All posts; Tags Include "Clinical Research"
- July 9, 2010
- 01:37 AM
- 875 views
Friday Weird Science: The Human Penis Bone
by Evil Monkey in Neurotopia
Today's post is some seriously OLD science. Old science and WEIRD science, coming to you courtesy of Mt. Sinai hospital in NYC, 1913.
And it's also the WEIRDEST conjunction of this:
And this:
That Sci has ever seen.
Gerster AG, Mandlebaum FS. "XI. On the Formation of Bone in the Human Penis." Annals of Surgery, 1913.
The pictures below are curiously safe for work. I suppose that picture up there wasn't. oops. Read the rest of this post... | Read the comments on this post...... Read more »
GERSTER, A., & MANDLEBAUM, F. (1913) ON THE FORMATION OF BONE IN THE HUMAN PENIS. Annals of Surgery, 57(6), 896-901. DOI: 10.1097/00000658-191306000-00012
- November 2, 2009
- 08:37 PM
- 2,154 views
Hot News: Curry, Curcumin, Cancer & Cure
by Laika in Laika's Medliblog
*Hot* News via Twitter and various news media a few days ago. Big headlines tell the following in respectively The Sun, Herald, Ireland, BBC News / NHS Health and Reuters:
Curry is a ‘cure for cancer‘
Spices in curry may help cure cancer
Curry spice ‘kills cancer cells‘
Scientists say curry compound kills cancer cells
The message of these headlines [...]... Read more »
O'Sullivan-Coyne, G., O'Sullivan, G., O'Donovan, T., Piwocka, K., & McKenna, S. (2009) Curcumin induces apoptosis-independent death in oesophageal cancer cells. British Journal of Cancer, 101(9), 1585-1595. DOI: 10.1038/sj.bjc.6605308
López-Lázaro, M. (2008) Anticancer and carcinogenic properties of curcumin: Considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Molecular Nutrition . DOI: 10.1002/mnfr.200700238
Castedo, M., Perfettini, J., Roumier, T., Andreau, K., Medema, R., & Kroemer, G. (2004) Cell death by mitotic catastrophe: a molecular definition. Oncogene, 23(16), 2825-2837. DOI: 10.1038/sj.onc.1207528
- November 30, 1999
- 12:00 AM
- 2,552 views
Cheap Cell-Phone Microscopes Might Make Distance Ed Science Labs Feasible
by Michael Windelspecht in RicochetScience
Review of recent advances in cell phone microscopes... Read more »
Zhu, H., Yaglidere, O., Su, T., Tseng, D., & Ozcan, A. (2011) Cost-effective and compact wide-field fluorescent imaging on a cell-phone. Lab on a Chip. DOI: 10.1039/C0LC00358A
- November 30, 1999
- 12:00 AM
- 2,211 views
Dr. A H Bandivdekar finds the inhibitor for sexual transmission of HIV virus.
by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets
Dr. A H Bandivdekar Indian scientist found the exact way by which HIV virus gains entry in to human blood in sexual transmission of HIV virus, which is one of the biggest reason for HIV virus infections and AIDS.
There are certain individuals who are tested positive and do not develop symptoms of AIDS or AIDS this is because there is diffrerance in their genetic constitution.
In latancy period there is a resistance for replication of HIV virus in lymphocytes in these infected individuals. The........ Read more »
B V Waghmare. (2011) Dr. A H Bandivdekar finds the inhibitor for sexual transmission of HIV virus. . http://bvwaghmare.blogspot.com/. info:/bvwaghmare
- November 30, 1999
- 12:00 AM
- 2,387 views
genetically engineered stem cell treatment, gen therapy for HIV virus infection, AIDS.
by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets
Scientists have collected stem cells from patients own body , and engineered them , and induced in to them gens which expresses three RNA-based anti-HIV moieties as follows .
1.tat/rev short hairpin RNA,
2.TAR decoy,
3.CCR5 ribozyme.
Amongst these anti HIV moieties CCR5 ribozyme is capable of hampering production of CCR5 protein a essential protein which is responsible for HIV virus entry in to new host cell , there it can lower a viral load , in to patient and help anti retroviral drugs t........ Read more »
B V Waghmare. (2010) Information on genetically engineered stem cell treatment, gen therapy for HIV virus infection, AIDS. . bvwaghmare.blogspot.com. info:/
- November 30, 1999
- 12:00 AM
- 2,103 views
Novel Approach for anti AIDS drug development.
by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets
HIV virus when it incorporates its DNA in human T-Lymphocytes , it integrates in a very controlled manner so that it takes care that our T-Lymphocytes cells do not get destroyed before they code and generate HIV virus proteins and genetic material and form enough new HIV viruses.
