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  • September 26, 2016
  • 01:35 PM
  • 14 views

Why do more men than women commit suicide?

by Dr. Jekyll in Lunatic Laboratories

Why do more men die when they attempt suicide than women? The answer could lie in four traits, finds scientists. There are over 6,000 British lives lost to suicide each year, and nearly 75 per cent of those are male. However, research has found women are more likely to suffer from depression, and to attempt to take their own life.

... Read more »

Deshpande, G., Baxi, M., Witte, T., & Robinson, J. (2016) A Neural Basis for the Acquired Capability for Suicide. Frontiers in Psychiatry. DOI: 10.3389/fpsyt.2016.00125  

  • September 26, 2016
  • 02:48 AM
  • 25 views

On HERV-H, autism, ADHD and methylphenidate?

by Paul Whiteley in Questioning Answers

Today's post is a bit of a mash-up including two paper: the first from Emanuela  Balestrieri and colleagues [1] (open-access available here) talking about "increased HERV-H [Human Endogenous Retroviruses - H] transcriptional activity in all autistic patients" included in their cohort (author's words not mine) and the second from D'Agati and colleagues [2] (open-access available here) describing "the reduction of HERV-H expression and the significant improvement of ADHD&n........ Read more »

Balestrieri E, Cipriani C, Matteucci C, Capodicasa N, Pilika A, Korca I, Sorrentino R, Argaw-Denboba A, Bucci I, Miele MT.... (2016) Transcriptional activity of human endogenous retrovirus in Albanian children with autism spectrum disorders. The new microbiologica, 39(3), 228-31. PMID: 27602423  

  • September 25, 2016
  • 09:29 PM
  • 32 views

Big news in iPS cell transplants

by adam phillips in It Ain't Magic

iPS cell-derived retinal cells have been successfully transplanted from one money to another without need of immunosuppressant drugs.... Read more »

  • September 25, 2016
  • 02:57 PM
  • 40 views

Linking perception to action

by Dr. Jekyll in Lunatic Laboratories

Researchers studying how the brain uses perception of the environment to guide action offer a new understanding of the neural circuits responsible for transforming sensation into movement.

... Read more »

  • September 24, 2016
  • 03:26 AM
  • 64 views

Correcting ophthalmic problems in autism

by Paul Whiteley in Questioning Answers

'Does Correction of Strabismus Improve Quality of Life in Children with Autism Spectrum Disorder?' went the title of the paper by Pinar Ozer and colleagues [1]. Yes, it may very well do was the answer (but with certain caveats and the requirement for a lot more research in this area).Strabismus, a condition where the eyes don't line up in the same direction, can sometime have some quite noticeable effects on a person's vision and indeed, has been linked to various other non-vision related sympto........ Read more »

  • September 23, 2016
  • 04:14 PM
  • 62 views

PD-L1 expression associates with non-inactivated VHL ccRCC

by Joana Guedes in BHD Research Blog

The loss of the of the tumor suppressor gene VHL and the subsequent deregulation of VHL/HIF/VEGF signalling are known to play a role in development of clear cell renal cell carcinoma (ccRCC). Renal tumours associated with BHD syndrome are histologically diverse and include a percentage of ccRCC (Pavlovich et al., 2002). Anti-angiogenic therapies targeting the VHL/HIF/VEGF pathway have emerged in past years (Rini et al., 2006) but the development of resistance to these therapeutic agents is leadi........ Read more »

  • September 23, 2016
  • 07:00 AM
  • 67 views

Friday Fellow: Rosy Crust

by Piter Boll in Earthling Nature

by Piter Kehoma Boll If you are walking through a forest in Europe you may find the bark of some trees covered by a thin rosy or orange crust. Commonly known as rosy crust, its scientific name is Peniophora incarnata. As … Continue reading →... Read more »

Suay, I., Arenal, F,, Asensio, F. J., Basilio, A., Cabello, M. A., Díez, M. T., García, J. B., González del Val, A., Gorrochategui, J., Hernández, P.... (2000) Screening of basidiomycetes for antimicrobial activities. Antonie van Leeuwenhoek, 78(2), 129-140. DOI: 10.1023/A:1026552024021  

  • September 23, 2016
  • 02:42 AM
  • 71 views

Epilepsy and systemic autoimmune diseases: birds of a feather?

