All posts; Tags Include "Cancer"
- August 26, 2016
- 05:03 AM
- 82 views
A new Birt-Hogg-Dubé Syndrome review
by Joana Guedes in BHD Research Blog
Gupta et al. (2016b) recently published a review about Birt-Hogg-Dubé Syndrome (BHD) exploring the key points and research advances in genetics and pathogenesis, clinical manifestations, diagnosis and disease management.... Read more »
Gupta N, Sunwoo BY, & Kotloff RM. (2016) Birt-Hogg-Dubé Syndrome. Clinics in chest medicine, 37(3), 475-86. PMID: 27514594
- August 16, 2016
- 10:43 AM
- 117 views
The Angry Silence
by AG McCluskey in Zongo's Cancer Diaries
The experience of cancer patients has changed in many ways over the last 30 years. One massive improvement is that patients can talk about their diseases more freely.
And this may not just make them feel better, it might help to make them better too.......... Read more »
Lutgendorf, S., & Andersen, B. (2015) Biobehavioral approaches to cancer progression and survival: Mechanisms and interventions. American Psychologist, 70(2), 186-197. DOI: 10.1037/a0035730
MacMillan Cancer Support. (2016) Cancer: Then and Now. Diagnosis, treatment and aftercare from 1970–2016. MacMillan Cancer Support. info:/
- August 5, 2016
- 07:00 AM
- 227 views
Friday Fellow: Beggar’s tick
by Piter Boll in Earthling Nature
by Piter Kehoma Boll What if the cure for cancer has been living in your garden all this time and you have been trying to get rid of it because it is an annoying weed? I cannot assure you that … Continue reading →... Read more »
Brandão, M., Krettli, A., Soares, L., Nery, C., & Marinuzzi, H. (1997) Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds. Journal of Ethnopharmacology, 57(2), 131-138. DOI: 10.1016/S0378-8741(97)00060-3
Chang, J., Chiang, L., Chen, C., Liu, L., Wang, K., & Lin, C. (2001) Antileukemic Activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb. The American Journal of Chinese Medicine, 29(02), 303-312. DOI: 10.1142/S0192415X01000320
Chiang, L., Chang, J., Chen, C., Ng, L., & Lin, C. (2003) Anti-Herpes Simplex Virus Activity of Bidens pilosa and Houttuynia cordata. The American Journal of Chinese Medicine, 31(03), 355-362. DOI: 10.1142/S0192415X03001090
Deba, F., Xuan, T., Yasuda, M., & Tawata, S. (2008) Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. var. Radiata. Food Control, 19(4), 346-352. DOI: 10.1016/j.foodcont.2007.04.011
Kviecinski, M., Felipe, K., Schoenfelder, T., de Lemos Wiese, L., Rossi, M., Gonçalez, E., Felicio, J., Filho, D., & Pedrosa, R. (2008) Study of the antitumor potential of Bidens pilosa (Asteraceae) used in Brazilian folk medicine. Journal of Ethnopharmacology, 117(1), 69-75. DOI: 10.1016/j.jep.2008.01.017
Oliveira, F., Andrade-Neto, V., Krettli, A., & Brandão, M. (2004) New evidences of antimalarial activity of Bidens pilosa roots extract correlated with polyacetylene and flavonoids. Journal of Ethnopharmacology, 93(1), 39-42. DOI: 10.1016/j.jep.2004.03.026
Pereira, R., Ibrahim, T., Lucchetti, L., da Silva, A., & de Moraes, V. (1999) Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L. Immunopharmacology, 43(1), 31-37. DOI: 10.1016/S0162-3109(99)00039-9
Sun, Y., Zhou, Q., Wang, L., & Liu, W. (2009) Cadmium tolerance and accumulation characteristics of Bidens pilosa L. as a potential Cd-hyperaccumulator. Journal of Hazardous Materials, 161(2-3), 808-814. DOI: 10.1016/j.jhazmat.2008.04.030
- August 1, 2016
- 07:22 AM
- 173 views
Live Long & Prosper!