Professors Abraham Loyter, Assaf Friedler and their colleagues have reported that they have developed a peptide called as “MIX”
Peptide “MIX” is able to increase activity of HIV virus enzyme ........ Read more »
B V Waghmare. (2010) Developing a peptide that kills HIV virus. bvwaghmare.blogspot.com. info:/
- November 30, 1999
- 12:00 AM
- 1,896 views
HIV vaccine research: Protein which train B cells for production of antibodies against HIV which successfully neutralize HIV
by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets
HIV virus rapidly undergoes mutation, which is main hurdle in developing vaccine against HIV.There is a region on HIV virus which shows less variations, called as Cd4 binding site ,therefore a protein which stimulate antibody formation against this region can be developed and used as a vaccine.
Researchers at Vaccine Research Center (VRC) and the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health have studied genes which code for such proteins which can........ Read more »
B V Waghmare. (2011) HIV vaccine development : Proteins which trains B Cells for production of antibodies which successfully neutralize HIV by binding with it . http://bvwaghmare.blogspot.com. info:/(DOI/arXiv/etc.)
- November 30, 1999
- 12:00 AM
- 1,791 views
Using folate receptor alpha flurorescence imaging in ovarian cancer
by Sally Church in Pharma Strategy Blog
The idea behind this concept is that fluorescence technology can be used to help guide ovarian cancer surgery more effectively, since the tumors tend to be small and hard to see for surgeons performing the excision.... Read more »
van Dam, G., Themelis, G., Crane, L., Harlaar, N., Pleijhuis, R., Kelder, W., Sarantopoulos, A., de Jong, J., Arts, H., van der Zee, A.... (2011) Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nature Medicine. DOI: 10.1038/nm.2472
- November 30, 1999
- 12:00 AM
- 2,332 views
The Aging Effects of the Sun Revealed on Trucker’s Face
by United Academics in United Academics
The man on the picture, William McElligott, spent 28 years of his life driving a delivery truck in Chicago. Only the left side of his face was exposed to the sun, with the result that it now looks much older than his right side. His case is a rare reminder of the aging effects of the sun, but also of the need to take precautions when working under certain conditions.... Read more »
Gordon, J., & Brieva, J. (2012) Unilateral Dermatoheliosis. New England Journal of Medicine, 366(16). DOI: 10.1056/NEJMicm1104059
- November 30, 1999
- 12:00 AM
- 1,296 views
More evidence that antibiotics are over-prescribed - How should that change?
by Rogue Medic in Rogue Medic
Today Lancet Infectious Diseases posted an early release of an article that shows that the antibiotic amoxicillin still does not work on viruses.
Many doctors still routinely prescribe antibiotics for viral infections.
Bias, perhaps the biggest confounder in medical research, is controlled for very well.
What does the study show?... Read more »
Little, P., Stuart, B., Moore, M., Coenen, S., Butler, C., Godycki-Cwirko, M., Mierzecki, A., Chlabicz, S., Torres, A., Almirall, J.... (2012) Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial. The Lancet Infectious Diseases. DOI: 10.1016/S1473-3099(12)70300-6
Butler CC, Hood K, Kelly MJ, Goossens H, Verheij T, Little P, Melbye H, Torres A, Mölstad S, Godycki-Cwirko M.... (2010) Treatment of acute cough/lower respiratory tract infection by antibiotic class and associated outcomes: a 13 European country observational study in primary care. The Journal of antimicrobial chemotherapy, 65(11), 2472-8. PMID: 20852271
- November 30, 1999
- 12:00 AM
- 2,258 views
Understanding PREDIMED and the Mediterranean diet: heart-healthy or hype?