by Paul Whiteley in Questioning Answers

A couple of years back on this blog I talked about some rather intriguing research suggesting that epilepsy and autoimmune disease might not be unstrange diagnostic bedfellows (see here) and that a "potential role of autoimmunity must be given due consideration in epilepsy." [1]Today, I'm continuing that research theme as the findings from Zhang Lin and colleagues [2] caught my eye concluding that: "There is an association between epilepsy and SAD [systemic autoimmune diseases], which ........ Read more »

  • September 22, 2016
  • 03:14 PM
  • 87 views

Historical analysis examines sugar industry role in heart disease research

by Dr. Jekyll in Lunatic Laboratories

Using archival documents, a new report examines the sugar industry's role in coronary heart disease research and suggests the industry sponsored research to influence the scientific debate to cast doubt on the hazards of sugar and to promote dietary fat as the culprit in heart disease.

... Read more »

  • September 22, 2016
  • 09:27 AM
  • 97 views

Will tardigrades get humanity into space?

by gdw in FictionalFieldwork

The mighty water bear Tardigrades, aka water bears, are tiny animals that can be found just about everywhere on earth, with a slight preference for the moisture in moss. They happily amble along on their four pairs of legs and slurp up plant cells, algae, and even smaller invertebrates that can’t get away fast enough […]... Read more »

Boothby TC, Tenlen JR, Smith FW, Wang JR, Patanella KA, Nishimura EO, Tintori SC, Li Q, Jones CD, Yandell M.... (2015) Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade. Proceedings of the National Academy of Sciences of the United States of America, 112(52), 15976-81. PMID: 26598659  

Koutsovoulos G, Kumar S, Laetsch DR, Stevens L, Daub J, Conlon C, Maroon H, Thomas F, Aboobaker AA, & Blaxter M. (2016) No evidence for extensive horizontal gene transfer in the genome of the tardigrade Hypsibius dujardini. Proceedings of the National Academy of Sciences of the United States of America, 113(18), 5053-8. PMID: 27035985  

Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T.... (2016) Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nature communications, 12808. PMID: 27649274  

  • September 22, 2016
  • 03:14 AM
  • 78 views

"Paediatricians are seeing more children with developmental-behavioural conditions"

by Paul Whiteley in Questioning Answers

The findings reported by Harriet Hiscock and colleagues [1] are brought to the blogging table today, specifically that suggestion that paediatricians, at least in Australia, might be encountering an increased number of "developmental/behavioural conditions" as part of their workload.Looking at the clinical experiences of some 180 paediatricians who took part in the study in late 2013 and comparing them with data from 2008, researchers probed a number of practices relating to "(i) conditions seen........ Read more »

  • September 21, 2016
  • 12:35 PM
  • 85 views

Protect kids from toxic secondhand smoke, experts urge

by Dr. Jekyll in Lunatic Laboratories

It's advice most smokers with children probably take lightly, but they shouldn't. Parents and policy advocates should take a "zero tolerance" approach to exposing children to secondhand cigarette smoke, which can be responsible for lifelong cardiovascular consequences in addition to respiratory and other health issues.

... Read more »

  • September 20, 2016
  • 04:31 PM
  • 105 views

Potentially harmful chemicals widespread in household dust

by Dr. Jekyll in Lunatic Laboratories

Household dust exposes people to a wide range of toxic chemicals from everyday products, according to a new study. A multi-institutional team conducted a first-of-a-kind meta-analysis, compiling data from dust samples collected throughout the United States to identify the top ten toxic chemicals commonly found in dust.

... Read more »

  • September 20, 2016
  • 03:11 AM
  • 123 views

First trimester maternal vitamin D status and offspring autism risk?

by Paul Whiteley in Questioning Answers

Vitamin D - the sunshine vitamin/hormone - is seemingly everywhere these days in research terms. At the time of writing this post we have news that vitamin D might cut the risk of severe asthma attacks if taken alongside prescribed asthma medication. The week before that it was the suggestion that vitamin D might be part of the explanation as to why childhood learning difficulties were more commonly found in children conceived during the winter months. Vitamin D is seemingly shouldering quite a ........ Read more »

