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  • August 31, 2014
  • 11:31 PM
  • 121 views

August lives up to its definition: respected and impressive

by Cobb & Hecht in Do You Believe In Dog?

The things we noticed in and around canine science over the past two weeks, Storified in one neat location for your convenience:[View the story "Do You Believe in Dog? [16-31 August 2014]" on Storify] Further reading:Feuerbacher E.N. (2014). Shut up and pet me! Domestic dogs (Canis lupus familiaris) prefer petting to vocal praise in concurrent and single-alternative choice procedures, Behavioural Processes, DOI: http://dx.doi.org/10.1016/j.beproc.2014.08.019 Gygax L. (2014). The A to Z of sta........ Read more »

  • August 31, 2014
  • 06:36 PM
  • 114 views

Whitman Was Not a Neuroscientist

by The Neurocritic in The Neurocritic

Do I contradict myself?Very well then I contradict myself,(I am large, I contain multitudes.)-Walt Whitman, "Song of Myself" (from Leaves of Grass)Science is the search for objective truth based on physical laws of the universe. Scientific theories try to explain the consistent and predictable behavior of natural systems. They are generally reductionist, meaning that complex systems are reduced to simpler and more fundamental elements. The principles of physics, for instance, are expressed in th........ Read more »

  • August 31, 2014
  • 06:28 PM
  • 107 views

Chikungunya Virus and NDP52: a deadly association?

by thelonevirologist in Virology Tidbits

Chikungunya virus (CHIKV) is the causative agent of an arthropod (mosquito) transmitted disease which is characterised by a high fever, rash, joint pain, and arthritis which was reported in 1952 in Tanzania but has spread since to Europe, the Americas, Asia, and Australia and currently epidemic in the Americas. In this post, the importance of p62/SQSTM1 and NDP52 is discussed in the light of apoptosis induction and viral assembly.... Read more »

Kujala P, Ikäheimonen A, Ehsani N, Vihinen H, Auvinen P, & Kääriäinen L. (2001) Biogenesis of the Semliki Forest virus RNA replication complex. Journal of virology, 75(8), 3873-84. PMID: 11264376  

Krejbich-Trotot P, Gay B, Li-Pat-Yuen G, Hoarau JJ, Jaffar-Bandjee MC, Briant L, Gasque P, & Denizot M. (2011) Chikungunya triggers an autophagic process which promotes viral replication. Virology journal, 432. PMID: 21902836  

Mostowy S, Sancho-Shimizu V, Hamon MA, Simeone R, Brosch R, Johansen T, & Cossart P. (2011) p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. The Journal of biological chemistry, 286(30), 26987-95. PMID: 21646350  

Xie Z, & Klionsky DJ. (2007) Autophagosome formation: core machinery and adaptations. Nature cell biology, 9(10), 1102-9. PMID: 17909521  

von Muhlinen N, Akutsu M, Ravenhill BJ, Foeglein Á, Bloor S, Rutherford TJ, Freund SM, Komander D, & Randow F. (2012) LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy. Molecular cell, 48(3), 329-42. PMID: 23022382  

Joubert PE, Werneke SW, de la Calle C, Guivel-Benhassine F, Giodini A, Peduto L, Levine B, Schwartz O, Lenschow DJ, & Albert ML. (2012) Chikungunya virus-induced autophagy delays caspase-dependent cell death. The Journal of experimental medicine, 209(5), 1029-47. PMID: 22508836  

Judith D, Mostowy S, Bourai M, Gangneux N, Lelek M, Lucas-Hourani M, Cayet N, Jacob Y, Prévost MC, Pierre P.... (2013) Species-specific impact of the autophagy machinery on Chikungunya virus infection. EMBO reports, 14(6), 534-44. PMID: 23619093  

  • August 31, 2014
  • 05:34 PM
  • 82 views

Mushroom extracts might prevent dental cavities

by Valerie Ashton in The Molecular Scribe

Recently published research suggests red camphor mushroom extracts might prevent the proliferation of bacteria that cause dental cavities and gum disease.... Read more »

  • August 31, 2014
  • 05:20 PM
  • 101 views

Heroin’s Anthrax Problem

by Rebecca Kreston in BODY HORRORS

Anthrax is a deadly disease with high rates of morbidity and mortality. Because it is, thankfully, also quite rare, it is relatively easy to track its whereabouts and going-ons when an outbreak occurs. Typically, outbreaks of anthrax have been traced to groups of people involved in high-risk activities involving grazing animals and their byproducts: anthrax favors shepherds, butchers, wool-sorters, leather workers, and even the odd drum-playing hippies. In 2009, however, an outbreak upended this........ Read more »

  • August 31, 2014
  • 02:38 PM
  • 111 views

New Synthetic Amino Acid for a New Class of Drugs

by Gabriel in Lunatic Laboratories

Creating new drug molecules is challenging, developing drugs that are highly effective against a target, but with minimal (or no) toxicity and side-effects to the patient can be an exercise in futility. These drug properties are directly conferred by the 3D structure of the drug molecule. So ideally, the drug should have a shape that is perfectly complementary to a disease-causing target, so that it binds it with high specificity.With that, scientists have developed a synthetic amino acid that c........ Read more »

