All posts; Tags Include "Gene Therapy"
- September 22, 2016
- 09:27 AM
- 325 views
Will tardigrades get humanity into space?
by gdw in FictionalFieldwork
The mighty water bear Tardigrades, aka water bears, are tiny animals that can be found just about everywhere on earth, with a slight preference for the moisture in moss. They happily amble along on their four pairs of legs and slurp up plant cells, algae, and even smaller invertebrates that can’t get away fast enough […]... Read more »
Boothby TC, Tenlen JR, Smith FW, Wang JR, Patanella KA, Nishimura EO, Tintori SC, Li Q, Jones CD, Yandell M.... (2015) Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade. Proceedings of the National Academy of Sciences of the United States of America, 112(52), 15976-81. PMID: 26598659
Koutsovoulos G, Kumar S, Laetsch DR, Stevens L, Daub J, Conlon C, Maroon H, Thomas F, Aboobaker AA, & Blaxter M. (2016) No evidence for extensive horizontal gene transfer in the genome of the tardigrade Hypsibius dujardini. Proceedings of the National Academy of Sciences of the United States of America, 113(18), 5053-8. PMID: 27035985
Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T.... (2016) Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nature communications, 12808. PMID: 27649274
- August 25, 2016
- 09:40 AM
- 412 views
How to rebuild a brain
by gdw in FictionalFieldwork
After the stroke The human brain is complicated. Very complicated. And like any piece of complex machinery that relies on the smooth functioning of many components, it’s not immune to malfunction. When a part of the brain doesn’t get proper nutrition through a nice and smooth blood flow, things go awry and a stroke occurs. […]... Read more »
Chowdhury R, Stevens S, Gorman D, Pan A, Warnakula S, Chowdhury S, Ward H, Johnson L, Crowe F, Hu FB.... (2012) Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease: systematic review and meta-analysis. BMJ (Clinical research ed.). PMID: 23112118
Hurst K, Lee R, Sideso E, Giles M, & Handa A. (2016) Delays in the presentation to stroke services of patients with transient ischaemic attack and minor stroke. The British journal of surgery. PMID: 27529453
Mayurasakorn K, Niatsetskaya ZV, Sosunov SA, Williams JJ, Zirpoli H, Vlasakov I, Deckelbaum RJ, & Ten VS. (2016) DHA but Not EPA Emulsions Preserve Neurological and Mitochondrial Function after Brain Hypoxia-Ischemia in Neonatal Mice. PloS one, 11(8). PMID: 27513579
Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, & Zlokovic BV. (2016) 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nature medicine. PMID: 27548576
- January 8, 2016
- 09:59 PM
- 446 views
CRISPR Successfully Restores Gene Function in Animal Model of Duchenne Muscular Dystrophy
by Marie Benz in MedicalResearch.com
MedicalResearch.com Interview with: Rhonda Bassel-Duby, Ph.D. and Dr. Chengzu Long, PhD Department of Molecular Biology UT Southwestern Medical Center Dallas, TX 75390-9148 Medical Research: What is the background for this study? What are the main findings? Response: Duchenne muscular dystrophy (DMD), … Continue reading →
The post CRISPR Successfully Restores Gene Function in Animal Model of Duchenne Muscular Dystrophy appeared first on MedicalResearch.com.
... Read more »
Rhonda Bassel-Duby, Ph.D. and, & Dr. Chengzu Long, Graduate Student. (2016) CRISPR Successfully Restores Gene Function in Animal Model of Duchenne Muscular Dystrophy. MedicalResearch.com. info:/
- October 12, 2015
- 08:23 AM
- 660 views
Promising Study Supports Gene Therapy For Wet Macular Degeneration
by Marie Benz in MedicalResearch.com
MedicalResearch.com Interview with: Professor P. Elizabeth Rakoczy Centre for Ophthalmology and Visual Sciences The University of Western Australia Head of Department - Molecular Ophthalmology Lions Eye Institute Australia Medical Research: What is the background for this study? Prof. Rakoczy: Wet age … Continue reading →
The post Promising Study Supports Gene Therapy For Wet Macular Degeneration appeared first on MedicalResearch.com.
