychotic agents". Augmentation therapy by the way, refers to the addition of minocycline ........ Read more »

  • August 27, 2014
  • 07:35 PM
  • 92 views

(False?) Positive Psychology Meets Genomics

by Neuroskeptic in Neuroskeptic_Discover

Academic bunfight ahoy! A new paper from Nick Brown – famed debunker of the “Positivity Ratio” – and his colleagues, takes aim at another piece of research on feel-good emotions. The target is a 2013 paper published in PNAS from positive psychology leader Barbara Fredrickson and colleagues: A functional genomic perspective on human well-being. The […]The post (False?) Positive Psychology Meets Genomics appeared first on Neuroskeptic.... Read more »

Brown, N., MacDonald, D., Samanta, M., Friedman, H., & Coyne, J. (2014) A critical reanalysis of the relationship between genomics and well-being. Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.1407057111  

  • August 27, 2014
  • 05:39 PM
  • 80 views

Climate change research roundup: hiding heat in the Atlantic and the Arctic carbon cycle

by Jonathan Trinastic in Goodnight Earth

A quick roundup of new climate change research in Science: the Atlantic Ocean may be hiding the missing heat to explain the global warming hiatus, and photochemical processes in the Arctic are releasing more CO2 than previously thought.... Read more »

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