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  • March 26, 2016
  • 04:40 PM
  • 407 views

Organic nanowires destroy the competition

by Dr. Jekyll in Lunatic Laboratories

Last month, we spoke of our vision of the future of humanity here at the lab. It makes sense that humanity would one-day step away from the static, non-living computer constructs we have designed. Moving us instead towards an organic alternative, one that can be readily repaired, replaced, or changed. While we cannot pretend to know what the future may hold, a new discovery helps bolster the stance we presented.

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Lampa-Pastirk, S., Veazey, J., Walsh, K., Feliciano, G., Steidl, R., Tessmer, S., & Reguera, G. (2016) Thermally activated charge transport in microbial protein nanowires. Scientific Reports, 23517. DOI: 10.1038/srep23517  

  • March 25, 2016
  • 06:51 PM
  • 449 views

Mental illness, that’s a funny term isn’t it?

by Dr. Jekyll in Lunatic Laboratories

In today’s lexicon, the term mental illness is used pretty widely. It can be used to describe someone suffering from depression, to PTSD, to even someone suicidal. In fact, today it is sort of a catch all term for anyone who is involved in a mass shooting here in the US. We are getting off […]... Read more »

Elkington, K., Teplin, L., Abram, K., Jakubowski, J., Dulcan, M., & Welty, L. (2015) Psychiatric Disorders and Violence: A Study of Delinquent Youth After Detention. Journal of the American Academy of Child , 54(4), 302-31200000. DOI: 10.1016/j.jaac.2015.01.002  

Su, J., Chen, J., Lippold, K., Monavarfeshani, A., Carrillo, G., Jenkins, R., & Fox, M. (2016) Collagen-derived matricryptins promote inhibitory nerve terminal formation in the developing neocortex. The Journal of Cell Biology, 212(6), 721-736. DOI: 10.1083/jcb.201509085  

Jacobs, R., Barba, A., Gowins, J., Klumpp, H., Jenkins, L., Mickey, B., Ajilore, O., Peciña, M., Sikora, M., Ryan, K.... (2016) Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder. Psychological Medicine, 1-13. DOI: 10.1017/S0033291715002615  

  • March 25, 2016
  • 04:48 PM
  • 419 views

Study finds vast diversity among bacteriophages

by Dr. Jekyll in Lunatic Laboratories

Viruses that infect bacteria are among the most abundant life forms on Earth. Indeed, our oceans, soils and potentially even our bodies would be overrun with bacteria were it not for bacteria-eating viruses, called bacteriophages, that keep the microbial balance of ecological niches in check. Now, a new study suggests that bacteriophages made of RNA — a close chemical cousin of DNA — likely play a much larger role in shaping the bacterial makeup of worldwide habitats than previously ........ Read more »

Krishnamurthy, S., Janowski, A., Zhao, G., Barouch, D., & Wang, D. (2016) Hyperexpansion of RNA Bacteriophage Diversity. PLOS Biology, 14(3). DOI: 10.1371/journal.pbio.1002409  

  • March 23, 2016
  • 06:37 PM
  • 466 views

Road rage and toxoplasmosis: Return of the parasite

by Dr. Jekyll in Lunatic Laboratories

It was a clear case of a false alarm, toxoplasmosis, a parasite that infects mice and cats was thought to have an effect on humans. However, after a thorough review of the data it was off the hook, or so we thought. Individuals with a psychiatric disorder involving recurrent bouts of extreme, impulsive anger--road rage, for example--are more than twice as likely to have been exposed to a common parasite than healthy individuals with no psychiatric diagnosis.

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Coccaro, E., Lee, R., Groer, M., Can, A., Coussons-Read, M., & Postolache, T. (2016) Toxoplasma gondii Infection: Relationship With Aggression in Psychiatric Subjects. The Journal of Clinical Psychiatry, 334-341. DOI: 10.4088/JCP.14m09621  

  • March 22, 2016
  • 06:59 PM
  • 337 views

Ancient viruses lurk in our DNA

by Dr. Jekyll in Lunatic Laboratories

Think your DNA is all human? Think again. And a new discovery suggests it’s even less human than scientists previously thought. Nineteen new pieces of non-human DNA — left by viruses that first infected our ancestors hundreds of thousands of years ago — have just been found, lurking between our own genes.

... Read more »

Wildschutte, J., Williams, Z., Montesion, M., Subramanian, R., Kidd, J., & Coffin, J. (2016) Discovery of unfixed endogenous retrovirus insertions in diverse human populations. Proceedings of the National Academy of Sciences, 201602336. DOI: 10.1073/pnas.1602336113  

  • March 21, 2016
  • 04:46 PM
  • 343 views

Sleep suppresses brain rebalancing

by Dr. Jekyll in Lunatic Laboratories

Why humans and other animals sleep is one of the remaining deep mysteries of physiology. One prominent theory in neuroscience is that sleep is when the brain replays memories "offline" to better encode them ("memory consolidation"). A prominent and competing theory is that sleep is important for rebalancing activity in brain networks that have been perturbed during learning while awake.

