Biology posts
- December 17, 2016
- 05:51 AM
- 323 views
Pregnancy influenza infection not linked to offspring autism
by Paul Whiteley in Questioning Answers
"There was no association between maternal influenza [flu] infection anytime during pregnancy and increased ASD [autism spectrum disorder] risk."So said the findings reported by Ousseny Zerbo and colleagues [1] continuing a research theme from this author (see here for example) looking at how various infections 'encountered' during critical periods of pregnancy may / may not impact on offspring autism risk. This time around the focus was on viral infections and in partic........ Read more »
Zerbo O, Qian Y, Yoshida C, Fireman BH, Klein NP, & Croen LA. (2016) Association Between Influenza Infection and Vaccination During Pregnancy and Risk of Autism Spectrum Disorder. JAMA pediatrics. PMID: 27893896
- December 16, 2016
- 05:25 AM
- 303 views
Patient participation in clinical trials
by Joana Guedes in BHD Research Blog
Clinical trials are crucial to help doctors and scientists understand how to safely treat a particular condition, to evaluate new treatments and to test drug safety and efficacy. They have an important role in every step of managing a condition with different clinical trials helping with prevention, diagnosis, treatments and follow-up support.... Read more »
Moorcraft SY, Marriott C, Peckitt C, Cunningham D, Chau I, Starling N, Watkins D, & Rao S. (2016) Patients' willingness to participate in clinical trials and their views on aspects of cancer research: results of a prospective patient survey. Trials, 17. PMID: 26745891
- December 16, 2016
- 05:00 AM
- 305 views
Friday Fellow: Common Stonewort
by Piter Boll in Earthling Nature
by Piter Kehoma Boll It’s always hard to introduce a less charismatic species here. Not because they are less interesting to me, but because I cannot find good information available. But I try to do my best to show all … Continue reading →... Read more »
Ariosa, Y., Quesada, A., Aburto, J., Carrasco, D., Carreres, R., Leganes, F., & Fernandez Valiente, E. (2004) Epiphytic Cyanobacteria on Chara vulgaris Are the Main Contributors to N2 Fixation in Rice Fields. Applied and Environmental Microbiology, 70(9), 5391-5397. DOI: 10.1128/AEM.70.9.5391-5397.2004
- December 16, 2016
- 03:16 AM
- 315 views
Non-febrile seizures in children with autism vs unaffected siblings
by Paul Whiteley in Questioning Answers
"Children with idiopathic ASD [autism spectrum disorder] are significantly more likely to have non-febrile seizures than their unaffected siblings, suggesting that non-febrile seizures may be ASD-specific."So said the findings from Lena McCue and colleagues [1] (open-access) continuing a research theme looking at one of the important 'comorbidities' that seems to be over-represented when it comes to a diagnosis of autism (see here). Idiopathic autism or ASD refers to autism as the........ Read more »
McCue, L., Flick, L., Twyman, K., Xian, H., & Conturo, T. (2016) Prevalence of non-febrile seizures in children with idiopathic autism spectrum disorder and their unaffected siblings: a retrospective cohort study. BMC Neurology, 16(1). DOI: 10.1186/s12883-016-0764-3
- December 15, 2016
- 02:59 AM
- 368 views
ADHD, not autism, might count when it comes to 'comorbid psychiatric symptomatology'
by Paul Whiteley in Questioning Answers
A quote to begin this fairly brief post: "Our study concluded that higher levels of ADHD [attention-deficit hyperactivity disorder] severity-not ASD [autism spectrum disorder] severity-were associated with a higher prevalence of comorbid psychiatric symptomatology in school-age children with ASD. These findings may encourage clinicians to thoroughly assess ADHD symptomatology in ASD children to better inform treatment planning."That was the research bottom line reported by Ro........ Read more »
Mansour R, Dovi AT, Lane DM, Loveland KA, & Pearson DA. (2016) ADHD severity as it relates to comorbid psychiatric symptomatology in children with Autism Spectrum Disorders (ASD). Research in developmental disabilities, 52-64. PMID: 27889487
- December 14, 2016
- 08:40 PM
- 273 views
ZIKV replication and the induction of p53: a tale of three places ?
