by Marie Benz in MedicalResearch.com
MedicalResearch.com Interview with: Prof. Dimitrios Karussis M.D., Ph.D. Professor of Neurology Head, Multiple Sclerosis Center Hadassah BrainLabs Medical Research: What is the background for this study? What are the main findings? Prof. Karussis: BrainStorm Cell Therapeutics is developing innovative, autologous stem cell … Continue reading →
The post Stem Cell Derived Growth Factors May Slow Progression of ALS appeared first on MedicalResearch.com.
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Prof. Dimitrios Karussis. (2016) Stem Cell Derived Growth Factors May Slow Progression of ALS. MedicalResearch.com. info:/
by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets
Antibodies developed in HIV infected individuals do not protect them against further proliferation of HIV, but protect proliferation of HIV in animals.
That means it is possible to develop a vaccine which will completely protect human from HIV infection.... Read more »
B V Waghmare. (2015) HIV Vaccine heading toward success. Combination of HIV neutralizing antibodies and Nanoparticle protien eOD-GT8 60mer are good hope for getting a effective anti HIV vaccine. http://bvwaghmare.blogspot.com. info:/
by Marie Benz in MedicalResearch.com
MedicalResearch.com Interview with: Benjamin Freedman, Ph.D. Assistant Professor | University of Washington Department of Medicine | Division of Nephrology Member, Kidney Research Institute Member, Institute for Stem Cell and Regenerative Medicine Seattle WA 98109 Medical Research: What is the background … Continue reading →
The post Gene-edited Kidney Organoids Re-Create Human Disease appeared first on MedicalResearch.com.
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Benjamin Freedman, Ph.D. (2015) Gene-edited Kidney Organoids Re-Create Human Disease. MedicalResearch.com. info:/
by Daisuke Kurihara in the Node
In multicellular animals and plants, the single-celled zygote develops into the embryo. In the model plant Arabidopsis thaliana, the zygote divides asymmetrically to form a small cytoplasmic apical cell, which is the precursor of the proembryo, and a large vacuolated basal cell, which develops into the extra-embryonic suspensor (Figure 1). Communication between the intra-embryo (proembryo[...]
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The post Live-cell analysis of plant embryogenesis: Live-cell imaging, optical manipulation........ Read more »
Kawashima, T., & Goldberg, R. (2010) The suspensor: not just suspending the embryo. Trends in Plant Science, 15(1), 23-30. DOI: 10.1016/j.tplants.2009.11.002
Javelle, M., Vernoud, V., Rogowsky, P., & Ingram, G. (2011) Epidermis: the formation and functions of a fundamental plant tissue. New Phytologist, 189(1), 17-39. DOI: 10.1111/j.1469-8137.2010.03514.x
Lafon-Placette, C., & Köhler, C. (2014) Embryo and endosperm, partners in seed development. Current Opinion in Plant Biology, 64-69. DOI: 10.1016/j.pbi.2013.11.008
Yeung, E., & Meinke, D. W. (1993) Embryogenesis in Angiosperms: Development of the Suspensor. Plant Cell, 5(10), 1371-1381. DOI: 10.1105/tpc.5.10.1371
Kurihara, D., Hamamura, Y., & Higashiyama, T. (2013) Live-cell analysis of plant reproduction: Live-cell imaging, optical manipulation, and advanced microscopy technologies. Development, Growth , 55(4), 462-473. DOI: 10.1111/dgd.12040
Bhatia, S., & Ingber, D. (2014) Microfluidic organs-on-chips. Nature Biotechnology, 32(8), 760-772. DOI: 10.1038/nbt.2989
Sanati Nezhad, A. (2014) Microfluidic platforms for plant cells studies. Lab on a Chip, 14(17), 3262-3274. DOI: 10.1039/C4LC00495G
Park, J., Kurihara, D., Higashiyama, T., & Arata, H. (2014) Fabrication of microcage arrays to fix plant ovules for long-term live imaging and observation. Sensors and Actuators B: Chemical, 178-185. DOI: 10.1016/j.snb.2013.09.060
Gooh, K., Ueda, M., Aruga, K., Park, J., Arata, H., Higashiyama, T., & Kurihara, D. (2015) Live-Cell Imaging and Optical Manipulation of Arabidopsis Early Embryogenesis. Developmental Cell, 34(2), 242-251. DOI: 10.1016/j.devcel.2015.06.008
van den Berg C, Willemsen V, Hendriks G, Weisbeek P, & Scheres B. (1997) Short-range control of cell differentiation in the Arabidopsis root meristem. Nature, 390(6657), 287-289. PMID: 9384380
Higashiyama, T., Yabe, S., Sasaki, N., Nishimura, Y., Kuroiwa, H., & Kuroiwa, T. (2001) Pollen Tube Attraction by the Synergid Cell. Science, 293(5534), 1480-1483. DOI: 10.1126/science.1062429
Tirlapur, U., & König, K. (2002) Targeted transfection by femtosecond laser. Nature, 418(6895), 290-291. DOI: 10.1038/418290a
by D. Bullara in the Node
D. Bullara* and Y. De Decker *domenico.bullara@mail.com When Catarina Vicente (Community Manager of “The Node”) proposed us to write a post about our recent paper on pattern formation in zebrafish [Bullara2015] we were very glad for the opportunity she was giving us to tell the background story about our work in this blog. We[...]