... Read more »
Professor P. Elizabeth Rakoczy. (2015) Promising Study Supports Gene Therapy For Wet Macular Degeneration. MedicalResearch.com. info:/
- March 29, 2015
- 05:45 PM
- 699 views
A novel method makes gene therapy safer
by Valerie Ashton in The Molecular Scribe
An international team of researchers have validated a method for identifying human insulator genes that dampen the over-activity of therapeutic genes delivered during gene therapy.... Read more »
Liu M, Maurano MT, Wang H, Qi H, Song CZ, Navas PA, Emery DW, Stamatoyannopoulos JA, & Stamatoyannopoulos G. (2015) Genomic discovery of potent chromatin insulators for human gene therapy. Nature biotechnology, 33(2), 198-203. PMID: 25580597
- October 12, 2014
- 02:45 AM
- 848 views
How EBOLA Treatment Works
by Viputheshwar Sitaraman in Draw Science
A basic insight into the biology behind the experimental EBOLA treatment. [Infographic]... Read more »
Qiu, X., Wong, G., Audet, J., Bello, A., Fernando, L., Alimonti, J., Fausther-Bovendo, H., Wei, H., Aviles, J., Hiatt, E.... (2014) Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature, 514(7520), 47-53. DOI: 10.1038/nature13777
- October 9, 2014
- 12:04 AM
- 909 views
RotM: Interview with Prof. Kenro Kusumi
by Coffee Table Science in CTS
Prof. Kenro Kusumi (R) with authors of the paper,
Jeanne Wilson-Rawls (L) and Elizabeth Hutchins (centre).
Photo credit: Joel Robertson.
We, continue our Researcher of the Month initiative, with an interview with Professor Kenro Kusumi, who studies development, regeneration and diseases of the spine in his lab at the School of Life Sciences at the Arizona State University. Prof. Kusumi's ... Read more »
Eckalbar WL, Hutchins ED, Markov GJ, Allen AN, Corneveaux JJ, Lindblad-Toh K, Di Palma F, Alföldi J, Huentelman MJ, & Kusumi K. (2013) Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes. BMC genomics, 49. PMID: 23343042
Rinkevich Y, Lindau P, Ueno H, Longaker MT, & Weissman IL. (2011) Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip. Nature, 476(7361), 409-13. PMID: 21866153
Hutchins, E., Markov, G., Eckalbar, W., George, R., King, J., Tokuyama, M., Geiger, L., Emmert, N., Ammar, M., Allen, A.... (2014) Transcriptomic Analysis of Tail Regeneration in the Lizard Anolis carolinensis Reveals Activation of Conserved Vertebrate Developmental and Repair Mechanisms. PLoS ONE, 9(8). DOI: 10.1371/journal.pone.0105004
- August 16, 2014
- 09:14 AM
- 821 views
High Sugar & Plants
by Viputheshwar Sitaraman in Draw Science
Activating PPARy can cure high blood sugar, but the problem is that current treatment has serious side effects. Accordingly, we turn to plants and natural medicine to provide new chemical formulas for PPARy agonists to help cure hyperglycemia.[Infographic]... Read more »
Wang L, Waltenberger B, Pferschy-Wenzig EM, Blunder M, Liu X, Malainer C, Blazevic T, Schwaiger S, Rollinger JM, Heiss EH.... (2014) Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochemical pharmacology. PMID: 25083916
- August 4, 2014
- 03:00 PM
- 840 views
One Gene, One Cancer
by Viputheshwar Sitaraman in Draw Science
A mutation in the BRAF gene, called V599E, is purportedly the cause of several different cell pathways leading to the symptoms of melanoma. This mutation is present in many patients with melanoma, and stopping it could mean a cure or treatment. [Infographic]... Read more »
Hingorani SR, Jacobetz MA, Robertson GP, Herlyn M, & Tuveson DA. (2003) Suppression of BRAF(V599E) in human melanoma abrogates transformation. Cancer research, 63(17), 5198-202. PMID: 14500344
- July 20, 2014
- 09:13 PM
- 963 views
Parasite Cures Cancer
by Viputheshwar Sitaraman in Draw Science
