All posts; Tags Include "Biomedical Engineering"
- February 12, 2017
- 11:10 AM
- 192 views
More than Meets the Eye
by Aurametrix team in Aurametrix Blog
Eyeglasses are almost as old as the civilization itself. They have not changed much since Benjamin Franklin's bifocals in the 18th century. Nor were they made obsolete by laser surgery and contacts. Still, eyeglass technology leaves much to be desired. But new technologies are unfolding before our eyes. ... Read more »
Douali MG, & Silver JD. (2004) Self-optimised vision correction with adaptive spectacle lenses in developing countries. Ophthalmic , 24(3), 234-41. PMID: 15130172
Gudlavalleti VS, Allagh KP, & Gudlavalleti AS. (2014) Self-adjustable glasses in the developing world. Clinical ophthalmology (Auckland, N.Z.), 405-13. PMID: 24570581
Hasan N, Banerjee A, Kim H, & Mastrangelo CH. (2017) Tunable-focus lens for adaptive eyeglasses. Optics express, 25(2), 1221-1233. PMID: 28158006
Ruano S, Cuevas C, Gallego G, & García N. (2017) Augmented Reality Tool for the Situational Awareness Improvement of UAV Operators. Sensors (Basel, Switzerland), 17(2). PMID: 28178189
- September 22, 2016
- 09:27 AM
- 452 views
Will tardigrades get humanity into space?
by gdw in FictionalFieldwork
The mighty water bear Tardigrades, aka water bears, are tiny animals that can be found just about everywhere on earth, with a slight preference for the moisture in moss. They happily amble along on their four pairs of legs and slurp up plant cells, algae, and even smaller invertebrates that can’t get away fast enough […]... Read more »
Boothby TC, Tenlen JR, Smith FW, Wang JR, Patanella KA, Nishimura EO, Tintori SC, Li Q, Jones CD, Yandell M.... (2015) Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade. Proceedings of the National Academy of Sciences of the United States of America, 112(52), 15976-81. PMID: 26598659
Koutsovoulos G, Kumar S, Laetsch DR, Stevens L, Daub J, Conlon C, Maroon H, Thomas F, Aboobaker AA, & Blaxter M. (2016) No evidence for extensive horizontal gene transfer in the genome of the tardigrade Hypsibius dujardini. Proceedings of the National Academy of Sciences of the United States of America, 113(18), 5053-8. PMID: 27035985
Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T.... (2016) Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nature communications, 12808. PMID: 27649274
- May 31, 2016
- 11:30 PM
- 707 views
42: the answer to life, the universe and everything (i.e., consciousness)
by Piter Boll in Earthling Nature
by Piter Kehoma Boll In his work “The Hitchhiker’s Guide to the Galaxy”, Douglas Adams defined that the answer to life, the universe and everything is 42. Now a group of scientists measured glucose metabolism in brains in a resting … Continue reading →... Read more »
Stender, J., Mortensen, K., Thibaut, A., Darkner, S., Laureys, S., Gjedde, A., & Kupers, R. (2016) The Minimal Energetic Requirement of Sustained Awareness after Brain Injury. Current Biology. DOI: 10.1016/j.cub.2016.04.024
- May 25, 2016
- 09:00 AM
- 757 views
Are our gut bacteria the key to immortality?
by gdw in FictionalFieldwork
The fight against aging Ever since the ancient Sumerians, men has sought eternal life. We still do. Anti-aging science has become quite an industry. As we dive deeper and deeper into our biological foundations, we’re learning more and more about how and why we age. A lot of mysteries remain, but there’s still talk about […]... Read more »
De Winter, G. (2014) Aging as Disease. Medicine, Health Care and Philosophy, 18(2), 237-243. DOI: 10.1007/s11019-014-9600-y
Biagi E, Franceschi C, Rampelli S, Severgnini M, Ostan R, Turroni S, Consolandi C, Quercia S, Scurti M, Monti D.... (2016) Gut Microbiota and Extreme Longevity. Current biology : CB. PMID: 27185560
- May 10, 2016
- 07:40 AM
- 577 views
Do dragons dream of tasty crickets?
by gdw in FictionalFieldwork
(Also appeared on United Academics) Sleep cycles When we leave the day behind us and nestle ourselves in our cosy beds, we sleep. Sleep, however, comes in stages that repeat themselves. It’s a five-stage cycle that last about 90 minutes in humans. Four stages of non-REM sleep are followed by a period of REM (Rapid […]... Read more »
Ólafsdóttir HF, Barry C, Saleem AB, Hassabis D, & Spiers HJ. (2015) Hippocampal place cells construct reward related sequences through unexplored space. eLife. PMID: 26112828
Shein-Idelson M, Ondracek JM, Liaw HP, Reiter S, & Laurent G. (2016) Slow waves, sharp waves, ripples, and REM in sleeping dragons. Science (New York, N.Y.), 352(6285), 590-5. PMID: 27126045
- February 6, 2016
- 07:42 AM
- 742 views
Domestic Dog
by Jason Organ in Eatlemania!
