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  • January 12, 2016
  • 05:15 PM
  • 267 views

Stem Cell Derived Growth Factors May Slow Progression of ALS

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Prof. Dimitrios Karussis M.D., Ph.D. Professor of Neurology Head, Multiple Sclerosis Center Hadassah BrainLabs Medical Research: What is the background for this study? What are the main findings? Prof. Karussis: BrainStorm Cell Therapeutics is developing innovative, autologous stem cell … Continue reading →
The post Stem Cell Derived Growth Factors May Slow Progression of ALS appeared first on MedicalResearch.com.
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Prof. Dimitrios Karussis. (2016) Stem Cell Derived Growth Factors May Slow Progression of ALS. MedicalResearch.com. info:/

  • November 29, 2015
  • 01:41 PM
  • 314 views

It is possible to develop successful HIV vaccine

by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets

Antibodies developed in HIV infected individuals do not protect them against further proliferation of HIV, but protect proliferation of HIV in animals.
That means it is possible to develop a vaccine which will completely protect human from HIV infection.... Read more »

B V Waghmare. (2015) HIV Vaccine heading toward success. Combination of HIV neutralizing antibodies and Nanoparticle protien eOD-GT8 60mer are good hope for getting a effective anti HIV vaccine. http://bvwaghmare.blogspot.com. info:/

  • October 24, 2015
  • 11:16 AM
  • 275 views

Gene-edited Kidney Organoids Re-Create Human Disease

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Benjamin Freedman, Ph.D. Assistant Professor | University of Washington Department of Medicine | Division of Nephrology Member, Kidney Research Institute Member, Institute for Stem Cell and Regenerative Medicine Seattle WA 98109 Medical Research: What is the background … Continue reading →
The post Gene-edited Kidney Organoids Re-Create Human Disease appeared first on MedicalResearch.com.
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Benjamin Freedman, Ph.D. (2015) Gene-edited Kidney Organoids Re-Create Human Disease. MedicalResearch.com. info:/

  • October 15, 2015
  • 10:58 PM
  • 391 views

Live-cell analysis of plant embryogenesis: Live-cell imaging, optical manipulation, and micro-engineering technologies

by Daisuke Kurihara in the Node

In multicellular animals and plants, the single-celled zygote develops into the embryo. In the model plant Arabidopsis thaliana, the zygote divides asymmetrically to form a small cytoplasmic apical cell, which is the precursor of the proembryo, and a large vacuolated basal cell, which develops into the extra-embryonic suspensor (Figure 1). Communication between the intra-embryo (proembryo[...]

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The post Live-cell analysis of plant embryogenesis: Live-cell imaging, optical manipulation........ Read more »

Kawashima, T., & Goldberg, R. (2010) The suspensor: not just suspending the embryo. Trends in Plant Science, 15(1), 23-30. DOI: 10.1016/j.tplants.2009.11.002  

Javelle, M., Vernoud, V., Rogowsky, P., & Ingram, G. (2011) Epidermis: the formation and functions of a fundamental plant tissue. New Phytologist, 189(1), 17-39. DOI: 10.1111/j.1469-8137.2010.03514.x  

Lafon-Placette, C., & Köhler, C. (2014) Embryo and endosperm, partners in seed development. Current Opinion in Plant Biology, 64-69. DOI: 10.1016/j.pbi.2013.11.008  

Yeung, E., & Meinke, D. W. (1993) Embryogenesis in Angiosperms: Development of the Suspensor. Plant Cell, 5(10), 1371-1381. DOI: 10.1105/tpc.5.10.1371  

Kurihara, D., Hamamura, Y., & Higashiyama, T. (2013) Live-cell analysis of plant reproduction: Live-cell imaging, optical manipulation, and advanced microscopy technologies. Development, Growth , 55(4), 462-473. DOI: 10.1111/dgd.12040  

