I must thank Leah Hardy (@LeahFHardy) for bringing to my attention the paper by Qinglong Shang and colleagues  (open-access available here) reporting that: "Ad36 [Human adenovirus 36] infection is associated with an increased risk of obesity development."Based on a meta-analysis of the available research literature examining whether Ad-36 - "a nonenveloped icosahedral virus comprised of double-stranded DNA and is one of 56 serotypes in 7 subgroups of human adenoviruses" - might........ Read more »
Shang Q, Wang H, Song Y, Wei L, Lavebratt C, Zhang F, & Gu H. (2014) Serological data analyses show that adenovirus 36 infection is associated with obesity: a meta-analysis involving 5739 subjects. Obesity (Silver Spring, Md.), 22(3), 895-900. PMID: 23804409
Rapid eye movement or REM sleep actively converts waking experiences into lasting memories and abilities in young brains reports a new study. The finding broadens the understanding of children’s sleep needs and calls into question the increasing use of REM-disrupting medications such as stimulants and antidepressants.
... Read more »
Michelle C. Dumoulin Bridi, Sara J. Aton, Julie Seibt, Leslie Renouard, Tammi Coleman1, & Marcos G. Frank. (2015) Rapid eye movement sleep promotes cortical plasticity in the developing brain. Science Advances. info:/10.1126/sciadv.1500105
The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed. A group of researchers discovered a new mechanism of DNA repair, which opens up new perspectives for the treatment and prevention of neurodegenerative diseases.... Read more »
Nikolay A. Pestov, Nadezhda S. Gerasimova, Olga I. Kulaeva, & Vasily M. Studitsky. (2015) Structure of transcribed chromatin is a sensor of DNA damage. Science Advances. info:/10.1126/sciadv.1500021
When you smile at a party, your facial expression is emotionally consistent with the happy context and as a consequence other guests will in future be more likely to remember that they've seen your face before, and where you were when they saw you. That's according to a team of Italian researchers led by Stefania Righi who have explored how memory for a face is affected by the emotion shown on that face and the congruence between that emotional expression and its surrounding context.The research........ Read more »
Righi, S., Gronchi, G., Marzi, T., Rebai, M., & Viggiano, M. (2015) You are that smiling guy I met at the party! Socially positive signals foster memory for identities and contexts. Acta Psychologica, 1-7. DOI: 10.1016/j.actpsy.2015.05.001
Can we learn without being aware of what we're learning? Many psychologists say that 'unconscious', or implicit, learning exists.
But in a new paper, London-based psychologists Vadillo, Konstantinidis, and Shanks call the evidence for this into question.
Vadillo et al. focus on one particular example of implicit learning, the contextual cueing paradigm. This involves a series of stimulus patterns, each consisting of a number of "L" shapes and one "T" shape in various orientations. For ... Read more »
Vadillo MA, Konstantinidis E, & Shanks DR. (2015) Underpowered samples, false negatives, and unconscious learning. Psychonomic bulletin . PMID: 26122896
Animal models can be useful for understanding disease pathology and as preclinical models for drug testing. As BHD patients develop renal cell carcinomas (RCCs) of varied histologies, associated with a loss of FLCN, BHD animal models could be used to study of a wide range of renal cancer subtypes. Current BHD mouse models include kidney-specific Flcn-knockouts (Chen et al., 2008, Baba et al., 2008) and ubiquitous knockouts (Hasumi et al., 2009, Hartman et al., 2009, Hudon et al., 2010). The form........ Read more »
Chen J, Huang D, Rubera I, Futami K, Wang P, Zickert P, Khoo SK, Dykema K, Zhao P, Petillo D.... (2015) Disruption of tubular Flcn expression as a mouse model for renal tumor induction. Kidney international. PMID: 26083655
Adding some ‘worry time’ to your day could work better than pills.... Read more »
Koffel EA, Koffel JB, & Gehrman PR. (2015) A meta-analysis of group cognitive behavioral therapy for insomnia. Sleep medicine reviews, 6-16. PMID: 24931811
Sivertsen B, Omvik S, Pallesen S, Bjorvatn B, Havik OE, Kvale G, Nielsen GH, & Nordhus IH. (2006) Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. JAMA, 295(24), 2851-8. PMID: 16804151
A new research article shows that the ventral striatum includes a representation of the value attributed to potential choices in a gambling task, and of the decision eventually reached.... Read more »
Strait, C., Sleezer, B., & Hayden, B. (2015) Signatures of Value Comparison in Ventral Striatum Neurons. PLOS Biology, 13(6). DOI: 10.1371/journal.pbio.1002173
I was really rather happy to see the "preliminary evidence" reported by Rebecca Schmidt and colleagues  when it came to examining whether selected vitamin D metabolic gene variants might show linkage to autism spectrum disorder (ASD) based on data derived from the CHARGE initiative.For quite a while now I've discussed the various peer-reviewed science on the topic of vitamin D deficiency / insufficiency with autism in mind on this blog (see here and see here for example). Specifically, h........ Read more »
Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Sconberg JL, Schmidt LC, Volk HE, & Tassone F. (2015) Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early human development, 91(8), 483-489. PMID: 26073892
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Foot Strike Pattern and Injury Rates... Read more »
Warr BJ, Fellin RE, Sauer SG, Goss DL, Frykman PN, & Seay JF. (2015) Characterization of Foot-Strike Patterns: Lack of an Association With Injuries or Performance in Soldiers. Military medicine, 180(7), 830-4. PMID: 26126256
Physicists at the University of Sussex have found a way of using everyday technology found in kitchen microwaves and mobile telephones to bring quantum physics closer to helping solve enormous scientific problems that the most powerful of today’s supercomputers cannot even begin to embark upon.... Read more »