by AG McCluskey in Zongo's Cancer Diaries
Good news for cancer patients in the UK, as 10-year survival rates show big improvements.... Read more »
MacMillan Cancer Support. (2016) Cancer: Then and Now. Diagnosis, treatment and aftercare from 1970–2016. MacMillan Cancer Support. info:/
- July 14, 2016
- 11:30 PM
- 326 views
Evolutionary dynamics of acid and VEGF production in tumours
by Artem Kaznatcheev in Evolutionary Games Group
Today was my presentation day at ECMTB/SMB 2016. I spoke in David Basanta’s mini-symposium on the games that cancer cells play and postered during the poster session. The mini-symposium started with a brief intro from David, and had 25 minute talks from Jacob Scott, myself, Alexander Anderson, and John Nagy. David, Jake, Sandy, and John […]... Read more »
Hauert, C., De Monte, S., Hofbauer, J., & Sigmund, K. (2002) Replicator dynamics for optional public good games. Journal of Theoretical Biology, 218(2), 187-94. PMID: 12381291
- July 8, 2016
- 12:38 PM
- 302 views
FNIP1 and FNIP2 inhibit Hsp90 chaperone cycle and enhance drug binding
by Joana Guedes in BHD Research Blog
Heat shock protein-90 (Hsp90) is a molecular chaperone required for folding, stability and activity of many proteins, known as clients, including drivers of tumour initiation, progression and metastasis (Rohl et al. 2013). ATPase binding and hydrolysis is essential for the chaperone function of Hsp90. ATPase function is regulated by other proteins known as co-chaperones. In an interesting new study, Woodford et al. (2016) show that the stability of the tumour suppressor folliculin (FLCN), whose ........ Read more »
Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W.... (2016) The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nature communications, 12037. PMID: 27353360
- June 17, 2016
- 07:11 AM
- 232 views
Computer Says No: Anti-cancer therapy and Autoimmune disease: Part II
by AG McCluskey in Zongo's Cancer Diaries
Scientists have been investigating the use of cancer therapies to treat Autoimmune disease. And the reasoning behind this? Treat the immune system like a computer program...... Read more »
Dr Harold L Atkins, MDcorrespondenceemail, Marjorie Bowman, MScN, David Allan, MD, Grizel Anstee, MD, Prof Douglas L Arnold, MD, Prof Amit Bar-Or, MD, Isabelle Bence-Bruckler, MD, Paul Birch, MLT, Prof Christopher Bredeson, MD, Jacqueline Chen, PhD, Prof . (2016) Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet. info:/http://dx.doi.org/10.1016/S0140-6736(16)30169-6
Craciunescu, O., Steffey, B., Kelsey, C., Larrier, N., Paarz-Largay, C., Prosnitz, R., Chao, N., Chute, J., Gasparetto, C., Horwitz, M.... (2011) Renal Shielding and Dosimetry for Patients With Severe Systemic Sclerosis Receiving Immunoablation With Total Body Irradiation in the Scleroderma: Cyclophosphamide or Transplantation Trial. International Journal of Radiation Oncology*Biology*Physics, 79(4), 1248-1255. DOI: 10.1016/j.ijrobp.2010.05.036
AG McCluskey. (2016) Computer Says No. Zongo's Cancer Diaries. info:/
- June 17, 2016
- 05:49 AM
- 305 views
FLCN activates mTORC1 by maintaining lysosomal leucine level
by Joana Guedes in BHD Research Blog
The intracellular amino acid pool within the lysosome has been shown to activate the mTORC1 signaling pathway (Zoncu et al., 2011; Jewell et al., 2013). However, how the sequester of the signaling molecules within the lysosome occurs remains poorly understood. New research from Wu et al. (2016) shows that the suppression of FLCN, a tumour suppressor gene associated with the Birt-Hogg-Dubé (BHD) syndrome, controls mTORC1 activity by modulating the lysosomal leucine levels. FLCN exerts this new f........ Read more »
Wu X, Zhao L, Chen Z, Ji X, Qiao X, Jin Y, & Liu W. (2016) FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1. PloS one, 11(6). PMID: 27280402
- June 13, 2016
- 07:24 AM
- 208 views
Collateral Damage: Anti-cancer therapy and Autoimmune disease: Part I
by AG McCluskey in Zongo's Cancer Diaries
This post describes what Autoimmune diseases are. Part II will describe the potential of anti-cancer therapies as treatments for Autoimmune disease.... Read more »
Bell, E., & Bird, L. (2005) Autoimmunity. Nature, 435(7042), 583-583. DOI: 10.1038/435583a
AG McCluskey. (2016) Collateral Damage. Zongo's Cancer Diaries. info:/
- June 10, 2016
- 06:14 AM
- 319 views
BHD syndrome and thyroid conditions
by Joana Guedes in BHD Research Blog
Dong et al., (2016) have recently reported two BHD syndrome patients also affected with papillary thyroid cancer. Lesions were bilateral and multifocal and small lymph node metastases occurred. Due to the small number of patients in the study the authors are unsure whether thyroid cancer in BHD patients is susceptible to exhibiting bilaterally and lymph node metastasis. However, they suggest considering thyroidectomy and prophylactic lymph node dissection for thyroid cancer patients with BHD. Th........ Read more »
Dong L, Gao M, Hao WJ, Zheng XQ, Li YG, Li XL, & Yu Y. (2016) Case Report of Birt-Hogg-Dubé Syndrome: Germline Mutations of FLCN Detected in Patients With Renal Cancer and Thyroid Cancer. Medicine, 95(22). PMID: 27258496
- June 6, 2016
- 11:08 AM
- 254 views
Best Laid Plans
by AG McCluskey in Zongo's Cancer Diaries
REVEALED: UK cancer scientists' pensions invested in tobacco.