Bhatia, S., & Ingber, D. (2014) Microfluidic organs-on-chips. Nature Biotechnology, 32(8), 760-772. DOI: 10.1038/nbt.2989  

Sanati Nezhad, A. (2014) Microfluidic platforms for plant cells studies. Lab on a Chip, 14(17), 3262-3274. DOI: 10.1039/C4LC00495G  

Gooh, K., Ueda, M., Aruga, K., Park, J., Arata, H., Higashiyama, T., & Kurihara, D. (2015) Live-Cell Imaging and Optical Manipulation of Arabidopsis Early Embryogenesis. Developmental Cell, 34(2), 242-251. DOI: 10.1016/j.devcel.2015.06.008  

van den Berg C, Willemsen V, Hendriks G, Weisbeek P, & Scheres B. (1997) Short-range control of cell differentiation in the Arabidopsis root meristem. Nature, 390(6657), 287-289. PMID: 9384380  

Higashiyama, T., Yabe, S., Sasaki, N., Nishimura, Y., Kuroiwa, H., & Kuroiwa, T. (2001) Pollen Tube Attraction by the Synergid Cell. Science, 293(5534), 1480-1483. DOI: 10.1126/science.1062429  

Tirlapur, U., & König, K. (2002) Targeted transfection by femtosecond laser. Nature, 418(6895), 290-291. DOI: 10.1038/418290a  

  • September 23, 2015
  • 08:51 AM
  • 351 views

“Eppur (non) si muove”: why cellular movements may not be essential to the formation of Turing patterns in biology.

by D. Bullara in the Node

D. Bullara* and Y. De Decker *domenico.bullara@mail.com   When Catarina Vicente (Community Manager of “The Node”) proposed us to write a post about our recent paper on pattern formation in zebrafish [Bullara2015] we were very glad for the opportunity she was giving us to tell the background story about our work in this blog. We[...]

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The post “Eppur (non) si muove”: why cellular movements may not be essential to the formation of Turing patterns in biology......... Read more »

De Decker Y, Tsekouras GA, Provata A, Erneux T, & Nicolis G. (2004) Propagating waves in one-dimensional discrete networks of coupled units. Physical review. E, Statistical, nonlinear, and soft matter physics, 69(3 Pt 2), 36203. PMID: 15089388  

Hamada, H., Watanabe, M., Lau, H., Nishida, T., Hasegawa, T., Parichy, D., & Kondo, S. (2013) Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning. Development, 141(2), 318-324. DOI: 10.1242/dev.099804  

Hiscock, T., & Megason, S. (2015) Mathematically guided approaches to distinguish models of periodic patterning. Development, 142(3), 409-419. DOI: 10.1242/dev.107441  

Nakamasu, A., Takahashi, G., Kanbe, A., & Kondo, S. (2009) Interactions between zebrafish pigment cells responsible for the generation of Turing patterns. Proceedings of the National Academy of Sciences, 106(21), 8429-8434. DOI: 10.1073/pnas.0808622106  

Turing, A. (1952) The Chemical Basis of Morphogenesis. Philosophical Transactions of the Royal Society B: Biological Sciences, 237(641), 37-72. DOI: 10.1098/rstb.1952.0012  

Yamaguchi, M., Yoshimoto, E., & Kondo, S. (2007) Pattern regulation in the stripe of zebrafish suggests an underlying dynamic and autonomous mechanism. Proceedings of the National Academy of Sciences, 104(12), 4790-4793. DOI: 10.1073/pnas.0607790104  

Yamanaka, H., & Kondo, S. (2014) In vitro analysis suggests that difference in cell movement during direct interaction can generate various pigment patterns in vivo. Proceedings of the National Academy of Sciences, 111(5), 1867-1872. DOI: 10.1073/pnas.1315416111  

  • September 20, 2015
  • 06:47 PM
  • 380 views

Novel mouse alleles allow for sequential mutagenesis using the dual recombinase technology

by dkirsch in the Node

Genetically engineered mouse models have been used extensively to study a wide variety of biological processes in vivo, and innovations in genetic engineering have made it possible to dissect more intricate biological questions. For example, the first mice that showed successful germline transmission of foreign DNA were created in the 1980s, and this allowed the[...]