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The post “Eppur (non) si muove”: why cellular movements may not be essential to the formation of Turing patterns in biology......... Read more »
Bullara, D., & De Decker, Y. (2015) Pigment cell movement is not required for generation of Turing patterns in zebrafish skin. Nature Communications, 6971. DOI: 10.1038/ncomms7971
De Decker Y, Tsekouras GA, Provata A, Erneux T, & Nicolis G. (2004) Propagating waves in one-dimensional discrete networks of coupled units. Physical review. E, Statistical, nonlinear, and soft matter physics, 69(3 Pt 2), 36203. PMID: 15089388
Hamada, H., Watanabe, M., Lau, H., Nishida, T., Hasegawa, T., Parichy, D., & Kondo, S. (2013) Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning. Development, 141(2), 318-324. DOI: 10.1242/dev.099804
Hiscock, T., & Megason, S. (2015) Mathematically guided approaches to distinguish models of periodic patterning. Development, 142(3), 409-419. DOI: 10.1242/dev.107441
Inaba M, Yamanaka H, & Kondo S. (2012) Pigment pattern formation by contact-dependent depolarization. Science, 335(6069), 677. PMID: 22323812
Nakamasu, A., Takahashi, G., Kanbe, A., & Kondo, S. (2009) Interactions between zebrafish pigment cells responsible for the generation of Turing patterns. Proceedings of the National Academy of Sciences, 106(21), 8429-8434. DOI: 10.1073/pnas.0808622106
Patterson, L., & Parichy, D. (2013) Interactions with Iridophores and the Tissue Environment Required for Patterning Melanophores and Xanthophores during Zebrafish Adult Pigment Stripe Formation. PLoS Genetics, 9(5). DOI: 10.1371/journal.pgen.1003561
Singh, A., Schach, U., & Nüsslein-Volhard, C. (2014) Proliferation, dispersal and patterned aggregation of iridophores in the skin prefigure striped colouration of zebrafish. Nature Cell Biology, 16(6), 604-611. DOI: 10.1038/ncb2955
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Yamaguchi, M., Yoshimoto, E., & Kondo, S. (2007) Pattern regulation in the stripe of zebrafish suggests an underlying dynamic and autonomous mechanism. Proceedings of the National Academy of Sciences, 104(12), 4790-4793. DOI: 10.1073/pnas.0607790104
Yamanaka, H., & Kondo, S. (2014) In vitro analysis suggests that difference in cell movement during direct interaction can generate various pigment patterns in vivo. Proceedings of the National Academy of Sciences, 111(5), 1867-1872. DOI: 10.1073/pnas.1315416111
by dkirsch in the Node
Genetically engineered mouse models have been used extensively to study a wide variety of biological processes in vivo, and innovations in genetic engineering have made it possible to dissect more intricate biological questions. For example, the first mice that showed successful germline transmission of foreign DNA were created in the 1980s, and this allowed the[...]
