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This website focusses on attempts to better understand the way the body, brain and mind interact. The lead scientist, Dr Lorimer Moseley, is particularly interested in the role of the brain and mind in chronic and complex pain disorders. Through collaborations with clinicians, scientists, patients and friends, the team is exploring how the brain and its representation of the body change when pain persists, how the mind influences physiological regulation of the body, how the changes in the brain and mind can be normalised via treatment, and how we can teach people about it all in a way that is both interesting and accurate. The website includes links to published articles, current projects, teaching resources for clinicians and lecturers and other info that the team thinks is intriguing, important or irresistible.

Lorimer Moseley
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  • July 7, 2011
  • 05:30 PM

Bizarro World at the World Congress of Physical Therapy

by Lorimer Moseley in BodyInMind

The World Congress of Physical Therapy was a bit like Bizarro world for me. Steven Kamper, provided a great post summarizing the conference, but I wanted to build on it a little. ... Read more »

  • July 5, 2011
  • 02:32 AM

rTMS and chronic pain: Our two penny’s worth

by Lorimer Moseley in BodyInMind

Some of you might have heard of repetitive transcranial magnetic stimulation (rTMS) and its use in chronic pain - what is the efficacy?... Read more »

  • June 29, 2011
  • 01:20 AM

Promising results from a graded retraining programme in chronic back pain

by Lorimer Moseley in BodyInMind

TweetReduction in pain and disability with a graded sensorimotor retraining program in chronic back pain Our team recently returned home from Darwin, where we all attended the Australian Pain Society’s Annual Scientific Meeting.  We all presented some of our work up there and had a lot of fun while we were at it.  I presented [...]... Read more »

  • June 23, 2011
  • 05:58 AM

Clinical features and PATHOPHYSIOLOGY OF CRPS – a long-awaited review

by Lorimer Moseley in BodyInMind

At the world congress on pain in Glasgow, 2008, a small group of CRPS researchers got around a table and asked each other something like ‘isn’t it high time we got together and wrote a current concepts in CRPS pathophysiology paper?’ ... Read more »

Marinus J, Moseley GL, Birklein F, Baron R, Maihöfner C, Kingery WS, & van Hilten JJ. (2011) Clinical features and pathophysiology of complex regional pain syndrome. Lancet neurology, 10(7), 637-48. PMID: 21683929  

  • June 6, 2011
  • 05:30 PM

Back Pains, Rubbery Brains, Doubts Remain

by Lorimer Moseley in BodyInMind

A while back Ben Wand blogged here about grey matter density changes in the brain and chronic pain. A new study, published in the Journal of Neuroscience by David Seminowicz et al tells what appears to be a similar story.... Read more »

  • June 2, 2011
  • 10:30 AM

Giving him the (fake) finger. Introducing the plastic finger illusion.

by Lorimer Moseley in BodyInMind

Does proprioceptive input, from muscle spindles and joint receptors for example, contribute to our sense of body ownership?... Read more »

[1] Botvinick M, & Cohen J. (1998) Rubber hands 'feel' touch that eyes see. Nature, 391(6669), 756. PMID: 9486643  

[2] Walsh LD, Moseley GL, Taylor JL, & Gandevia SC. (2011) Proprioceptive signals contribute to the sense of body ownership. The Journal of physiology. PMID: 21521765  

  • May 31, 2011
  • 03:30 AM

The cortical body matrix. Reloaded.

by Lorimer Moseley in BodyInMind

People with chronic pain have some pretty odd perceptual disturbances. In an attempt to integrate this smorgasboard of body-related dysfunction, we recently proposed the idea of a cortical body matrix.... Read more »

  • May 26, 2011
  • 03:10 AM

Don’t just rub it better, cross it over – the analgesic effect of crossing your arms.

by Lorimer Moseley in BodyInMind

There is a new paper just out in Pain that raises the possibility of a quick and easy analgesic strategy – crossing your arms. My mum reckons that her mum was onto that decades ago ... Read more »

[1]Gallace A, Torta DM, Moseley GL, & Iannetti GD. (2011) The analgesic effect of crossing the arms. Pain, 152(6), 1418-23. PMID: 21440992  

  • May 23, 2011
  • 05:41 PM

Subgroups in low back pain – were the assumptions correct?

by Lorimer Moseley in BodyInMind

Our study aimed to evaluate a treatment-based classification algorithm for low back pain. This algorithm was created to provide a clinical decision-making paradigm to help guide treatment selection for back pain. Were the assumptions correct?... Read more »

