by AG McCluskey in Zongo's Cancer Diaries
This post covers multi-drug resistance in tumours....and why a cancer cell is like a Nightclub!... Read more »
Review article. (2000) Cancer multidrug resistance. Nature Biotechnology, 18(Supp). DOI: 10.1038/80051
AG McCluskey. (2016) Nae Trainers!. Zongo's Cancer Diaries. info:/
by Jeffrey Daniels in United Academics
Beyond the well-known Solar System, there is an immensity of other unique systems... Read more »
Johanna K. Teske, Stephen A. Shectman, Steve S. Vogt, Matías Díaz, R. Paul Butler, Jeffrey D. Crane, Ian B. Thompson, & Pamela Arriagada. (2016) The Magellan PFS Planet Search Program: Radial Velocity and Stellar Abundance Analyses of the 360 AU, Metal-Poor Binary "Twins" HD 133131A . Astronomical Journal,. arXiv: 1608.06216v2
Orosz, J., Welsh, W., Carter, J., Fabrycky, D., Cochran, W., Endl, M., Ford, E., Haghighipour, N., MacQueen, P., Mazeh, T.... (2012) Kepler-47: A Transiting Circumbinary Multiplanet System. Science, 337(6101), 1511-1514. DOI: 10.1126/science.1228380
R. Di Stefano, & A. Ray. (2016) Globular Clusters as Cradles of Life and Advanced Civilizations. ASTROPHYSICAL JOURNAL , 827(1). arXiv: 1601.03455v1
Marcelo Tucci Maia, Jorge Melendez, & Ivan Ramirez. (2014) High precision abundances in the 16 Cyg binary system: a signature of the rocky core in the giant planet. ASTROPHYSICAL JOURNAL LETTERS , 790(2). arXiv: 1407.4132v1
Anglada-Escudé, G., Amado, P., Barnes, J., Berdiñas, Z., Butler, R., Coleman, G., de la Cueva, I., Dreizler, S., Endl, M., Giesers, B.... (2016) A terrestrial planet candidate in a temperate orbit around Proxima Centauri. Nature, 536(7617), 437-440. DOI: 10.1038/nature19106
Borucki, W., Agol, E., Fressin, F., Kaltenegger, L., Rowe, J., Isaacson, H., Fischer, D., Batalha, N., Lissauer, J., Marcy, G.... (2013) Kepler-62: A Five-Planet System with Planets of 1.4 and 1.6 Earth Radii in the Habitable Zone. Science, 340(6132), 587-590. DOI: 10.1126/science.1234702
Stephen R. Kane, & Dawn M. Gelino. (2014) On the Inclination and Habitability of the HD 10180 System. ASTROPHYSICAL JOURNAL, 792(2). arXiv: 1408.4150v1
by Joshua Fisher in Text Savvy
Even if the benefits of retrieval practice were limited to improvements in recall (as prior research has demonstrated), such improvements do not stand in the way of improvements to higher-order reasoning, such as inference-making. (And shaping the path for students, such as improving informational contiguity can have a positive effect too.)... Read more »
Eglington, L., & Kang, S. (2016) Retrieval Practice Benefits Deductive Inference. Educational Psychology Review. DOI: 10.1007/s10648-016-9386-y
by AG McCluskey in Zongo's Cancer Diaries
This post describes the concept behind combination therapies for cancer. Why are they needed? Why can they fail...?... Read more »
Komarova, N., & Boland, C. (2013) Cancer: Calculated treatment. Nature, 499(7458), 291-292. DOI: 10.1038/499291a
AG McCluskey. (2016) Strength in Numbers. Zongo's Cancer Diaries. info:/
by Rita dos Santos Silva in United Academics
Researchers from the U.S. National Institutes of Health, working in collaboration with Turkish and British teams, discovered a new inflammatory disease.... Read more »
Zhou, Q., Wang, H., Schwartz, D., Stoffels, M., Park, Y., Zhang, Y., Yang, D., Demirkaya, E., Takeuchi, M., Tsai, W.... (2015) Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nature Genetics, 48(1), 67-73. DOI: 10.1038/ng.3459
Elliott, P., Nielsen, S., Marco-Casanova, P., Fiil, B., Keusekotten, K., Mailand, N., Freund, S., Gyrd-Hansen, M., & Komander, D. (2014) Molecular Basis and Regulation of OTULIN-LUBAC Interaction. Molecular Cell, 54(3), 335-348. DOI: 10.1016/j.molcel.2014.03.018
by Rita dos Santos Silva in United Academics
Researchers from the U.S. National Institutes of Health, working in collaboration with Turkish and British teams, discovered a new inflammatory disease.... Read more »
Zhou, Q., Wang, H., Schwartz, D., Stoffels, M., Park, Y., Zhang, Y., Yang, D., Demirkaya, E., Takeuchi, M., Tsai, W.... (2015) Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nature Genetics, 48(1), 67-73. DOI: 10.1038/ng.3459
Elliott, P., Nielsen, S., Marco-Casanova, P., Fiil, B., Keusekotten, K., Mailand, N., Freund, S., Gyrd-Hansen, M., & Komander, D. (2014) Molecular Basis and Regulation of OTULIN-LUBAC Interaction. Molecular Cell, 54(3), 335-348. DOI: 10.1016/j.molcel.2014.03.018
by AG McCluskey in Zongo's Cancer Diaries
The experience of cancer patients has changed in many ways over the last 30 years. One massive improvement is that patients can talk about their diseases more freely.