....And this UK cancer scientist, for one, is Not Happy....... Read more »
AG McCluskey. (2016) Best Laid Plans. Zongo's Cancer Diaries. info:/
- June 1, 2016
- 09:38 AM
- 258 views
Video Tip of the Week: Your DNA, Your Say. GA4GH wants to hear from you. And you.
The Global Alliance for Genomics and Health (GA4GH) has come up a few times on our blog. The last time we highlighted them for a tip, it was about their Beacon tool. The idea of the Beacon is that it could interrogate a database but in a very subtle way, without needing access to the […]... Read more »
Lawler, M., Siu, L., Rehm, H., Chanock, S., Alterovitz, G., Burn, J., Calvo, F., Lacombe, D., Teh, B., North, K.... (2015) All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care through the Global Alliance for Genomics and Health. Cancer Discovery, 5(11), 1133-1136. DOI: 10.1158/2159-8290.CD-15-0821
- May 27, 2016
- 03:07 AM
- 319 views
Wandering and autism continued... yet again
by Paul Whiteley in Questioning Answers
I know that I'm probably starting to sound like a broken record on the topic of wandering (elopement) and autism on this blog (see here and see here and see here) but I am yet again going to briefly talk about peer-reviewed research in this area simply because it's just too damned important not to.This time around the results from Catherine Rice and colleagues [1] are the source of my musings and the conclusion that: "wandering among children with ASD [autism spectrum disorder], regard........ Read more »
Rice, C., Zablotsky, B., Avila, R., Colpe, L., Schieve, L., Pringle, B., & Blumberg, S. (2016) Reported Wandering Behavior among Children with Autism Spectrum Disorder and/or Intellectual Disability. The Journal of Pediatrics. DOI: 10.1016/j.jpeds.2016.03.047
- May 26, 2016
- 11:22 AM
- 314 views
Patent-ly Obvious...?
by AG McCluskey in Zongo's Cancer Diaries
Did you know that there may be bits of your own body that you don't own? That may be owned by someone else? No?? Then you need to know more about Gene Patenting...... Read more »
Rosenfeld, J., & Mason, C. (2013) Pervasive sequence patents cover the entire human genome. Genome Medicine, 5(3), 27. DOI: 10.1186/gm431
Liddicoat J, Whitton T, & Nicol D. (2015) Are the gene-patent storm clouds dissipating? A global snapshot. Nature biotechnology, 33(4), 347-52. PMID: 25850055
AG McCluskey. (2016) Patent-ly Obvious..?. Zongo's Cancer Diaries. info:/
- May 16, 2016
- 11:45 PM
- 387 views
Acidity and vascularization as linear goods in cancer
by Artem Kaznatcheev in Evolutionary Games Group
Last month, Robert Vander Velde discussed a striking similarity between the linear version of our model of two anti-correlated goods and the Haert et al. (2002) optional public good game. Robert didn’t get a chance to go into the detailed math behind the scenes, so I wanted to do that today. The derivations here will […]... Read more »
Hauert, C., De Monte, S., Hofbauer, J., & Sigmund, K. (2002) Replicator dynamics for optional public good games. Journal of Theoretical Biology, 218(2), 187-94. PMID: 12381291
- May 13, 2016
- 08:32 AM
- 339 views
The One And Only
by AG McCluskey in Zongo's Cancer Diaries
In future, the way that a patient's cancer is diagnosed and treated will be different. Every person is unique. And therefore every person's cancer is unique too...