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The post Novel mouse alleles allow for sequential mutagenesis using the dual recombinase technology appeared first on ........ Read more »
Zhang, M., & Kirsch, D. (2015) The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis. Disease Models , 8(9), 1155-1166. DOI: 10.1242/dmm.021204
by Marie Benz in MedicalResearch.com
MedicalResearch.com Interview with: Patricia Sancho, PhD, Lecturer Barts Cancer Institute - a Cancer Research UK Centre of Excellence Queen Mary University of London Centre for Stem Cells in Cancer & Ageing / John Vane Science Centre, Charterhouse Square, London Medical Research: … Continue reading →
The post Attacking Pancreatic Cancer Stem Cells May Lead To Better Treatment appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
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Patricia Sancho, PhD, Lecturer. (2015) Attacking Pancreatic Cancer Stem Cells May Lead To Better Treatment. MedicalResearch.com. info:/
by Mark Lasbury in As Many Exceptions As Rules
How would you react if you were told that the DNA testing shows that you are not your child’s parent or your parents’ child? Demand another test? – you bet. But wait, you or your parent might be a tetragametic chimeric, carrying around DNA from another person in your body. You might have had a dizygotic twin that you didn’t know about!... Read more »
Yu, N., Kruskall, M., Yunis, J., Knoll, J., Uhl, L., Alosco, S., Ohashi, M., Clavijo, O., Husain, Z., Yunis, E.... (2002) Disputed Maternity Leading to Identification of Tetragametic Chimerism. New England Journal of Medicine, 346(20), 1545-1552. DOI: 10.1056/NEJMoa013452
Yu, Q., Li, Q., Gao, S., Su, Y., & Deng, Z. (2011) Congenital Tetragametic Blood Chimerism Explains a Case of Questionable Paternity*. Journal of Forensic Sciences, 56(5), 1346-1348. DOI: 10.1111/j.1556-4029.2011.01794.x
Kanda, T., Ogawa, M., & Sato, K. (2013) Confined Blood Chimerism in Monochorionic Dizygotic Twins Conceived Spontaneously. American Journal of Perinatology Reports, 03(01), 33-36. DOI: 10.1055/s-0032-1331377
Lee, H., Yoon, S., Ko, J., Seong, M., Park, S., Choi, J., & Oh, S. (2014) Monochorionic dizygotic twins with discordant sex and confined blood chimerism. European Journal of Pediatrics, 173(9), 1249-1252. DOI: 10.1007/s00431-014-2312-8
by Xiaofei Sun in the Node
The process of embryo implantation consists of multiple steps: blastocyst apposition, adhesion to uterine luminal epithelial (LE) cells, and removal of the epithelial cells encasing the blastocysts. How the blastocyst trophectoderm breaches the luminal epithelial barrier has been studied for decades, the mechanism of the abstraction of LE cells was not clearly understood. Since the[...]
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The post The blastocyst achieves on-time implantation by entosis appeared first on the Node.
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Cha J, Bartos A, Park C, Sun X, Li Y, Cha SW, Ajima R, Ho HY, Yamaguchi TP, & Dey SK. (2014) Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signaling. Cell reports, 8(2), 382-92. PMID: 25043182
Cha J, Sun X, & Dey SK. (2012) Mechanisms of implantation: strategies for successful pregnancy. Nature medicine, 18(12), 1754-1767. PMID: 23223073
Cross JC. (2005) How to make a placenta: mechanisms of trophoblast cell differentiation in mice--a review. Placenta. PMID: 15837063
Daikoku T, Cha J, Sun X, Tranguch S, Xie H, Fujita T, Hirota Y, Lydon J, DeMayo F, Maxson R.... (2011) Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity. Developmental cell, 21(6), 1014-25. PMID: 22100262
Finn CA, & Hinchliffe JR. (1964) Reaction of the Mouse Uterus during Implantation and Deciduoma Formation as Demonstrated by Changes in the Distribution of Alkaline Phosphatase. Journal of reproduction and fertility, 331-338. PMID: 14248593
Finn CA, & McLaren A. (1967) A study of the early stages of implantation in mice. Journal of Reproduction and Fertility, 259-267. info:/10.1530/jrf.0.0130259
Joswig A, Gabriel HD, Kibschull M, & Winterhager E. (2003) Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reproductive biology and endocrinology, 44. PMID: 12801416
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Li Y, Sun X, & Dey SK. (2015) Entosis allows timely elimination of the luminal epithelial barrier for embryo implantation. Cell reports, 11(3), 358-365. PMID: 25865893
Parr EL, Tung HN, & Parr MB. (1987) Apoptosis as the mode of uterine epithelial cell death during embryo implantation in mice and rats. Biology of reproduction, 36(1), 211-225. PMID: 3567276
Sun X, Zhang L, Xie H, Wan H, Magella B, Whitsett JA, & Dey SK. (2012) Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation. Proceedings of the National Academy of Sciences of the United States of America, 109(4), 1145-1150. PMID: 22233806
Wang H, & Dey SK. (2006) Roadmap to embryo implantation: clues from mouse models. Nature reviews. Genetics, 7(3), 185-199. PMID: 16485018
by Mike Levin in the Node
My lab works on developmental bioelectricity, studying how cells communicate via endogenous gradients of plasma membrane resting potential (Vmem) in order to coordinate their activity during pattern regulation (Levin, 2013; Levin, 2014b; Tseng and Levin, 2013). It is well-known that resting potential is an important regulatory parameter for individual cells’ proliferation, differentiation, and oncogenic potential[...]