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The post Novel mouse alleles allow for sequential mutagenesis using the dual recombinase technology appeared first on ........ Read more »

Zhang, M., & Kirsch, D. (2015) The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis. Disease Models , 8(9), 1155-1166. DOI: 10.1242/dmm.021204  

  • September 14, 2015
  • 08:43 AM
  • 190 views

Attacking Pancreatic Cancer Stem Cells May Lead To Better Treatment

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Patricia Sancho, PhD, Lecturer Barts Cancer Institute - a Cancer Research UK Centre of Excellence Queen Mary University of London Centre for Stem Cells in Cancer & Ageing / John Vane Science Centre, Charterhouse Square, London Medical Research: … Continue reading →
The post Attacking Pancreatic Cancer Stem Cells May Lead To Better Treatment appeared first on MedicalResearch.com Medical Research Studies with Interviews and News.
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Patricia Sancho, PhD, Lecturer. (2015) Attacking Pancreatic Cancer Stem Cells May Lead To Better Treatment. MedicalResearch.com. info:/

  • September 9, 2015
  • 08:15 AM
  • 703 views

When You’re Not Just Yourself

by Mark Lasbury in As Many Exceptions As Rules

How would you react if you were told that the DNA testing shows that you are not your child’s parent or your parents’ child? Demand another test? – you bet. But wait, you or your parent might be a tetragametic chimeric, carrying around DNA from another person in your body. You might have had a dizygotic twin that you didn’t know about!... Read more »

Yu, N., Kruskall, M., Yunis, J., Knoll, J., Uhl, L., Alosco, S., Ohashi, M., Clavijo, O., Husain, Z., Yunis, E.... (2002) Disputed Maternity Leading to Identification of Tetragametic Chimerism. New England Journal of Medicine, 346(20), 1545-1552. DOI: 10.1056/NEJMoa013452  

Yu, Q., Li, Q., Gao, S., Su, Y., & Deng, Z. (2011) Congenital Tetragametic Blood Chimerism Explains a Case of Questionable Paternity*. Journal of Forensic Sciences, 56(5), 1346-1348. DOI: 10.1111/j.1556-4029.2011.01794.x  

Lee, H., Yoon, S., Ko, J., Seong, M., Park, S., Choi, J., & Oh, S. (2014) Monochorionic dizygotic twins with discordant sex and confined blood chimerism. European Journal of Pediatrics, 173(9), 1249-1252. DOI: 10.1007/s00431-014-2312-8  

  • September 1, 2015
  • 10:25 AM
  • 298 views

The blastocyst achieves on-time implantation by entosis

by Xiaofei Sun in the Node

The process of embryo implantation consists of multiple steps: blastocyst apposition, adhesion to uterine luminal epithelial (LE) cells, and removal of the epithelial cells encasing the blastocysts. How the blastocyst trophectoderm breaches the luminal epithelial barrier has been studied for decades, the mechanism of the abstraction of LE cells was not clearly understood. Since the[...]

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The post The blastocyst achieves on-time implantation by entosis appeared first on the Node.
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Finn CA, & McLaren A. (1967) A study of the early stages of implantation in mice. Journal of Reproduction and Fertility, 259-267. info:/10.1530/jrf.0.0130259

Krehbiel RH. (1937) Cytological Studies of the Decidual Reaction in the Rat during Early Pregnancy and in the Production of Deciduomata. Physiological Zoology, 212-234. info:/

Sun X, Zhang L, Xie H, Wan H, Magella B, Whitsett JA, & Dey SK. (2012) Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation. Proceedings of the National Academy of Sciences of the United States of America, 109(4), 1145-1150. PMID: 22233806  

