by Artem Kaznatcheev in Evolutionary Games Group
Recently, I have been interacting more and more closely with experiment. This has put me in the fortunate position of balancing the design and analysis of both theoretical and experimental models. It is tempting to think of theorists as people that come up with ideas to explain an existing body of facts, and of mathematical […]... Read more »
Shnerb, N.M., Louzoun, Y., Bettelheim, E., & Solomon, S. (2000) The importance of being discrete: life always wins on the surface. Proceedings of the National Academy of Sciences, 97(19), 10322-4. PMID: 10962027
by thelonevirologist in Virology Tidbits
Zika Virus (ZIKV) is a emerging positive strand RNA virus that belongs to the genus of Flaviviridae. Human infections are mostly asymptomatic although a causative link to microcephaly and Guillan-Barre Syndrome (GBS) have been proposed.
So far however no reliable animal model to study ZIKV associated disease has been identified but in order to test a potential vaccine and order to gain a better understanding of ZIKV pathogenesis animal models are being developed. Similar to DENV, these models ........ Read more »
Musso D, & Gubler DJ. (2016) Zika Virus. Clinical microbiology reviews, 29(3), 487-524. PMID: 27029595
Chan KW, Watanabe S, Kavishna R, Alonso S, & Vasudevan SG. (2015) Animal models for studying dengue pathogenesis and therapy. Antiviral research, 5-14. PMID: 26304704
DICK GW. (1952) Zika virus. II. Pathogenicity and physical properties. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(5), 521-34. PMID: 12995441
Rossi SL, Tesh RB, Azar SR, Muruato AE, Hanley KA, Auguste AJ, Langsjoen RM, Paessler S, Vasilakis N, & Weaver SC. (2016) Characterization of a Novel Murine Model to Study Zika Virus. The American journal of tropical medicine and hygiene. PMID: 27022155
Lazear, H., Govero, J., Smith, A., Platt, D., Fernandez, E., Miner, J., & Diamond, M. (2016) A Mouse Model of Zika Virus Pathogenesis. Cell Host . DOI: 10.1016/j.chom.2016.03.010
Bell TM, Field EJ, & Narang HK. (1971) Zika virus infection of the central nervous system of mice. Archiv fur die gesamte Virusforschung, 35(2), 183-93. PMID: 5002906
Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F.... (2015) Biology of Zika Virus Infection in Human Skin Cells. Journal of virology, 89(17), 8880-96. PMID: 26085147
Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell stem cell. PMID: 26952870
Nowakowski TJ, Pollen AA, Di Lullo E, Sandoval-Espinosa C, Bershteyn M, & Kriegstein AR. (2016) Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells. Cell stem cell. PMID: 27038591
Atkins GJ, & Sheahan BJ. (2016) Molecular Determinants of Alphavirus Neuropathogenesis in Mice. The Journal of general virology. PMID: 27028153
Liang J, Piao Y, Henry V, Tiao N, & de Groot JF. (2015) Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy. Oncotarget, 6(31), 31479-92. PMID: 26362401
Lefèvre F, Guillomot M, D'Andréa S, Battegay S, & La Bonnardière C. (1998) Interferon-delta: the first member of a novel type I interferon family. Biochimie, 80(8-9), 779-88. PMID: 9865499
Lazear HM, Daniels BP, Pinto AK, Huang AC, Vick SC, Doyle SE, Gale M Jr, Klein RS, & Diamond MS. (2015) Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier. Science translational medicine, 7(284). PMID: 25904743
Rowland, A., Washington, C., Sheffield, J., Pardo-Villamizar, C., & Segars, J. (2016) Zika virus infection in semen: a call to action and research. Journal of Assisted Reproduction and Genetics, 33(4), 435-437. DOI: 10.1007/s10815-016-0684-6
by Gal Haimovich in Green Fluorescent Blog
The hottest buzz-word in biology today is CRISPR: an adaptive immune system in bacteria and archea. At its basis is a nuclease, named Cas9, which is targeted to DNA by a short single-guide RNA (sgRNA). This turned out to be … Continue reading →... Read more »
Deng W, Shi X, Tjian R, Lionnet T, & Singer RH. (2015) CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells. Proceedings of the National Academy of Sciences of the United States of America, 112(38), 11870-5. PMID: 26324940
Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna JA, & Yeo GW. (2016) Programmable RNA Tracking in Live Cells with CRISPR/Cas9. Cell, 1-9. PMID: 26997482
