160 posts · 121,643 views
This is the blog of the evolutionary games group that launched as an extension of the earlier evolutionary game theory reading group at McGill University. It is organized by Artem Kaznatcheev and collaborates closely with Thomas R. Shultz‘s Laboratory for Natural and Simulated Cognition. We are primarily interested in the evolution of ethnocentrism, the interplay of evolution and cognition, and the effects of network topology on evolutionary simulations. Our reading concentrates on papers that apply nice analytic or computational models to questions in EGT. If you are interested in contributing to this project then feel free to email me!
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- March 31, 2016
- 02:00 AM
- 64 views
Mutation-bias driving the evolution of mutation rates
by Julian Xue in Evolutionary Games Group
In classic game theory, we are often faced with multiple potential equilibria between which to select with no unequivocal way to choose between these alternatives. If you’ve ever heard Artem justify dynamic approaches, such as evolutionary game theory, then you’ve seen this equilibrium selection problem take center stage. Natural selection has an analogous ‘problem’ of […]... Read more »
Yampolsky, L.Y., & Stoltzfus, A. (2001) Bias in the introduction of variation as an orienting factor in evolution. Evolution , 3(2), 73-83. PMID: 11341676
- March 26, 2016
- 11:45 PM
- 87 views
Don’t treat the player, treat the game: buffer therapy and bevacizumab
by Artem Kaznatcheev in Evolutionary Games Group
No matter how much I like modeling for the sake of modeling, or science for the sake of science, working in a hospital adds some constraints. At some point people look over at you measuring games in the Petri dish and ask “why are you doing this?” They expect an answer that involves something that […]... Read more »
Gatenby, R.A., & Gawlinski, E.T. (2003) The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer Research, 63(14), 3847-54. PMID: 12873971
- March 17, 2016
- 09:45 PM
- 119 views
Variation for supply driven evolution
by Julian Xue in Evolutionary Games Group
I’ve taken a very long hiatus (nearly 5 years!) from this blog. I suppose getting married and getting an MD are good excuses, but Artem has very kindly let me return. And I greatly appreciate this chance, because I’d like to summarize an idea I had been working on for a while. So far, only two publication has […]... Read more »
Xue, J.Z., Costopoulos, A., & Guichard, F. (2015) A Trait-based framework for mutation bias as a driver of long-term evolutionary trends. Complexity. DOI: 10.1002/cplx.21660
- February 9, 2016
- 11:30 PM
- 206 views
Lotka-Volterra, replicator dynamics, and stag hunting bacteria
by Artem Kaznatcheev in Evolutionary Games Group
Happy year of the monkey! Last time in the Petri dish, I considered the replicator dynamics between type-A and type-B cells abstractly. In the comments, Arne Traulsen pointed me to Li et al. (2015): We have attempted something similar in spirit with bacteria. Looking at frequencies alone, it looked like coordination. But taking into account […]... Read more »
Li, X.-Y., Pietschke, C., Fraune, S., Altrock, P.M., Bosch, T.C., & Traulsen, A. (2015) Which games are growing bacterial populations playing?. Journal of the Royal Society Interface, 12(108), 20150121. PMID: 26236827
- February 4, 2016
- 11:30 PM
- 249 views
Hadza hunter-gatherers, social networks, and models of cooperation
by Artem Kaznatcheev in Evolutionary Games Group
At the heart of the Great Lakes region of East Africa is Tanzania — a republic comprised of 30 mikoa, or provinces. Its border is marked off by the giant lakes Victoria, Tanganyika, and Malawi. But the lake that interests me the most is an internal one: 200 km from the border with Kenya at […]... Read more »
Apicella, C.L., Marlowe, F.W., Fowler, J.H., & Christakis, N.A. (2012) Social networks and cooperation in hunter-gatherers. Nature, 481(7382), 497-501. PMID: 22281599
- January 27, 2016
- 11:00 PM
- 254 views
Measuring games in the Petri dish
by Artem Kaznatcheev in Evolutionary Games Group
For the next couple of months, Jeffrey Peacock is visiting Moffitt. He’s a 4th year medical student at the University of Central Florida with a background in microbiology and genetic engineering of bacteria and yeast. Together with Andriy Marusyk and Jacob Scott, he will move to human cells and run some in vitro experiments with […]... Read more »
Archetti, M., Ferraro, D.A., & Christofori, G. (2015) Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 112(6), 1833-8. PMID: 25624490
- January 19, 2016
- 11:45 PM
- 259 views
A year in books: Neanderthals to the National Cancer Act to now
