All posts; Tags Include "Psychopharmacology"
- January 8, 2016
- 07:47 AM
- 729 views
Opioid Drugs for Mental Anguish: Basic Research and Clinical Trials
by The Neurocritic in The Neurocritic
The prescription opioid crisis of overdosing and overprescribing has reached epic proportions, according to the North American media. Just last week, we learned that 91% of patients who survive opioid overdose are prescribed more opioids! The CDC calls it an epidemic, and notes there's been “a 200% increase in the rate of overdose deaths involving opioid pain relievers and heroin.” A recent paper in the Annual Review of Public Health labels it a “public health crisis” and proposes “int........ Read more »
Panksepp, J., & Yovell, Y. (2014) Preclinical Modeling of Primal Emotional Affects (SEEKING, PANIC and PLAY): Gateways to the Development of New Treatments for Depression. Psychopathology, 47(6), 383-393. DOI: 10.1159/000366208
Tenore, P. (2008) Psychotherapeutic Benefits of Opioid Agonist Therapy. Journal of Addictive Diseases, 27(3), 49-65. DOI: 10.1080/10550880802122646
Watt, D., & Panksepp, J. (2009) Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives. Neuropsychoanalysis, 11(1), 7-51. DOI: 10.1080/15294145.2009.10773593
Yovell, Y., Bar, G., Mashiah, M., Baruch, Y., Briskman, I., Asherov, J., Lotan, A., Rigbi, A., & Panksepp, J. (2015) Ultra-Low-Dose Buprenorphine as a Time-Limited Treatment for Severe Suicidal Ideation: A Randomized Controlled Trial. American Journal of Psychiatry. DOI: 10.1176/appi.ajp.2015.15040535
- December 29, 2015
- 07:04 AM
- 880 views
Social Pain Revisited: Opioids for Severe Suicidal Ideation
by The Neurocritic in The Neurocritic
Does the pain of mental anguish rely on the same neural machinery as physical pain? Can we treat these dreaded ailments with the same medications? These issues have come to the fore in the field of social/cognitive/affective neuroscience.As many readers know, Lieberman and Eisenberger (2015) recently published a controversial paper claiming that a brain region called the dorsal anterior cingulate cortex (dACC, shown above) is “selective” for pain.1 This finding fits with their long-time narr........ Read more »
Panksepp, J., & Yovell, Y. (2014) Preclinical Modeling of Primal Emotional Affects (SEEKING, PANIC and PLAY): Gateways to the Development of New Treatments for Depression. Psychopathology, 47(6), 383-393. DOI: 10.1159/000366208
Woo CW, Koban L, Kross E, Lindquist MA, Banich MT, Ruzic L, Andrews-Hanna JR, & Wager TD. (2014) Separate neural representations for physical pain and social rejection. Nature communications, 5380. PMID: 25400102
Yovell, Y., Bar, G., Mashiah, M., Baruch, Y., Briskman, I., Asherov, J., Lotan, A., Rigbi, A., & Panksepp, J. (2015) Ultra-Low-Dose Buprenorphine as a Time-Limited Treatment for Severe Suicidal Ideation: A Randomized Controlled Trial. American Journal of Psychiatry. DOI: 10.1176/appi.ajp.2015.15040535
- October 26, 2015
- 01:47 AM
- 650 views
On the Long Way Down: The Neurophenomenology of Ketamine
by The Neurocritic in The Neurocritic
Is ketamine a destructive club drug that damages the brain and bladder? With psychosis-like effects widely used as a model of schizophrenia? Or is ketamine an exciting new antidepressant, the “most important discovery in half a century”?For years, I've been utterly fascinated by these separate strands of research that rarely (if ever) intersect. Why is that? Because there's no such thing as “one receptor, one behavior.” And because like most scientific endeavors, neuro-pharmacology/psyc........ Read more »
Pollak, T., De Simoni, S., Barimani, B., Zelaya, F., Stone, J., & Mehta, M. (2015) Phenomenologically distinct psychotomimetic effects of ketamine are associated with cerebral blood flow changes in functionally relevant cerebral foci: a continuous arterial spin labelling study. Psychopharmacology. DOI: 10.1007/s00213-015-4078-8
- July 23, 2011
- 07:37 PM
- 2,310 views
Neuro Bliss and Neuro Codeine
by The Neurocritic in The Neurocritic
