Medicine posts
- August 6, 2016
- 03:24 PM
- 25 views
Microcephaly discoveries in non-Zika cases explain abnormal brain growth
by Dr. Jekyll in Lunatic Laboratories
Long before Zika virus made it a household word, the birth defect called microcephaly puzzled scientists and doctors -- even as it changed the lives of the babies born with it during the pre-Zika era. But new discoveries reported by an international team of scientists may help explain what happens in the developing brains of babies still in the womb, causing them to be born with small brains and heads.
... Read more »
Li, H., Bielas, S., Zaki, M., Ismail, S., Farfara, D., Um, K., Rosti, R., Scott, E., Tu, S., Chi, N.... (2016) Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly. The American Journal of Human Genetics, 99(2), 501-510. DOI: 10.1016/j.ajhg.2016.07.004
- August 5, 2016
- 03:10 PM
- 49 views
From Sci Fi to reality: Unlocking the secret to growing new limbs
by Dr. Jekyll in Lunatic Laboratories
Many lower organisms retain the miraculous ability to regenerate form and function of almost any tissue after injury. Humans share many of our genes with these organisms, but our capacity for regeneration is limited. So scientists are studying the genetics of these organisms to find out how regenerative mechanisms might be activated in humans.
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King, B., & Yin, V. (2016) A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration. PLOS ONE, 11(6). DOI: 10.1371/journal.pone.0157106
- August 5, 2016
- 07:00 AM
- 38 views
Friday Fellow: Beggar’s tick
by Piter Boll in Earthling Nature
by Piter Kehoma Boll What if the cure for cancer has been living in your garden all this time and you have been trying to get rid of it because it is an annoying weed? I cannot assure you that … Continue reading →... Read more »
Brandão, M., Krettli, A., Soares, L., Nery, C., & Marinuzzi, H. (1997) Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds. Journal of Ethnopharmacology, 57(2), 131-138. DOI: 10.1016/S0378-8741(97)00060-3
Chang, J., Chiang, L., Chen, C., Liu, L., Wang, K., & Lin, C. (2001) Antileukemic Activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb. The American Journal of Chinese Medicine, 29(02), 303-312. DOI: 10.1142/S0192415X01000320
Chiang, L., Chang, J., Chen, C., Ng, L., & Lin, C. (2003) Anti-Herpes Simplex Virus Activity of Bidens pilosa and Houttuynia cordata. The American Journal of Chinese Medicine, 31(03), 355-362. DOI: 10.1142/S0192415X03001090
Deba, F., Xuan, T., Yasuda, M., & Tawata, S. (2008) Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. var. Radiata. Food Control, 19(4), 346-352. DOI: 10.1016/j.foodcont.2007.04.011
Kviecinski, M., Felipe, K., Schoenfelder, T., de Lemos Wiese, L., Rossi, M., Gonçalez, E., Felicio, J., Filho, D., & Pedrosa, R. (2008) Study of the antitumor potential of Bidens pilosa (Asteraceae) used in Brazilian folk medicine. Journal of Ethnopharmacology, 117(1), 69-75. DOI: 10.1016/j.jep.2008.01.017
Oliveira, F., Andrade-Neto, V., Krettli, A., & Brandão, M. (2004) New evidences of antimalarial activity of Bidens pilosa roots extract correlated with polyacetylene and flavonoids. Journal of Ethnopharmacology, 93(1), 39-42. DOI: 10.1016/j.jep.2004.03.026
Pereira, R., Ibrahim, T., Lucchetti, L., da Silva, A., & de Moraes, V. (1999) Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L. Immunopharmacology, 43(1), 31-37. DOI: 10.1016/S0162-3109(99)00039-9
Sun, Y., Zhou, Q., Wang, L., & Liu, W. (2009) Cadmium tolerance and accumulation characteristics of Bidens pilosa L. as a potential Cd-hyperaccumulator. Journal of Hazardous Materials, 161(2-3), 808-814. DOI: 10.1016/j.jhazmat.2008.04.030
- August 5, 2016
- 05:09 AM
- 49 views
Multiple germline mutations in rare inherited cancer syndrome genes
by Joana Guedes in BHD Research Blog
A recent study by Whitworth et al. (2016) reports five new cases of multiple germline mutations in inherited cancer syndrome genes, three of them involve the combination of mutations in FLCN with NF1, TP53, and MSH2, respectively.... Read more »
Whitworth J, Skytte AB, Sunde L, Lim DH, Arends MJ, Happerfield L, Frayling IM, van Minkelen R, Woodward ER, Tischkowitz MD.... (2016) Multilocus Inherited Neoplasia Alleles Syndrome: A Case Series and Review. JAMA oncology, 2(3), 373-9. PMID: 26659639
- August 5, 2016
- 02:59 AM
- 57 views
Hospitalisation for mania following antibiotic exposure?