by Kismet in Biogerontology and Health
I am going to discuss the failings of the PREDIMED study, real and imagined. I will do this in a Question & Answer style. Several questions are inspired by theheart.org and NEJM comments and even statements by the low fat "gurus", Essselstyn, Ornish, McDougall or Pritikin. It is no surprise they are up in arms after the study has been published. It threatens their livelihood.... Read more »
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J.... (2013) Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. New England Journal of Medicine, 368(14), 1279-1290. DOI: 10.1056/NEJMoa1200303
- November 30, 1999
- 12:00 AM
- 1,148 views
Interlukin 32 biomarker which predict relapse of mycobacterium tuberculosis
by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets
Interlukin 32 a protien which is found in people which do test positie for mycobacterium tuberculosis infection but do not develop pulmonary disease, it is found that interlukin is important in killing micobacterium, thereby protect them from TB disease, this interleukin 32 can be used therapeutically in patients suffering with TB along with chemotherapy, which will enhance efficacy of anti tuberculosis chemo therapy... Read more »
B V Waghmare. (2014) Interlukin 32 biomarker that will predict relapse of tuberculosis infection and will be used in treatment of TB. http://www.medicalwebsite.org/2014/09/protein-that-protect-from-tb-infection.html. info:/
- November 30, 1999
- 12:00 AM
- 662 views
The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR
by Rogue Medic in Rogue Medic
This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.
Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »
Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139
Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521
- November 30, 1999
- 12:00 AM
- 1,354 views
The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR
by Rogue Medic in Rogue Medic
This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.
Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »
Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139
Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521
- November 30, 1999
- 12:00 AM
- 1,055 views
‘Hotspots’ for DNA breakage in neurons may promote brain genetic diversity, disease
by Tom Ulrich in Vector, a Boston Children's Hospital blog
As organs go, the brain seems to harbor an abundance of somatic mutations — genetic variants that arise after conception and affect only some of our neurons. In one recent study, researchers found about 1,500 variants in each of neurons they sampled.
New research revealing the propensity of DNA to break in certain spots backs up the idea of a genetically diverse brain. Reported in Cell last month, it also suggests a new avenue for thinking about brain development, brain tumors and neuro........ Read more »
Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, & Schwer B. (2016) Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell, 164(4), 644-55. PMID: 26871630
- November 30, 1999
- 12:00 AM
- 1,176 views
The PROCAMIO Trial – IV Procainamide vs IV Amiodarone for the Acute Treatment of Stable Wide Complex Tachycardia
by Rogue Medic in Rogue Medic
This is a very interesting trial that may surprise the many outspoken amiodarone advocates, but it should not surprise anyone who pays attention to research.
ALPS showed that we should stop giving amiodarone for unwitnessed shockable cardiac arrest. The lead researcher is still trying to spin amiodarone for witnessed shockable cardiac arrest, even though the results do not show improvement in the one outcome that matters – leaving the hospital with a brain that still works.[1],[2],[3]... Read more »
Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. The New England journal of medicine, 374(18), 1711-22. PMID: 27043165
Ortiz M, Martín A, Arribas F, Coll-Vinent B, Del Arco C, Peinado R, Almendral J, & PROCAMIO Study Investigators. (2016) Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. European heart journal. PMID: 27354046
Marill KA, deSouza IS, Nishijima DK, Senecal EL, Setnik GS, Stair TO, Ruskin JN, & Ellinor PT. (2010) Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(3), 297-306. PMID: 20370763
Marill KA, deSouza IS, Nishijima DK, Stair TO, Setnik GS, & Ruskin JN. (2006) Amiodarone is poorly effective for the acute termination of ventricular tachycardia. Annals of emergency medicine, 47(3), 217-24. PMID: 16492484
Tomlinson DR, Cherian P, Betts TR, & Bashir Y. (2008) Intravenous amiodarone for the pharmacological termination of haemodynamically-tolerated sustained ventricular tachycardia: is bolus dose amiodarone an appropriate first-line treatment?. Emergency medicine journal : EMJ, 25(1), 15-8. PMID: 18156531
Kułakowski P, Karczmarewicz S, Karpiński G, Soszyńska M, & Ceremuzyński L. (2000) Effects of intravenous amiodarone on ventricular refractoriness, intraventricular conduction, and ventricular tachycardia induction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2(3), 207-15. PMID: 11227590
Bonny A, De Sisti A, Márquez MF, Megbemado R, Hidden-Lucet F, & Fontaine G. (2012) Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia. World journal of cardiology, 4(10), 296-301. PMID: 23110246
Kowey PR. (1988) The calamity of cardioversion of conscious patients. The American journal of cardiology, 61(13), 1106-7. PMID: 3364364
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