by Paco Jariego in Mind the Post
Craig Venter is on a quest to find the Minimal bacterial genome. It seems the task is 70% complete now. We still don’t understand 30% of the minimum viable organism that we are able to build today, which means that, although we cannot understand what we cannot build, we need not necessarily understand what we can build.... Read more »
Hutchison, C., Chuang, R., Noskov, V., Assad-Garcia, N., Deerinck, T., Ellisman, M., Gill, J., Kannan, K., Karas, B., Ma, L.... (2016) Design and synthesis of a minimal bacterial genome. Science, 351(6280). DOI: 10.1126/science.aad6253
by Mark Lasbury in As Many Exceptions As Rules
People need the power of an elevator or our legs to rise high in a building, so how does water get from the roots of a tree to the very top leaves? Hint, it isn’t capillary action – even capillary tubes can move water only a few centimeters. The key is evaporation. But if water evaporates off plants, how do they survive during droughts? They have tricks to retain water, including developing big leaves and little leaves. Look carefully at some trees, you’ll find that they have t........ Read more »
von Caemmerer, S., & Baker, N. (2006) The Biology of Transpiration. From Guard Cells to Globe. PLANT PHYSIOLOGY, 143(1), 3-3. DOI: 10.1104/pp.104.900213
Terashima, I. (2005) Irradiance and phenotype: comparative eco-development of sun and shade leaves in relation to photosynthetic CO2 diffusion. Journal of Experimental Botany, 57(2), 343-354. DOI: 10.1093/jxb/erj014
by Mark Lasbury in As Many Exceptions As Rules
Would you believe that the anatomy of your ribs is why you can sing and an ape can’t, or that one of the same reasons you can speak is the same reason you are likely to choke to death on a hotdog? Biology is weird, and you can tell it I said so.... Read more »
Kurt, S., Fisher, S., & Ehret, G. (2012) Foxp2 Mutations Impair Auditory-Motor Association Learning. PLoS ONE, 7(3). DOI: 10.1371/journal.pone.0033130
Li, T., Zeng, Z., Zhao, Q., Wang, T., Huang, K., Li, J., Li, Y., Liu, J., Wei, Z., Wang, Y.... (2012) FoxP2 is significantly associated associated with schizophrenia and major depression in the Chinese Han Population . World Journal of Biological Psychiatry, 1-5. DOI: 10.3109/15622975.2011.615860
by thelonevirologist in Virology Tidbits
Zika Virus (ZIKV) was first isolated from monkeys in 1947 and until 2007 only isolated cases of infection in humans were reported although serologic studies suggested widespread distribution in Africa and Southeast Asia. In 2007 however ZIKV of the Asian lineage caused an outbreak in Yap/Federal Micronesia followed by an outbreak in French Polynesia in 2013 and the current outbreak in Central & South America and the Caribbean. ZIKV is mainly transmitted via infected Aedes spp.mosquitoes but sexu........ Read more »
DICK GW, KITCHEN SF, & HADDOW AJ. (1952) Zika virus. I. Isolations and serological specificity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(5), 509-20. PMID: 12995440
DICK GW. (1952) Zika virus. II. Pathogenicity and physical properties. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46(5), 521-34. PMID: 12995441
Calvet, G., Aguiar, R., Melo, A., Sampaio, S., de Filippis, I., Fabri, A., Araujo, E., de Sequeira, P., de Mendonça, M., de Oliveira, L.... (2016) Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. The Lancet Infectious Diseases. DOI: 10.1016/S1473-3099(16)00095-5
Brasil, P., Pereira, Jr., J., Raja Gabaglia, C., Damasceno, L., Wakimoto, M., Ribeiro Nogueira, R., Carvalho de Sequeira, P., Machado Siqueira, A., Abreu de Carvalho, L., Cotrim da Cunha, D.... (2016) Zika Virus Infection in Pregnant Women in Rio de Janeiro — Preliminary Report. New England Journal of Medicine. DOI: 10.1056/NEJMoa1602412
Chan JF, Choi GK, Yip CC, Cheng VC, & Yuen KY. (2016) Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease?. The Journal of infection. PMID: 26940504
Adibi, J., Marques, E., Cartus, A., & Beigi, R. (2016) Teratogenic effects of the Zika virus and the role of the placenta. The Lancet. DOI: 10.1016/S0140-6736(16)00650-4