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The post Gap junctions: versatile mediators of long-range de........ Read more »
Pai, V., Lemire, J., Pare, J., Lin, G., Chen, Y., & Levin, M. (2015) Endogenous Gradients of Resting Potential Instructively Pattern Embryonic Neural Tissue via Notch Signaling and Regulation of Proliferation. Journal of Neuroscience, 35(10), 4366-4385. DOI: 10.1523/JNEUROSCI.1877-14.2015
by Marie Benz in MedicalResearch.com
MedicalResearch.com Interview with: Dong-Wook Kim Center for Genome Engineering, Institute for Basic Science Yonsei University College of Medicine Seoul, Korea Medical Research: What is the background for this study? Response: Hemophilia A is an X-linked genetic disorder caused by mutations … Continue reading →
The post Patient-Derived Stem Cells May Be Able To Reverse Hemophilia A appeared first on MedicalResearch.com Medical Research Interviews and News.
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Dong-Wook Kim. (2015) Patient-Derived Stem Cells May Be Able To Reverse Hemophilia A. MedicalResearch.com. info:/
by Mark Lasbury in As Many Exceptions As Rules
It’s a miracle that a human body ever works like it’s supposed to. So many things can go wrong and there’s so few ways for things to be right. Ever hear of a defect called situs ambiguus? It’s a big problem. And what’s more, when something like transposition of the great arteries occurs, it’s only a second defect that keeps the patients alive.... Read more »
Kikuchi, K. (2015) Dedifferentiation, Transdifferentiation, and Proliferation: Mechanisms Underlying Cardiac Muscle Regeneration in Zebrafish. Current Pathobiology Reports, 3(1), 81-88. DOI: 10.1007/s40139-015-0063-5
Yousif, M., Elhassan, N., Ali, S., & Ahmed, Y. (2013) Isolated subpulmonic fibrous ring, mirror-image dextrocardia and situs solitus in a young lady unreported and a near miss. Interactive CardioVascular and Thoracic Surgery, 17(6), 1043-1044. DOI: 10.1093/icvts/ivt278
Anderson, R., Brown, N., Meno, C., & Spicer, D. (2015) The importance of being isomeric. Clinical Anatomy, 28(4), 477-486. DOI: 10.1002/ca.22517
Loomba RS, Hlavacek AM, Spicer DE, & Anderson RH. (2015) Isomerism or heterotaxy: which term leads to better understanding?. Cardiology in the young, 1-7. PMID: 26088959
by Mark Lasbury in As Many Exceptions As Rules
Do you know where your heart is located? Do you know exactly? Maybe not. It isn’t where most people think it is, and in some people it’s on the opposite side. Situs inversus is a mirror imaging of internal organs, and it’s caused by a faulty motorboat rotor on the embryo.... Read more »
Babu, D., & Roy, S. (2013) Left-right asymmetry: cilia stir up new surprises in the node. Open Biology, 3(5), 130052-130052. DOI: 10.1098/rsob.130052
Nonaka S, Yoshiba S, Watanabe D, Ikeuchi S, Goto T, Marshall WF, & Hamada H. (2005) De novo formation of left-right asymmetry by posterior tilt of nodal cilia. PLoS biology, 3(8). PMID: 16035921
Shiratori H, & Hamada H. (2014) TGFβ signaling in establishing left-right asymmetry. Seminars in cell , 80-4. PMID: 24704359
Resteghini, N., Nielsen, J., Hoimes, M., & Karam, A. (2014) Delayed splenic rupture presenting 70 days following blunt abdominal trauma. Clinical Imaging, 38(1), 73-74. DOI: 10.1016/j.clinimag.2013.09.003
by Max_Yun in the Node
Salamanders are remarkable organisms. Following the amputation or loss of complex structures such as parts of their eyes, hearts and brains, tails -including the spinal cord-, jaws and even full limbs, they are able to set up a regeneration programme which leads to the exact replacement of the missing structure, even as adults. As such, […]... Read more »
Eguchi, G., Eguchi, Y., Nakamura, K., Yadav, M., Millán, J., & Tsonis, P. (2011) Regenerative capacity in newts is not altered by repeated regeneration and ageing. Nature Communications, 384. DOI: 10.1038/ncomms1389