And this may not just make them feel better, it might help to make them better too.......... Read more »
Lutgendorf, S., & Andersen, B. (2015) Biobehavioral approaches to cancer progression and survival: Mechanisms and interventions. American Psychologist, 70(2), 186-197. DOI: 10.1037/a0035730
MacMillan Cancer Support. (2016) Cancer: Then and Now. Diagnosis, treatment and aftercare from 1970–2016. MacMillan Cancer Support. info:/
by AG McCluskey in Zongo's Cancer Diaries
Good news for cancer patients in the UK, as 10-year survival rates show big improvements.... Read more »
MacMillan Cancer Support. (2016) Cancer: Then and Now. Diagnosis, treatment and aftercare from 1970–2016. MacMillan Cancer Support. info:/
by Joshua Fisher in Text Savvy
When research has more fairly compared PS-I with I-PS, it has concluded that, in general, the sequence doesn't matter all that much, though there are some positive trends on conceptual and transfer assessments for PS-I.... Read more »
Loibl, K., Roll, I., & Rummel, N. (2016) Towards a Theory of When and How Problem Solving Followed by Instruction Supports Learning. Educational Psychology Review. DOI: 10.1007/s10648-016-9379-x
by Joshua Fisher in Text Savvy
In the latest research, the authors found that a blocked schedule (presenting examples from one category at a time) outperformed an interleaved schedule (interspersing examples from all the categories) for category learning when the examples to be classified were more highly discriminable. This result was consistent across the two experiments in the study (p = 0.055 and p = 0.04). Importantly, however, although interleaving was a better strategy for learning categories of lower discriminability,........ Read more »
Noh, S., Yan, V., Bjork, R., & Maddox, W. (2016) Optimal sequencing during category learning: Testing a dual-learning systems perspective. Cognition, 23-29. DOI: 10.1016/j.cognition.2016.06.007
by AG McCluskey in Zongo's Cancer Diaries
Scientists have been investigating the use of cancer therapies to treat Autoimmune disease. And the reasoning behind this? Treat the immune system like a computer program...... Read more »
Dr Harold L Atkins, MDcorrespondenceemail, Marjorie Bowman, MScN, David Allan, MD, Grizel Anstee, MD, Prof Douglas L Arnold, MD, Prof Amit Bar-Or, MD, Isabelle Bence-Bruckler, MD, Paul Birch, MLT, Prof Christopher Bredeson, MD, Jacqueline Chen, PhD, Prof . (2016) Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet. info:/http://dx.doi.org/10.1016/S0140-6736(16)30169-6
Craciunescu, O., Steffey, B., Kelsey, C., Larrier, N., Paarz-Largay, C., Prosnitz, R., Chao, N., Chute, J., Gasparetto, C., Horwitz, M.... (2011) Renal Shielding and Dosimetry for Patients With Severe Systemic Sclerosis Receiving Immunoablation With Total Body Irradiation in the Scleroderma: Cyclophosphamide or Transplantation Trial. International Journal of Radiation Oncology*Biology*Physics, 79(4), 1248-1255. DOI: 10.1016/j.ijrobp.2010.05.036
AG McCluskey. (2016) Computer Says No. Zongo's Cancer Diaries. info:/
by Joshua Fisher in Text Savvy
Performing the discrete mode of presentation test strongly enhances the salience of the relevant variable, perimeter, and somewhat decreases that of area. This enhancement supports appropriate solution strategies that lead to improved performance. This effect is robust and transfers to continuous mode of presentation for at least 10 days. In line with this conclusion, a student who performed the continuous test after the discrete one commented that, “It [continuous] was harder this time bu........ Read more »
Babai, R., Nattiv, L., & Stavy, R. (2016) Comparison of perimeters: improving students’ performance by increasing the salience of the relevant variable. ZDM, 48(3), 367-378. DOI: 10.1007/s11858-016-0766-z
by AG McCluskey in Zongo's Cancer Diaries
Did you know that there may be bits of your own body that you don't own? That may be owned by someone else? No?? Then you need to know more about Gene Patenting...... Read more »
Rosenfeld, J., & Mason, C. (2013) Pervasive sequence patents cover the entire human genome. Genome Medicine, 5(3), 27. DOI: 10.1186/gm431
Liddicoat J, Whitton T, & Nicol D. (2015) Are the gene-patent storm clouds dissipating? A global snapshot. Nature biotechnology, 33(4), 347-52. PMID: 25850055
AG McCluskey. (2016) Patent-ly Obvious..?. Zongo's Cancer Diaries. info:/
by Dr. Jekyll in Lunatic Laboratories
Feelings of shame and humiliation bother obese air passengers more than tight seat belts and tiny seats, according to a study published by Ben-Gurion University of the Negev (BGU) researchers. Participants interviewed for the study recounted the typical challenges they encounter while boarding, in-flight and deplaning.