[6] Fritz, J., Lindsay, W., Matheson, J., Brennan, G., Hunter, S., Moffit, S., Swalberg, A., & Rodriquez, B. (2007) Is There a Subgroup of Patients With Low Back Pain Likely to Benefit From Mechanical Traction?. Spine, 32(26). DOI: 10.1097/BRS.0b013e31815d001a  

  • May 19, 2011
  • 10:37 AM

Subgroups in low back pain – a treatment-based classification algorithm

by Lorimer Moseley in BodyInMind

This study aimed to evaluate a treatment-based classification algorithm for low back pain. This algorithm was created to provide a clinical decision-making paradigm to help guide treatment selection for back pain. ... Read more »

[6] Fritz, J., Lindsay, W., Matheson, J., Brennan, G., Hunter, S., Moffit, S., Swalberg, A., & Rodriquez, B. (2007) Is There a Subgroup of Patients With Low Back Pain Likely to Benefit From Mechanical Traction?. Spine, 32(26). DOI: 10.1097/BRS.0b013e31815d001a  

  • May 17, 2011
  • 03:00 AM

It’s semantical my dear Watson

by Lorimer Moseley in BodyInMind

I recently read an interesting article from Vraceany et al titled “Less specific arm illnesses". The authors make some very good points about what are frequently futile clinical approaches. However, the foundations they erect to support these arguments made me think about how we approach the whole idea of what is and isn’t biopsychosocial treatment.... Read more »

Vranceanu AM, Barsky A, & Ring D. (2011) Less specific arm illnesses. Journal of hand therapy : official journal of the American Society of Hand Therapists, 24(2), 118-23. PMID: 21392938  

  • April 18, 2011
  • 11:42 PM

Neuroimmunology for dummies. Part 1: Immune system in learning and memory – T cells.

by Lorimer Moseley in BodyInMind

A common way to investigate what role particular biological markers play is to breed (in the loosest sense of the word - ie genetically engineer) an animal that doesn’t have those biomarkers. Mice are the usual suckers. Mice can be ‘bred’ to have no T cells (T cells are otherwise known as T lymphocytes, white blood cells that are produced primarily in the thymus - hence the ‘T’...... Read more »

[2] Brynskikh, A., Warren, T., Zhu, J., & Kipnis, J. (2008) Adaptive immunity affects learning behavior in mice. Brain, Behavior, and Immunity, 22(6), 861-869. DOI: 10.1016/j.bbi.2007.12.008  

[3] Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N, Cohen H, Kipnis J, & Schwartz M. (2006) Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nature neuroscience, 9(2), 268-75. PMID: 16415867  

[4] Derecki, N., Cardani, A., Yang, C., Quinnies, K., Crihfield, A., Lynch, K., & Kipnis, J. (2010) Regulation of learning and memory by meningeal immunity: a key role for IL-4. Journal of Experimental Medicine, 207(5), 1067-1080. DOI: 10.1084/jem.20091419  

[7] Marchand, F., Perretti, M., & McMahon, S. (2005) Role of the Immune system in chronic pain. Nature Reviews Neuroscience, 6(7), 521-532. DOI: 10.1038/nrn1700  

[8] Uçeyler N, Valenza R, Stock M, Schedel R, Sprotte G, & Sommer C. (2006) Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain. Arthritis and rheumatism, 54(8), 2656-64. PMID: 16871547  

  • April 13, 2011
  • 08:17 PM

Mutterings of a neurocentric. Or, neuroimmunology for dummies

by Lorimer Moseley in BodyInMind

TweetI was going to call this post ‘Immune effects on thinking, memory, neuroplasticity and neurogenesis’ but I thought it sounded a bit high-brow.  In fact, for the first time in my brief bloglife I have found myself stuck on an opening, but I think I might know why. It is 5.20am, I rode my bike [...]... Read more »

[2] Teitelbaum SL. (2000) Bone resorption by osteoclasts. Science (New York), 289(5484), 1504-8. PMID: 10968780  

[3] Besedovsky, H., & Rey, A. (2007) Physiology of psychoneuroimmunology: A personal view. Brain, Behavior, and Immunity, 21(1), 34-44. DOI: 10.1016/j.bbi.2006.09.008  

  • March 31, 2011
  • 09:30 AM

What’s in a name? Nociception by any other name will hurt, or not hurt, just as much

by Lorimer Moseley in BodyInMind

A while back I wrote a piece about Consciousness and Pain, in which I argued that consciousness might be the key ingredient for pain. I even tried my hand at a bit of maths, with this little equation (not to be taken too exactly): pain = nociception + consciousness.... Read more »