Yun, M., Davaapil, H., & Brockes, J. (2015) Recurrent turnover of senescent cells during regeneration of a complex structure. eLife. DOI: 10.7554/eLife.05505
van Deursen, J. (2014) The role of senescent cells in ageing. Nature, 509(7501), 439-446. DOI: 10.1038/nature13193
Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A.... (2014) Geriatric muscle stem cells switch reversible quiescence into senescence. Nature, 506(7488), 316-321. DOI: 10.1038/nature13013
Yun, M., Gates, P., & Brockes, J. (2013) Regulation of p53 is critical for vertebrate limb regeneration. Proceedings of the National Academy of Sciences, 110(43), 17392-17397. DOI: 10.1073/pnas.1310519110
Muñoz-Espín D, Cañamero M, Maraver A, Gómez-López G, Contreras J, Murillo-Cuesta S, Rodríguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M.... (2013) Programmed cell senescence during mammalian embryonic development. Cell, 155(5), 1104-1118. PMID: 24238962
Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J.... (2013) Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning. Cell, 155(5), 1119-1130. DOI: 10.1016/j.cell.2013.10.041
Demaria, M., Ohtani, N., Youssef, S., Rodier, F., Toussaint, W., Mitchell, J., Laberge, R., Vijg, J., Van Steeg, H., Dollé, M.... (2014) An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA. Developmental Cell, 31(6), 722-733. DOI: 10.1016/j.devcel.2014.11.012
by cathlau in the Node
This is my first post for the Node, so I thought I would introduce myself a little bit… I just finished my MSc in Experimental Psychology (Behavioural Neuroscience) and now I am striving towards becoming a science communicator. Although, I would like to share the research that I am interested in and was involved in, […]... Read more »
Adamec, R., & Shallow, T. (1993) Lasting effects on rodent anxiety of a single exposure to a cat. Physiology , 54(1), 101-109. DOI: 10.1016/0031-9384(93)90050-P
Cohen, H., Zohar, J., Gidron, Y., Matar, M., Belkind, D., Loewenthal, U., Kozlovsky, N., & Kaplan, Z. (2006) Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats. Biological Psychiatry, 59(12), 1208-1218. DOI: 10.1016/j.biopsych.2005.12.003
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by Anne-Lise Routier-Kierzkowska in the Node
Quantifying shape, growth and gene expression at the cellular level are key to understanding morphogenesis, i.e. how organs are shaped. Many image processing tools have been developed towards this goal that operate on either 2D or 3D images. 2D tools are fast, easy to use, and typically involve datasets of modest size. However organs and […]... Read more »
Barbier de Reuille, P., Routier-Kierzkowska, A., Kierzkowski, D., Bassel, G., Schüpbach, T., Tauriello, G., Bajpai, N., Strauss, S., Weber, A., Kiss, A.... (2015) MorphoGraphX: A platform for quantifying morphogenesis in 4D. eLife. DOI: 10.7554/eLife.05864
Kierzkowski, D., Nakayama, N., Routier-Kierzkowska, A., Weber, A., Bayer, E., Schorderet, M., Reinhardt, D., Kuhlemeier, C., & Smith, R. (2012) Elastic Domains Regulate Growth and Organogenesis in the Plant Shoot Apical Meristem. Science, 335(6072), 1096-1099. DOI: 10.1126/science.1213100
Aegerter-Wilmsen, T., Heimlicher, M., Smith, A., de Reuille, P., Smith, R., Aegerter, C., & Basler, K. (2012) Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development, 139(17), 3221-3231. DOI: 10.1242/dev.082800
Vlad, D., Kierzkowski, D., Rast, M., Vuolo, F., Dello Ioio, R., Galinha, C., Gan, X., Hajheidari, M., Hay, A., Smith, R.... (2014) Leaf Shape Evolution Through Duplication, Regulatory Diversification, and Loss of a Homeobox Gene. Science, 343(6172), 780-783. DOI: 10.1126/science.1248384
