40 posts · 17,180 views
This is a blog about cancer and cancer research, aimed at a general audience. Zongo has been a cancer researcher for almost 20 years. In this blog, he describes how cancers form and progress, how they are treated and how researchers study these diseases.
anthony.mccluskey12
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- November 13, 2016
- 08:39 AM
- 53 views
Damn You, Darwin! Pt1. Cat & Mouse
by AG McCluskey in Zongo's Cancer Diaries
The emergence of therapy resistance in tumours can be described using Darwinian evolutionary theory. This post provides a brief description of Darwin's theory. The next post will apply the theory to tumour development.... Read more »
Darwin, Charles. (1876) The Origin of Species By Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life. Cambridge University Press. DOI: 10.1017/CBO9780511694295
AG McCluskey. (2016) Damn You Darwin! Pt1: Cat . Zongo's Cancer Diaries. info:/
- October 11, 2016
- 10:37 AM
- 165 views
Nae Trainers!
by AG McCluskey in Zongo's Cancer Diaries
This post covers multi-drug resistance in tumours....and why a cancer cell is like a Nightclub!... Read more »
Review article. (2000) Cancer multidrug resistance. Nature Biotechnology, 18(Supp). DOI: 10.1038/80051
AG McCluskey. (2016) Nae Trainers!. Zongo's Cancer Diaries. info:/
- September 12, 2016
- 06:19 AM
- 232 views
Strength In Numbers
by AG McCluskey in Zongo's Cancer Diaries
This post describes the concept behind combination therapies for cancer. Why are they needed? Why can they fail...?... Read more »
Komarova, N., & Boland, C. (2013) Cancer: Calculated treatment. Nature, 499(7458), 291-292. DOI: 10.1038/499291a
AG McCluskey. (2016) Strength in Numbers. Zongo's Cancer Diaries. info:/
- August 16, 2016
- 10:43 AM
- 271 views
The Angry Silence
by AG McCluskey in Zongo's Cancer Diaries
The experience of cancer patients has changed in many ways over the last 30 years. One massive improvement is that patients can talk about their diseases more freely.
And this may not just make them feel better, it might help to make them better too.......... Read more »
Lutgendorf, S., & Andersen, B. (2015) Biobehavioral approaches to cancer progression and survival: Mechanisms and interventions. American Psychologist, 70(2), 186-197. DOI: 10.1037/a0035730
MacMillan Cancer Support. (2016) Cancer: Then and Now. Diagnosis, treatment and aftercare from 1970–2016. MacMillan Cancer Support. info:/
- August 1, 2016
- 07:22 AM
- 310 views
Live Long & Prosper!
by AG McCluskey in Zongo's Cancer Diaries
Good news for cancer patients in the UK, as 10-year survival rates show big improvements.... Read more »
MacMillan Cancer Support. (2016) Cancer: Then and Now. Diagnosis, treatment and aftercare from 1970–2016. MacMillan Cancer Support. info:/
- June 17, 2016
- 07:11 AM
- 354 views
Computer Says No: Anti-cancer therapy and Autoimmune disease: Part II
by AG McCluskey in Zongo's Cancer Diaries
Scientists have been investigating the use of cancer therapies to treat Autoimmune disease. And the reasoning behind this? Treat the immune system like a computer program...... Read more »
Dr Harold L Atkins, MDcorrespondenceemail, Marjorie Bowman, MScN, David Allan, MD, Grizel Anstee, MD, Prof Douglas L Arnold, MD, Prof Amit Bar-Or, MD, Isabelle Bence-Bruckler, MD, Paul Birch, MLT, Prof Christopher Bredeson, MD, Jacqueline Chen, PhD, Prof . (2016) Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet. info:/http://dx.doi.org/10.1016/S0140-6736(16)30169-6
Craciunescu, O., Steffey, B., Kelsey, C., Larrier, N., Paarz-Largay, C., Prosnitz, R., Chao, N., Chute, J., Gasparetto, C., Horwitz, M.... (2011) Renal Shielding and Dosimetry for Patients With Severe Systemic Sclerosis Receiving Immunoablation With Total Body Irradiation in the Scleroderma: Cyclophosphamide or Transplantation Trial. International Journal of Radiation Oncology*Biology*Physics, 79(4), 1248-1255. DOI: 10.1016/j.ijrobp.2010.05.036
AG McCluskey. (2016) Computer Says No. Zongo's Cancer Diaries. info:/
- June 13, 2016
- 07:24 AM
- 309 views
Collateral Damage: Anti-cancer therapy and Autoimmune disease: Part I
by AG McCluskey in Zongo's Cancer Diaries
This post describes what Autoimmune diseases are. Part II will describe the potential of anti-cancer therapies as treatments for Autoimmune disease.... Read more »
Bell, E., & Bird, L. (2005) Autoimmunity. Nature, 435(7042), 583-583. DOI: 10.1038/435583a
AG McCluskey. (2016) Collateral Damage. Zongo's Cancer Diaries. info:/
- June 6, 2016
- 11:08 AM
- 376 views
Best Laid Plans
by AG McCluskey in Zongo's Cancer Diaries
REVEALED: UK cancer scientists' pensions invested in tobacco.