Wang H, & Dey SK. (2006) Roadmap to embryo implantation: clues from mouse models. Nature reviews. Genetics, 7(3), 185-199. PMID: 16485018  

  • August 13, 2015
  • 11:09 AM
  • 305 views

Gap junctions: versatile mediators of long-range developmental signals

by Mike Levin in the Node

My lab works on developmental bioelectricity, studying how cells communicate via endogenous gradients of plasma membrane resting potential (Vmem) in order to coordinate their activity during pattern regulation (Levin, 2013; Levin, 2014b; Tseng and Levin, 2013). It is well-known that resting potential is an important regulatory parameter for individual cells’ proliferation, differentiation, and oncogenic potential[...]

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The post Gap junctions: versatile mediators of long-range de........ Read more »

Pai, V., Lemire, J., Pare, J., Lin, G., Chen, Y., & Levin, M. (2015) Endogenous Gradients of Resting Potential Instructively Pattern Embryonic Neural Tissue via Notch Signaling and Regulation of Proliferation. Journal of Neuroscience, 35(10), 4366-4385. DOI: 10.1523/JNEUROSCI.1877-14.2015  

  • August 3, 2015
  • 04:29 PM
  • 228 views

Patient-Derived Stem Cells May Be Able To Reverse Hemophilia A

by Marie Benz in MedicalResearch.com

MedicalResearch.com Interview with: Dong-Wook Kim Center for Genome Engineering, Institute for Basic Science Yonsei University College of Medicine Seoul, Korea Medical Research: What is the background for this study? Response: Hemophilia A is an X-linked genetic disorder caused by mutations … Continue reading →
The post Patient-Derived Stem Cells May Be Able To Reverse Hemophilia A appeared first on MedicalResearch.com Medical Research Interviews and News.
... Read more »

Dong-Wook Kim. (2015) Patient-Derived Stem Cells May Be Able To Reverse Hemophilia A. MedicalResearch.com. info:/

  • July 29, 2015
  • 10:30 AM
  • 571 views

It’s 11 PM, Do You Know Where Your Organs Are?

by Mark Lasbury in As Many Exceptions As Rules

It’s a miracle that a human body ever works like it’s supposed to. So many things can go wrong and there’s so few ways for things to be right. Ever hear of a defect called situs ambiguus? It’s a big problem. And what’s more, when something like transposition of the great arteries occurs, it’s only a second defect that keeps the patients alive.... Read more »

Yousif, M., Elhassan, N., Ali, S., & Ahmed, Y. (2013) Isolated subpulmonic fibrous ring, mirror-image dextrocardia and situs solitus in a young lady unreported and a near miss. Interactive CardioVascular and Thoracic Surgery, 17(6), 1043-1044. DOI: 10.1093/icvts/ivt278  

Anderson, R., Brown, N., Meno, C., & Spicer, D. (2015) The importance of being isomeric. Clinical Anatomy, 28(4), 477-486. DOI: 10.1002/ca.22517  

Loomba RS, Hlavacek AM, Spicer DE, & Anderson RH. (2015) Isomerism or heterotaxy: which term leads to better understanding?. Cardiology in the young, 1-7. PMID: 26088959  

  • July 22, 2015
  • 08:10 AM
  • 609 views

Organs Don’t Always Follow The Plan

by Mark Lasbury in As Many Exceptions As Rules

Do you know where your heart is located? Do you know exactly? Maybe not. It isn’t where most people think it is, and in some people it’s on the opposite side. Situs inversus is a mirror imaging of internal organs, and it’s caused by a faulty motorboat rotor on the embryo.... Read more »

Babu, D., & Roy, S. (2013) Left-right asymmetry: cilia stir up new surprises in the node. Open Biology, 3(5), 130052-130052. DOI: 10.1098/rsob.130052  

