by CAPB in Companion Animal Psychology Blog
The best time to start disaster preparation for your pet is now.Recently, like many people in this part of the world, we heard there was a big storm on the way. The third of three windstorms was said to be the most powerful. Since we live in an area with many beautiful trees and the power lines are above ground, it does not take much to knock out the power.In the end, we were lucky. The storm was not as strong as predicted, and it changed track and went further north. But it’s a reminder that ........ Read more »
Heath SE, & Linnabary RD. (2015) Challenges of Managing Animals in Disasters in the U.S. Animals : an open access journal from MDPI, 5(2), 173-92. PMID: 26479228
Yamazaki, S. (2015) A Survey of Companion-Animal Owners Affected by the East Japan Great Earthquake in Iwate and Fukushima Prefectures, Japan. Anthrozoös, 28(2), 291-304. DOI: 10.1080/08927936.2015.11435403
by Doug Keene in The Jury Room
Our scientists are not divided but we the people are very divided on the issue of climate change. You would think that when 97% of scientists agree the global weather patterns (aka “climate change”) are changing (aka “warming”) that Americans would give up and just say “okay, yeah, it’s happening”. But if you think that, […]
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Divided [North] America: What divides America? Survey says: Values and Politics
What do (13,000) Americans really think about climat........ Read more »
Dunlap, R., McCright, A., & Yarosh, J. (2016) The Political Divide on Climate Change: Partisan Polarization Widens in the U.S. Environment: Science and Policy for Sustainable Development, 58(5), 4-23. DOI: 10.1080/00139157.2016.1208995
by John J. Fraser, PT, MS, OCS in Sports Medicine Research (SMR): In the Lab & In the Field
Patients with chronic ankle instability who received a 4-week supervised rehabilitation program consisting of therapeutic exercise, joint mobilization, and neural mobilizations had greater clinical improvements compared with patients who were treated with therapeutic exercise alone.... Read more »
Plaza-Manzano, G., Vergara-Vila, M., Val-Otero, S., Rivera-Prieto, C., Pecos-Martin, D., Gallego-Izquierdo, T., Ferragut-Garcías, A., & Romero-Franco, N. (2016) Manual therapy in joint and nerve structures combined with exercises in the treatment of recurrent ankle sprains: A randomized, controlled trial. Manual Therapy, 141-149. DOI: 10.1016/j.math.2016.08.006
by Paul Whiteley in Questioning Answers
"In this study, we again show that acetaminophen use is associated with ASD [autism spectrum disorder]."That was one of the results reported by Stephen Schultz & Georgianna Gould [1] (open-access available here) as part of their survey of the US "National Database for Autism Research (NDAR) of the National Institute of Mental Health (NIMH)" looking at "whether ASD is associated with acetaminophen use." Acetaminophen by the way, is another name for paracetamol, the over-the-counter ........ Read more »
Schultz ST, & Gould GG. (2016) Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder. Autism-open access, 6(2). PMID: 27695658
by thelonevirologist in Virology Tidbits
Zika Virus (ZIKV) was first isolated in 1947 from a sentinel monkey in Uganda and associated with human infection in 1954 when neutralizing antibodies were detected in the sera of residents in India, with antibodies also being found in residents from various African countries. ZIKV is mosquitoe-borne Flavivirus that is predominantly transmitted via Aedes Agypti, although sexual transmission (female to male, male to female, male to male) and transmission via blood transfusion has also been report........ Read more »
Pei J, Zhao M, Ye Z, Gou H, Wang J, Yi L, Dong X, Liu W, Luo Y, Liao M.... (2014) Autophagy enhances the replication of classical swine fever virus in vitro. Autophagy, 10(1), 93-110. PMID: 24262968