Chen S. Gopalakrishnan R, Schaer T, Marger F, Hovius R, Bertrand D, Pojer F, Heinis C. (2014) Di-thiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides. Nature Chemistry. info:/10.1038/nchem.2043

  • August 30, 2014
  • 02:54 PM
  • 145 views

Direct mind-to-mind communication in humans

by Shelly Fan in Neurorexia

Image credit: www.techspot.com Here’s something right out of science fiction: a team of neuroscientists in Spain developed a system that allows a person to transmit the...... Read more »

Grau C, Ginhoux R, Riera A, Nguyen TL, Chauvat H, Berg M, Amengual JL, Pascual-Leone A, & Ruffini G. (2014) Conscious Brain-to-Brain Communication in Humans Using Non-Invasive Technologies. PloS one, 9(8). PMID: 25137064  

  • August 30, 2014
  • 02:23 PM
  • 106 views

Predictor of Sudden Death helps identify ICD candidates

by Gabriel in Lunatic Laboratories

New guidelines for patients with hypertrophic cardiomyopathy (HCM) identify candidates for implantable cardioverter defibrillators (ICDs). These devices help protect patients from arrhythmias (an irregular heartbeat) which can limit blood flow to vital organs, like the brain for example. Identifying which pacents would benefit from an ICD has been difficult. But the new guidelines, which were recently published, will help determine the patients most likely to benefit from ICDs by testing to see ........ Read more »

Perry M. Elliott, (Chairperson) (UK)*, Aris Anastasakis, (Greece), Michael A. Borger, (Germany), Martin Borggrefe, (Germany), Franco Cecchi, (Italy), Philippe Charron, (France), Albert Alain Hagege, (France), Antoine Lafont, (France), Giuseppe Limongelli,. (2014) 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). European Heart Journal . info:/10.1093/eurheartj/ehu284

  • August 30, 2014
  • 08:12 AM
  • 117 views

The Myth Of “Roid Rage”?

by Neuroskeptic in Neuroskeptic_Discover

Are men who inject testosterone and other anabolic steroids at risk of entering a violent “roid rage“? Many people think so. Whenever a professional athlete commits a violent crime, it’s not long before someone suggests that steroids may have been involved. The most recent example of this is the case of Jonathan “War Machine” Koppenhaver. […]The post The Myth Of “Roid Rage”? appeared first on Neuroskeptic.... Read more »

  • August 30, 2014
  • 03:34 AM
  • 108 views

Under-recognised co-occurring conditions in autism

by Paul Whiteley in Questioning Answers

A brief post to direct you to the paper by Nicolaidis and colleagues [1] talking about primary care for adults on the autism spectrum and mention of an issue quite important to this blog: "the recognition of associated conditions"."When 900 years old you reach, look as good you will not".Alongside the announcement of what seems like an interesting workshop organised by the US IACC (Interagency Autism Coordinating Committee) titled: "IACC Workshop on Under-Recognized Co-Occurring Condit........ Read more »

Nicolaidis C, Kripke CC, & Raymaker D. (2014) Primary Care for Adults on the Autism Spectrum. The Medical clinics of North America, 98(5), 1169-1191. PMID: 25134878  

  • August 30, 2014
  • 03:31 AM
  • 56 views

Neurobiological Basis of Music Therapy

by Vivek Misra in The UberBrain

The basic and one of oldest socio-cognitive domains of Human species is music. Listening to music regularly helps to keep the neurons and synapses more active. Depending on the way sound waves are heard or pronounced, they have an impact in the way neurological (brain and nerve) system work in the human body. Neurological studies have identified that music is a valuable tool for evaluating the brain system [1]. Its observed that while listening to music, different parts of the brain are involved........ Read more »

Peretz, I., & Zatorre, R. (2005) Brain Organization for Music Processing. Annual Review of Psychology, 56(1), 89-114. DOI: 10.1146/annurev.psych.56.091103.070225  

Patton, J., Routh, D., & Stinard, T. (2013) Where do children study? Behavioral observations. Bulletin of the Psychonomic Society, 24(6), 439-440. DOI: 10.3758/BF03330575  

Chan AS, Ho YC, & Cheung MC. (1998) Music training improves verbal memory. Nature, 396(6707), 128. PMID: 9823892  

TSANG, C., TRAINOR, L., SANTESSO, D., TASKER, S., & SCHMIDT, L. (2006) Frontal EEG Responses as a Function of Affective Musical Features. Annals of the New York Academy of Sciences, 930(1), 439-442. DOI: 10.1111/j.1749-6632.2001.tb05764.x  

Luu P, Tucker DM, & Makeig S. (2004) Frontal midline theta and the error-related negativity: neurophysiological mechanisms of action regulation. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 115(8), 1821-35. PMID: 15261861  

Koelsch S. (2010) Towards a neural basis of music-evoked emotions. Trends in cognitive sciences, 14(3), 131-7. PMID: 20153242  