Nonaka S, Yoshiba S, Watanabe D, Ikeuchi S, Goto T, Marshall WF, & Hamada H. (2005) De novo formation of left-right asymmetry by posterior tilt of nodal cilia. PLoS biology, 3(8). PMID: 16035921  

  • June 28, 2015
  • 10:11 AM
  • 348 views

Cellular Senescence in Regeneration

by Max_Yun in the Node

Salamanders are remarkable organisms. Following the amputation or loss of complex structures such as parts of their eyes, hearts and brains, tails -including the spinal cord-, jaws and even full limbs, they are able to set up a regeneration programme which leads to the exact replacement of the missing structure, even as adults. As such, […]... Read more »

Eguchi, G., Eguchi, Y., Nakamura, K., Yadav, M., Millán, J., & Tsonis, P. (2011) Regenerative capacity in newts is not altered by repeated regeneration and ageing. Nature Communications, 384. DOI: 10.1038/ncomms1389  

van Deursen, J. (2014) The role of senescent cells in ageing. Nature, 509(7501), 439-446. DOI: 10.1038/nature13193  

Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A.... (2014) Geriatric muscle stem cells switch reversible quiescence into senescence. Nature, 506(7488), 316-321. DOI: 10.1038/nature13013  

Yun, M., Gates, P., & Brockes, J. (2013) Regulation of p53 is critical for vertebrate limb regeneration. Proceedings of the National Academy of Sciences, 110(43), 17392-17397. DOI: 10.1073/pnas.1310519110  

Muñoz-Espín D, Cañamero M, Maraver A, Gómez-López G, Contreras J, Murillo-Cuesta S, Rodríguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M.... (2013) Programmed cell senescence during mammalian embryonic development. Cell, 155(5), 1104-1118. PMID: 24238962  

Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J.... (2013) Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning. Cell, 155(5), 1119-1130. DOI: 10.1016/j.cell.2013.10.041  

Demaria, M., Ohtani, N., Youssef, S., Rodier, F., Toussaint, W., Mitchell, J., Laberge, R., Vijg, J., Van Steeg, H., Dollé, M.... (2014) An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA. Developmental Cell, 31(6), 722-733. DOI: 10.1016/j.devcel.2014.11.012  

  • June 27, 2015
  • 06:38 AM
  • 303 views

Friendly hello and a bit about stress & adult hippocampal neurogenesis

by cathlau in the Node

This is my first post for the Node, so I thought I would introduce myself a little bit… I just finished my MSc in Experimental Psychology (Behavioural Neuroscience) and now I am striving towards becoming a science communicator. Although, I would like to share the research that I am interested in and was involved in, […]... Read more »

Cohen, H., Zohar, J., Gidron, Y., Matar, M., Belkind, D., Loewenthal, U., Kozlovsky, N., & Kaplan, Z. (2006) Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats. Biological Psychiatry, 59(12), 1208-1218. DOI: 10.1016/j.biopsych.2005.12.003  

Hanson, N., Owens, M., Boss-Williams, K., Weiss, J., & Nemeroff, C. (2011) Several stressors fail to reduce adult hippocampal neurogenesis. Psychoneuroendocrinology, 36(10), 1520-1529. DOI: 10.1016/j.psyneuen.2011.04.006  

Schoenfeld, T., & Gould, E. (2012) Stress, stress hormones, and adult neurogenesis. Experimental Neurology, 233(1), 12-21. DOI: 10.1016/j.expneurol.2011.01.008  

Tanapat, P., Hastings, N., Rydel, T., Galea, L., & Gould, E. (2001) Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanism. The Journal of Comparative Neurology, 437(4), 496-504. DOI: 10.1002/cne.1297  

  • June 15, 2015
  • 08:59 AM
  • 396 views

MorphoGraphX: A platform for quantifying morphogenesis in 4D

by Anne-Lise Routier-Kierzkowska in the Node

Quantifying shape, growth and gene expression at the cellular level are key to understanding morphogenesis, i.e. how organs are shaped. Many image processing tools have been developed towards this goal that operate on either 2D or 3D images. 2D tools are fast, easy to use, and typically involve datasets of modest size. However organs and […]... Read more »