The Eatles are cleaning the skull of a domestic dog. Come read about osteoporosis research in the Organ Lab at Indiana University School of Medicine... Read more »
Allen MR, Territo PR, Lin C, Persohn S, Jiang L, Riley AA, McCarthy BP, Newman CL, Burr DB, & Hutchins GD. (2015) In Vivo UTE-MRI Reveals Positive Effects of Raloxifene on Skeletal-Bound Water in Skeletally Mature Beagle Dogs. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(8), 1441-4. PMID: 25644867
Allen MR, McNerny EM, Organ JM, & Wallace JM. (2015) True Gold or Pyrite: A Review of Reference Point Indentation for Assessing Bone Mechanical Properties In Vivo. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(9), 1539-50. PMID: 26235703
Aref M, Gallant MA, Organ JM, Wallace JM, Newman CL, Burr DB, Brown DM, & Allen MR. (2013) In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following 6 months of treatment in skeletally mature beagle dogs. Bone, 56(2), 449-53. PMID: 23871851
Skoglund P, Ersmark E, Palkopoulou E, & Dalén L. (2015) Ancient wolf genome reveals an early divergence of domestic dog ancestors and admixture into high-latitude breeds. Current biology : CB, 25(11), 1515-9. PMID: 26004765
- January 10, 2016
- 03:21 PM
- 532 views
Gene drive - take the wheel against malaria
by Syed Ather in Heuristic
Scientists are coming closer and closer to the dreams of genetic engineering just about
anything for any purpose. Now we can drive those dreams home by engineering mosquitos in
order to eliminate malaria, one of the biggest health and economic threats faced by
developing nations.... Read more »
Gantz, V., Jasinskiene, N., Tatarenkova, O., Fazekas, A., Macias, V., Bier, E., & James, A. (2015) Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito . Proceedings of the National Academy of Sciences, 112(49). DOI: 10.1073/pnas.1521077112
- March 17, 2015
- 08:00 AM
- 1,718 views
I See, Said The Blind Man
by Mark E. Lasbury in The 'Scope
I can’t stand it when I get dust in my eye. Can you imagine having a neural implant in your eye? Star Trek’s Geordi LaForge had implanted electrodes that, along with his visor, let him see. Visual neural prostheses are no longer a thing of science fiction, making the blind see is science fact. The only difference is that he saw in all wavelengths of the electromagnetic spectrum. But there’s no reason we can’t do that as well. ... Read more »
Wang, J., Wu, X., Lu, Y., Wu, H., Kan, H., & Chai, X. (2014) Face recognition in simulated prosthetic vision: face detection-based image processing strategies. Journal of Neural Engineering, 11(4), 46009. DOI: 10.1088/1741-2560/11/4/046009
Jung, J., Aloni, D., Yitzhaky, Y., & Peli, E. (2014) Active confocal imaging for visual prostheses. Vision Research. DOI: 10.1016/j.visres.2014.10.023
Nirenberg, S., & Pandarinath, C. (2012) Retinal prosthetic strategy with the capacity to restore normal vision. Proceedings of the National Academy of Sciences, 109(37), 15012-15017. DOI: 10.1073/pnas.1207035109
Stingl, K., Bartz-Schmidt, K., Gekeler, F., Kusnyerik, A., Sachs, H., & Zrenner, E. (2013) Functional Outcome in Subretinal Electronic Implants Depends on Foveal Eccentricity. Investigative Ophthalmology , 54(12), 7658-7665. DOI: 10.1167/iovs.13-12835
- February 9, 2015
- 01:30 PM
- 1,129 views
Slime mould and researcher set to play piano duet
by GrrlScientist in Maniraptora
SUMMARY: A single-celled organism will perform a piano duet with a computer musician at Plymouth University on 1 March 2015. The public is invited. ... Read more »
Nakagaki Toshiyuki, Yamada Hiroyasu, & Tóth Ágota. (2000) Intelligence: Maze-solving by an amoeboid organism. Nature, 407(470). DOI: 10.1038/35035159
Saigusa Tetsu, Toshiyuki Nakagaki, & Yoshiki Kuramoto. (2008) Amoebae Anticipate Periodic Events. Physical Review Letters, 100(1). DOI: http://dx.doi.org/10.1103/physrevlett.100.018101
Miranda Eduardo R. , Adamatzky Andrew, & Jones Jeff . (2011) Sounds Synthesis with Slime Mould of Physarum polycephalum. Journal of Bionic Engineering, 107-113. arXiv: 1212.1203
- February 3, 2015
- 08:05 AM
- 1,237 views
Tryin' To Make A Tricorder
by Mark E. Lasbury in The 'Scope