by Paul Whiteley in Questioning Answers
"Individuals hospitalized with acute mania have a markedly increased rate of bacterial infections, as evidenced by the recent prescription of antimicrobial agents. The prevention and effective treatment of bacterial infections may be important interventions for the management of individuals with mania."That was the research bottom-line reported by Robert Yolken and colleagues [1] (yes, that Robert Yolken) who continued a theme of how immune function/response might be something pretty important w........ Read more »
Yolken R, Adamos M, Katsafanas E, Khushalani S, Origoni A, Savage C, Schweinfurth L, Stallings C, Sweeney K, & Dickerson F. (2016) Individuals hospitalized with acute mania have increased exposure to antimicrobial medications. Bipolar disorders. PMID: 27425597
- August 4, 2016
- 02:07 PM
- 65 views
Biomimicry is a promising approach for driving innovation
by Dr. Jekyll in Lunatic Laboratories
A new case study shows that biomimicry, a relatively new field that seeks to emulate nature to find solutions to human problems, can potentially expand intellectual property, increase energy savings and accelerate product innovation.
... Read more »
Emily Barbara Kennedy, & Thomas Andrew Marting. (2016) Biomimicry: Streamlining the Front End of Innovation for Environmentally Sustainable Products. Research-Technology Management. info:/10.1080/08956308.2016.1185342
- August 4, 2016
- 03:11 AM
- 74 views
Take your vitamin D says the UK Government
by Paul Whiteley in Questioning Answers
"Vitamin D supplements 'advised for everyone'" was just one media headline following the publication of a report (see here) - "a government commissioned report" - by the advisory board of the Scientific Advisory Committee on Nutrition (SACN) here in Blighty recently.After oodles and oodles of peer-reviewed research (quite a bit of it covered in that SACN report) potentially linking issues with vitamin D availability to everything from depression (see here) to schizophrenia (see here) a........ Read more »
Muscogiuri G, Altieri B, Annweiler C, Balercia G, Pal HB, Boucher BJ, Cannell JJ, Foresta C, Grübler MR, Kotsa K.... (2016) Vitamin D and chronic diseases: the current state of the art. Archives of toxicology. PMID: 27425218
- August 3, 2016
- 01:52 PM
- 84 views
New neurons created through exercise don't cause you to forget old memories
by Dr. Jekyll in Lunatic Laboratories
Fellow exercise enthusiasts, you can breath a sigh of relief and so can your brain. Research has found that exercise causes more new neurons to be formed in a critical brain region, and contrary to an earlier study, these new neurons do not cause the individual to forget old memories, according to new research.
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Kodali, M., Megahed, T., Mishra, V., Shuai, B., Hattiangady, B., & Shetty, A. (2016) Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory. Journal of Neuroscience, 36(31), 8112-8122. DOI: 10.1523/JNEUROSCI.0766-16.2016
- August 3, 2016
- 09:13 AM
- 91 views
Do we need a doping Olympics? The ethics of doping in sports
by gdw in FictionalFieldwork
There is only her and the track. The people standing on her left and right do not matter now. She has only one adversary: time. In her head she plays how the future might…will unfold. Forty seven strides. That’s all she needs. All things on the periphery disappear. Her world, her universe becomes a single […]... Read more »
Savulescu J, Foddy B, & Clayton M. (2004) Why we should allow performance enhancing drugs in sport. British journal of sports medicine, 38(6), 666-70. PMID: 15562155
Gaviglio CM, Osborne M, Kelly VG, Kilduff LP, & Cook CJ. (2015) Salivary testosterone and cortisol responses to four different rugby training exercise protocols. European journal of sport science, 15(6), 497-504. PMID: 25743223
Smith AC, & Stewart B. (2015) Why the war on drugs in sport will never be won. Harm reduction journal, 53. PMID: 26556215
Park HY, Hwang H, Park J, Lee S, & Lim K. (2016) The effects of altitude/hypoxic training on oxygen delivery capacity of the blood and aerobic exercise capacity in elite athletes - a meta-analysis. Journal of exercise nutrition , 20(1), 15-22. PMID: 27298808