Pei J, Deng J, Ye Z, Wang J, Gou H, Liu W, Zhao M, Liao M, Yi L, & Chen J. (2016) Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells. Autophagy, 12(10), 1738-1758. PMID: 27463126
Summerfield A, Knötig SM, & McCullough KC. (1998) Lymphocyte apoptosis during classical swine fever: implication of activation-induced cell death. Journal of virology, 72(3), 1853-61. PMID: 9499036
Frankel LB, Lubas M, & Lund AH. (2016) Emerging connections between RNA and autophagy. Autophagy, 1-21. PMID: 27715443
He L, Zhang YM, Lin Z, Li WW, Wang J, & Li HL. (2012) Classical swine fever virus NS5A protein localizes to endoplasmic reticulum and induces oxidative stress in vascular endothelial cells. Virus genes, 45(2), 274-82. PMID: 22718084
He L, Zhang Y, Fang Y, Liang W, Lin J, & Cheng M. (2014) Classical swine fever virus induces oxidative stress in swine umbilical vein endothelial cells. BMC veterinary research, 279. PMID: 25439655
Zhang F, Hammack C, Ogden SC, Cheng Y, Lee EM, Wen Z, Qian X, Nguyen HN, Li Y, Yao B.... (2016) Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic acids research, 44(18), 8610-8620. PMID: 27580721
Calvet, G., Aguiar, R., Melo, A., Sampaio, S., de Filippis, I., Fabri, A., Araujo, E., de Sequeira, P., de Mendonça, M., de Oliveira, L.... (2016) Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. The Lancet Infectious Diseases, 16(6), 653-660. DOI: 10.1016/S1473-3099(16)00095-5
Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-Artur P, Eyrolle-Guignot D, Salje H, Van Kerkhove MD, Abadie V, Garel C.... (2016) Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study. Lancet (London, England), 387(10033), 2125-32. PMID: 26993883
Cloëtta D, Thomanetz V, Baranek C, Lustenberger RM, Lin S, Oliveri F, Atanasoski S, & Rüegg MA. (2013) Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(18), 7799-810. PMID: 23637172
Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S.... (2016) The Brazilian Zika virus strain causes birth defects in experimental models. Nature, 534(7606), 267-71. PMID: 27279226
De Carvalho NS, De Carvalho BF, Fugaça CA, Dóris B, & Biscaia ES. (2016) Zika virus infection during pregnancy and microcephaly occurrence: a review of literature and Brazilian data. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 20(3), 282-9. PMID: 27102780
Arroba AI, Rodríguez-de la Rosa L, Murillo-Cuesta S, Vaquero-Villanueva L, Hurlé JM, Varela-Nieto I, & Valverde ÁM. (2016) Autophagy resolves early retinal inflammation in Igf1-deficient mice. Disease models , 9(9), 965-74. PMID: 27483352
Paul P, & Münz C. (2016) Autophagy and Mammalian Viruses: Roles in Immune Response, Viral Replication, and Beyond. Advances in virus research, 149-95. PMID: 27112282
McLean JE, Wudzinska A, Datan E, Quaglino D, & Zakeri Z. (2011) Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication. The Journal of biological chemistry, 286(25), 22147-59. PMID: 21511946
Liang Q, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV.... (2016) Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell stem cell. PMID: 27524440
Barrows NJ, Campos RK, Powell ST, Prasanth KR, Schott-Lerner G, Soto-Acosta R, Galarza-Muñoz G, McGrath EL, Urrabaz-Garza R, Gao J.... (2016) A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection. Cell host , 20(2), 259-70. PMID: 27476412
Tang, H., Hammack, C., Ogden, S., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E.... (2016) Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell, 18(5), 587-590. DOI: 10.1016/j.stem.2016.02.016
Goodfellow FT, Tesla B, Simchick G, Zhao Q, Hodge T, Brindley MA, & Stice SL. (2016) Zika Virus Induced Mortality and Microcephaly in Chicken Embryos. Stem cells and development. PMID: 27627457
Sir D, Kuo CF, Tian Y, Liu HM, Huang EJ, Jung JU, Machida K, & Ou JH. (2012) Replication of hepatitis C virus RNA on autophagosomal membranes. The Journal of biological chemistry, 287(22), 18036-43. PMID: 22496373