Barbier de Reuille, P., Routier-Kierzkowska, A., Kierzkowski, D., Bassel, G., Schüpbach, T., Tauriello, G., Bajpai, N., Strauss, S., Weber, A., Kiss, A.... (2015) MorphoGraphX: A platform for quantifying morphogenesis in 4D. eLife. DOI: 10.7554/eLife.05864  

Kierzkowski, D., Nakayama, N., Routier-Kierzkowska, A., Weber, A., Bayer, E., Schorderet, M., Reinhardt, D., Kuhlemeier, C., & Smith, R. (2012) Elastic Domains Regulate Growth and Organogenesis in the Plant Shoot Apical Meristem. Science, 335(6072), 1096-1099. DOI: 10.1126/science.1213100  

Aegerter-Wilmsen, T., Heimlicher, M., Smith, A., de Reuille, P., Smith, R., Aegerter, C., & Basler, K. (2012) Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development, 139(17), 3221-3231. DOI: 10.1242/dev.082800  

Vlad, D., Kierzkowski, D., Rast, M., Vuolo, F., Dello Ioio, R., Galinha, C., Gan, X., Hajheidari, M., Hay, A., Smith, R.... (2014) Leaf Shape Evolution Through Duplication, Regulatory Diversification, and Loss of a Homeobox Gene. Science, 343(6172), 780-783. DOI: 10.1126/science.1248384  

Montenegro-Johnson, T., Stamm, P., Strauss, S., Topham, A., Tsagris, M., Wood, A., Smith, R., & Bassel, G. (2015) Digital Single-Cell Analysis of Plant Organ Development Using 3DCellAtlas. The Plant Cell, 27(4), 1018-1033. DOI: 10.1105/tpc.15.00175  

Santuari, L., Scacchi, E., Rodriguez-Villalon, A., Salinas, P., Dohmann, E., Brunoud, G., Vernoux, T., Smith, R., & Hardtke, C. (2011) Positional Information by Differential Endocytosis Splits Auxin Response to Drive Arabidopsis Root Meristem Growth. Current Biology, 21(22), 1918-1923. DOI: 10.1016/j.cub.2011.10.002  

Yoshida, S., Barbier de Reuille, P., Lane, B., Bassel, G., Prusinkiewicz, P., Smith, R., & Weijers, D. (2014) Genetic Control of Plant Development by Overriding a Geometric Division Rule. Developmental Cell, 29(1), 75-87. DOI: 10.1016/j.devcel.2014.02.002  

Bassel, G., Stamm, P., Mosca, G., Barbier de Reuille, P., Gibbs, D., Winter, R., Janka, A., Holdsworth, M., & Smith, R. (2014) Mechanical constraints imposed by 3D cellular geometry and arrangement modulate growth patterns in the Arabidopsis embryo. Proceedings of the National Academy of Sciences, 111(23), 8685-8690. DOI: 10.1073/pnas.1404616111  

  • June 11, 2015
  • 08:58 AM
  • 402 views

Active hematopoietic sites in Drosophila Adult

by LolitikaMandal in the Node

Studies in the last decade have established Drosophila as the best invertebrate model to study hematopoiesis. Blood cell development in the fruitfly has been shown to have similarities to that of vertebrates both at the level of its origins and important signaling molecules necessary for their formation and differentiation (Evans et al., 2003). It was believed […]... Read more »

Evans, C.J.,, Sinenko, S.A.,, Mandal, L.,, Martinez-Agosto, J.A.,, Hartenstein, V.,, & Banerjee, U. (2007) Genetic Dissection of Hematopoiesis Using Drosophila as a Model System. Advances in Developmental Biology, 259-299. DOI: 10.1016/S1574-3349(07)18011-X  