by thelonevirologist in Virology Tidbits
Zika Virus (ZIKV) is a mosquitoe-borne Flavivirus (MBFV), related to other Flavivirus’ that are transmitted by mosquitoes such as Dengue Virus (DENV), Yellow Fever Virus (YFV) or Tick Borne Encephalitis Virus (TBEV) and as such the viral genome is released into the cytoplasm following viral entry and translated into a single polyprotein that is cleaved by both viral and cellular proteases into the 3 structural and 7 non-structural proteins.
Here the induction of p53 dependent apoptosis an........ Read more »
Li H, Saucedo-Cuevas L, Shresta S, & Gleeson JG. (2016) The Neurobiology of Zika Virus. Neuron, 92(5), 949-958. PMID: 27930910
Vasilakis N, & Weaver SC. (2016) Flavivirus transmission focusing on Zika. Current opinion in virology, 30-35. PMID: 27936448
Offerdahl DK, Dorward DW, Hansen BT, & Bloom ME. (2016) Cytoarchitecture of Zika virus infection in human neuroblastoma and Aedes albopictus cell lines. Virology, 54-62. PMID: 27863275
Barreto-Vieira DF, Barth OM, Silva MA, Santos CC, Santos Ada S, F JB Filho, & Filippis AM. (2016) Ultrastructure of Zika virus particles in cell cultures. Memorias do Instituto Oswaldo Cruz, 111(8), 532-4. PMID: 27581122
Junjhon J, Pennington JG, Edwards TJ, Perera R, Lanman J, & Kuhn RJ. (2014) Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells. Journal of virology, 88(9), 4687-97. PMID: 24522909
Chatel-Chaix L, & Bartenschlager R. (2014) Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside--caught in the web. Journal of virology, 88(11), 5907-11. PMID: 24623440
Gillespie, L., Hoenen, A., Morgan, G., & Mackenzie, J. (2010) The Endoplasmic Reticulum Provides the Membrane Platform for Biogenesis of the Flavivirus Replication Complex. Journal of Virology, 84(20), 10438-10447. DOI: 10.1128/JVI.00986-10
Miorin L, Romero-Brey I, Maiuri P, Hoppe S, Krijnse-Locker J, Bartenschlager R, & Marcello A. (2013) Three-dimensional architecture of tick-borne encephalitis virus replication sites and trafficking of the replicated RNA. Journal of virology, 87(11), 6469-81. PMID: 23552408
Li H, Saucedo-Cuevas L, Regla-Nava JA, Chai G, Sheets N, Tang W, Terskikh AV, Shresta S, & Gleeson JG. (2016) Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation. Cell stem cell, 19(5), 593-598. PMID: 27545505
Liang Q, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV.... (2016) Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell stem cell, 19(5), 663-671. PMID: 27524440
Schuck S, Prinz WA, Thorn KS, Voss C, & Walter P. (2009) Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. The Journal of cell biology, 187(4), 525-36. PMID: 19948500
Ghouzzi VE, Bianchi FT, Molineris I, Mounce BC, Berto GE, Rak M, Lebon S, Aubry L, Tocco C, Gai M.... (2016) ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53. Cell death , 7(10). PMID: 27787521
Shao Q, Herrlinger S, Yang SL, Lai F, Moore JM, Brindley MA, & Chen JF. (2016) Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage. Development (Cambridge, England), 143(22), 4127-4136. PMID: 27729407
Wu KY, Zuo GL, Li XF, Ye Q, Deng YQ, Huang XY, Cao WC, Qin CF, & Luo ZG. (2016) Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell research, 26(6), 645-54. PMID: 27174054
Pingen M, Bryden SR, Pondeville E, Schnettler E, Kohl A, Merits A, Fazakerley JK, Graham GJ, & McKimmie CS. (2016) Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection. Immunity, 44(6), 1455-69. PMID: 27332734