  • September 19, 2016
  • 02:59 AM
  • 127 views

Constipation in schizophrenia

by Paul Whiteley in Questioning Answers

"Constipation and dyspepsia are disturbing gastrointestinal symptoms that are often ignored in research on physical comorbidities of schizophrenia."Go on."The prevalence of constipation was 31.3%, and of dyspepsia 23.6%."So said the findings reported by Tomi Virtanen and colleagues [1] who assessed "dyspepsia and constipation in a sample of outpatients with schizophrenia spectrum psychoses." Alongside the general practitioner assessment of such functional bowel complaints, researchers also ........ Read more »

  • September 18, 2016
  • 03:59 PM
  • 104 views

How to Detect Circular Virus Genomes from Metagenomes

by Geoffrey Hannigan in Prophage

When analyzing virus metagenomic data, we often find it helpful to identify...... Read more »

Minot, S., Sinha, R., Chen, J., Li, H., Keilbaugh, S., Wu, G., Lewis, J., & Bushman, F. (2011) The human gut virome: Inter-individual variation and dynamic response to diet. Genome Research, 21(10), 1616-1625. DOI: 10.1101/gr.122705.111  

Manrique, P., Bolduc, B., Walk, S., van der Oost, J., de Vos, W., & Young, M. (2016) Healthy human gut phageome. Proceedings of the National Academy of Sciences, 113(37), 10400-10405. DOI: 10.1073/pnas.1601060113  

  • September 18, 2016
  • 03:01 PM
  • 118 views

The new findings heart repair research

by Dr. Jekyll in Lunatic Laboratories

Scientists trying to find ways to regenerate a damaged heart have shed more light on the molecular mechanisms that could one day make this a reality. Whilst other organs such as the liver can regenerate, the heart muscle has very little ability to do so after suffering damage, such as a heart attack.
In the womb the body is able to produce heart muscle cells but soon after birth it effectively stops producing them.... Read more »

  • September 18, 2016
  • 07:03 AM
  • 132 views

5 Things We Learned This Week | Open-Access Science | Week 37, 2016

by TakFurTheKaffe in Tak Fur The Kaffe

New theories in ocean circulation and acidification, shorter sea ice season in polar bear habitats, and new tools to track bird migrations and hair protein analysis in forensic IDs. Here are five of the latest scientific studies published open-access this week.... Read more »

Stern, H., & Laidre, K. (2016) Sea-ice indicators of polar bear habitat. The Cryosphere, 10(5), 2027-2041. DOI: 10.5194/tc-10-2027-2016  

Shamoun-Baranes, J., Farnsworth, A., Aelterman, B., Alves, J., Azijn, K., Bernstein, G., Branco, S., Desmet, P., Dokter, A., Horton, K.... (2016) Innovative Visualizations Shed Light on Avian Nocturnal Migration. PLOS ONE, 11(8). DOI: 10.1371/journal.pone.0160106  

Parker, G., Leppert, T., Anex, D., Hilmer, J., Matsunami, N., Baird, L., Stevens, J., Parsawar, K., Durbin-Johnson, B., Rocke, D.... (2016) Demonstration of Protein-Based Human Identification Using the Hair Shaft Proteome. PLOS ONE, 11(9). DOI: 10.1371/journal.pone.0160653  

  • September 17, 2016
  • 01:50 PM
  • 137 views

Largest-ever study reveals environmental impact of genetically modified crops

by Dr. Jekyll in Lunatic Laboratories

According to new research, widespread adoption of genetically modified crops has decreased the use of insecticides, but increased the use of weed-killing herbicides as weeds become more resistant. This is the largest study of genetically modified crops and pesticide use to date. The team of economists studied annual data from more than 5,000 soybean and 5,000 maize farmers in the U.S. from 1998 to 2011, far exceeding previous studies that have been limited to one or two years of data.

... Read more »

  • September 17, 2016
  • 08:27 AM
  • 135 views

Comorbidities surrounding paediatric chronic fatigue syndrome / myalgic encephalomyelitis (CFS / ME)

by Paul Whiteley in Questioning Answers

"This large nationwide registry linkage study confirms that the clinical picture in CFS/ME [chronic fatigue syndrome / myalgic encephalomyelitis] is complex."That sentence, taken from the paper by Inger Bakken and colleagues [1] (open-access available here), is perhaps the under-statement of the year as authors sought to "describe comorbidities diagnosed in primary care in children diagnosed with CFS/ME in specialist health care" and "describe the timing of the diagnoses from prim........ Read more »

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