Bell TM, Field EJ, & Narang HK. (1971) Zika virus infection of the central nervous system of mice. Archiv fur die gesamte Virusforschung, 35(2), 183-93. PMID: 5002906
Tang, H., Hammack, C., Ogden, S., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell. DOI: 10.1016/j.stem.2016.02.016
Biegel JM, & Pager CT. (2016) Hepatitis C Virus Exploitation of Processing Bodies. Journal of virology. PMID: 26937026
Katzenell S, & Leib DA. (2016) Herpes simplex virus and interferon signaling induce novel autophagic clusters in sensory neurons. Journal of virology. PMID: 26912623
Ryan EL, Hollingworth R, & Grand RJ. (2016) Activation of the DNA Damage Response by RNA Viruses. Biomolecules, 6(1). PMID: 26751489
Riz I, Hawley TS, & Hawley RG. (2015) KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models. Oncotarget, 6(17), 14814-31. PMID: 26109433
Park JM, Choi JY, Yi JM, Chung JW, Leem SH, Koh SS, & Kang TH. (2015) NDR1 modulates the UV-induced DNA-damage checkpoint and nucleotide excision repair. Biochemical and biophysical research communications, 461(3), 543-8. PMID: 25912875
Joffre C, Codogno P, Fanto M, Hergovich A, & Camonis J. (2016) STK38 at the crossroad between autophagy and apoptosis. Autophagy, 1-2. PMID: 26890257
Joffre C, Dupont N, Hoa L, Gomez V, Pardo R, Gonçalves-Pimentel C, Achard P, Bettoun A, Meunier B, Bauvy C.... (2015) The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy. Current biology : CB, 25(19), 2479-92. PMID: 26387716
Kanu N, & Behrens A. (2007) ATMIN defines an NBS1-independent pathway of ATM signalling. The EMBO journal, 26(12), 2933-41. PMID: 17525732
Matsui A, Kamada Y, & Matsuura A. (2013) The role of autophagy in genome stability through suppression of abnormal mitosis under starvation. PLoS genetics, 9(1). PMID: 23382696
Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F.... (2015) Biology of Zika Virus Infection in Human Skin Cells. Journal of virology, 89(17), 8880-96. PMID: 26085147
Beller M, Thiel K, Thul PJ, & Jäckle H. (2010) Lipid droplets: a dynamic organelle moves into focus. FEBS letters, 584(11), 2176-82. PMID: 20303960
Bukong TN, Momen-Heravi F, Kodys K, Bala S, & Szabo G. (2014) Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90. PLoS pathogens, 10(10). PMID: 25275643
Shrivastava S, Devhare P, Sujijantarat N, Steele R, Kwon YC, Ray R, & Ray RB. (2015) Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway. Journal of virology, 90(3), 1387-96. PMID: 26581990
Schorey JS, Cheng Y, Singh PP, & Smith VL. (2015) Exosomes and other extracellular vesicles in host-pathogen interactions. EMBO reports, 16(1), 24-43. PMID: 25488940
by thelonevirologist in Virology Tidbits
Both DNA and RNA viruses are dependent of cell proliferation for replication. Thus viruses often posses proteins which are able to interact with cellular proteins which are responsible for maintaining the regulation of the cell cycle. In general viruses could either slow the cell cycle or activate the cell cycle.
Using IBV and SARS as examples, the complex interaction between the activation of the DNA damage response and viral induced cell cycle arrest are discussed. ... Read more »
Flynn RL, & Zou L. (2011) ATR: a master conductor of cellular responses to DNA replication stress. Trends in biochemical sciences, 36(3), 133-40. PMID: 20947357
Rawlinson SM, & Moseley GW. (2015) The nucleolar interface of RNA viruses. Cellular microbiology, 17(8), 1108-20. PMID: 26041433
Wulan WN, Heydet D, Walker EJ, Gahan ME, & Ghildyal R. (2015) Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses. Frontiers in microbiology, 553. PMID: 26082769
Xu LH, Huang M, Fang SG, & Liu DX. (2011) Coronavirus infection induces DNA replication stress partly through interaction of its nonstructural protein 13 with the p125 subunit of DNA polymerase δ. The Journal of biological chemistry, 286(45), 39546-59. PMID: 21918226
Wang, F., Fei, H., Cui, Y., Sun, Y., Li, Z., Wang, X., Yang, X., Zhang, J., & Sun, B. (2014) The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis, 19(9), 1389-1398. DOI: 10.1007/s10495-014-1010-3
Dove B, Brooks G, Bicknell K, Wurm T, & Hiscox JA. (2006) Cell cycle perturbations induced by infection with the coronavirus infectious bronchitis virus and their effect on virus replication. Journal of virology, 80(8), 4147-56. PMID: 16571830