Lindsay Lohan drinking Neuro Bliss.NEUROBRANDS®, LLC is a company that markets a series of colorful and attractively designed "nutritional drinks", known as Neuro® Drinks.Neuro Gasm Is Part Of The New Neuro CultureFor a company that has great product placement (with many celebrity endorsements), carefully crafted packaging, and regularly issued press releases, they sure are modest about their marketing efforts:"Neuro Drinks® offer consumers an alternative to products that perpetuate our self........ Read more »
Gomez-Ramirez, M., Kelly, S., Montesi, J., & Foxe, J. (2008) The Effects of l-theanine on Alpha-Band Oscillatory Brain Activity During a Visuo-Spatial Attention Task. Brain Topography, 22(1), 44-51. DOI: 10.1007/s10548-008-0068-z
- February 17, 2011
- 03:18 PM
- 3,512 views
A Decade of Penn Medicine Research Translates into a New Drug for Depression
by Kim Menard in Penn Medicine News Blog
Tucked away in two separate labs at the Department of Psychiatry at Penn Medicine, researchers have spent more than a decade researching and testing a new treatment for depression. The drug became the first new medicine to treat depression in more than a decade when it received FDA approval in January.... Read more »
Page ME, Cryan JF, Sullivan A, Dalvi A, Saucy B, Manning DR, & Lucki I. (2002) Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist. The Journal of pharmacology and experimental therapeutics, 302(3), 1220-7. PMID: 12183683
Rickels K, Athanasiou M, Robinson DS, Gibertini M, Whalen H, & Reed CR. (2009) Evidence for efficacy and tolerability of vilazodone in the treatment of major depressive disorder: a randomized, double-blind, placebo-controlled trial. The Journal of clinical psychiatry, 70(3), 326-33. PMID: 19284933
- November 23, 2010
- 03:40 PM
- 1,332 views
Drug Development for Cognitive Enhancement
by William Yates, M.D. in Brain Posts
AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate)Cognitive enhancement seeks to improve cognitive function in healthy adults. Although medicine typically focuses on treatment of medical disorders, a significant effort is underway to explore the mechanism of human attention, concentration, memory and other cognitive functions. Cognitive enhancement does not replace other methods of cognitive performance. There is no substitute for repetitive practice and learning conten........ Read more »
DEJONGH, R., BOLT, I., SCHERMER, M., & OLIVIER, B. (2008) Botox for the brain: enhancement of cognition, mood and pro-social behavior and blunting of unwanted memories. Neuroscience , 32(4), 760-776. DOI: 10.1016/j.neubiorev.2007.12.001
- August 31, 2010
- 03:58 PM
- 1,932 views
The Clinical Neuroscience iPad Library
by William Yates, M.D. in Brain Posts
Carrying around a library of pdf files has now become easy with the introduction of the iPad and net book computers. It is now possible to keep a library of key references that can be accessed at the patient bedside for reference use. This brings up the question of what pdf files are most valuable for clinicians. I have spent some time thinking about this and elected to come up with a dozen suggestions. The criteria for selection included:Valuable for clinicians caring ........ Read more »
Nock MK, Hwang I, Sampson N, Kessler RC, Angermeyer M, Beautrais A, Borges G, Bromet E, Bruffaerts R, de Girolamo G.... (2009) Cross-national analysis of the associations among mental disorders and suicidal behavior: findings from the WHO World Mental Health Surveys. PLoS medicine, 6(8). PMID: 19668361
Davies P, & Koppel J. (2009) Mechanism-based treatments for Alzheimer's disease. Dialogues in clinical neuroscience, 11(2), 159-69. PMID: 19585951
Hariri AR. (2009) The neurobiology of individual differences in complex behavioral traits. Annual review of neuroscience, 225-47. PMID: 19400720
Chew E, & Zafonte RD. (2009) Pharmacological management of neurobehavioral disorders following traumatic brain injury--a state-of-the-art review. Journal of rehabilitation research and development, 46(6), 851-79. PMID: 20104408
Fornaro M, & Martino M. (2010) Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management. Neuropsychiatric disease and treatment, 209-18. PMID: 20628627
- August 30, 2010
- 12:58 PM
- 1,845 views
Ketamine for Depression: Yay or Neigh?