Montenegro-Johnson, T., Stamm, P., Strauss, S., Topham, A., Tsagris, M., Wood, A., Smith, R., & Bassel, G. (2015) Digital Single-Cell Analysis of Plant Organ Development Using 3DCellAtlas. The Plant Cell, 27(4), 1018-1033. DOI: 10.1105/tpc.15.00175
Santuari, L., Scacchi, E., Rodriguez-Villalon, A., Salinas, P., Dohmann, E., Brunoud, G., Vernoux, T., Smith, R., & Hardtke, C. (2011) Positional Information by Differential Endocytosis Splits Auxin Response to Drive Arabidopsis Root Meristem Growth. Current Biology, 21(22), 1918-1923. DOI: 10.1016/j.cub.2011.10.002
Yoshida, S., Barbier de Reuille, P., Lane, B., Bassel, G., Prusinkiewicz, P., Smith, R., & Weijers, D. (2014) Genetic Control of Plant Development by Overriding a Geometric Division Rule. Developmental Cell, 29(1), 75-87. DOI: 10.1016/j.devcel.2014.02.002
Bassel, G., Stamm, P., Mosca, G., Barbier de Reuille, P., Gibbs, D., Winter, R., Janka, A., Holdsworth, M., & Smith, R. (2014) Mechanical constraints imposed by 3D cellular geometry and arrangement modulate growth patterns in the Arabidopsis embryo. Proceedings of the National Academy of Sciences, 111(23), 8685-8690. DOI: 10.1073/pnas.1404616111
by LolitikaMandal in the Node
Studies in the last decade have established Drosophila as the best invertebrate model to study hematopoiesis. Blood cell development in the fruitfly has been shown to have similarities to that of vertebrates both at the level of its origins and important signaling molecules necessary for their formation and differentiation (Evans et al., 2003). It was believed […]... Read more »
Evans, C.J.,, Sinenko, S.A.,, Mandal, L.,, Martinez-Agosto, J.A.,, Hartenstein, V.,, & Banerjee, U. (2007) Genetic Dissection of Hematopoiesis Using Drosophila as a Model System. Advances in Developmental Biology, 259-299. DOI: 10.1016/S1574-3349(07)18011-X
Mikkola, H., & Orkin, S.H. (2006) The journey of developing hematopoietic stem cells. Development, 133(19), 3733-3744. DOI: 10.1242/dev.02568
Mandal, L., Banerjee, U., & Hartenstein, V. (2004) Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm. Nature Genetics, 36(9), 1019-1023. DOI: 10.1038/ng1404
by Kate Gao in the Node
By Peng Kate Gao Developmental neuroscience has traditionally focused on understanding the structural assembly of the nervous system. However, recently it has increasingly been recognized that development also plays a key role in orchestrating the functional assembly of neural circuits1. The neocortex, the center of higher functions in the mammalian brain, can be characterized by its stereotypic lamination at […]... Read more »
Pivetta, C., Esposito, M., Sigrist, M., & Arber, S. (2014) Motor-Circuit Communication Matrix from Spinal Cord to Brainstem Neurons Revealed by Developmental Origin. Cell, 156(3), 537-548. DOI: 10.1016/j.cell.2013.12.014
He, S., Li, Z., Ge, S., Yu, Y., & Shi, S. (2015) Inside-Out Radial Migration Facilitates Lineage-Dependent Neocortical Microcircuit Assembly. Neuron, 86(5), 1159-1166. DOI: 10.1016/j.neuron.2015.05.002
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by steven orzack in the Node
Few things interest many people more than sex. For some, this means interest in practices and partners. For others, it means producing a son. There is an ocean of claims about how to do this. A quick Google search reveals claims that a woman can up the odds of a son by taking cough syrup, […]... Read more »
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by Abzhanov in the Node
Nature’s most interesting secrets can sometimes be found in our own backyards. One such secret is related to all birds, those pigeons, thrushes and sparrows that we see everyday. This familiarity means that we do not think too much of birds passing them by on our way to work or school. However, if the birds […]... Read more »
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