  • August 29, 2014
  • 08:36 PM
  • 105 views

Foot Orthotics and Patellofemoral Pain

by Craig Payne in Running Research Junkie

Foot Orthotics and Patellofemoral Pain... Read more »

  • August 29, 2014
  • 07:15 PM
  • 108 views

A change of mind: from bitter recollections to sweet memories

by Shelly Fan in Neurorexia

There are a LOT of articles on this study already, but most don’t go into the technical details – the part that, in my opinion,...... Read more »

  • August 29, 2014
  • 05:00 PM
  • 66 views

Visualizing the evolution of a scientific conference with altmetrics

by Peter Kraker in Science and the Web

From September 3 to 5, I will be attending STI 2014, the 19th International Conference on Science and Technology Indicators. There, I will present a paper entitled “Altmetrics-based Visualizations Depicting the Evolution of a Knowledge Domain” that I co-authored with Philipp Weißensteiner and Peter Brusilovsky (download the PDF here). In this work-in-progress paper, we present an approach to visualizing the topical evolution of a scientific conference over time.... Read more »

Kraker, P., Weißensteiner, P., & Brusilovsky, P. (2014) Altmetrics-based Visualizations Depicting the Evolution of a Knowledge Domain. 19th International Conference on Science and Technology Indicators (STI 2014), 330-333. info:/

  • August 29, 2014
  • 03:10 PM
  • 108 views

The Ever Mutating Ebola Virus

by Gabriel in Lunatic Laboratories

Ebola has a nasty reputation for the way it damages the body. It's rightfully earned when you look at the death rate. But when you look at the actual details of an Ebola infection, a surprising fact surfaces: The virus isn't what ends up killing you, it's your own immune system. Sure they are trying different ways to outsmart the virus, but it's mutating... quickly. In fact, scientists have rapidly sequenced and analyzed more than 99 Ebola virus genomes. The hope it to better understand the enem........ Read more »

Gire, S., Goba, A., Andersen, K., Sealfon, R., Park, D., Kanneh, L., Jalloh, S., Momoh, M., Fullah, M., Dudas, G.... (2014) Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science. DOI: 10.1126/science.1259657  

  • August 29, 2014
  • 01:31 PM
  • 95 views

August 29, 2014

by Erin Campbell in HighMag Blog

Stem cells in adults are responsible for tissue renewal and many cancers. So, the hunt for stem cells is important and has already been successful, with stem cell populations identified in countless types of tissues. Stem cells in the ovary, however, were shy to show themselves until a recent study using a marker for the Wnt protein Lgr5.In adults, stem cells are responsible for maintaining homeostasis during normal wear and tear of a tissue. The ovary and its ovary surface epithelium (OSE) expe........ Read more »

Ng, A., Tan, S., Singh, G., Rizk, P., Swathi, Y., Tan, T., Huang, R., Leushacke, M., & Barker, N. (2014) Lgr5 marks stem/progenitor cells in ovary and tubal epithelia. Nature Cell Biology, 16(8), 745-757. DOI: 10.1038/ncb3000  

  • August 29, 2014
  • 12:27 PM
  • 65 views

The psychology of wearable computing - does Google Glass affect where people look?

by BPS Research Digest in BPS Research Digest

Computing eyewear such as Google Glass can record information far more discreetly than a handheld camera. As a result, privacy concerns have been raised, whether in a bar or changing for the gym. Are users of this tech likely to use their new toys responsibly? Early research was promising, suggesting that the very act of recording our gaze may lead us to be extra considerate in where we look. Unfortunately a new study finds that while wearing gaze-monitoring devices may initially encourage ........ Read more »

Nasiopoulos, E., Risko, E., Foulsham, T., & Kingstone, A. (2014) Wearable computing: Will it make people prosocial?. British Journal of Psychology. DOI: 10.1111/bjop.12080  

  • August 29, 2014
  • 12:00 PM
  • 61 views

Replication and reputation: Whose career matters?

by Dorothy Bishop in bishopblog

This post is a commentary on a piece by Matthew Lieberman in Edge, in which he expresses concerns about the way in which researchers are undertaking replication studies. He argues that some people are making careers out of trying to disprove others, and in so doing are damaging science.
I argue that we need to develop a more mature understanding that the move towards more replication is not about making or breaking careers: it is about providing an opportunity to move science forward, improve o........ Read more »

  • August 29, 2014
  • 09:26 AM
  • 93 views

Breaking research: A study in fruit flies finds a possible drug target to compensate for symptoms of Parkinson’s disease

by Bethany Christmann in Fly on the Wall

Parkinson’s disease is caused by the progressive death of neurons important for movement and results in symptoms such as shaking or rigidity in the limbs, slow movements, and difficulty walking. The primary treatment is a drug called L-Dopa, which compensates for the neuron loss but eventually becomes less effective as more and more neurons die […]... Read more »

  • August 29, 2014
  • 09:25 AM
  • 133 views

The Friday Five for 8/29/14

by Bill Sullivan in The 'Scope

5 of the hottest science news stories this week include a lab-grown thymus, big Alzheimer’s news, and how to make the perfect pizza.... Read more »

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