....And this UK cancer scientist, for one, is Not Happy....... Read more »
AG McCluskey. (2016) Best Laid Plans. Zongo's Cancer Diaries. info:/
- May 26, 2016
- 11:22 AM
- 463 views
Patent-ly Obvious...?
by AG McCluskey in Zongo's Cancer Diaries
Did you know that there may be bits of your own body that you don't own? That may be owned by someone else? No?? Then you need to know more about Gene Patenting...... Read more »
Rosenfeld, J., & Mason, C. (2013) Pervasive sequence patents cover the entire human genome. Genome Medicine, 5(3), 27. DOI: 10.1186/gm431
Liddicoat J, Whitton T, & Nicol D. (2015) Are the gene-patent storm clouds dissipating? A global snapshot. Nature biotechnology, 33(4), 347-52. PMID: 25850055
AG McCluskey. (2016) Patent-ly Obvious..?. Zongo's Cancer Diaries. info:/
- May 13, 2016
- 08:32 AM
- 462 views
The One And Only
by AG McCluskey in Zongo's Cancer Diaries
In future, the way that a patient's cancer is diagnosed and treated will be different. Every person is unique. And therefore every person's cancer is unique too...
Welcome to Personalised Medicine.... Read more »
Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L., Martin, S., Wedge, D.... (2016) Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. DOI: 10.1038/nature17676
Morganella, S., Alexandrov, L., Glodzik, D., Zou, X., Davies, H., Staaf, J., Sieuwerts, A., Brinkman, A., Martin, S., Ramakrishna, M.... (2016) The topography of mutational processes in breast cancer genomes. Nature Communications, 11383. DOI: 10.1038/ncomms11383
AG McCluskey. (2016) The One And Only. Zongo's Cancer Diaries. info:/
- May 6, 2016
- 08:47 AM
- 477 views
Fight The Good Fight?
by AG McCluskey in Zongo's Cancer Diaries
A lot of cancer research funding in the UK comes from charities. But how do they raise the funds? And does the end justify the means?... Read more »
O'Toole, L., Nurse, P., & Radda, G. (2003) An analysis of cancer research funding in the UK. Nature Reviews Cancer, 3(2), 139-143. DOI: 10.1038/nrc994
AG McCluskey. (2016) Fight The Good Fight?. Zongo's Cancer Diaries. info:/
- April 29, 2016
- 05:41 AM
- 421 views
Review, Refine, Redesign
by AG McCluskey in Zongo's Cancer Diaries
Drug Discovery, Part III
How is a an Initial Hit optimised and turned into a Lead Compound?... Read more »
Hughes, J., Rees, S., Kalindjian, S., & Philpott, K. (2011) Principles of early drug discovery. British Journal of Pharmacology, 162(6), 1239-1249. DOI: 10.1111/j.1476-5381.2010.01127.x
AG McCluskey. (2016) Review, Refine, Redesign. Zongo's Cancer Diaries. info:/
- April 26, 2016
- 10:42 AM
- 431 views
You Scratch My Back
by AG McCluskey in Zongo's Cancer Diaries
Where does the idea of a scientist as a crazed loner come from. Let's work together!... Read more »
Brown, R., Deletic, A., & Wong, T. (2015) Interdisciplinarity: How to catalyse collaboration. Nature, 525(7569), 315-317. DOI: 10.1038/525315a
AG McCluskey. (2016) You Scratch My Back.. Zongo's Cancer Diaries. info:/
- March 25, 2016
- 05:42 AM
- 412 views
Blocks & Locks...
by AG McCluskey in Zongo's Cancer Diaries
Drug Discovery, Part II
This posts talks about the next stages of Drug Discovery. How is an initial hit first found? And why is it like Lego?... Read more »
Harvey, A., Edrada-Ebel, R., & Quinn, R. (2015) The re-emergence of natural products for drug discovery in the genomics era. Nature Reviews Drug Discovery, 14(2), 111-129. DOI: 10.1038/nrd4510
AG McCluskey. (2016) Blocks . Zongo's Cancer Diaries. info:/
- March 11, 2016
- 08:26 AM
- 525 views
Kill "Bill" !!!