Liou JS, Wu YC, Yen WY, Tang YS, Kakadiya RB, Su TL, & Yih LH. (2014) Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest. Toxicology and applied pharmacology, 278(3), 249-58. PMID: 24823293
Wrighton, K. (2015) Autophagy: Chaperone-mediated autophagy degrades CHK1. Nature Reviews Molecular Cell Biology, 16(6), 328-328. DOI: 10.1038/nrm4003
Filippi-Chiela EC, Villodre ES, Zamin LL, & Lenz G. (2011) Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells. PloS one, 6(6). PMID: 21695150
Lee IH, Kawai Y, Fergusson MM, Rovira II, Bishop AJ, Motoyama N, Cao L, & Finkel T. (2012) Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science (New York, N.Y.), 336(6078), 225-8. PMID: 22499945
Wojciechowski J, Horky M, Gueorguieva M, & Wesierska-Gadek J. (2003) Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine-induced apoptosis of human MCF-7 breast cancer cells. International journal of cancer. Journal international du cancer, 106(4), 486-95. PMID: 12845642
Xu L, Khadijah S, Fang S, Wang L, Tay FP, & Liu DX. (2010) The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication. Journal of virology, 84(17), 8571-83. PMID: 20573827
Han C, Liu Y, Wan G, Choi HJ, Zhao L, Ivan C, He X, Sood AK, Zhang X, & Lu X. (2014) The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Cell reports, 8(5), 1447-60. PMID: 25176654
Li FQ, Tam JP, & Liu DX. (2007) Cell cycle arrest and apoptosis induced by the coronavirus infectious bronchitis virus in the absence of p53. Virology, 365(2), 435-45. PMID: 17493653
Yuan L, Chen Z, Song S, Wang S, Tian C, Xing G, Chen X, Xiao ZX, He F, & Zhang L. (2015) p53 degradation by a coronavirus papain-like protease suppresses type I interferon signaling. The Journal of biological chemistry, 290(5), 3172-82. PMID: 25505178
Ding L, Huang Y, Du Q, Dong F, Zhao X, Zhang W, Xu X, & Tong D. (2014) TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and biophysical research communications, 445(2), 497-503. PMID: 24548406
Huang Y, Ding L, Li Z, Dai M, Zhao X, Li W, Du Q, Xu X, & Tong D. (2013) Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling. The Journal of general virology, 94(Pt 8), 1807-17. PMID: 23677787
by Jalees Rehman in The Next Regeneration
Can shame be good for you? We often think of shame as a shackling emotion which thwarts our individuality and creativity. A sense of shame could prevent us from choosing a partner we truly love, speaking out against societal traditions which propagate injustice or pursuing a profession that is deemed unworthy by our peers. But if shame is so detrimental, why did we evolve with this emotion? A team of researchers led by Daniel Sznycer from the Center for Evolutionary Psychology at the University ........ Read more »
Sznycer D, Tooby J, Cosmides L, Porat R, Shalvi S, & Halperin E. (2016) Shame closely tracks the threat of devaluation by others, even across cultures. Proceedings of the National Academy of Sciences of the United States of America. PMID: 26903649
by Perikis Livas in Chilon
Το ερέθισμα των Περσικών πολέμων (502-449 π.Χ) και η ανέλπιστη νίκη των Ελλήνων, έβγαλαν την κυρίως Ελλάδα από τ&e........; Read more »
Chilon. (2016) Ο οίκος των Αχαιμενιδών. Chilon . info:/
by Danielle Stevenson in BHD Research Blog
The majority of BHD patients develop pulmonary cysts and approximately 1 in 3 will suffer a pneumothorax. Although BHD pulmonary cysts have defining characteristics compared to other cystic lung diseases (as discussed in recent reviews), the underlying pathogenesis is not yet clearly understood. A recent review from Kennedy, Khabibullin & Henske (2016) summarises the current understanding of BHD pulmonary pathology relative to the stretch hypothesis for cyst formation.... Read more »
Kennedy JC, Khabibullin D, & Henske EP. (2016) Mechanisms of Pulmonary Cyst Pathogenesis in Birt-Hogg-Dube Syndrome: The Stretch Hypothesis. Seminars in cell . PMID: 26877139
by Jens Wilkinson in It Ain't Magic
An interview with Yuko Kiyosue, discussing the 3D images of living cells that gained her and her colleagues a recent award for best paper in Science magazine.... Read more »