- August 3, 2016
- 04:30 AM
- 86 views
Quick Clinical Model to Identify Chronic Ankle Instability
by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field
Clinicians may be able to use the single-leg hop test and Star Excursion Balance Test to identify people with chronic ankle instability.... Read more »
Ko J, Rosen AB, & Brown CN. (2016) Comparison Between Single and Combined Clinical Postural Stability Tests in Individuals With and Without Chronic Ankle Instability. Clinical Journal of Sport Medicine. PMID: 27347871
- August 3, 2016
- 03:57 AM
- 85 views
Omega-3 fatty acids, gut bacteria and mouse behaviour
by Paul Whiteley in Questioning Answers
I read with great interest the paper by Ruairi Robertson and colleagues [1] (open-access available here) recently, talking about how "neurobehavioural changes induced by altering n-3 PUFA [omega-3 polyunsaturated fatty acids] status are closely associated with comprehensive alterations in gut microbiota composition, HPA-axis activity and inflammation" in mice.Coming out of the 'bacterial research powerhouse' that is University College Cork, such research potentially unites some im........ Read more »
Robertson RC, Oriach CS, Murphy K, Moloney GM, Cryan JF, Dinan TG, Paul Ross R, & Stanton C. (2016) Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood. Brain, behavior, and immunity. PMID: 27423492
- August 2, 2016
- 02:03 PM
- 102 views
Cardiac complications from energy drinks?
by Dr. Jekyll in Lunatic Laboratories
The high levels of caffeine in energy drinks may lead to cardiac complications. A new case report adds to previous reports of adverse cardiovascular events related to consuming energy drinks, including abnormal heart rhythms (arrhythmias).
... Read more »
Sattari M, Sattari A, & Kazory A. (2016) Energy Drink Consumption and Cardiac Complications: A Case for Caution. Journal of addiction medicine, 10(4), 280-2. PMID: 27471919
- August 1, 2016
- 10:43 PM
- 100 views
Autism, urinary porphyrins and mercury
by Paul Whiteley in Questioning Answers
I appreciate that the title of this post is probably going to result in an immediate 'click away' for some folk but for those who've endured it I'd like to talk briefly about the findings reported by Eman Khaled and colleagues [1]. Namely the observation that: "ASD [autism spectrum disorder] children in the present study had increased blood Hg [mercury] and Pb [lead] levels compared with healthy control children indicating that disordered porphyrin metabolism might ........ Read more »
Khaled EM, Meguid NA, Bjørklund G, Gouda A, Bahary MH, Hashish A, Sallam NM, Chirumbolo S, & El-Bana MA. (2016) Altered urinary porphyrins and mercury exposure as biomarkers for autism severity in Egyptian children with autism spectrum disorder. Metabolic brain disease. PMID: 27406246
- August 1, 2016
- 07:36 PM
- 93 views
This Month in Blastocystis Research - Interactive Edition
by Christen Rune Stensvold in Blastocystis Parasite Blog
What are your thoughts on Blastocystis carriage and age? Please comment!... Read more »
Forsell J, Granlund M, Samuelsson L, Koskiniemi S, Edebro H, & Evengård B. (2016) High occurrence of Blastocystis sp. subtypes 1-3 and Giardia intestinalis assemblage B among patients in Zanzibar, Tanzania. Parasites , 9(1), 370. PMID: 27356981
Poulsen CS, Efunshile AM, Nelson JA, & Stensvold CR. (2016) Epidemiological Aspects of Blastocystis Colonization in Children in Ilero, Nigeria. The American journal of tropical medicine and hygiene, 95(1), 175-9. PMID: 27139454
- August 1, 2016
- 03:10 PM
- 96 views
FAMIN or feast? Newly discovered mechanism influences how immune cells 'eat' invaders
by Dr. Jekyll in Lunatic Laboratories
A new mechanism that affects how our immune cells perform - and hence their ability to prevent disease - has been discovered by an international team of researchers. To date, researchers have identified hundreds of genetic variants that increase or decrease the risk of developing diseases from cancer and diabetes to tuberculosis and mental health disorders.