Agarwal A, Joshi G, Nagar DP, Sharma AK, Sukumaran D, Pant SC, Parida MM, & Dash PK. (2016) Mosquito saliva induced cutaneous events augment Chikungunya virus replication and disease progression. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 126-35. PMID: 26925703
Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA.... (2016) SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy, 12(10), 1917-1930. PMID: 27391408
Yang MR, Lee SR, Oh W, Lee EW, Yeh JY, Nah JJ, Joo YS, Shin J, Lee HW, Pyo S.... (2008) West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus. Cellular microbiology, 10(1), 165-76. PMID: 17697133
Reid CR, & Hobman TC. (2017) The nucleolar helicase DDX56 redistributes to West Nile virus assembly sites. Virology, 169-177. PMID: 27821284
Balinsky CA, Schmeisser H, Ganesan S, Singh K, Pierson TC, & Zoon KC. (2013) Nucleolin interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles. Journal of virology, 87(24), 13094-106. PMID: 24027323
Danthi P. (2016) Viruses and the Diversity of Cell Death. Annual review of virology, 3(1), 533-553. PMID: 27501259
Parquet MC, Kumatori A, Hasebe F, Morita K, & Igarashi A. (2001) West Nile virus-induced bax-dependent apoptosis. FEBS letters, 500(1-2), 17-24. PMID: 11434919
Chu JJ, & Ng ML. (2003) The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose. The Journal of general virology, 84(Pt 12), 3305-14. PMID: 14645911
Lee CJ, Liao CL, & Lin YL. (2005) Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection. Journal of virology, 79(13), 8388-99. PMID: 15956583
Zhao P, Han T, Guo JJ, Zhu SL, Wang J, Ao F, Jing MZ, She YL, Wu ZH, & Ye LB. (2012) HCV NS4B induces apoptosis through the mitochondrial death pathway. Virus research, 169(1), 1-7. PMID: 22542667
Hunt TA, Urbanowski MD, Kakani K, Law LM, Brinton MA, & Hobman TC. (2007) Interactions between the West Nile virus capsid protein and the host cell-encoded phosphatase inhibitor, I2PP2A. Cellular microbiology, 9(11), 2756-66. PMID: 17868381
Buckley A, & Gould EA. (1988) Detection of virus-specific antigen in the nuclei or nucleoli of cells infected with Zika or Langat virus. The Journal of general virology, 1913-20. PMID: 2841406
Netsawang J, Noisakran S, Puttikhunt C, Kasinrerk W, Wongwiwat W, Malasit P, Yenchitsomanus PT, & Limjindaporn T. (2010) Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis. Virus research, 147(2), 275-83. PMID: 19944121
Giovannoni F, Damonte EB, & García CC. (2015) Cellular promyelocytic leukemia protein is an important dengue virus restriction factor. PloS one, 10(5). PMID: 25962098
Giovannoni F, Damonte EB, & García CC. (2015) Correction: Cellular Promyelocytic Leukemia Protein Is an Important Dengue Virus Restriction Factor. PloS one, 10(8). PMID: 26313937
Licon Luna RM, Lee E, Müllbacher A, Blanden RV, Langman R, & Lobigs M. (2002) Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice. Journal of virology, 76(7), 3202-11. PMID: 11884544
Tudzarova S, Mulholland P, Dey A, Stoeber K, Okorokov AL, & Williams GH. (2016) p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress. Cell cycle (Georgetown, Tex.), 15(21), 2958-2972. PMID: 27611229
Fang D, Cao Q, & Lou H. (2016) Sld3-MCM Interaction Facilitated by Dbf4-Dependent Kinase Defines an Essential Step in Eukaryotic DNA Replication Initiation. Frontiers in microbiology, 885. PMID: 27375603
Waring, P., & Mullbacher, A. (1999) Cell death induced by the Fas/Fas ligand pathway and its role in pathology. Immunology and Cell Biology, 77(4), 312-317. DOI: 10.1046/j.1440-1711.1999.00837.x