A parasite commonly found in the intestines of cats turns out to be an immune system boost against cancer! [Infographic]... Read more »
Baird, J., Fox, B., Sanders, K., Lizotte, P., Cubillos-Ruiz, J., Scarlett, U., Rutkowski, M., Conejo-Garcia, J., Fiering, S., & Bzik, D. (2013) Avirulent Toxoplasma gondii Generates Therapeutic Antitumor Immunity by Reversing Immunosuppression in the Ovarian Cancer Microenvironment. Cancer Research, 73(13), 3842-3851. DOI: 10.1158/0008-5472.CAN-12-1974
- June 18, 2014
- 11:22 PM
- 864 views
Cancer Vaccine
by Viputheshwar Sitaraman in Draw Science
Finally, a possible vaccine for cancer. [Infographic]... Read more »
Yukai He,, Yuan Hong,, Yibing Peng,, Lisa Butterfield,, Sheng Guo,, David Bartlett,, David Munn1,, Jose Guevara-Patino,, Junfeng Pang,, & Nahid Mivechi,. (2014) Engineering AFP and GPC3 to create highly immunogenic gene vaccines to prevent carcinogen-induced murine autochthonous hepatocellular carcinoma. The Journal of Immunology, 192(1). info:/
- June 10, 2014
- 01:00 PM
- 799 views
[Creepy] Plasmids and Antibiotic Resistance
by Dr. Jekyll in Lunatic Laboratories
If the title didn’t give it away, plasmids are creepy. For those of you who are confused by that statement let’s cover what a plasmid is exactly. Plasmids are very […]... Read more »
Maria A. Schumacher, Nam K. Tonthat, Stephen M. Kwong, Naga babu Chinnam, Michael A. Liu, Ronald A. Skurray, & Neville Firth. (2014) Mechanism of staphylococcal multiresistance plasmid replication origin assembly by the RepA protein. Proceedings of the National Academy of Sciences. info:/10.1073/pnas.1406065111
- June 3, 2014
- 09:56 AM
- 825 views
Gene Scissors
by Viputheshwar Sitaraman in Draw Science
Gene scissors allow scientists to cut out any gene: a dream for gene therapy! [Infographic]... Read more »
Gaj, T., Gersbach, C., & Barbas, C. (2013) ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends in Biotechnology, 31(7), 397-405. DOI: 10.1016/j.tibtech.2013.04.004
- February 9, 2014
- 09:52 AM
- 1,302 views
Gene therapy for the heart
My post today is about state-of-the-art gene therapy that delivers genes straight to heart, where the genes activate proteins critical in restoring cardiac tissue in people affected by heart failure. The technique, developed at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai, is undergoing clinical trial.Cardiovascular disease is the leading cause of death worldwide. Heart failure--a condition by which the heart weakens and no longer pumps blood efficiently througho........ Read more »
Tilemann L, Lee A, Ishikawa K, Aguero J, Rapti K, Santos-Gallego C, Kohlbrenner E, Fish KM, Kho C, & Hajjar RJ. (2013) SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure. Science translational medicine, 5(211). PMID: 24225946
Yang L, & Xiao X. (2013) Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution. Virology journal, 50. PMID: 23394344
- January 28, 2014
- 06:38 AM
- 873 views
Geneticaly developed toxin destroy HIV carrying lymphocytes
by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets
Drug that destroy HIV carrying lymphocytes; can impart complete treatment so that patient will not have to take antiretroviral drugs through out life as after certain period after attaining nill HIV count discontinuation of antiretroviral drug therapy there will be no hidden HIV virus in human body cells lymphocytes that relapse HIV infection and reproduce HIV count. ... Read more »
B V Waghmare. (2014) Drug that destroy HIV carrying lymphocytes; will result in complete treatment that will not require to taking antiretroviral drugs through out life. . http://bvwaghmare.blogspot.com. info:/