... Read more »
M Zaeem Cader, Katharina Boroviak, Qifeng Zhang, Ghazaleh Assadi, Sarah L Kempster, Gavin W Sewell, Svetlana Saveljeva, Jonathan W Ashcroft, Simon Clare, Subhankar Mukhopadhyay, Karen P Brown, Markus Tschurtschenthaler, Tim Raine, Brendan Doe, Edwin R Chilvers, Jules L Griffin, Nicole C Kaneider, R Andres Floto, Mauro D'Amato, Allan Bradley, Michael J O Wakelam.... (2016) C13orf31 (FAMIN) is a central regulator of immunometabolic function. Nature Immunology. info:/10.1038/ni.3532
- August 1, 2016
- 07:22 AM
- 89 views
Live Long & Prosper!
by AG McCluskey in Zongo's Cancer Diaries
Good news for cancer patients in the UK, as 10-year survival rates show big improvements.... Read more »
MacMillan Cancer Support. (2016) Cancer: Then and Now. Diagnosis, treatment and aftercare from 1970–2016. MacMillan Cancer Support. info:/
- August 1, 2016
- 04:10 AM
- 105 views
Physical activity in children and youth: themes and consensus
by Paul Whiteley in Questioning Answers
'Physical activity boosts kids' brain power and academic prowess' went the press release accompanying the consensus statement published by Jens Bangsbo and colleagues [1] (open-access).The consensus statement brought together researchers from around the world "and from a variety of academic disciplines" to emphasise how undertaking all-manner of different kinds of exercise "are still a good investment in academic achievement" when it comes to children aged between 6-18 years of age.The stat........ Read more »
Bangsbo J, Krustrup P, Duda J, Hillman C, Andersen LB, Weiss M, Williams CA, Lintunen T, Green K, Hansen PR.... (2016) The Copenhagen Consensus Conference 2016: children, youth, and physical activity in schools and during leisure time. British journal of sports medicine. PMID: 27354718
- July 31, 2016
- 03:38 PM
- 105 views
Tracking how HIV disrupts immune system informs vaccine development
by Dr. Jekyll in Lunatic Laboratories
One of the main mysteries confounding development of an HIV vaccine is why some people infected with the virus make the desired antibodies after several years, but a vaccine can't seem to induce the same response.
... Read more »
M. Anthony Moody1,2,3,*,†, Isabela Pedroza-Pacheco4,†, Nathan A. Vandergrift1,5, Cecilia Chui4, Krissey E. Lloyd1, Robert Parks1, Kelly A. Soderberg1, Ane T. Ogbe4, Myron S. Cohen6, Hua-Xin Liao1,5, Feng Gao1,5, Andrew J. McMichael, David C. Montefiori, Laurent Verkoczy, Garnett Kelsoe, Jinghe Huang, Patrick R. Shea, Mark Connors, Persephone Borrow, & Barton F. Haynes. (2016) Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies. Science Immunology . info:/10.1126/sciimmunol.aag0851
- July 30, 2016
- 03:58 PM
- 145 views
Fish oil vs. lard -- why some fat can help or hinder your diet
by Dr. Jekyll in Lunatic Laboratories
A diet high in saturated fat can make your brain struggle to control what you eat. If people are looking to lose weight, stay clear of saturated fat. Consuming these types of fatty food affects a part of the brain called the hypothalamus, which helps regulate hunger.
... Read more »
Viggiano, E., Mollica, M., Lionetti, L., Cavaliere, G., Trinchese, G., De Filippo, C., Chieffi, S., Gaita, M., Barletta, A., De Luca, B.... (2016) Effects of an High-Fat Diet Enriched in Lard or in Fish Oil on the Hypothalamic Amp-Activated Protein Kinase and Inflammatory Mediators. Frontiers in Cellular Neuroscience. DOI: 10.3389/fncel.2016.00150
- July 30, 2016
- 03:32 AM
- 145 views
More scientific flesh on the bones of non-coeliac gluten/wheat sensitivity
by Paul Whiteley in Questioning Answers
I was really, really pleased to read the paper by Melanie Uhde and colleagues [1] (open-access) I don't mind telling you. Covering a topic close to my blogging and research heart - sensitivity to wheat or gluten but not coeliac disease - the authors provide some much needed scientific clarification when it comes to how gluten or wheat might impact on some of those "who reported symptoms in response to wheat intake and in whom coeliac disease and wheat allergy were ruled out." Some media int........ Read more »
Uhde, M., Ajamian, M., Caio, G., De Giorgio, R., Indart, A., Green, P., Verna, E., Volta, U., & Alaedini, A. (2016) Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut. DOI: 10.1136/gutjnl-2016-311964
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