Weidt, S., Randall, J., Webster, S., Standing, E., Rodriguez, A., Webb, A., Lekitsch, B., & Hensinger, W. (2015) Ground-State Cooling of a Trapped Ion Using Long-Wavelength Radiation. Physical Review Letters, 115(1). DOI: 10.1103/PhysRevLett.115.013002
Biologically active molecules released by digesting bread and pasta can survive digestion and potentially pass through the gut lining, suggests new research. The study reveals the molecules released when real samples of bread and pasta are digested, providing new information for research into gluten sensitivity.... Read more »
Stuknytė, M., Maggioni, M., Cattaneo, S., De Luca, P., Fiorilli, A., Ferraretto, A., & De Noni, I. (2015) Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium. Food Research International, 208-214. DOI: 10.1016/j.foodres.2015.04.002
Research into how bacteria fight viruses has spurred a revolution in genetic engineering referred to as "CRISPR". CRISPR provides unprecedented ways to easily modify the genome of any living creature, including humans.... Read more »
Sander JD, & Joung JK. (2014) CRISPR-Cas systems for editing, regulating and targeting genomes. Nature biotechnology, 32(4), 347-55. PMID: 24584096
Garneau, J., Dupuis, M., Villion, M., Romero, D., Barrangou, R., Boyaval, P., Fremaux, C., Horvath, P., Magadán, A., & Moineau, S. (2010) The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature, 468(7320), 67-71. DOI: 10.1038/nature09523
Horie, M., Honda, T., Suzuki, Y., Kobayashi, Y., Daito, T., Oshida, T., Ikuta, K., Jern, P., Gojobori, T., Coffin, J.... (2010) Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature, 463(7277), 84-87. DOI: 10.1038/nature08695
Horvath, P., & Barrangou, R. (2010) CRISPR/Cas, the Immune System of Bacteria and Archaea. Science, 327(5962), 167-170. DOI: 10.1126/science.1179555
Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R., Church, G., Corn, J., Daley, G., Doudna, J., Fenner, M.... (2015) A prudent path forward for genomic engineering and germline gene modification. Science, 348(6230), 36-38. DOI: 10.1126/science.aab1028
In keeping with the theme of “standing” being better for us from earlier this week, I thought I’d tackle another journal article discussing the merits of standing. This time, the research included participants well-beyond the 2nd and 3rd grade, but still used students … Continue reading →... Read more »
Knight, A., & Baer, M. (2014) Get Up, Stand Up: The Effects of a Non-Sedentary Workspace on Information Elaboration and Group Performance. Social Psychological and Personality Science, 5(8), 910-917. DOI: 10.1177/1948550614538463
For many shy people, online social networking sites have an obvious appeal – a way to socialise without the unpredictable immediacy of a face-to-face encounter. However, a new study finds that people who are socially anxious betray their awkwardness on Facebook, much as they do in the offline world. The researchers Aaron Weidman and Cheri Levinson said their findings could hint at ways for socially anxious people to conceal their nervousness and attract more online friends.Seventy-seven studen........ Read more »
Weidman, A., & Levinson, C. (2015) I’m still socially anxious online: Offline relationship impairment characterizing social anxiety manifests and is accurately perceived in online social networking profiles. Computers in Human Behavior, 12-19. DOI: 10.1016/j.chb.2014.12.045
"Individuals with acute bipolar depression show immune alterations. Some of the alterations are similar to those found in acute mania."That was the bottom line reported by Faith Dickerson and colleagues  following their analysis of blood samples provided by "82 individuals with acute bipolar depression, 147 with acute mania, and 280 controls." Looking for the presence of various antibodies to "human herpesviruses, gliadin, Toxoplasma gondii, and endogenous retroviruses as well as for C-reacti........ Read more »
Comparison of running injuries between shod and barefoot ... Read more »
Altman, A., & Davis, I. (2015) Prospective comparison of running injuries between shod and barefoot runners. British Journal of Sports Medicine. DOI: 10.1136/bjsports-2014-094482
For decades, researchers in the genetics field have theorized that the protein spools around which DNA is wound, histones, remain constant in the brain, never changing after development in the womb. Now, researchers from the Icahn School of Medicine at Mount Sinai have discovered that histones are steadily replaced in brain cells throughout life – a process which helps to switch genes on and off.... Read more »
Maze, I., Wenderski, W., Noh, K., Bagot, R., Tzavaras, N., Purushothaman, I., Elsässer, S., Guo, Y., Ionete, C., Hurd, Y.... (2015) Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron, 87(1), 77-94. DOI: 10.1016/j.neuron.2015.06.014
Scientific activity as a social enterprise must maintain its credibility. The Transparency and Openness Promotion (TOP) Guidelines are presented as a recent and innovative initiative for scientific journals, and as one of the ways to guard this social value. … Read More →... Read more »
Alberts, B., Cicerone, R., Fienberg, S., Kamb, A., McNutt, M., Nerem, R., Schekman, R., Shiffrin, R., Stodden, V., Suresh, S.... (2015) Self-correction in science at work. Science, 348(6242), 1420-1422. DOI: 10.1126/science.aab3847
This week’s Video Tip of the Week covers a different aspect of bioinformatics than some of our other tips. But having been trained as a cell biologist, I do consider imaging software as an important part of the crucial software ecosystem. Also, since it’s a holiday week and traffic may be light in the US, […]... Read more »
Barbier de Reuille, P., Routier-Kierzkowska, A., Kierzkowski, D., Bassel, G., Schüpbach, T., Tauriello, G., Bajpai, N., Strauss, S., Weber, A., Kiss, A.... (2015) MorphoGraphX: A platform for quantifying morphogenesis in 4D. eLife. DOI: 10.7554/eLife.05864
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