Chen BC, Legant WR, Wang K, Shao L, Milkie DE, Davidson MW, Janetopoulos C, Wu XS, Hammer JA 3rd, Liu Z.... (2014) Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution. Science (New York, N.Y.), 346(6208), 1257998. PMID: 25342811
by thelonevirologist in Virology Tidbits
Arboviruses such as Dengue Virus (DENV), Chikungunya Virus (CHIKV) or Zika Virus (ZIKV) are arthropod borne viruses that are transmitted to humans via a relatively small number of mosquito species, in particular Aedes spp. and Culex spp., and only rarely does human-to-human transmission occur. Humans and other vertebrate animals may serve as a secondary host and in the absence of human-to-human transmission as a reservoir host. Indeed, uninfected (female) mosquitoes only become infected followin........ Read more »
Clem RJ. (2016) Arboviruses and apoptosis: the role of cell death in determining vector competence. The Journal of general virology. PMID: 26872460
Franz AW, Kantor AM, Passarelli AL, & Clem RJ. (2015) Tissue Barriers to Arbovirus Infection in Mosquitoes. Viruses, 7(7), 3741-67. PMID: 26184281
Hegde S, Rasgon JL, & Hughes GL. (2015) The microbiome modulates arbovirus transmission in mosquitoes. Current opinion in virology, 97-102. PMID: 26363996
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Apte-Deshpande AD, Paingankar MS, Gokhale MD, & Deobagkar DN. (2014) Serratia odorifera mediated enhancement in susceptibility of Aedes aegypti for chikungunya virus. The Indian journal of medical research, 139(5), 762-8. PMID: 25027087
Kamalakannan V, Shiny A, Babu S, & Narayanan RB. (2015) Autophagy protects monocytes from Wolbachia heat shock protein 60-induced apoptosis and senescence. PLoS neglected tropical diseases, 9(4). PMID: 25849993
Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, & Eissa NT. (2007) Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity, 27(1), 135-44. PMID: 17658277
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Remijsen Q, Kuijpers TW, Wirawan E, Lippens S, Vandenabeele P, & Vanden Berghe T. (2011) Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell death and differentiation, 18(4), 581-8. PMID: 21293492
Stoiber W, Obermayer A, Steinbacher P, & Krautgartner WD. (2015) The Role of Reactive Oxygen Species (ROS) in the Formation of Extracellular Traps (ETs) in Humans. Biomolecules, 5(2), 702-23. PMID: 25946076
Miller, S., Kastner, S., Krijnse-Locker, J., Buhler, S., & Bartenschlager, R. (2007) The Non-structural Protein 4A of Dengue Virus Is an Integral Membrane Protein Inducing Membrane Alterations in a 2K-regulated Manner. Journal of Biological Chemistry, 282(12), 8873-8882. DOI: 10.1074/jbc.M609919200
Ruggieri V, Mazzoccoli C, Pazienza V, Andriulli A, Capitanio N, & Piccoli C. (2014) Hepatitis C virus, mitochondria and auto/mitophagy: exploiting a host defense mechanism. World journal of gastroenterology, 20(10), 2624-33. PMID: 24627598
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Schroeder B, Schulze RJ, Weller SG, Sletten AC, Casey CA, & McNiven MA. (2015) The small GTPase Rab7 as a central regulator of hepatocellular lipophagy. Hepatology (Baltimore, Md.), 61(6), 1896-907. PMID: 25565581
Goeritzer M, Vujic N, Schlager S, Chandak PG, Korbelius M, Gottschalk B, Leopold C, Obrowsky S, Rainer S, Doddapattar P.... (2015) Active autophagy but not lipophagy in macrophages with defective lipolysis. Biochimica et biophysica acta, 1851(10), 1304-16. PMID: 26143381
Liu K, & Czaja MJ. (2013) Regulation of lipid stores and metabolism by lipophagy. Cell death and differentiation, 20(1), 3-11. PMID: 22595754
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Fang YT, Wan SW, Lu YT, Yao JH, Lin CF, Hsu LJ, Brown MG, Marshall JS, Anderson R, & Lin YS. (2014) Autophagy facilitates antibody-enhanced dengue virus infection in human pre-basophil/mast cells. PloS one, 9(10). PMID: 25329914
Metz P, Chiramel A, Chatel-Chaix L, Alvisi G, Bankhead P, Mora-Rodriguez R, Long G, Hamacher-Brady A, Brady NR, & Bartenschlager R. (2015) Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62. Journal of virology, 89(15), 8026-41. PMID: 26018155