... Read more »

  • March 18, 2016
  • 02:36 PM
  • 421 views

Using precision medicine to define the genetics of autoimmune disease

by Dr. Jekyll in Lunatic Laboratories

Demonstrating the potential of precision medicine, an international study used next-generation DNA sequencing technology to identify more than 1,000 gene variants that affect susceptibility to systemic lupus erythematosus (SLE). Precision medicine is an emerging field that aims to deliver highly personalized health care by understanding how individual differences in genetics, environment, and lifestyle impact health and disease.

... Read more »

Raj, P., Rai, E., Song, R., Khan, S., Wakeland, B., Viswanathan, K., Arana, C., Liang, C., Zhang, B., Dozmorov, I.... (2016) Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity. eLife. DOI: 10.7554/eLife.12089  

  • March 18, 2016
  • 09:22 AM
  • 355 views

The Rise And Fall Of Alexandria’s Library

by Rita dos Santos Silva in United Academics

Knowledge sharing: from Alexandria’s Library to Open Access... Read more »

  • March 17, 2016
  • 08:08 AM
  • 326 views

I like my corpses like I like my pretzels. Salted.

by Katy Meyers Emery in Bones Don't Lie

I’ve been reading a lot of interesting food non-fiction books in my sparse free time as a way to relax after long days of dissertation preparation and article writing. I’ve […]... Read more »

  • March 16, 2016
  • 04:51 PM
  • 422 views

Viruses ‘piggyback’ on hosts success

by Dr. Jekyll in Lunatic Laboratories

In the microscopic life that thrives around coral reefs, researchers have discovered an interplay between viruses and microbes that defies conventional wisdom. As the density of microbes rises in an ecosystem, the number of viruses infecting those microbes rises with it. It has generally been assumed that this growing population of viruses, in turn, kills more and more microbes, keeping the microbial population in check. It’s a model known as “kill-the-winner” — the winners being the blo........ Read more »

Knowles, B., Silveira, C., Bailey, B., Barott, K., Cantu, V., Cobián-Güemes, A., Coutinho, F., Dinsdale, E., Felts, B., Furby, K.... (2016) Lytic to temperate switching of viral communities. Nature. DOI: 10.1038/nature17193  

  • March 15, 2016
  • 03:44 PM
  • 359 views

Where aging memories get stored in the brain

by Dr. Jekyll in Lunatic Laboratories

Think back to when you were a child. Now instead, try to think of something that happened just a few minutes ago; would you believe that you are using different portions of the brain? When we remember events which occurred recently, the hippocampus is activated. This area in the temporal lobe of the brain is a hub for learning and memory. But what happens, if we try to remember things that took place years or decades ago?

... Read more »

  • March 15, 2016
  • 09:37 AM
  • 327 views

mtDNA sucks for inferring hominin relationships

by zacharoo in Lawn Chair Anthropology

Ancient DNA studies keep on delivering awesome findings about human evolution. Continuing this trend, Matthias Meyer and colleagues report today in Nature nuclear DNA (nDNA) sequenced from ~430,000 year old humans from the Sima de los Huesos (SH) site in Spain. SH is badass not only because the name translates as “pit of bones,” but also because […]... Read more »

Bermudez de Castro, JM., Martinón-Torres, M., Lozano, M., Sarmiento, S., & Muela, A. (2004) Paleodemography of the Atapuerca: Sima De Los Huesos Hominin Sample: A Revision and New Approaches to the Paleodemography of the European Middle Pleistocene Population. Journal of Anthropological Research, 60(1), 5-26. DOI: 10.1086/jar.60.1.3631006  

Krause, J., Fu, Q., Good, J., Viola, B., Shunkov, M., Derevianko, A., & Pääbo, S. (2010) The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature, 464(7290), 894-897. DOI: 10.1038/nature08976  

Meyer, M., Fu, Q., Aximu-Petri, A., Glocke, I., Nickel, B., Arsuaga, J., Martínez, I., Gracia, A., de Castro, J., Carbonell, E.... (2013) A mitochondrial genome sequence of a hominin from Sima de los Huesos. Nature, 505(7483), 403-406. DOI: 10.1038/nature12788  

Meyer, M., Arsuaga, J., de Filippo, C., Nagel, S., Aximu-Petri, A., Nickel, B., Martínez, I., Gracia, A., de Castro, J., Carbonell, E.... (2016) Nuclear DNA sequences from the Middle Pleistocene Sima de los Huesos hominins. Nature. DOI: 10.1038/nature17405  