... Read more »
Yaniv Poria, & Jeremy Beal. (2016) An Exploratory Study about Obese People’s Flight Experience . Journal of travel research. info:/10.1177/0047287516643416
by Nesru Koroso in United Academics
The Directory of Open Access Journals bans dubious journals from its index.... Read more »
Baker, M. (2016) Open-access index delists thousands of journals. Nature. DOI: 10.1038/nature.2016.19871
Van Noorden, R. (2014) Open-access website gets tough. Nature, 512(7512), 17-17. DOI: 10.1038/512017a
by AG McCluskey in Zongo's Cancer Diaries
In future, the way that a patient's cancer is diagnosed and treated will be different. Every person is unique. And therefore every person's cancer is unique too...
Welcome to Personalised Medicine.... Read more »
Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L., Martin, S., Wedge, D.... (2016) Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. DOI: 10.1038/nature17676
Morganella, S., Alexandrov, L., Glodzik, D., Zou, X., Davies, H., Staaf, J., Sieuwerts, A., Brinkman, A., Martin, S., Ramakrishna, M.... (2016) The topography of mutational processes in breast cancer genomes. Nature Communications, 11383. DOI: 10.1038/ncomms11383
AG McCluskey. (2016) The One And Only. Zongo's Cancer Diaries. info:/
by Chiara Civardi in United Academics
Emerge into Brazil’s swamp, with Chiara and the Wildlife Conservation Society.... Read more »
Rodrigo Luiz Simas de Aguiar, & Keny Marques Lima. (2012) A arte rupestre em cavernas da região noroeste de Mato Grosso do Sul discussões preliminares. Espeleo-Tema, 23(2). info:/
by Pieter Carrière in United Academics
Dealing with psychotic patients takes more than looking at their diagnostic labels.... Read more »
Heering, H., van Haren, N., & Derks, E. (2013) A two-factor structure of first rank symptoms in patients with a psychotic disorder. Schizophrenia Research, 147(2-3), 269-274. DOI: 10.1016/j.schres.2013.04.032
Heering, H., Koevoets, G., Koenders, L., Machielsen, M., Meijer, C., Kubota, M., de Nijs, J., Cahn, W., Hulshoff Pol, H., de Haan, L.... (2015) Structural MRI Differences between Patients with and without First Rank Symptoms: A Delusion?. Frontiers in Psychiatry. DOI: 10.3389/fpsyt.2015.00107
Nelson B, Whitford TJ, Lavoie S, & Sass LA. (2014) What are the neurocognitive correlates of basic self-disturbance in schizophrenia? Integrating phenomenology and neurocognition: Part 2 (aberrant salience). Schizophrenia research, 152(1), 20-7. PMID: 23863772
Perälä, J., Suvisaari, J., Saarni, S., Kuoppasalmi, K., Isometsä, E., Pirkola, S., Partonen, T., Tuulio-Henriksson, A., Hintikka, J., Kieseppä, T.... (2007) Lifetime Prevalence of Psychotic and Bipolar I Disorders in a General Population. Archives of General Psychiatry, 64(1), 19. DOI: 10.1001/archpsyc.64.1.19
by AG McCluskey in Zongo's Cancer Diaries
A lot of cancer research funding in the UK comes from charities. But how do they raise the funds? And does the end justify the means?... Read more »
O'Toole, L., Nurse, P., & Radda, G. (2003) An analysis of cancer research funding in the UK. Nature Reviews Cancer, 3(2), 139-143. DOI: 10.1038/nrc994
AG McCluskey. (2016) Fight The Good Fight?. Zongo's Cancer Diaries. info:/
by Rita dos Santos Silva in United Academics
Treating immune disorders might have gotten easier with a new mouse model.... Read more »
Beura, L., Hamilton, S., Bi, K., Schenkel, J., Odumade, O., Casey, K., Thompson, E., Fraser, K., Rosato, P., Filali-Mouhim, A.... (2016) Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature, 532(7600), 512-516. DOI: 10.1038/nature17655
Mestas, J., & Hughes, C. (2004) Of Mice and Not Men: Differences between Mouse and Human Immunology. The Journal of Immunology, 172(5), 2731-2738. DOI: 10.4049/jimmunol.172.5.2731
Shultz, D. (2016) Can ‘dirty mice’ save animal research?. Science. DOI: 10.1126/science.aaf4153
Reardon, S. (2016) Dirty room-mates make lab mice more useful. Nature, 532(7599), 294-295. DOI: 10.1038/532294a
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