[1] Merksey, H. (1986) Pain terms: a current list with definitions and notes on usage. Pain Suppl. 3 S215-S221. info:/

  • March 28, 2011
  • 04:30 PM

Of shiny pictures and poorer outcomes: Spinal MRI and back pain

by Lorimer Moseley in BodyInMind

Diagnosing low back pain is a nightmare. It established that apart from the 15% of back pain cases which can be attributed to a specific spinal pathology, the majority of cases fall under the unsatisfactory umbrella label of “non-specific low back pain”... Read more »

van Ravesteijn H, van Dijk I, Darmon D, van de Laar F, Lucassen P, Hartman TO, van Weel C, & Speckens A. (2011) The reassuring value of diagnostic tests: A systematic review. Patient education and counseling. PMID: 21382687  

Kalichman L, Li L, Kim DH, Guermazi A, Berkin V, O'Donnell CJ, Hoffmann U, Cole R, & Hunter DJ. (2008) Facet joint osteoarthritis and low back pain in the community-based population. Spine, 33(23), 2560-5. PMID: 18923337  

Kalichman L, Hodges P, Li L, Guermazi A, & Hunter DJ. (2010) Changes in paraspinal muscles and their association with low back pain and spinal degeneration: CT study. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 19(7), 1136-44. PMID: 20033739  

  • March 22, 2011
  • 04:28 PM

Can photoshop make my bottom smaller?

by Lorimer Moseley in BodyInMind

I had my annual viewing of Susan Boyle on Britain’s got talent this morning. Then I came across this amazing demonstration of what photoshop can do. Is it possible that if you think you look a particular way, your body changes the way it works to match that?... Read more »

Brian Wansink and Koert van Ittersum. (2006) The Visual Illusions of Food: Why Plates, Bowls, and Spoons Can Bias Consumption Volum. The FASEB Journal. info:/

Moseley GL, Olthof N, Venema A, Don S, Wijers M, Gallace A, & Spence C. (2008) Psychologically induced cooling of a specific body part caused by the illusory ownership of an artificial counterpart. Proceedings of the National Academy of Sciences of the United States of America, 105(35), 13169-73. PMID: 18725630  

  • March 21, 2011
  • 02:13 AM

Your somatic markers know when to hold ‘em

by Lorimer Moseley in BodyInMind

There is a very large body of data that show that the body affects the mind. That is, bodily processes and responses to stimuli affect our thoughts about those stimuli and our behavioural responses to them. Some of the most intriguing research in this area has been done by Antonio Damasio..... Read more »

  • March 10, 2011
  • 08:30 AM

Maintenance spinal manipulation: The cherry-pickers quandary

by Lorimer Moseley in BodyInMind

A closer look at a new study that purportedly demonstrates a real benefit to spinal manipulation in chronic back pain and seems to validate that controversial practice of regularly seeing patients between flare-ups for a “quick click” to keep the spine tip-top.... Read more »

  • March 7, 2011
  • 03:30 PM

Sadness, soreness and staying alert—all in the same place

by Lorimer Moseley in BodyInMind

Sadness, soreness and staying alert - are they all in the same place of the brain?... Read more »

Shackman AJ, Salomons TV, Slagter HA, Fox AS, Winter JJ, & Davidson RJ. (2011) The integration of negative affect, pain and cognitive control in the cingulate cortex. Nature reviews. Neuroscience, 12(3), 154-67. PMID: 21331082  

Dum RP, Levinthal DJ, & Strick PL. (2009) The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(45), 14223-35. PMID: 19906970  

Kanske P, Heissler J, Schönfelder S, Bongers A, & Wessa M. (2010) How to Regulate Emotion? Neural Networks for Reappraisal and Distraction. Cerebral cortex (New York, N.Y. : 1991). PMID: 21041200  

  • February 24, 2011
  • 08:43 AM

Does smoking hurt as well as harm? (or, as if you needed another reason)

by Lorimer Moseley in BodyInMind

TweetI have a couple of mates who are veritable smoke-stacks. They love smoking but sort of hate being a smoker. I must confess that, at least within my community, smoking is now officially uncool and my mates are sick of people telling them good reasons to give up.  Well, as if they needed another reason, [...]... Read more »

Pisinger C, Aadahl M, Toft U, Birke H, Zytphen-Adeler J, & Jørgensen T. (2011) The association between active and passive smoking and frequent pain in a general population. European journal of pain (London, England), 15(1), 77-83. PMID: 20627783  

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