Mikkola, H., & Orkin, S.H. (2006) The journey of developing hematopoietic stem cells. Development, 133(19), 3733-3744. DOI: 10.1242/dev.02568  

  • June 10, 2015
  • 08:14 AM
  • 373 views

Cortical Microcircuit Assembly: The Migratory Path Matters

by Kate Gao in the Node

By Peng Kate Gao Developmental neuroscience has traditionally focused on understanding the structural assembly of the nervous system. However, recently it has increasingly been recognized that development also plays a key role in orchestrating the functional assembly of neural circuits1. The neocortex, the center of higher functions in the mammalian brain, can be characterized by its stereotypic lamination at […]... Read more »

Rakic, P. (1988) Specification of cerebral cortical areas. Science, 241(4862), 170-176. DOI: 10.1126/science.3291116  

Hubel, D., & Wiesel, T. (1974) Uniformity of monkey striate cortex: A parallel relationship between field size, scatter, and magnification factor. The Journal of Comparative Neurology, 158(3), 295-305. DOI: 10.1002/cne.901580305  

  • June 9, 2015
  • 11:42 AM
  • 465 views

The human sex ratio at conception and the conception of scientific “facts”

by steven orzack in the Node

Few things interest many people more than sex. For some, this means interest in practices and partners. For others, it means producing a son. There is an ocean of claims about how to do this. A quick Google search reveals claims that a woman can up the odds of a son by taking cough syrup, […]... Read more »

Austad, S. (2015) The human prenatal sex ratio: A major surprise: Fig. 1. Proceedings of the National Academy of Sciences, 112(16), 4839-4840. DOI: 10.1073/pnas.1505165112  

Orzack, S., Stubblefield, J., Akmaev, V., Colls, P., Munné, S., Scholl, T., Steinsaltz, D., & Zuckerman, J. (2015) The human sex ratio from conception to birth. Proceedings of the National Academy of Sciences, 112(16). DOI: 10.1073/pnas.1416546112  

Parkes, A. (1926) The Mammalian Sex-Ratio. Biological Reviews, 2(1), 1-51. DOI: 10.1111/j.1469-185X.1926.tb00600.x  

  • May 28, 2015
  • 04:44 AM
  • 698 views

How The Bird Got Its Beak

by Abzhanov in the Node

Nature’s most interesting secrets can sometimes be found in our own backyards. One such secret is related to all birds, those pigeons, thrushes and sparrows that we see everyday. This familiarity means that we do not think too much of birds passing them by on our way to work or school. However, if the birds […]... Read more »

Bhullar, B., Marugán-Lobón, J., Racimo, F., Bever, G., Rowe, T., Norell, M., & Abzhanov, A. (2012) Birds have paedomorphic dinosaur skulls. Nature, 487(7406), 223-226. DOI: 10.1038/nature11146  

Alberch,P., Gould,S.J., Oster,G.F., & Wake,D.B. (1979) Size and shape in ontogeny and phylogeny. Paleobiology , 296-317. info:/

Hodges, S., & Arnold, M. (1995) Spurring Plant Diversification: Are Floral Nectar Spurs a Key Innovation?. Proceedings of the Royal Society B: Biological Sciences, 262(1365), 343-348. DOI: 10.1098/rspb.1995.0215  

Mallarino, R., & Abzhanov, A. (2012) Paths Less Traveled: Evo-Devo Approaches to Investigating Animal Morphological Evolution. Annual Review of Cell and Developmental Biology, 28(1), 743-763. DOI: 10.1146/annurev-cellbio-101011-155732  

Bhullar, B., Morris, Z., Sefton, E., Tok, A., Tokita, M., Namkoong, B., Camacho, J., Burnham, D., & Abzhanov, A. (2015) A molecular mechanism for the origin of a key evolutionary innovation, the bird beak and palate, revealed by an integrative approach to major transitions in vertebrate history. Evolution. DOI: 10.1111/evo.12684  

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