Reich, D., Green, R., Kircher, M., Krause, J., Patterson, N., Durand, E., Viola, B., Briggs, A., Stenzel, U., Johnson, P.... (2010) Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature, 468(7327), 1053-1060. DOI: 10.1038/nature09710  

  • March 14, 2016
  • 06:10 PM
  • 403 views

Crucial communication: language management in Australian asylum interviews

by Laura Smith-Khan in Language on the Move

Asylum seekers in Australia face a few very public hurdles. Successive governments have used increasingly restrictive refugee policies to gain...... Read more »

Smith-Khan, L. (2016) Negotiating narratives, accessing asylum: Evaluating language policy as multi-level practice, beliefs and management. Multilingua. DOI: 10.1515/multi-2015-0072  

  • March 14, 2016
  • 02:19 PM
  • 343 views

Decrypting a collagen’s role in schizophrenia

by Dr. Jekyll in Lunatic Laboratories

What would be worse than having bad joints? How about schizophrenia and bad joints? To be fair that isn’t what is suggested, but they may, in fact, be linked. A small peptide generated from a collagen protein may protect the brain from schizophrenia by promoting the formation of neuronal synapses and study may lead to new approaches to treating the mental disorder.

... Read more »

Su, J., Chen, J., Lippold, K., Monavarfeshani, A., Carrillo, G., Jenkins, R., & Fox, M. (2016) Collagen-derived matricryptins promote inhibitory nerve terminal formation in the developing neocortex. The Journal of Cell Biology, 212(6), 721-736. DOI: 10.1083/jcb.201509085  

  • March 14, 2016
  • 02:19 PM
  • 248 views

Decrypting a collagen’s role in schizophrenia

by Dr. Jekyll in Lunatic Laboratories

What would be worse than having bad joints? How about schizophrenia and bad joints? To be fair that isn’t what is suggested, but they may, in fact, be linked. A small peptide generated from a collagen protein may protect the brain from schizophrenia by promoting the formation of neuronal synapses and study may lead to […]... Read more »

Su, J., Chen, J., Lippold, K., Monavarfeshani, A., Carrillo, G., Jenkins, R., & Fox, M. (2016) Collagen-derived matricryptins promote inhibitory nerve terminal formation in the developing neocortex. The Journal of Cell Biology, 212(6), 721-736. DOI: 10.1083/jcb.201509085  

  • March 13, 2016
  • 03:40 PM
  • 375 views

New learning procedure for neural networks

by Dr. Jekyll in Lunatic Laboratories

Rustling leaves, a creaking branch: To a mouse, these sensory impressions may, at first, seem harmless — but not if a cat suddenly bursts out of the bush. If so, they were clues of impending life-threatening danger. Researcher Robert Gütig has now found how the brain can link sensory perceptions to events occurring after a delay.

... Read more »

Gutig, R. (2016) Spiking neurons can discover predictive features by aggregate-label learning. Science, 351(6277). DOI: 10.1126/science.aab4113  

  • March 12, 2016
  • 03:08 PM
  • 366 views

People with anxiety show fundamental differences in perception

by Dr. Jekyll in Lunatic Laboratories

People suffering from anxiety perceive the world in a fundamentally different way than others, according to a new study. The research may help explain why certain people are more prone to anxiety. The study shows that people diagnosed with anxiety are less able to distinguish between a neutral, “safe” stimulus (in this case, the sound of a tone) and one that had earlier been associated with gaining or losing money.

... Read more »

  • March 10, 2016
  • 02:50 PM
  • 419 views

Alzheimer’s on and now Alzheimer’s off?

by Dr. Jekyll in Lunatic Laboratories

Alzheimer's disease, is anything more frustrating than seeing someone -- who otherwise looks healthy -- start to forget who you are? Worse than that, we don't know exactly what causes Alzheimer's disease, or how to stop it. Well actually that might be changing. Don't get too excited, because we've had false starts before, but an international group of scientists have succeeded in sorting out the mechanism of Alzheimer's disease development and possibly distinguished its key trigger.

... Read more »

  • March 9, 2016
  • 02:36 PM
  • 377 views

Want a younger brain? Stay in school — and take the stairs

by Dr. Jekyll in Lunatic Laboratories

Taking the stairs is normally associated with keeping your body strong and healthy. But new research shows that it improves your brain’s health too — and that education also has a positive effect. Researchers found that the more flights of stairs a person climbs, and the more years of school a person completes, the “younger” their brain physically appears.

... Read more »

  • March 9, 2016
  • 10:54 AM
  • 361 views

Restoring Lost Narratives: Early Medieval Muslim Graves in France

by Katy Meyers Emery in Bones Don't Lie

When people ask me why archaeology is important, or why I’ve chosen to study human remains and funerary practices, I often cite the importance of bringing individual stories back into […]... Read more »

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