Star Trek technology is coming true; modern medicine has borrowed the idea of the tricorder. There’s currently a $10 million X Prize to produce a working model. The goal is take doctors out of the picture and allow consumers to assess their own health status. To win the money, ten teams have developed hand held devices that can diagnose 16 diseases and monitor half a dozen vital signs in real time. ... Read more »
Fridman GY, Tang H, Feller-Kopman D, & Hong Y. (2015) MouthLab: A Tricorder Concept Optimized for Rapid Medical Assessment. Annals of biomedical engineering. PMID: 25605586
Chandler, D. (2014) A Doctor in the Palm of Your Hand: How the Qualcomm Tricorder X-Prize could help to revolutionize medical diagnosis. IEEE Pulse, 5(2), 50-54. DOI: 10.1109/MPUL.2013.2296803
Gulec SA, Daghighian F, & Essner R. (2006) PET-Probe: Evaluation of Technical Performance and Clinical Utility of a Handheld High-Energy Gamma Probe in Oncologic Surgery. Annals of surgical oncology. PMID: 16865592
- January 27, 2015
- 07:30 AM
- 1,325 views
Star Date: Pretty Darn Soon
by Mark E. Lasbury in The 'Scope
Star Trek celebrates its 50th anniversary in 2016. In preparation for the celebrations, we’re checking in on how close we are to making Star Trek technology a reality. The replicator made food and recycled trash, and later was used to make parts for the Enterprise. A machine fabricated what they needed on the spot. We have that now on the space station! Do you know how 3-D printing works and how we print parts, food, and even living tissue? Here’s how.... Read more »
Yu, A., & Khan, M. (2015) On-demand three-dimensional printing of surgical supplies in conflict zones. Journal of Trauma and Acute Care Surgery, 78(1), 201-203. DOI: 10.1097/TA.0000000000000481
Murphy, S., & Atala, A. (2014) 3D bioprinting of tissues and organs. Nature Biotechnology, 32(8), 773-785. DOI: 10.1038/nbt.2958
Kolesky, D., Truby, R., Gladman, A., Busbee, T., Homan, K., & Lewis, J. (2014) Bioprinting: 3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs (Adv. Mater. 19/2014). Advanced Materials, 26(19), 2966-2966. DOI: 10.1002/adma.201470124
- December 22, 2014
- 12:35 PM
- 1,014 views
Mind-Controlled Prosthetics
by Viputheshwar Sitaraman in Draw Science
Researchers at JHU have demonstrated a prosthetic arm that is controlled completely by the user's thoughts. [Infographic]... Read more »
Collinger, J., Wodlinger, B., Downey, J., Wang, W., Tyler-Kabara, E., Weber, D., McMorland, A., Velliste, M., Boninger, M., & Schwartz, A. (2013) High-performance neuroprosthetic control by an individual with tetraplegia. The Lancet, 381(9866), 557-564. DOI: 10.1016/S0140-6736(12)61816-9
- September 17, 2014
- 08:28 AM
- 1,499 views
Builders and Blocks – Engineering Blood Vessels with Stem Cells
by Jalees Rehman in The Next Regeneration
Back in 2001, when we first began studying how regenerative cells (stem cells or more mature progenitor cells) enhance blood vessel growth, our group as well as many of our colleagues focused on one specific type of blood vessel: arteries. Arteries are responsible for supplying oxygen to all organs and tissues of the body and arteries are more likely to develop gradual plaque build-up (atherosclerosis) than veins or networks of smaller blood vessels (capillaries). Once the amount of plaque in an........ Read more »
Paul JD, Coulombe KL, Toth PT, Zhang Y, Marsboom G, Bindokas VP, Smith DW, Murry CE, & Rehman J. (2013) SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. Journal of molecular and cellular cardiology, 124-31. PMID: 24090675
- August 4, 2014
- 07:29 AM
- 1,309 views
Interview: Battling HIV-treatment With Computer Simulation
by Pieter Carriere in United Academics
Prof. Mancini computationally models HIV and other viruses’ dynamics and explains its clinical relevance.... Read more »
Mancini, E., Castiglione, F., Bernaschi, M., de Luca, A., & Sloot, P. (2012) HIV Reservoirs and Immune Surveillance Evasion Cause the Failure of Structured Treatment Interruptions: A Computational Study. PLoS ONE, 7(4). DOI: 10.1371/journal.pone.0036108
- July 23, 2014
- 08:00 AM
- 927 views
Let's Get Loud
by Mark Lasbury in As Many Exceptions As Rules
Loud noises are common in nature. New research is giving clues as to how and why animals make such noise. A new study investigates the reasons that howler monkeys howl. Protection and marking territory are main reasons, including for protection of infants or feeding areas.