- December 16, 2013
- 10:14 AM
- 954 views
Genetic Factors Contribute to Being Skinny
by William Yates, M.D. in Brain Posts
An increasing body of research supports a genetic contribution to obesity.However, relatively few genetic studies of the opposite or lean phenotype have been done.The lean phenotype is important to study because being very underweight is linked to mortality risk and several clinical disorders including anorexia nervosa.Typically, I review neuroscience research manuscripts from other scientists in Brain Posts.Today I want to summarize some of my own research published recently in the journal PLOS........ Read more »
Yates WR, Johnson C, McKee P, Cannon-Albright LA. (2013) Genetic Analysis of Low BMI Phenotype in the Utah Population Database. PLOS One. info:/10.1371/journal.pone.0080287
- November 29, 2013
- 04:22 PM
- 897 views
MANS BEST FRIEND AND THE TREATMENT OF HAEMOPHILIA A
by Emtel in Antisense Science
We all injure ourselves often- a cut finger when doing the washing up, that scab we can’t resist picking. We don’t usually think much of it, maybe a quick curse, but the wound stops bleeding, stops hurting and heals. But what would happen if scabs didn’t form and if small cuts didn’t stop bleeding? Well for some people this is the case. Haemophilia A, a haemorrhagic disorder, is generally an X-linked recessive trait and effects 1 in 10000 males. It involves defects of p........ Read more »
Du LM, Nurden P, Nurden AT, Nichols TC, Bellinger DA, Jensen ES, Haberichter SL, Merricks E, Raymer RA, Fang J.... (2013) Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A. Nature communications, 2773. PMID: 24253479
- July 26, 2013
- 10:30 AM
- 1,732 views
Genetics of Blindness: Inherited Retinal Diseases
by Daniel Koboldt in Massgenomics
The genetics of inherited vision disorders — notably retinitis pigmentosa (RP) and age-related macular degeneration (AMD) — are an area of intense research. Numerous genes responsible for inherited retinopathies have been identified in the past ten years. At the time of writing, there are at least 242 different genetic disorders, with 202 different genes identified [...]... Read more »
Suma P. Shankar. (2013) Hereditary Retinal and Choroidal Dystrophies. Elsevier. DOI: 10.1016/B978-0-12-383834-6.00147-6
- July 7, 2013
- 09:23 AM
- 1,500 views
Male DNA in the Female Brain
by TheCellularScale in The Cellular Scale
When you are pregnant, people like to tell you all sorts of things about yourself.probably the most complimentary thing I have been compared to."you are going to have a boy/girl""you are carrying high/low""you look like an olive on a toothpick/beached whale""you probably have some of your husband's DNA/baby's cells in your brain now."huh?That last one requires a little more explanation. How could new external foreign cells get into my brain? First of all there is the blood-brain barrier which pr........ Read more »
Dawe GS, Tan XW, & Xiao ZC. (2007) Cell migration from baby to mother. Cell adhesion , 1(1), 19-27. PMID: 19262088
- May 14, 2013
- 07:12 AM
- 736 views
Turtle genome shows breathing is optional
by Andrew Porterfield in United Academics
Genome of the western painted turtle has developed a remarkable ability to go without oxygen for months. And this genomic change could point to better heart attack and stroke treatments for us.... Read more »
Abramyan, J., Badenhorst, D., Biggar, K., Borchert, G., Botka, C., Bowden, R., Braun, E., Bronikowski, A., Bruneau, B., Buck, L.... (2013) The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biology, 14(3). DOI: 10.1186/gb-2013-14-3-r28
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