Gump JM, Staskiewicz L, Morgan MJ, Bamberg A, Riches DW, & Thorburn A. (2014) Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1. Nature cell biology, 16(1), 47-54. PMID: 24316673
Park JS, Oh SY, Lee DH, Lee YS, Sung SH, Ji HW, Lee MJ, Lee YH, Rhee SG, & Bae SH. (2016) p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death. Free radical research, 50(12), 1408-1421. PMID: 27780373
Urbanowski MD, & Hobman TC. (2013) The West Nile virus capsid protein blocks apoptosis through a phosphatidylinositol 3-kinase-dependent mechanism. Journal of virology, 87(2), 872-81. PMID: 23115297
Abraham AG, & O'Neill E. (2014) PI3K/Akt-mediated regulation of p53 in cancer. Biochemical Society transactions, 42(4), 798-803. PMID: 25109960
- December 14, 2016
- 07:43 AM
- 275 views
The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons
by Christian de Guttry in genome ecology evolution etc
The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons About 450 mya bony vertebrates radiated into Lobe-finned fish, from which tetrapods appeared later, and Ray-finned fish, which include Teleost (Fig.1). Nowadays they make up to 96 percent of … Continue reading →... Read more »
Braasch I, Gehrke AR, Smith JJ, Kawasaki K, Manousaki T, Pasquier J, Amores A, Desvignes T, Batzel P, Catchen J.... (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature genetics, 48(4), 427-37. PMID: 26950095
- December 14, 2016
- 03:07 AM
- 337 views
Urinary metabolomics in autism turns up tryptophan (again)
by Paul Whiteley in Questioning Answers
"The tryptophan metabolic pathway collectively displays the largest perturbations in ASD [autism spectrum disorder]."So said the findings reported by Federica Gevi and colleagues [1] (open-access) who provide yet more 'metabolomic' data when it comes to autism to add to the already quite voluminous peer-reviewed matter on this topic (see here for example).Just in case you aren't analytical chemistry-saavy, metabolomics is basically the study of the various chemical fingerprints that th........ Read more »
Gevi, F., Zolla, L., Gabriele, S., & Persico, A. (2016) Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism. Molecular Autism, 7(1). DOI: 10.1186/s13229-016-0109-5
- December 13, 2016
- 04:25 AM
- 345 views
'My child is not talking'. Online concerns and internet-based screening for autism?
by Paul Whiteley in Questioning Answers
"Online communities are used as platforms by parents to verify developmental and health concerns related to their child."That was the starting point for the study results reported by Ben-Sasson & Yom-Tov [1] (open-access available here) who approached an increasingly important issue related to how the Internet and social media in particular, is fast becoming one of the 'go-to' options when it comes to parental concerns about their child's development and the question: could it be autism........ Read more »
Ben-Sasson A, & Yom-Tov E. (2016) Online Concerns of Parents Suspecting Autism Spectrum Disorder in Their Child: Content Analysis of Signs and Automated Prediction of Risk. Journal of medical Internet research, 18(11). PMID: 27876688
- December 12, 2016
- 03:16 PM
- 444 views
Bacteria Help Pitcher Plants Trap Prey
by Elizabeth Preston in Inkfish
Pity the insect that tumbles into a pitcher plant's trap. The slippery walls and waiting pool of water ensure it won't clamber back out. There's nothing left to do but wait to be digested.