by Artem Kaznatcheev in Evolutionary Games Group
A tradition I started a couple of years ago is to read at least one non-fiction book per month and then to share my thoughts on the reading at the start of the following year. Last year, my dozen books were mostly on philosophy, psychology, and political economy. My brief comments on them ended up […]... Read more »
Monge, J., Kricun, M., Radovčić, J., Radovčić, D., Mann, A., & Frayer, D. (2013) Fibrous Dysplasia in a 120,000 Year Old Neandertal from Krapina, Croatia. PLoS ONE, 8(6). DOI: 10.1371/journal.pone.0064539
- December 6, 2015
- 11:45 PM
- 345 views
Evolutionary dynamics of cancer in the bone
by Artem Kaznatcheev in Evolutionary Games Group
I don’t know about you, dear reader, but when I was a senior in highschool, I was busy skipping class to play CounterStrike. And I wasn’t even any good at it. Pranav Warman, however, is busy spending his senior year curing cancer. Or at least modeling it. On Friday, David Basanta, Pranav, and I spent […]... Read more »
Basanta, D., Scott, J.G., Fishman, M.N., Ayala, G., Hayward, S.W., & Anderson, A.R. (2012) Investigating prostate cancer tumour-stroma interactions: clinical and biological insights from an evolutionary game. British journal of Cancer, 106(1), 174-81. PMID: 22134510
- November 29, 2015
- 11:45 PM
- 440 views
Diversity and persistence of group tags under replicator dynamics
by Artem Kaznatcheev in Evolutionary Games Group
Everyday I walk to the Stabile Research Building to drink espresso and sit in my cozy — although oversaturated with screens — office. Oh, and to chat about research with great people like Arturo Araujo, David Basanta, Jill Gallaher, Jacob Scott, Robert Vander Velde and other Moffitters. This walk to the office takes about 30 […]... Read more »
Jansson, F. (2015) What games support the evolution of an ingroup bias?. Journal of theoretical biology, 100-10. PMID: 25794651
- November 25, 2015
- 03:45 AM
- 397 views
From linear to nonlinear payoffs in the double public goods game
by Artem Kaznatcheev in Evolutionary Games Group
If you recall, dear reader, around this time last year, Robert Vander Velde, David Basanta, Jacob Scott and I got excited about the Archetti (2013,2014) approach to modeling non-linear public goods in cancer. We’ve been working on this intermittently for the last year, but aim to focus now that I have settled in here at […]... Read more »
Archetti, M. (2013) Evolutionary game theory of growth factor production: implications for tumour heterogeneity and resistance to therapies. British Journal of Cancer, 109(4), 1056-62. PMID: 23922110
- November 22, 2015
- 11:45 PM
- 408 views
Radicalization, expertise, and skepticism among doctors & engineers: the value of philosophy in education
by Artem Kaznatcheev in Evolutionary Games Group
This past Friday was a busy day for a lot of the folks in Integrated Mathematical Oncology here at the Moffitt Cancer Center. Everybody was rushing around to put the final touches on a multi-million dollar research center grant application to submit to the National Cancer Institute. Although the time was not busy for me, […]... Read more »
Gambetta, D., & Hertog, S. (2009) Why are there so many Engineers among Islamic Radicals?. European Journal of Sociology, 50(02), 201. DOI: 10.1017/S0003975609990129
- November 19, 2015
- 08:30 PM
- 442 views
Cytokine storms during CAR T-cell therapy for lymphoblastic leukemia
by Artem Kaznatcheev in Evolutionary Games Group
For most of the last 70 years or so, treating cancer meant one of three things: surgery, radiation, or chemotherapy. In most cases, some combination of these remains the standard of care. But cancer research does not stand still. More recent developments have included a focus on immunotherapy: using, modifying, or augmenting the patient’s natural […]... Read more »
Maude, S.L., Teachey, D.T., Porter, D.L., & Grupp, S.A. (2015) CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Blood, 125(26), 4017-23. PMID: 25999455
- March 31, 2015
- 11:45 PM
- 656 views
Operationalizing the local environment for replicator dynamics
by Artem Kaznatcheev in Evolutionary Games Group
Recently, Jake Taylor-King arrived in Tampa and last week we were brainstorming some projects to work on together. In the process, I dug up an old idea I’ve been playing with as my understanding of the Ohtsuki-Nowak transform matured. The basic goal is to work towards an operational account of spatial structure without having to […]... Read more »
Ohtsuki, H., & Nowak, M. (2006) The replicator equation on graphs. Journal of Theoretical Biology, 243(1), 86-97. DOI: 10.1016/j.jtbi.2006.06.004
- March 28, 2015