Ronan B, Flamand O, Vescovi L, Dureuil C, Durand L, Fassy F, Bachelot MF, Lamberton A, Mathieu M, Bertrand T.... (2014) A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nature chemical biology, 10(12), 1013-9. PMID: 25326666
Di Venanzio G, Stepanenko TM, & García Véscovi E. (2014) Serratia marcescens ShlA pore-forming toxin is responsible for early induction of autophagy in host cells and is transcriptionally regulated by RcsB. Infection and immunity, 82(9), 3542-54. PMID: 24914224
Kathiria AS, Butcher LD, Feagins LA, Souza RF, Boland CR, & Theiss AL. (2012) Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells. PloS one, 7(2). PMID: 22363587
Kuadkitkan A, Wikan N, Fongsaran C, & Smith DR. (2010) Identification and characterization of prohibitin as a receptor protein mediating DENV-2 entry into insect cells. Virology, 406(1), 149-61. PMID: 20674955
Le Clec'h W, Braquart-Varnier C, Raimond M, Ferdy JB, Bouchon D, & Sicard M. (2012) High virulence of Wolbachia after host switching: when autophagy hurts. PLoS pathogens, 8(8). PMID: 22876183
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Skelton E, Rancès E, Frentiu FD, Kusmintarsih ES, Iturbe-Ormaetxe I, Caragata EP, Woolfit M, & O'Neill SL. (2015) A Native Wolbachia Endosymbiont Does Not Limit Dengue Virus Infection in the Mosquito Aedes notoscriptus (Diptera: Culicidae). Journal of medical entomology. PMID: 26721865
Stevanovic AL, Arnold PA, & Johnson KN. (2015) Wolbachia-mediated antiviral protection in Drosophila larvae and adults following oral infection. Applied and environmental microbiology, 81(23), 8215-23. PMID: 26407882
Tang WC, Lin RJ, Liao CL, & Lin YL. (2014) Rab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replication. Journal of virology, 88(12), 6793-804. PMID: 24696471
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Paul, D., & Bartenschlager, R. (2015) Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave. Annual Review of Virology, 2(1), 289-310. DOI: 10.1146/annurev-virology-100114-055007
Perera R, Riley C, Isaac G, Hopf-Jannasch AS, Moore RJ, Weitz KW, Pasa-Tolic L, Metz TO, Adamec J, & Kuhn RJ. (2012) Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. PLoS pathogens, 8(3). PMID: 22457619
Panyasrivanit M, Khakpoor A, Wikan N, & Smith DR. (2009) Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes. The Journal of general virology, 90(Pt 2), 448-56. PMID: 19141455
Huang J, Li Y, Qi Y, Zhang Y, Zhang L, Wang Z, Zhang X, & Gui L. (2014) Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection. Molecular and cellular biochemistry, 397(1-2), 157-65. PMID: 25138703
Lee, Y., Hu, H., Kuo, S., Lei, H., Lin, Y., Yeh, T., Liu, C., & Liu, H. (2013) Dengue virus infection induces autophagy: an in vivo study. Journal of Biomedical Science, 20(1), 65. DOI: 10.1186/1423-0127-20-65
by Perikis Livas in Chilon
Η Ιερά Εξέταση ήταν Εκκλησιαστικός θεσμός δικαστικού χαρακτήρα της Ρωμαιοκαθολικής Εκκλησί&al........; Read more »
Chilon-Pitheys. (2016) Η Ιερά Εξέταση. Chilon . info:/
First appeared on my Huffington Post blog on February 15, 2016. In 1994, researchers from Harvard and Stanford published a paper in which they described three mice: one was yellow and fat, one mottled and fat, and the last one was brown and lean. An ordinary image, except for one thing: despite being so different, all three mice were genetically identical. If their genes were exactly the same, what was causing such striking differences in the mice?Three genetically identical mice that do n........ Read more »
Duhl DM, Vrieling H, Miller KA, Wolff GL, & Barsh GS. (1994) Neomorphic agouti mutations in obese yellow mice. Nature genetics, 8(1), 59-65. PMID: 7987393
Tung CS, & Sanbonmatsu KY. (2004) Atomic model of the Thermus thermophilus 70S ribosome developed in silico. Biophysical journal, 87(4), 2714-22. PMID: 15454463
Sanbonmatsu KY, Joseph S, & Tung CS. (2005) Simulating movement of tRNA into the ribosome during decoding. Proceedings of the National Academy of Sciences of the United States of America, 102(44), 15854-9. PMID: 16249344
Sanbonmatsu KY. (2016) Towards structural classification of long non-coding RNAs. Biochimica et biophysica acta, 1859(1), 41-5. PMID: 26537437
by thelonevirologist in Virology Tidbits