Adams Waldorf, K., Stencel-Baerenwald, J., Kapur, R., Studholme, C., Boldenow, E., Vornhagen, J., Baldessari, A., Dighe, M., Thiel, J., Merillat, S.... (2016) Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nature Medicine. DOI: 10.1038/nm.4193
Metz P, Chiramel A, Chatel-Chaix L, Alvisi G, Bankhead P, Mora-Rodriguez R, Long G, Hamacher-Brady A, Brady NR, & Bartenschlager R. (2015) Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62. Journal of virology, 89(15), 8026-41. PMID: 26018155
Ho HK, White CC, Fernandez C, Fausto N, Kavanagh TJ, Nelson SD, & Bruschi SA. (2005) Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity. Toxicological sciences : an official journal of the Society of Toxicology, 86(2), 354-64. PMID: 15901913
Ravikumar, B., Sarkar, S., Davies, J., Futter, M., Garcia-Arencibia, M., Green-Thompson, Z., Jimenez-Sanchez, M., Korolchuk, V., Lichtenberg, M., Luo, S.... (2010) Regulation of Mammalian Autophagy in Physiology and Pathophysiology. Physiological Reviews, 90(4), 1383-1435. DOI: 10.1152/physrev.00030.2009
Menzies FM, Fleming A, & Rubinsztein DC. (2015) Compromised autophagy and neurodegenerative diseases. Nature reviews. Neuroscience, 16(6), 345-57. PMID: 25991442
Li, Y., Chen, B., Zou, W., Wang, X., Wu, Y., Zhao, D., Sun, Y., Liu, Y., Chen, L., Miao, L.... (2016) The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity. The Journal of Cell Biology. DOI: 10.1083/jcb.201602090
De Leo MG, Staiano L, Vicinanza M, Luciani A, Carissimo A, Mutarelli M, Di Campli A, Polishchuk E, Di Tullio G, Morra V.... (2016) Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL. Nature cell biology, 18(8), 839-50. PMID: 27398910
Draganov D, Gopalakrishna-Pillai S, Chen YR, Zuckerman N, Moeller S, Wang C, Ann D, & Lee PP. (2015) Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Scientific reports, 16222. PMID: 26552848
Selimovic D, Porzig BB, El-Khattouti A, Badura HE, Ahmad M, Ghanjati F, Santourlidis S, Haikel Y, & Hassan M. (2015) Corrigendum to "Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells". [Cell Signal. 25(1)Jan 2013 308-18]. Cellular signalling. PMID: 25666930
by CESRA in Solar Radio Science
We discuss properties of type III bursts that change the sign of their drift rate from negative to positive and vice versa. Moreover, these bursts may change the sign of their drift rates more than once. These particular type III bursts were observed simultaneously by the radio telescopes UTR-2, URAN-2, [...]... Read more »
V. Melnik et al. (2015) Decameter type III bursts with changing frequency drift-rate signs . Solar Physics. info:/
by Paul Whiteley in Questioning Answers
'The times they are a changin'' said a Nobel prize winner and that's also a sentiment that seems true when it comes to chronic fatigue syndrome / myalgic encephalomyeltis (CFS/ME) too (see here for example).Anyone who has followed the tos-and-fros of the PACE trial - the one that suggested that CBT (cognitive behavioural therapy) and GET (graded exercise therapy) might provide some significant relief of symptoms associated with CFS/ME - will probably have heard the ........ Read more »
Geraghty KJ, & Esmail A. (2016) Chronic fatigue syndrome: is the biopsychosocial model responsible for patient dissatisfaction and harm?. The British journal of general practice : the journal of the Royal College of General Practitioners, 66(649), 437-8. PMID: 27481982
by Dr. Jekyll in Lunatic Laboratories
Bladder cancer is the seventh most common cancer in males worldwide. Every year, about 20,000 people in Japan are diagnosed with bladder cancer, of whom around 8,000--mostly men--succumb to the disease. Bladder cancers can be grouped into two types: non-muscle-invasive cancers, which have a five-year survival rate of 90 percent, and muscle-invasive cancers, which have poor prognoses.