- 11:00 AM
- 716 views
Misbeliefs, evolution and games: a positive case
by Sergio Graziosi in Evolutionary Games Group
A recurrent theme here in TheEGG is the limits and reliability of knowledge. These get explored from many directions: on epistemological grounds, from the philosophy of science angle, but also formally, through game theory and simulations. In this post, I will explore the topic of misbeliefs as adaptations. Misbeliefs will be intended as ideas about […]... Read more »
Kaznatcheev, A., Montrey, M., & Shultz, T.R. (2014) Evolving useful delusions: Subjectively rational selfishness leads to objectively irrational cooperation. Proceedings of the 36th annual conference of the Cognitive Science Society. arXiv: 1405.0041v1
- March 16, 2015
- 11:45 PM
- 765 views
Pairing tools and problems: a lesson from the methods of mathematics and the Entscheidungsproblem
by Artem Kaznatcheev in Evolutionary Games Group
Three weeks ago it was my lot to present at the weekly integrated mathematical oncology department meeting. Given the informal setting, I decided to grab one gimmick and run with it. I titled my talk: ‘2’. It was an overview of two recent projects that I’ve been working on: double public goods for acid mediated […]... Read more »
Kaznatcheev, A. (2013) Complexity of evolutionary equilibria in static fitness landscapes. arXiv. arXiv: 1308.5094v1
- March 2, 2015
- 11:55 PM
- 794 views
Short history of iterated prisoner’s dilemma tournaments
by Artem Kaznatcheev in Evolutionary Games Group
Nineteen Eighty — if I had to pick the year that computational modeling invaded evolutionary game theory then that would be it. In March, 1980 — exactly thirty-five years ago — was when Robert Axelrod, a professor of political science at University of Michigan, published the results of his first tournament for iterated prisoner’s dilemma […]... Read more »
Axelrod, R. (1980) More effective choice in the prisoner's dilemma. Journal of Conflict Resolution, 24(3), 379-403. DOI: 10.1177/002200278002400301
- February 28, 2015
- 09:15 AM
- 726 views
Five motivations for theoretical computer science
by Abel Molina in Evolutionary Games Group
There are some situations, perhaps lucky ones, where it is felt that an activity needs no external motivation or justification. For the rest, it can be helpful to think of what the task at hand can be useful for. This of course doesn’t answer the larger question of what is worth doing, since it just distributes […]... Read more »
Barton, N.H., Novak, S., & Paixão, T. (2014) Diverse forms of selection in evolution and computer science. Proceedings of the National Academy of Sciences of the United States of America, 111(29), 10398-9. PMID: 25009183
- February 25, 2015
- 11:45 PM
- 894 views
Operationalizing replicator dynamics and partitioning fitness functions
by Artem Kaznatcheev in Evolutionary Games Group
As you know, dear regular reader, I have a rather uneasy relationship with reductionism, especially when doing mathematical modeling in biology. In mathematical oncology, for example, it seems that there is a hope that through our models we can bring a more rigorous mechanistic understanding of cancer, but at the same time there is the […]... Read more »
Archetti, M., Ferraro, D.A., & Christofori, G. (2015) Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 112(6), 1833-8. PMID: 25624490
- February 21, 2015
- 11:55 PM
- 725 views
Pairwise games as a special case of public goods
by Artem Kaznatcheev in Evolutionary Games Group
Usually, when we are looking at public goods games, we consider an agent interacting with a group of n other agents. In our minds, we often imagine n to be large, or sometimes even take the limit as n goes to infinity. However, this isn’t the only limit that we should consider when we are […]... Read more »
Bomze, I.M. (1983) Lotka-Volterra equation and replicator dynamics: A two-dimensional classification. Biological Cybernetics, 48(3), 201-211. DOI: 10.1007/BF00318088
- February 14, 2015
- 10:00 PM
- 643 views
Evolutionary non-commutativity suggests novel treatment strategies
by Dan Nichol in Evolutionary Games Group
In the Autumn of 2011 I received an email from Jacob Scott, now a good friend and better mentor, who was looking for an undergraduate to code an evolutionary simulation. Jake had just arrived in Oxford to start his DPhil in applied mathematics and by chance had dined at St Anne’s College with Peter Jeavons, […]... Read more »
Tan, L., Serene, S., Chao, H.X., & Gore, J. (2011) Hidden randomness between fitness landscapes limits reverse evolution. Physical Review Letters, 106(19), 198102. PMID: 21668204
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