As discussed before, Zika Virus (ZIKV) is an emerging arbovirus, spread by Aedes Agypti and Aedes albopictus, which was first isolated in 1947 in Uganda from a Macaca monkey with the first human case being detected in Nigeria (1954). In subsequent decades sporadic cases linked to ZIKV have been reported in Africa and Asia, with a first epidemic reported in 2008 (Yap/Federated States of Micronesia) and a larger one in French Polynesia and Oceania 2013-2014 with the first cases in the Americas wer........ Read more »
SMITHBURN KC, & BUGHER JC. (1953) Ultrafiltration of recently isolated neurotropic viruses. Journal of bacteriology, 66(2), 173-7. PMID: 13084555
Diagne CT, Diallo D, Faye O, Ba Y, Faye O, Gaye A, Dia I, Faye O, Weaver SC, Sall AA.... (2015) Potential of selected Senegalese Aedes spp. mosquitoes (Diptera: Culicidae) to transmit Zika virus. BMC infectious diseases, 492. PMID: 26527535
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MACNAMARA FN. (1954) Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 48(2), 139-45. PMID: 13157159
Zanluca C, de Melo VC, Mosimann AL, Dos Santos GI, Dos Santos CN, & Luz K. (2015) First report of autochthonous transmission of Zika virus in Brazil. Memorias do Instituto Oswaldo Cruz, 110(4), 569-72. PMID: 26061233
Schuler-Faccini L, Ribeiro EM, Feitosa IM, Horovitz DD, Cavalcanti DP, Pessoa A, Doriqui MJ, Neri JI, Neto JM, Wanderley HY.... (2016) Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015. MMWR. Morbidity and mortality weekly report, 65(3), 59-62. PMID: 26820244
Carneiro LA, & Travassos LH. (2016) Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus. Microbes and infection / Institut Pasteur. PMID: 26774331
Musso D, Nhan T, Robin E, Roche C, Bierlaire D, Zisou K, Shan Yan A, Cao-Lormeau VM, & Broult J. (2014) Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Euro surveillance : bulletin Europeen sur les maladies transmissibles , 19(14). PMID: 24739982
Aubry M, Richard V, Green J, Broult J, & Musso D. (2016) Inactivation of Zika virus in plasma with amotosalen and ultraviolet A illumination. Transfusion, 56(1), 33-40. PMID: 26283013
Musso D, Roche C, Robin E, Nhan T, Teissier A, & Cao-Lormeau VM. (2015) Potential sexual transmission of Zika virus. Emerging infectious diseases, 21(2), 359-61. PMID: 25625872
Oster, A., Brooks, J., Stryker, J., Kachur, R., , ., Mead, P., Pesik, N., & Petersen, L. (2016) Interim Guidelines for Prevention of Sexual Transmission of Zika Virus — United States, 2016. MMWR. Morbidity and Mortality Weekly Report, 65(5), 1-2. DOI: 10.15585/mmwr.mm6505e1er
by Perikis Livas in Chilon
Ο Ανδρέας Βεσάλιος (Andreas Vesalius, γνωστός και ως Βεζάλιος ή Βεζάλ) γεννήθηκε την 31 Δεκεμβρίου 1514, ή νωρίς το πρ&ome........; Read more »
Πυθεύς. (2016) Ανδρέας Βεσάλιος……….ο ιδρυτής της σύγχρονης ανατομίας. Chilon . info:/
by Mark Lasbury in As Many Exceptions As Rules
If you don't let your plants sleep at night, they die....really! Several species of plants fold their leaves up and reduce their activity at night, every night. If kept from doing that, they turn brown and shrivel up. It's called nyctinasty, and it is different from tropic movements that are directed against specifically positioned stimuli. And what directs their movements? Water! - plants are hydraulic machines.... Read more »
Ueda, M., & Nakamura, Y. (2006) Metabolites involved in plant movement and ?memory?: nyctinasty of legumes and trap movement in the Venus flytrap. Natural Product Reports, 23(4), 548. DOI: 10.1039/b515708k
by thelonevirologist in Virology Tidbits
Zika Virus (ZIKV) is an arbovirus belonging to the Flaviviridae transmitted primarily by mosquitoes (including Aedes Agypti). Although first identified in a resuscitate monkey from the forests in Uganda in the year 1947 with estimated first emergence probably in 1920, the first human case was only reported in 1964. ZIKV has been shown to be distributed Northern Africa as well as in Southeast Asia; however only a few human cases in Africa and Asia were identified until 2007, when a ZIKV outbreak ........ Read more »
Ioos S, Mallet HP, Leparc Goffart I, Gauthier V, Cardoso T, & Herida M. (2014) Current Zika virus epidemiology and recent epidemics. Medecine et maladies infectieuses, 44(7), 302-7. PMID: 25001879