Welcome to Personalised Medicine.... Read more »
Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L., Martin, S., Wedge, D.... (2016) Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. DOI: 10.1038/nature17676
Morganella, S., Alexandrov, L., Glodzik, D., Zou, X., Davies, H., Staaf, J., Sieuwerts, A., Brinkman, A., Martin, S., Ramakrishna, M.... (2016) The topography of mutational processes in breast cancer genomes. Nature Communications, 11383. DOI: 10.1038/ncomms11383
AG McCluskey. (2016) The One And Only. Zongo's Cancer Diaries. info:/
- May 6, 2016
- 08:47 AM
- 346 views
Fight The Good Fight?
by AG McCluskey in Zongo's Cancer Diaries
A lot of cancer research funding in the UK comes from charities. But how do they raise the funds? And does the end justify the means?... Read more »
O'Toole, L., Nurse, P., & Radda, G. (2003) An analysis of cancer research funding in the UK. Nature Reviews Cancer, 3(2), 139-143. DOI: 10.1038/nrc994
AG McCluskey. (2016) Fight The Good Fight?. Zongo's Cancer Diaries. info:/
- May 6, 2016
- 06:55 AM
- 465 views
Seeing With Eyes Shut: How LSD Causes Hallucinations
by Agnese Mariotti in United Academics
Brain scans show the human brain under LSD and explain how hallucinations occur.... Read more »
Carhart-Harris, R., Muthukumaraswamy, S., Roseman, L., Kaelen, M., Droog, W., Murphy, K., Tagliazucchi, E., Schenberg, E., Nest, T., Orban, C.... (2016) Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences, 113(17), 4853-4858. DOI: 10.1073/pnas.1518377113
Carhart-Harris, R., Leech, R., Hellyer, P., Shanahan, M., Feilding, A., Tagliazucchi, E., Chialvo, D., & Nutt, D. (2014) The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs. Frontiers in Human Neuroscience. DOI: 10.3389/fnhum.2014.00020
Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C., Wedeen, V., & Sporns, O. (2008) Mapping the Structural Core of Human Cerebral Cortex. PLoS Biology, 6(7). DOI: 10.1371/journal.pbio.0060159
- April 29, 2016
- 09:38 AM
- 391 views
Hunting For The Signatures of Cancer
Signatures of Mutational Processes Extracted from the Mutational Catalogs of 21 Breast Cancer Genomes. Credit:http://dx.doi.org/10.1016/j.celrep.2012.12.008Cancer is the second leading cause of death worldwide, with approximately 14 million new cases and 8.2 million cancer related deaths each year (Source: WHO). A family history of cancer typically increases a person's risk of developing the disease, yet most cancer cases have no family history at all. This suggests that a combination of both ge........ Read more »
Siegel, R., Miller, K., & Jemal, A. (2015) Cancer statistics, 2015. CA: A Cancer Journal for Clinicians, 65(1), 5-29. DOI: 10.3322/caac.21254
Alexandrov LB. (2015) Understanding the origins of human cancer. Science (New York, N.Y.), 350(6265), 1175. PMID: 26785464
Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale AL.... (2013) Signatures of mutational processes in human cancer. Nature, 500(7463), 415-21. PMID: 23945592
Alexandrov LB, Nik-Zainal S, Siu HC, Leung SY, & Stratton MR. (2015) A mutational signature in gastric cancer suggests therapeutic strategies. Nature communications, 8683. PMID: 26511885
- April 29, 2016
- 05:41 AM
- 313 views
Review, Refine, Redesign
by AG McCluskey in Zongo's Cancer Diaries
Drug Discovery, Part III
How is a an Initial Hit optimised and turned into a Lead Compound?... Read more »
Hughes, J., Rees, S., Kalindjian, S., & Philpott, K. (2011) Principles of early drug discovery. British Journal of Pharmacology, 162(6), 1239-1249. DOI: 10.1111/j.1476-5381.2010.01127.x
AG McCluskey. (2016) Review, Refine, Redesign. Zongo's Cancer Diaries. info:/
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