... Read more »
Matsumoto, R., Tsuda, M., Yoshida, K., Tanino, M., Kimura, T., Nishihara, H., Abe, T., Shinohara, N., Nonomura, K., & Tanaka, S. (2016) Aldo-keto reductase 1C1 induced by interleukin-1β mediates the invasive potential and drug resistance of metastatic bladder cancer cells. Scientific Reports, 34625. DOI: 10.1038/srep34625
by Suvrat Kher in Rapid Uplift
How has changes in sea water chemistry and mass extinctions influenced the evolution and diversity of aragonite versus calcite marine skeletal groups through time..... Read more »
Hautmann, M. (2006) Shell mineralogical trends in epifaunal Mesozoic bivalves and their relationship to seawater chemistry and atmospheric carbon dioxide concentration. Facies, 52(3), 417-433. DOI: 10.1007/s10347-005-0029-x
Kiessling, W. (2015) RESEARCH FOCUS: Fuzzy seas. Geology, 43(2), 191-192. DOI: 10.1130/focus022015.1
PORTER, S. (2010) Calcite and aragonite seas and the de novo acquisition of carbonate skeletons. Geobiology, 8(4), 256-277. DOI: 10.1111/j.1472-4669.2010.00246.x
Zhuravlev, A., & Wood, R. (2009) Controls on carbonate skeletal mineralogy: Global CO2 evolution and mass extinctions. Geology, 37(12), 1123-1126. DOI: 10.1130/G30204A.1
by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field
Adolescents with persistent postconcussive symptoms experienced greater improvements in symptoms and quality of life after receiving a collaborative care treatment compared with adolescents who received the standard of care.... Read more »
McCarty CA, Zatzick D, Stein E, Wang J, Hilt R, Rivara FP, & Seattle Sports Concussion Research Collaborative. (2016) Collaborative Care for Adolescents With Persistent Postconcussive Symptoms: A Randomized Trial. Pediatrics. PMID: 27624513
by Paul Whiteley in Questioning Answers
Meta-analyses eh? You spend ages waiting for one and two come along in quick succession. Well today I'm posting about yet another meta-analysis of the peer-reviewed scientific literature suggesting that "excessive maternal BMI [body mass index] is associated with an increased ASD [autism spectrum disorder] risk in offspring." [1]The review by Ying Wang et al follows hot on the heels of the meta-analysis by Li and colleagues [2] (see here for my take) but further looked a........ Read more »
Wang, Y., Tang, S., Xu, S., Weng, S., & Liu, Z. (2016) Maternal Body Mass Index and Risk of Autism Spectrum Disorders in Offspring: A Meta-analysis. Scientific Reports, 34248. DOI: 10.1038/srep34248
by Emily Makowski in Sextraordinary!
Social interactions are highly sought-after and rewarding in many animals... Even when social interactions involve only one of our senses, they are still rewarding. For example, we like looking at photos of our friends on Facebook, or hearing the voice of a faraway relative via telephone. It’s the same with other animals; not only is socialization rewarding and can be used as an incentive for learning, but just the sights, sounds, and even smells of others are also rewarding. Hernandez et ........ Read more »
Hernandez AM, Perez EC, Mulard H, Mathevon N, & Vignal C. (2016) Mate call as reward: Acoustic communication signals can acquire positive reinforcing values during adulthood in female zebra finches (Taeniopygia guttata). Journal of comparative psychology (Washington, D.C. : 1983), 130(1), 36-43. PMID: 26881942
by Dr. Jekyll in Lunatic Laboratories
Although it has already been known for some time that the brain does not remain rigid in its structure even in adulthood, scientists have recently made a surprising discovery. The brain is not only able to adapt to changing conditions in long-term processes, but it can do this every month.
... Read more »
Barth, C., Steele, C., Mueller, K., Rekkas, V., Arélin, K., Pampel, A., Burmann, I., Kratzsch, J., Villringer, A., & Sacher, J. (2016) In-vivo Dynamics of the Human Hippocampus across the Menstrual Cycle. Scientific Reports, 32833. DOI: 10.1038/srep32833
by Sergio Graziosi in Writing my own user manual - Sergio Graziosi's Blog
In the previous two posts I’ve gone through the depressing exercise of exploring the misconstrued world-view that led the UK to leave the EU. The picture that emerges is not limited to the UK, but is a paradigm example of…Read more ›... Read more »
Nickerson, R. (1998) Confirmation bias: A ubiquitous phenomenon in many guises. Review of General Psychology, 2(2), 175-220. DOI: 10.1037//1089-2680.2.2.175
Lord, C., Ross, L., & Lepper, M. (1979) Biased assimilation and attitude polarization: The effects of prior theories on subsequently considered evidence. Journal of Personality and Social Psychology, 37(11), 2098-2109. DOI: 10.1037//0022-3514.37.11.2098
Corner, A., Whitmarsh, L., & Xenias, D. (2012) Uncertainty, scepticism and attitudes towards climate change: biased assimilation and attitude polarisation. Climatic Change, 114(3-4), 463-478. DOI: 10.1007/s10584-012-0424-6
Nikolov, D., Oliveira, D., Flammini, A., & Menczer, F. (2015) Measuring online social bubbles. PeerJ Computer Science. DOI: 10.7717/peerj-cs.38
Conover, M., Gonçalves, B., Flammini, A., & Menczer, F. (2012) Partisan asymmetries in online political activity. EPJ Data Science, 1(1). DOI: 10.1140/epjds6
by Dr. Jekyll in Lunatic Laboratories
Tauopathies are a group of neurodegenerative disorders, including Alzheimer's disease that are characterized by the deposition of aggregates of the tau protein inside brain cells. A new study reveals that the cutting of tau by an enzyme called caspase-2 may play a critical role in the disordered brain circuit function that occurs in these diseases.