The California pitcher plant (Darlingtonia californica) is also called the cobra lily for its curled-over shape that hides its exit from its victims. Unlike other pitcher plants, it doesn't fill its trap from above with rainwater but from below, drawing water up with its roots. But like others, it seems... Read more »
Armitage DW. (2016) Bacteria facilitate prey retention by the pitcher plant Darlingtonia californica. Biology letters, 12(11). PMID: 27881762
- December 12, 2016
- 06:00 AM
- 35 views
Ancient Predator of the Northern Plains Had Fiercest Bite of Any Mammal Ever, Study Says
by Blake de Pastino in Western Digs
A scrappy mammal that lived alongside dinosaurs 66 million years ago may not have been huge, but it packed the most powerful bite ever recorded in any mammal, living or extinct, scientists say.... Read more »
Wilson, G., Ekdale, E., Hoganson, J., Calede, J., & Vander Linden, A. (2016) A large carnivorous mammal from the Late Cretaceous and the North American origin of marsupials. Nature Communications, 13734. DOI: 10.1038/ncomms13734
- December 12, 2016
- 04:37 AM
- 326 views
Maternal immune activation (MIA) and Old World monkeys
by Paul Whiteley in Questioning Answers
Old World monkeys detailed in the title of this post, specifically refers to a type of animal called a rhesus macaque who were the 'participants' of choice as detailed in a recent study by Destanie Rose and colleagues [1] looking at a concept called maternal immune activation (MIA).Those who followed this blog down the years will no doubt have seen me discuss MIA before in the context of autism and/or schizophrenia (see here for example). The basic theory is that whilst in-utero a........ Read more »
Rose, D., Careaga, M., Van de Water, J., McAllister, K., Bauman, M., & Ashwood, P. (2016) Long-term altered immune responses following fetal priming in a non-human primate model of maternal immune activation. Brain, Behavior, and Immunity. DOI: 10.1016/j.bbi.2016.11.020
- December 11, 2016
- 02:07 PM
- 327 views
MS2 mRNA imaging in yeast: more evidence for artefacts
by Gal Haimovich in Green Fluorescent Blog
Previously, on the story of MS2 in yeast: Last year, Roy Parker published a short article, in which he claimed that using the MS2 system in yeast causes the accumulation of 3′ RNA fragments, probably due to inhibition of mRNA … Continue reading →... Read more »
Heinrich, S., Sidler, C., Azzalin, C., & Weis, K. (2016) Stem loop RNA labeling can affect nuclear and cytoplasmic mRNA processing. RNA. DOI: 10.1261/rna.057786.116
- December 10, 2016
- 04:28 AM
- 390 views
"Are we expecting too much from the extreme male brain theory of autism?"
by Paul Whiteley in Questioning Answers
The title of this post reflects the commentary published by Andrew Whitehouse [1] (open-access) discussing the meaning of the findings reported by Kung and colleagues [2] who quite categorically stated that there was: "No relationship between prenatal androgen exposure and autistic traits" in their study.OK, androgen exposure and psychology basically refers to the extreme male brain theory and autism which suggests that the so-called over-representation of autism in males is potentiall........ Read more »
Whitehouse AJ. (2016) Commentary: Are we expecting too much from the extreme male brain theory of autism? A reflection on Kung et al. (2016). Journal of child psychology and psychiatry, and allied disciplines, 57(12), 1463-1464. PMID: 27859346
- December 9, 2016
- 04:53 AM
- 355 views
'Big data' Taiwan and schizophrenia risk
by Paul Whiteley in Questioning Answers
Today I bring the findings reported by Chou and colleagues [1] (open-access available here) to the blogging table and how the research might of the Taiwan National Health Insurance Database (NHIRD) brought it's 'big data' ("n = 23 422 955") to bear on the question: what is the risk of developing schizophrenia where one or more first-degree or other relatives are affected?The answer: "Having an affected co-twin, first-degree relative, second-degree relative, or spouse was associate........ Read more »
Chou IJ, Kuo CF, Huang YS, Grainge MJ, Valdes AM, See LC, Yu KH, Luo SF, Huang LS, Tseng WY.... (2016) Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families. Schizophrenia bulletin. PMID: 27872260
- December 8, 2016
- 05:12 PM
- 471 views
Do We All Have Split Brains?