by AG McCluskey in Zongo's Cancer Diaries
Drug Discovery, Part I
How does Drug Discovery start? How are targets identified? Time for Epidemiology 101... Read more »
Lu, Y., Guan, G., Chen, J., Hu, B., Sun, C., Ma, Q., Wen, Y., Qiu, X., & Zhou, Y. (2015) Aberrant CXCR4 and β-catenin expression in osteosarcoma correlates with patient survival. Oncology Letters. DOI: 10.3892/ol.2015.3535
AG McCluskey. (2016) Kill "Bill". Zongo's Cancer Diaries. info:/
- March 4, 2016
- 11:30 AM
- 496 views
Damn Statistics!
by AG McCluskey in Zongo's Cancer Diaries
How are cancer risk factors identified? And why are they like cake?... Read more »
Pérez-Hernández,A.I., Catalán, V., Gómez-Ambrosi, J., AmaiaRodríguez, A., & Frühbeck, G. (2014) Mechanisms Linking Excess Adiposity and Carcinogenesis Promotion. Frontiers in Endocrinology. DOI: 10.3389/fendo.2014.00065
Bagnardi, V., Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V., Scotti, L., Jenab, M., Turati, F., Pasquali, E.... (2012) Light alcohol drinking and cancer: a meta-analysis. Annals of Oncology, 24(2), 301-308. DOI: 10.1093/annonc/mds337
Bouvard, V., Loomis, D., Guyton, K., Grosse, Y., Ghissassi, F., Benbrahim-Tallaa, L., Guha, N., Mattock, H., & Straif, K. (2015) Carcinogenicity of consumption of red and processed meat. The Lancet Oncology. DOI: 10.1016/S1470-2045(15)00444-1
AG McCluskey. (2016) Damn Statistics. Zongo's Cancer Diaries. info:/
- February 19, 2016
- 07:24 AM
- 492 views
Evidence Shmevidence 2: Consensus Nonsense
by AG McCluskey in Zongo's Cancer Diaries
The scientific consensus tells us what we currently know. But what is the "Consensus"? How does it work? And why do so many people get the wrong idea about it...?... Read more »
Kahan, D., Jenkins‐Smith, H., & Braman, D. (2011) Cultural cognition of scientific consensus. Journal of Risk Research, 14(2), 147-174. DOI: 10.1080/13669877.2010.511246
- February 12, 2016
- 06:34 AM
- 467 views
Evidence, Shmevidence
by AG McCluskey in Zongo's Cancer Diaries
The world is full of ideas. How does science decide which ideas are good and which are bad...?... Read more »
Scott O. Lilienfeld, Steven Jay Lynn, Rachel J. Ammirati. (2015) Science Versus Pseudoscience. The Encyclopedia of Clinical Psychology. DOI: 10.1002/9781118625392.wbecp572
AG McCluskey. (2016) Evidence, Shmevidence. Zongo's Cancer Diaries. info:/
- February 9, 2016
- 08:28 AM
- 443 views
Bring Me Sunshine...
by AG McCluskey in Zongo's Cancer Diaries
The latest Public Health statement is about the dangers of suntanning. But what IS a suntan? And how could it lead to cancer...?... Read more »
NICE. (2016) Sunlight exposure: risks and benefits. National Institute for Health . info:/
Newton-Bishop, J., Chang, Y., Elliott, F., Chan, M., Leake, S., Karpavicius, B., Haynes, S., Fitzgibbon, E., Kukalizch, K., Randerson-Moor, J.... (2011) Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate. European Journal of Cancer, 47(5), 732-741. DOI: 10.1016/j.ejca.2010.10.008
- January 27, 2016
- 11:32 AM
- 544 views
Technobabble 101
by AG McCluskey in Zongo's Cancer Diaries
Why are scientific articles so hard to read? Why? WHY???... Read more »
McCluskey, A.G., & Boyd, M. (2015) Inhibition of the BER Factor APE1 Disrupts Repair of Double-Strand DNA Damage in Cells Treated with Low Dose-Rate, but Not High Dose-Rate XRadiation. Journal of Nuclear Medicine , 06(06). DOI: 10.4172/2155-9619.1000269
AG McCluskey. (2016) Technobabble 101. Zongo's Cancer Diaries. info:/
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