... Read more »
Zhao, X., Kotilinek, L., Smith, B., Hlynialuk, C., Zahs, K., Ramsden, M., Cleary, J., & Ashe, K. (2016) Caspase-2 cleavage of tau reversibly impairs memory. Nature Medicine. DOI: 10.1038/nm.4199
by neurosci in Neuroscientifically Challenged
Where is the suprachiasmatic nucleus?
the suprachiasmatic nucleus is represented by a small green area within the hypothalamus (indicated by red arrow).
The suprachiasmatic nuclei are two small, paired nuclei that are found in the hypothalamus. Each suprachiasmatic nucleus only contains approximately 10,000 neurons. The nuclei rest on each side of the third ventricle, just above the optic chiasm. The location provides the rationale for........ Read more »
Colwell, C. (2011) Linking neural activity and molecular oscillations in the SCN. Nature Reviews Neuroscience, 12(10), 553-569. DOI: 10.1038/nrn3086
by Craig Payne in Running Research Junkie
Impact loads in barefoot and shoe running... Read more »
Sinclair, J. (2016) The effects of barefoot and barefoot inspired footwear on tibiofemoral kinetics during running. Human Movement. DOI: 10.1515/humo-2016-0022
by Paul Whiteley in Questioning Answers
I'm not gonna dwell too much on the findings reported by Lee and colleagues [1] talking about how "toddlers who suffer from AD [atopic dermatitis] at the age younger than 3 years are at a higher risk of developing ADHD [attention-deficit hyperactivity disorder] and ASD [autism spectrum disorder] during later childhood" because science already seems to understand that there may be an important connection between early allergic disease and later offspring behavioural/........ Read more »
Lee CY, Chen MH, Jeng MJ, Hsu JW, Tsai SJ, Bai YM, Hung GY, Yen HJ, Chen TJ, & Su TP. (2016) Longitudinal association between early atopic dermatitis and subsequent attention-deficit or autistic disorder: A population-based case-control study. Medicine, 95(39). PMID: 27684861
by Dr. Jekyll in Lunatic Laboratories
High cholesterol might harm more than our cardiovascular systems. New research using animal models suggests that high cholesterol levels trigger mitochondrial oxidative stress on cartilage cells, causing them to die, and ultimately leading to the development of osteoarthritis.
... Read more »
Farnaghi, S., Prasadam, I., Cai, G., Friis, T., Du, Z., Crawford, R., Mao, X., & Xiao, Y. (2016) Protective effects of mitochondria-targeted antioxidants and statins on cholesterol-induced osteoarthritis. The FASEB Journal. DOI: 10.1096/fj.201600600R
by SciELO in SciELO in Perspective
Bibliometric indicators represent much more than an indication of the visibility, relevance and impact of an article. A researcher’s entire career profile can be summarized in one or more numerical productivity and impact indicators of his research. However, citation metrics vary considerably according to the area of knowledge, the publication age, the type of document and the coverage of the database where citations were accrued. Is it possible to normalize them? Here we discuss the challenge........ Read more »
Ioannidis, J., Boyack, K., & Wouters, P. (2016) Citation Metrics: A Primer on How (Not) to Normalize. PLOS Biology, 14(9). DOI: 10.1371/journal.pbio.1002542
BLOWFIELD, M., & FRYNAS, J. (2005) Editorial Setting new agendas: critical perspectives on Corporate Social Responsibility in the developing world. International Affairs, 81(3), 499-513. DOI: 10.1111/j.1468-2346.2005.00465.x
Ball, P. (2015) Science papers rarely cited in negative ways. Nature. DOI: 10.1038/nature.2015.18643
Hutchins, B., Yuan, X., Anderson, J., & Santangelo, G. (2016) Relative Citation Ratio (RCR): A New Metric That Uses Citation Rates to Measure Influence at the Article Level. PLOS Biology, 14(9). DOI: 10.1371/journal.pbio.1002541
Ioannidis, J., Boyack, K., Small, H., Sorensen, A., & Klavans, R. (2014) Bibliometrics: Is your most cited work your best?. Nature, 514(7524), 561-562. DOI: 10.1038/514561a
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