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Yang TC, Shiu SL, Chuang PH, Lin YJ, Wan L, Lan YC, & Lin CW. (2009) Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells. Virus research, 143(1), 77-85. PMID: 19463724
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Tetro JA. (2016) Zika and microcephaly: Causation, correlation, or coincidence?. Microbes and infection / Institut Pasteur. PMID: 26774330
Foy BD, Kobylinski KC, Chilson Foy JL, Blitvich BJ, Travassos da Rosa A, Haddow AD, Lanciotti RS, & Tesh RB. (2011) Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerging infectious diseases, 17(5), 880-2. PMID: 21529401
Salvetti A, & Greco A. (2014) Viruses and the nucleolus: the fatal attraction. Biochimica et biophysica acta, 1842(6), 840-7. PMID: 24378568
Xu Z, Anderson R, & Hobman TC. (2011) The capsid-binding nucleolar helicase DDX56 is important for infectivity of West Nile virus. Journal of virology, 85(11), 5571-80. PMID: 21411523
Katoh H, Mori Y, Kambara H, Abe T, Fukuhara T, Morita E, Moriishi K, Kamitani W, & Matsuura Y. (2011) Heterogeneous nuclear ribonucleoprotein A2 participates in the replication of Japanese encephalitis virus through an interaction with viral proteins and RNA. Journal of virology, 85(21), 10976-88. PMID: 21865391
Buckley A, & Gould EA. (1988) Detection of virus-specific antigen in the nuclei or nucleoli of cells infected with Zika or Langat virus. The Journal of general virology, 1913-20. PMID: 2841406
Westaway EG, Khromykh AA, Kenney MT, Mackenzie JM, & Jones MK. (1997) Proteins C and NS4B of the flavivirus Kunjin translocate independently into the nucleus. Virology, 234(1), 31-41. PMID: 9234944
Buckley A, Gaidamovich S, Turchinskaya A, & Gould EA. (1992) Monoclonal antibodies identify the NS5 yellow fever virus non-structural protein in the nuclei of infected cells. The Journal of general virology, 1125-30. PMID: 1534119
Yang MR, Lee SR, Oh W, Lee EW, Yeh JY, Nah JJ, Joo YS, Shin J, Lee HW, Pyo S.... (2008) West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus. Cellular microbiology, 10(1), 165-76. PMID: 17697133
Shives KD, Beatman EL, Chamanian M, O'Brien C, Hobson-Peters J, & Beckham JD. (2014) West nile virus-induced activation of mammalian target of rapamycin complex 1 supports viral growth and viral protein expression. Journal of virology, 88(16), 9458-71. PMID: 24920798
Urbanowski MD, & Hobman TC. (2013) The West Nile virus capsid protein blocks apoptosis through a phosphatidylinositol 3-kinase-dependent mechanism. Journal of virology, 87(2), 872-81. PMID: 23115297
Blázquez AB, Martín-Acebes MA, & Saiz JC. (2014) Amino acid substitutions in the non-structural proteins 4A or 4B modulate the induction of autophagy in West Nile virus infected cells independently of the activation of the unfolded protein response. Frontiers in microbiology, 797. PMID: 25642225
Martín-Acebes MA, & Saiz JC. (2011) A West Nile virus mutant with increased resistance to acid-induced inactivation. The Journal of general virology, 92(Pt 4), 831-40. PMID: 21228127
Martín-Acebes MA, Blázquez AB, & Saiz JC. (2015) Reconciling West Nile virus with the autophagic pathway. Autophagy, 11(5), 861-4. PMID: 25946067
Naing ZW, Scott GM, Shand A, Hamilton ST, van Zuylen WJ, Basha J, Hall B, Craig ME, & Rawlinson WD. (2016) Congenital cytomegalovirus infection in pregnancy: a review of prevalence, clinical features, diagnosis and prevention. The Australian , 56(1), 9-18. PMID: 26391432
I often blog about viruses because, well, I work on viruses. Here's a quick summary of things I've blogged about that I find absolutely mind-blowing:1. About 10% of the human genome is made of genes we inherited from viruses that had replicated in our ancestors millions of years ago. 2. Viruses evolve as their hosts evolve (The Red Queen Effect), and in fact we can retrace their evolution in parallel with that of their hosts. The same is true within a single host, enabling us to retrace the evol........ Read more »
Lee, Y., & Bieniasz, P. (2007) Reconstitution of an Infectious Human Endogenous Retrovirus. PLoS Pathogens, 3(1). DOI: 10.1371/journal.ppat.0030010
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