by The Neurocritic in The Neurocritic
Venn diagram of psychoactive drugs [click for larger image]This post is part of a Nature Blog Focus on hallucinogenic drugs in medicine and mental health, inspired by a recent Nature Reviews Neuroscience paper, The neurobiology of psychedelic drugs: implications for the treatment of mood disorders, by Franz Vollenweider & Michael Kometer. This article will be available, open-access, until September 23. For more information on this Blog Focus, including a Table of Contents, please visit Th........ Read more »
Vollenweider, F., & Kometer, M. (2010) The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nature Reviews Neuroscience, 11(9), 642-651. DOI: 10.1038/nrn2884
- August 30, 2010
- 11:32 AM
- 1,708 views
Neuroscience of Murder and Aggression: Pharmacotherapy
by William Yates, M.D. in Brain Posts
Davis Love--2010 PGA ChampionshipThis is the final post in the series titled: Neuroscience of Murder and Aggression. The other four posts can be found in the links below:Overview and TED video of Dr. FallonEpidemiologyGeneticsBrain ImagingThe treatment of antisocial personality disorder, aggressive behavior and violence receives a limited amount of research attention. Despite the public health implications of this problem, the therapeutic treatment options are limited. Clinicians are........ Read more »
Gibbon S, Duggan C, Stoffers J, Huband N, Völlm BA, Ferriter M, & Lieb K. (2010) Psychological interventions for antisocial personality disorder. Cochrane database of systematic reviews (Online). PMID: 20556783
Khalifa N, Duggan C, Stoffers J, Huband N, Völlm BA, Ferriter M, & Lieb K. (2010) Pharmacological interventions for antisocial personality disorder. Cochrane database of systematic reviews (Online). PMID: 20687091
Pappadopulos E, Woolston S, Chait A, Perkins M, Connor DF, & Jensen PS. (2006) Pharmacotherapy of aggression in children and adolescents: efficacy and effect size. Journal of the Canadian Academy of Child and Adolescent Psychiatry , 15(1), 27-39. PMID: 18392193
Blader JC, Schooler NR, Jensen PS, Pliszka SR, & Kafantaris V. (2009) Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy. The American journal of psychiatry, 166(12), 1392-401. PMID: 19884222
- October 7, 2009
- 10:29 AM
- 2,225 views
Longitudinal analysis of street Ecstasy content
by DrugMonkey in DrugMonkey
A topic that arises every now and again, particularly when I am discussing Ecstasy-related medical emergency and death, is the nature of the psychoactive ingredients in Ecstasy tablets. For definitional purposes, I consider 3,4-methylenedioxymethamphetamine (MDMA) to be what is considered by the vast majority of consumers to be canonical "Ecstasy".
It is reasonably well-established in the peer reviewed literature and the ecstasydata.org harm reduction effort that some fraction of Ecstasy that ........ Read more »
Vogels, N., Brunt, T., Rigter, S., van Dijk, P., Vervaeke, H., & Niesink, R. (2009) Content of ecstasy in the Netherlands: 1993-2008. Addiction. DOI: 10.1111/j.1360-0443.2009.02707.x
topics
join us!
Do you write about peer-reviewed research in your blog? Use ResearchBlogging.org to make it easy for your readers — and others from around the world — to find your serious posts about academic research.
If you don't have a blog, you can still use our site to learn about fascinating developments in cutting-edge research from around the world.
Research Blogging is powered by SMG Technology.
To learn more, visit seedmediagroup.com.