A slightly older study notes that blue whale song has become lower in pitch since the whaling ban. The authors suggest that the reason for this may be that males don’t have to sing as loud (higher frequencies are loud........ Read more »
Van Belle S, Estrada A, & Garber PA. (2014) The function of loud calls in black howler monkeys (Alouatta pigra): Food, mate, or infant defense?. American journal of primatology. PMID: 24865565
Sueur J, Mackie D, & Windmill JF. (2011) So small, so loud: extremely high sound pressure level from a pygmy aquatic insect (Corixidae, Micronectinae). PloS one, 6(6). PMID: 21698252
McDonald, M., Hildebrand, J., & Mesnick, S. (2009) Worldwide decline in tonal frequencies of blue whale songs. Endangered Species Research, 13-21. DOI: 10.3354/esr00217
Anker A, Ahyong ST, Noël PY, & Palmer AR. (2006) Morphological phylogeny of alpheid shrimps: parallel preadaptation and the origin of a key morphological innovation, the snapping claw. Evolution; international journal of organic evolution, 60(12), 2507-28. PMID: 17263113
- July 20, 2014
- 09:13 PM
- 999 views
Parasite Cures Cancer
by Viputheshwar Sitaraman in Draw Science
A parasite commonly found in the intestines of cats turns out to be an immune system boost against cancer! [Infographic]... Read more »
Baird, J., Fox, B., Sanders, K., Lizotte, P., Cubillos-Ruiz, J., Scarlett, U., Rutkowski, M., Conejo-Garcia, J., Fiering, S., & Bzik, D. (2013) Avirulent Toxoplasma gondii Generates Therapeutic Antitumor Immunity by Reversing Immunosuppression in the Ovarian Cancer Microenvironment. Cancer Research, 73(13), 3842-3851. DOI: 10.1158/0008-5472.CAN-12-1974
- July 18, 2014
- 08:51 AM
- 1,353 views
Scientists Create Alcohol-Resistant Worms That Might Cure Alcoholism
by beredim in Strange Animals
Image showing the effects of alchohol in Caenorhabditis elegans and..humansCredit: Jon Pierce-Shimomura from The University of Texas, Austin.A couple of days ago, a team of neuroscientists from the University of Texas, Austin announced that they have created a new strain of mutant worms which is impervious to the intoxicating effects of alcohol!To create the alcohol-immune worms, the researchers implanted a modified human alcohol target – a neuronal channel called the BK channel SLO-1 tha........ Read more »
Davis, S., Scott, L., Hu, K., & Pierce-Shimomura, J. (2014) Conserved Single Residue in the BK Potassium Channel Required for Activation by Alcohol and Intoxication in C. elegans. Journal of Neuroscience, 34(29), 9562-9573. DOI: 10.1523/JNEUROSCI.0838-14.2014
- June 18, 2014
- 11:22 PM
- 902 views
Cancer Vaccine
by Viputheshwar Sitaraman in Draw Science
Finally, a possible vaccine for cancer. [Infographic]... Read more »
Yukai He,, Yuan Hong,, Yibing Peng,, Lisa Butterfield,, Sheng Guo,, David Bartlett,, David Munn1,, Jose Guevara-Patino,, Junfeng Pang,, & Nahid Mivechi,. (2014) Engineering AFP and GPC3 to create highly immunogenic gene vaccines to prevent carcinogen-induced murine autochthonous hepatocellular carcinoma. The Journal of Immunology, 192(1). info:/
- June 16, 2014
- 09:43 PM
- 977 views
Synthetic Biology: Engineering Life To Examine It
by Jalees Rehman in Fragments of Truth
Two scientific papers that were published in the journal Nature in the year 2000 marked the beginning of engineering biological circuits in cells. The paper "Construction of a genetic toggle switch in Escherichia coli" by Timothy Gardner, Charles Cantor and James Collins created a genetic toggle switch by simultaneously introducing an artificial DNA plasmid into a bacterial cell. This DNA plasmid contained two promoters (DNA sequences which regulate the expression of genes) and two rep........ Read more »
Daniel R, Rubens JR, Sarpeshkar R, & Lu TK. (2013) Synthetic analog computation in living cells. Nature, 497(7451), 619-23. PMID: 23676681
- May 30, 2014
- 06:10 PM
- 1,522 views
Does Human Fat Contain Stem Cells?
by Jalees Rehman in The Next Regeneration
Many research groups, including our own group, have been able to isolate stem cells from human fat. However, when it came to using this cells for treating cardiovascular disease, the cells behaved in a manner that we had not anticipated.... Read more »
Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, & Hedrick MH. (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue engineering, 7(2), 211-28. PMID: 11304456
Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, Pell CL, Johnstone BH, Considine RV, & March KL. (2004) Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation, 109(10), 1292-8. PMID: 14993122
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