by Neuroskeptic in Neuroskeptic_Discover
When you're doing two things at once - like listening to the radio while driving - your brain organizes itself into two, functionally independent networks, almost as if you temporarily have two brains. That's according to a fascinating new study from University of Wisconsin-Madison neuroscientists Shuntaro Sasai and colleagues. It's called Functional split brain in a driving/listening paradigm
In referring to 'split brains' in their title, Sasai et al. are linking their work to the litera... Read more »
Sasai, S., Boly, M., Mensen, A., & Tononi, G. (2016) Functional split brain in a driving/listening paradigm. Proceedings of the National Academy of Sciences, 201613200. DOI: 10.1073/pnas.1613200113
- December 8, 2016
- 03:14 PM
- 171 views
ExAC presents a catalogue of human protein-coding genetic variation
by Kamil S. Jaron in genome ecology evolution etc
Exploration of variability of human genomes represents a key step in the holy grail of human genetics - to link genotypes with phenotypes, it also provides insights to human evolution and history. For this purpose Exome Aggregation Consortium (ExAC) have … Continue reading →... Read more »
Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB.... (2016) Analysis of protein-coding genetic variation in 60,706 humans. Nature, 536(7616), 285-91. PMID: 27535533
- December 8, 2016
- 09:14 AM
- 311 views
What are Hierarchical Orthologous Groups (HOGs)?
by Christophe Dessimoz in Open Reading Frame
One central concept in the OMA project and other
work we do to infer relationships between genes is that of Hierarchical
Orthologous Groups, or “HOGs” for the initiated.
We’ve written several papers on aspects pertaining to HOGs—how to infer
them,
how to evaluate them, they being
increasingly adopted by orthology
resources, etc.—but there is
still a great deal of confusion as to what HOGs are and why they matter.
Natasha Glover, talented postdoc in the lab,........ Read more »
Altenhoff, A., Gil, M., Gonnet, G., & Dessimoz, C. (2013) Inferring Hierarchical Orthologous Groups from Orthologous Gene Pairs. PLoS ONE, 8(1). DOI: 10.1371/journal.pone.0053786
Boeckmann, B., Robinson-Rechavi, M., Xenarios, I., & Dessimoz, C. (2011) Conceptual framework and pilot study to benchmark phylogenomic databases based on reference gene trees. Briefings in Bioinformatics, 12(5), 423-435. DOI: 10.1093/bib/bbr034
Sonnhammer, E., Gabaldon, T., Sousa da Silva, A., Martin, M., Robinson-Rechavi, M., Boeckmann, B., Thomas, P., Dessimoz, C., & , . (2014) Big data and other challenges in the quest for orthologs. Bioinformatics, 30(21), 2993-2998. DOI: 10.1093/bioinformatics/btu492
- December 8, 2016
- 05:59 AM
- 371 views
Know your brain: Septum
by neurosci in Neuroscientifically Challenged
Where is the septum?
The term septum, when used in reference to the brain (it is a common anatomical term used to refer to a partition), indicates a subcortical structure in the forebrain that is found near the midline of the brain. The septum in humans can be separated into two structures: the septum pellucidum and septum verum. Each of these is sometimes........ Read more »
Sheehan, T., Chambers, R., & Russell, D. (2004) Regulation of affect by the lateral septum: implications for neuropsychiatry. Brain Research Reviews, 46(1), 71-117. DOI: 10.1016/j.brainresrev.2004.04.009
- December 8, 2016
- 04:51 AM
- 342 views
Prescription medication use and autism: good medicines management required
by Paul Whiteley in Questioning Answers
"Prescription drug use and polypharmacy rates among adults with ASD [autism spectrum disorder] are substantially higher than those in an age-, sex-, and race-matched cohort of adults without ASD."That sentence taken from the paper by Rini Vohra and colleagues [1] (open-access available here) is probably not likely to win any 'novel findings of the year' awards given the already quite voluminous data published on the medication use and autism (see here for example). What gives the ........ Read more »
Vohra R, Madhavan S, Sambamoorthi U, StPeter C, Poe S, Dwibedi N, & Ajmera M. (2016) Prescription Drug Use and Polypharmacy Among Medicaid-Enrolled Adults with Autism: A Retrospective Cross-Sectional Analysis. Drugs - real world outcomes. PMID: 27873285
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